Chroman-derived anti-androgens for treatment of androgen-mediated disorders
    12.
    发明授权
    Chroman-derived anti-androgens for treatment of androgen-mediated disorders 失效
    用于治疗雄激素介导的疾病的色甘酸衍生的抗雄激素

    公开(公告)号:US07709525B2

    公开(公告)日:2010-05-04

    申请号:US10789835

    申请日:2004-02-27

    IPC分类号: A61K31/353

    CPC分类号: C07D311/72 A61K31/353

    摘要: Methods for the prevention and/or alleviation of androgen-mediated disorders treatable by administering a chroman-derived anti-androgen compound are provided by the present invention. The invention further provides pharmaceutical and nutraceutical compositions containing chroman-derived anti-androgen compounds useful in the prevention and/or alleviation of androgen-mediated disorders, particularly prostate cancer.

    摘要翻译: 通过本发明提供了通过施用苯并二氢吡喃衍生的抗雄激素化合物可治疗的雄激素介导的疾病的预防和/或缓解方法。 本发明进一步提供了含有色氨酸衍生的抗雄激素化合物的药物和营养组合物,其用于预防和/或减轻雄激素介导的病症,特别是前列腺癌。

    Chroman-Derived Anti-Androgens For Treatment of Androgen-Mediated Disorders
    13.
    发明申请
    Chroman-Derived Anti-Androgens For Treatment of Androgen-Mediated Disorders 审中-公开
    用于治疗雄激素介导性疾病的色甘酸衍生的抗雄激素

    公开(公告)号:US20100056619A1

    公开(公告)日:2010-03-04

    申请号:US12581501

    申请日:2009-10-19

    IPC分类号: A61K31/352 C12N5/02

    CPC分类号: C07D311/72 A61K31/353

    摘要: Methods for the prevention and/or alleviation of androgen-mediated disorders by administering a chroman-derived anti-androgen compound are provided by the present invention. The invention further provides pharmaceutical and nutraceutical compositions containing chroman-derived anti-androgen compounds useful in the prevention and/or alleviation of androgen-mediated disorders, particularly prostate cancer.

    摘要翻译: 通过本发明提供通过施用苯并二氢吡喃衍生的抗雄激素化合物来预防和/或缓解雄激素介导的病症的方法。 本发明进一步提供了含有色氨酸衍生的抗雄激素化合物的药物和营养组合物,其用于预防和/或减轻雄激素介导的病症,特别是前列腺癌。

    Chroman-derived compounds for the treatment of cancer
    16.
    发明授权
    Chroman-derived compounds for the treatment of cancer 有权
    用于治疗癌症的色甘酸衍生化合物

    公开(公告)号:US07863324B2

    公开(公告)日:2011-01-04

    申请号:US12129338

    申请日:2008-05-29

    IPC分类号: A61K31/353

    CPC分类号: C07D311/72 A61K31/353

    摘要: The present invention provides methods for inhibiting the growth of androgen-independent prostate cancer tumor cells in a human comprising administering to the human. The invention further provides pharmaceutical and nutraceutical compositions containing chroman-derived compounds useful in the alleviation of cancer.

    摘要翻译: 本发明提供了抑制人中雄激素依赖性前列腺癌肿瘤细胞生长的方法,包括向人施用。 本发明进一步提供含有色素衍生化合物的药物和营养组合物,其可用于缓解癌症。

    Systems and methods for applying ultrasonic energy to the thoracic cavity
    19.
    发明申请
    Systems and methods for applying ultrasonic energy to the thoracic cavity 审中-公开
    将超声能量应用于胸腔的系统和方法

    公开(公告)号:US20080195002A1

    公开(公告)日:2008-08-14

    申请号:US12082822

    申请日:2008-04-15

    IPC分类号: A61N7/00

    摘要: Systems and methods apply ultrasound energy to the thoracic cavity. The systems and methods make use of an ultrasound energy applicator comprising an ultrasound transducer carried by a housing to generate ultrasound energy at a prescribed fundamental therapeutic frequency laying within a range of fundamental therapeutic frequencies not exceeding about 500 kHz. An ultrasonic coupling region is carried by the housing. The coupling region is adapted, in use, to contact skin. The coupling region is also sized to transcutaneously conduct ultrasound energy in a diverging beam that substantially covers an entire heart. The applicator can also include an assembly worn on the thorax, which stabilizes placement of the housing on the thorax during transcutaneous conduction of ultrasound energy.

    摘要翻译: 系统和方法将超声能量应用于胸腔。 所述系统和方法利用超声能量施加器,其包括由壳体承载的超声波换能器,以在不超过约500kHz的基本治疗频率的范围内以规定的基本治疗频率产生超声波能量。 超声波耦合区由壳体承载。 联接区域在使用中适于接触皮肤。 耦合区域还具有大小以便在基本上覆盖整个心脏的发散束中经皮地传导超声波能量。 施用器还可以包括佩戴在胸部上的组件,其在超声能量的经皮传导期间稳定了壳体在胸部上的放置。