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公开(公告)号：US20200016274A1
公开(公告)日：2020-01-16
申请号：US16425693
申请日：2019-05-29
Applicant: Translate Bio, Inc.
Inventor： Shrirang Karve , Zarna Patel , Ashish Sarode , Yi Zhang , Frank DeRosa , Michael Heartlein
IPC: A61K47/64 , A61K47/54 , A61K31/7105 , C12N15/85 , A61K47/69
Abstract: The present invention provides, among other things, methods and compositions of formulating nucleic acid-containing nanoparticles for efficient delivery of payload in vivo such that the method and compositions can be used to generate mRNA vaccines.
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公开(公告)号：US11547666B2
公开(公告)日：2023-01-10
申请号：US17058334
申请日：2019-05-30
Applicant: Translate Bio, Inc.
Inventor： Yi Zhang , Shrirang Karve , Frank DeRosa , Michael Heartlein
Abstract: Disclosed are cationic lipids which are compounds of Formula I. Cationic lipids provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.
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公开(公告)号：US11357726B2
公开(公告)日：2022-06-14
申请号：US16553747
申请日：2019-08-28
Applicant: Translate Bio, Inc.
Inventor： Shrirang Karve , Zarna Patel , Yi Zhang , Ashish Sarode , Rebecca L. Goldman , Frank DeRosa , Michael Heartlein
IPC: A61K9/12 , A61K9/127 , A61K9/14 , A61K9/51 , A61K31/7105
Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing a solution of pre-formed lipid nanoparticles and mRNA at a low concentration.
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公开(公告)号：US20210213140A1
公开(公告)日：2021-07-15
申请号：US17058557
申请日：2019-05-29
Applicant: Translate Bio, Inc.
Inventor： Yi Zhang , Shrirang Karve , Frank DeRosa , Michael Heartlein
Abstract: Cationic lipids provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.
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公开(公告)号：US12280147B2
公开(公告)日：2025-04-22
申请号：US17291919
申请日：2019-11-07
Applicant: Translate Bio, Inc.
Inventor： Shrirang Karve , Yi Zhang , Frank DeRosa , Michael Heartlein
IPC: A61K9/127 , A61K9/1273 , A61K38/17 , A61K38/45 , C08G65/48
Abstract: The compounds disclosed herein (e.g., compounds having a structure according to Formula (I/(II)/(III)/(IV), and (V)) are polymers wherein an organic polymeric segment (e.g., a polyethylene glycol (PEG) group) comprises covalent attachments to two or more lipid substructures, and each lipid substructure independently comprises a hydrophobic moiety and a hydrophilic moiety. The compounds provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.
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Patent Agency Ranking
公开(公告)号：US12257305B2
公开(公告)日：2025-03-25
申请号：US17295621
申请日：2019-11-20
Applicant: Translate Bio, Inc.
Inventor： Frank DeRosa , Shrirang Karve , Yi Zhang
IPC: C07C215/24 , A61K9/1272 , A61K47/14 , A61K47/54 , C07C217/08 , C07C229/12
Abstract: The compounds disclosed herein compound of Formula (I), substructures thereof, and pharmaceutically acceptable salts thereof. The compounds provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.
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公开(公告)号：US20250025419A1
公开(公告)日：2025-01-23
申请号：US18762242
申请日：2024-07-02
Applicant: Translate Bio, Inc.
Inventor： Shrirang Karve , Zarna Patel , Yi Zhang , Ashish Sarode , Rebecca L. Goldman , Frank DeRosa , Michael Heartlein
IPC: A61K9/127 , A61K9/14 , A61K9/51 , A61K31/7105
Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing a solution of pre-formed lipid nanoparticles and mRNA at a low concentration.
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公开(公告)号：US20230050672A1
公开(公告)日：2023-02-16
申请号：US17295621
申请日：2019-11-20
Applicant: Translate Bio, Inc.
Inventor： Frank DeRosa , Shrirang Karve , Yi Zhang
IPC: A61K47/14 , C07C229/12 , C07C215/24 , C07C217/08 , A61K47/54 , A61K9/127
Abstract: The compounds disclosed herein compound of Formula (I), substructures thereof, and pharmaceutically acceptable salts thereof. The compounds provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.
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公开(公告)号：US20220323355A1
公开(公告)日：2022-10-13
申请号：US17054886
申请日：2019-05-15
Applicant: Translate Bio, Inc.
Inventor： Frank DeRosa , Shrirang Karve , Yi Zhang , Michael Heartlein
Abstract: Disclosed are cationic lipids which are compounds of Formula (I′). Cationic lipids provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.
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公开(公告)号：US20220110884A1
公开(公告)日：2022-04-14
申请号：US17450629
申请日：2021-10-12
Applicant: Translate Bio, Inc.
Inventor： Shrirang Karve , Travis Jeanotte , Monic Shah , Yi Zhang , Kimberly Gillis , Frank DeRosa
Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing an mRNA solution containing low citrate concentration and a lipid solution at an ambient temperature. Thus, the present invention provides an effective, reliable, energy-saving and cost-effective method of encapsulating mRNA into lipid nanoparticles.
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