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11.发明申请Fatty Acid Conjugates of Quetiapine, Process for Making and Using the Same 审中-公开喹硫平的脂肪酸结合物，制备和使用它的方法公开(公告)号：US20110223207A1
公开(公告)日：2011-09-15
申请号：US13043764
申请日：2011-03-09
申请人： Travis Mickle , Sven Guenther , Sanjib Bera
发明人： Travis Mickle , Sven Guenther , Sanjib Bera
IPC分类号： A61K31/554 , A61K9/00 , A61K33/00 , A61P25/18
CPC分类号： A61K45/06 , A61K9/0053 , A61K31/554 , A61K39/39 , A61K47/542 , A61K47/543 , A61P25/18 , C07D285/36 , C07D417/04 , C07D417/14
摘要： The presently described technology provides a novel class of prodrugs of quetiapine that can be synthesized by chemically conjugating fatty acids to quetiapine. Pharmaceutical compositions and methods of synthesizing conjugates of the present technology are also provided. Methods of treating patients with the compositions of the present technology are also provided.
摘要翻译： 目前描述的技术提供了可以通过将脂肪酸与喹硫平化学偶联来合成的新一类喹硫平前药。 还提供了本技术合成缀合物的药物组合物和方法。 还提供了用本技术组合物治疗患者的方法。
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公开(公告)号：US20070203055A1
公开(公告)日：2007-08-30
申请号：US11635788
申请日：2006-12-08
申请人： Travis Mickle , Suma Krishnan , James Scott Moncrief , Christopher Lauderback , Sanjib Bera , Sven Guenther , Wendy Hirschelman
发明人： Travis Mickle , Suma Krishnan , James Scott Moncrief , Christopher Lauderback , Sanjib Bera , Sven Guenther , Wendy Hirschelman
IPC分类号： A61K38/14 , A61K38/10 , A61K38/08 , A61K31/485
摘要： The invention relates to pharmaceutical compounds and compositions comprised of a chemical moiety attached to an opioid such as oxycodone in a manner that substantially decreases the potential of the opioid to cause overdose. When delivered at the proper dosage the pharmaceutical composition provides therapeutic activity similar to that of the parent active agent. Further the compounds and compositions of the invention are useful in preventing addiction and susceptibility to addiction.
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公开(公告)号：US20050176644A1
公开(公告)日：2005-08-11
申请号：US10955006
申请日：2004-09-30
申请人： Travis Mickle , Suma Krishnan , James Moncrief , Christopher Lauderback , Sanjib Bera , Sven Guenther , Wendy Hirschelman
发明人： Travis Mickle , Suma Krishnan , James Moncrief , Christopher Lauderback , Sanjib Bera , Sven Guenther , Wendy Hirschelman
摘要： The invention relates to pharmaceutical compounds and compositions comprised of a chemical moiety attached to an opioid such as oxycodone in a manner that substantially decreases the potential of the opioid to cause overdose. When delivered at the proper dosage the pharmaceutical composition provides therapeutic activity similar to that of the parent active agent. Further the compounds and compositions of the invention are useful in preventing addiction and susceptibility to addiction.
摘要翻译： 本发明涉及药物化合物和组合物，其包含与阿片样物质如羟考酮连接的化学部分，其基本上降低阿片样物质引起过量的潜力。 当以适当剂量递送时，药物组合物提供与母体活性剂类似的治疗活性。 此外，本发明的化合物和组合物可用于预防成瘾和对成瘾的易感性。
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公开(公告)号：US20110040072A1
公开(公告)日：2011-02-17
申请号：US12722495
申请日：2010-03-11
IPC分类号： C07K7/06 , C07D489/08 , C07K5/087
CPC分类号： A61K9/0043 , A61K9/0019 , A61K47/55 , A61K47/64
摘要： The invention relates to pharmaceutical compounds and compositions comprised of a chemical moiety attached to oxycodone in a manner that substantially decreases the potential for overdose. When delivered at the proper dosage the pharmaceutical composition provides therapeutic activity similar to that of oxycodone and may also provide sustained release characteristics and/or reduced side-effects. Further the compounds and compositions of the invention are useful in preventing addiction and susceptibility to addiction of oxycodone.
摘要翻译： 本发明涉及药物化合物和组合物，其包含与羟考酮连接的化学部分，其基本上降低过量的潜力。 当以适当的剂量递送时，药物组合物提供类似于羟考酮的治疗活性，并且还可以提供持续释放特征和/或减少的副作用。 此外，本发明的化合物和组合物可用于预防成瘾和对羟考酮成瘾的易感性。
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15.发明授权Phenylethanoic acid, phenylpropanoic acid and phenylpropenoic acid conjugates and prodrugs of hydrocodone, method of making and use thereof 有权苯基乙酸，苯基丙酸和苯基丙酸共轭物和氢可酮的前体药物，其制备方法和用途公开(公告)号：US08871780B2
公开(公告)日：2014-10-28
申请号：US12828456
申请日：2010-07-01
申请人： Travis Mickle , Sven Guenther , Christal Mickle , Guochen Chi , Jaroslaw Kanski , Andrea K. Martin , Bindu Bera
发明人： Travis Mickle , Sven Guenther , Christal Mickle , Guochen Chi , Jaroslaw Kanski , Andrea K. Martin , Bindu Bera
IPC分类号： A61K31/485 , A61K45/06 , A61K47/48
CPC分类号： A61K47/48038 , A61K31/44 , A61K31/485 , A61K47/542
摘要： The presently described technology provides phenylethanoic acid, phenylpropanoic acid, phenylpropenoic acid, a salt thereof, a derivative thereof or a combination thereof chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs or compositions of hydrocodone which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.
摘要翻译： 目前描述的技术提供苯基乙酸，苯基丙酸，苯基丙酸，其盐，其衍生物或其化合物与氢可酮（吗啡喃-6-酮，4,5-α-环氧-3-甲氧基-17- 甲基）以形成氢可酮的新药前体药物或组合物，其潜在滥用氢可酮的可能性降低。 本技术还提供了治疗患者的方法，药物试剂盒和本技术合成缀合物的方法。
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16.发明申请PHENYLETHANOIC ACID, PHENYLPROPANOIC ACID AND PHENYLPROPENOIC ACID CONJUGATES AND PRODRUGS OF HYDROCODONE, METHOD OF MAKING AND USE THEREOF 有权苯乙酸，苯甲酸，苯丙酸和苯并三唑酸的共聚物及其制备方法及其应用公开(公告)号：US20110002991A1
公开(公告)日：2011-01-06
申请号：US12828456
申请日：2010-07-01
申请人： Travis Mickle , Sven Guenther , Christal Mickle , Guochen Chi , Jaroslaw Kanski , Andrea K. Martin , Bindu Bera
发明人： Travis Mickle , Sven Guenther , Christal Mickle , Guochen Chi , Jaroslaw Kanski , Andrea K. Martin , Bindu Bera
IPC分类号： A61K9/28 , C07D489/04 , A61K31/485 , A61P29/00 , A61P25/36 , A61P25/30
CPC分类号： A61K47/48038 , A61K31/44 , A61K31/485 , A61K47/542
摘要： The presently described technology provides phenylethanoic acid, phenylpropanoic acid, phenylpropenoic acid, a salt thereof, a derivative thereof or a combination thereof chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs or compositions of hydrocodone which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.
摘要翻译： 目前描述的技术提供苯基乙酸，苯基丙酸，苯基丙酸，其盐，其衍生物或其化合物与氢可酮（吗啡喃-6-酮，4,5-α-环氧-3-甲氧基-17- 甲基）以形成氢可酮的新药前体药物或组合物，其潜在滥用氢可酮的可能性降低。 本技术还提供了治疗患者的方法，药物试剂盒和本技术合成缀合物的方法。
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公开(公告)号：US20080260691A1
公开(公告)日：2008-10-23
申请号：US11718311
申请日：2005-11-02
申请人： Travis Mickle , Sven Guenther
发明人： Travis Mickle , Sven Guenther
CPC分类号： C07K9/003
摘要： The present invention relates ribavirin delivery systems and more specifically to compositions that comprise amino acids, as single amino acids or peptides, covalently attached to ribavarin and methods for administering conjugated ribavirin compositions.
摘要翻译： 本发明涉及利巴韦林递送系统，更具体地涉及包含共价连接到利巴韦林的氨基酸，单个氨基酸或肽的组合物和用于施用缀合的利巴韦林组合物的方法。
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公开(公告)号：US08461137B2
公开(公告)日：2013-06-11
申请号：US12828381
申请日：2010-07-01
申请人： Travis Mickle , Sven Guenther , Christal Mickle , Guochen Chi , Jaroslaw Kanski , Andrea K. Martin , Bindu Bera
发明人： Travis Mickle , Sven Guenther , Christal Mickle , Guochen Chi , Jaroslaw Kanski , Andrea K. Martin , Bindu Bera
IPC分类号： A61K45/06 , A61K31/485 , A61K47/48038
CPC分类号： A61K47/545 , A61K9/0019 , A61K9/20 , A61K9/2054 , A61K31/167 , A61K31/485 , A61K45/06 , A61K47/542 , A61K47/55 , A61K47/556 , A61P25/30 , C07D489/02 , C07D489/04 , C07D491/08 , A61K2300/00
摘要： The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs/compositions of hydrocodone, including benzoates and heteroaryl carboxylic acids, which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.
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19.发明申请Phenylethanoic Acid, Phenylpropanoic Acid and Phenylpropenoic Acid Conjugates and Prodrugs of Hydrocodone, Methods of Making and Use Thereof 审中-公开苯乙酸，苯丙酸和苯丙酸接头物和氢可酮的前药，其制备和使用方法公开(公告)号：US20120142720A1
公开(公告)日：2012-06-07
申请号：US13378857
申请日：2010-07-01
申请人： Travis Mickle , Sven Guenther , Christal Mickle , Guochen Chi , Jaroslaw Kanski , Andrea K. Martin , Bindu Bera
发明人： Travis Mickle , Sven Guenther , Christal Mickle , Guochen Chi , Jaroslaw Kanski , Andrea K. Martin , Bindu Bera
IPC分类号： A61K31/485 , A61P25/04 , A61P25/36 , C07D489/04
CPC分类号： A61K47/48038 , A61K31/44 , A61K31/485 , A61K47/542
摘要： The presently described technology provides phenylethanoic acid, phenylpropanoic acid, phenylpropenoic acid, a salt thereof, a derivative thereof or a combination thereof chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs or compositions of hydrocodone which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.
摘要翻译： 目前描述的技术提供苯基乙酸，苯基丙酸，苯基丙酸，其盐，其衍生物或其化合物与氢可酮（吗啡喃-6-酮，4,5-α-环氧-3-甲氧基-17- 甲基）以形成氢可酮的新药前体药物或组合物，其潜在滥用氢可酮的可能性降低。 本技术还提供了治疗患者的方法，药物试剂盒和本技术合成缀合物的方法。
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20.发明申请Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof 有权苯酮，苯甲酸衍生物和氢可酮的杂芳基羧酸共轭物，前药，其制备方法和用途公开(公告)号：US20120142719A1
公开(公告)日：2012-06-07
申请号：US13378800
申请日：2010-07-01
申请人： Travis Mickle , Sven Guenther , Christal Mickle , Guochen Chi , Jaroslaw Kansi , Andrea K. Martin , Bindu Bera
发明人： Travis Mickle , Sven Guenther , Christal Mickle , Guochen Chi , Jaroslaw Kansi , Andrea K. Martin , Bindu Bera
IPC分类号： A61K31/485 , A61P25/36 , A61P25/00 , C07D489/00
CPC分类号： A61K47/545 , A61K9/0019 , A61K9/20 , A61K9/2054 , A61K31/167 , A61K31/485 , A61K45/06 , A61K47/542 , A61K47/55 , A61K47/556 , A61P25/30 , C07D489/02 , C07D489/04 , C07D491/08 , A61K2300/00
摘要： The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs/compositions of hydrocodone, including benzoates and heteroaryl carboxylic acids, which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.
摘要翻译： 目前描述的技术提供包含与氢可酮（吗啡喃-6-酮，4,5-α-环氧-3-甲氧基-17-甲基）化学偶联的芳基羧酸的组合物，以形成新的前药/氢可酮组合物，包括苯甲酸酯和杂芳基 羧酸，其潜在的潜在滥用氢可酮。 本技术还提供了治疗患者的方法，药物试剂盒和本技术合成缀合物的方法。
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