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公开(公告)号：US07169752B2
公开(公告)日：2007-01-30
申请号：US10955006
申请日：2004-09-30
申请人： Travis Mickle , Suma Krishnan , James Scott Moncrief , Christopher Lauderback , Sanjib Bera , Sven Guenther , Wendy Hirschelman
发明人： Travis Mickle , Suma Krishnan , James Scott Moncrief , Christopher Lauderback , Sanjib Bera , Sven Guenther , Wendy Hirschelman
IPC分类号： A61K38/00 , A61K38/02 , A61K38/10 , A61K38/08 , A61K38/06 , A61K38/07 , A61K38/05 , C07K5/06 , C07K2/00 , C07K7/08 , C07K7/04 , C07K5/10 , C07K5/08
摘要： The invention relates to pharmaceutical compounds and compositions comprised of a chemical moiety attached to an opioid such as oxycodone in a manner that substantially decreases the potential of the opioid to cause overdose. When delivered at the proper dosage the pharmaceutical composition provides therapeutic activity similar to that of the parent active agent. Further the compounds and compositions of the invention are useful in preventing addiction and susceptibility to addiction.
摘要翻译： 本发明涉及药物化合物和组合物，其包含与阿片样物质如羟考酮连接的化学部分，其基本上降低阿片样物质引起过量的潜力。 当以适当剂量递送时，药物组合物提供与母体活性剂类似的治疗活性。 此外，本发明的化合物和组合物可用于预防成瘾和对成瘾的易感性。
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公开(公告)号：US20190142815A1
公开(公告)日：2019-05-16
申请号：US16244460
申请日：2019-01-10
申请人： Sven Guenther , Guochen Chi , Bindu Bera , Travis Mickle , Sanjib Bera
发明人： Sven Guenther , Guochen Chi , Bindu Bera , Travis Mickle , Sanjib Bera
IPC分类号： A61K31/4458 , C07F9/59 , A61K47/64 , A61K47/54 , C07D211/34 , A61K9/00 , C07K5/062 , C07K5/02 , C07D401/12 , A61K47/60
摘要： The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof or combinations thereof.
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3.发明授权公开(公告)号：US08715699B2
公开(公告)日：2014-05-06
申请号：US13518981
申请日：2010-12-22
申请人： Travis Mickle , Sven Guenther , Sanjib Bera
发明人： Travis Mickle , Sven Guenther , Sanjib Bera
IPC分类号： A61K31/554 , A61K9/00 , A61K33/00 , C07D417/04 , A61P25/18 , A61P25/24 , A61P25/22
CPC分类号： A61K47/542 , A61K9/0053 , A61K31/553 , A61K31/554 , A61K45/06 , C07D267/18
摘要： The presently described technology provides a novel class of prodrugs of quetiapine that can be synthesized by chemically conjugating amino acids to quetiapine. The present technology also provides methods of treating patients, pharmaceutical compositions and methods of synthesizing conjugates of the present technology.
摘要翻译： 目前描述的技术提供了可以通过将氨基酸与喹硫平化学偶联来合成的新一类喹硫平前药。 本技术还提供了治疗患者的方法，药物组合物和本技术合成缀合物的方法。
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公开(公告)号：US20070066537A1
公开(公告)日：2007-03-22
申请号：US10953111
申请日：2004-09-30
申请人： Travis Mickle , Suma Krishnan , James Moncrief , Christopher Lauderback , Thomas Piccariello , Sanjib Bera , Sven Guenther , Wendy Hirschelman
发明人： Travis Mickle , Suma Krishnan , James Moncrief , Christopher Lauderback , Thomas Piccariello , Sanjib Bera , Sven Guenther , Wendy Hirschelman
CPC分类号： A61K31/485 , A61K9/0019 , A61K9/0043 , A61K47/542 , A61K47/64
摘要： The invention relates to pharmaceutical compounds and compositions comprised of a chemical moiety attached to an opioid such as oxycodone in a manner that substantially decreases the potential of the opioid to cause overdose. When delivered at the proper dosage the pharmaceutical composition provides therapeutic activity similar to that of the parent active agent. Further the compounds and compositions of the invention are useful in preventing addiction and susceptibility to addiction.
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5.发明授权Methylphenidate-oxoacid conjugates, processes of making and using the same 有权哌甲酯 - 含氧酸共轭物，制备和使用它们的方法公开(公告)号：US09079928B2
公开(公告)日：2015-07-14
申请号：US14234440
申请日：2012-07-27
申请人： Sven Guenther , Guochen Chi , Bindu Bera , Travis Mickle , Sanjib Bera
发明人： Sven Guenther , Guochen Chi , Bindu Bera , Travis Mickle , Sanjib Bera
IPC分类号： C07D211/68 , C07D211/60 , C07F9/59 , A61K47/48 , C07D211/34 , C07K5/02 , C07K5/062 , C07D401/12
CPC分类号： A61K31/4458 , A61K9/0053 , A61K47/542 , A61K47/545 , A61K47/548 , A61K47/60 , A61K47/64 , C07D211/34 , C07D401/12 , C07F9/59 , C07K5/0202 , C07K5/06026
摘要： The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof or combinations thereof.
摘要翻译： 本技术涉及用于治疗与至少一种醇，胺，含氧酸，硫醇或其衍生物缀合的哌甲酯或哌甲酯衍生物的各种疾病和/或病症的前药和组合物。 在一些实施方案中，缀合物还包括至少一个接头。 本技术还涉及与至少一种醇，胺，含氧酸，硫醇或其衍生物或其组合缀合的哌甲酯或哌甲酯衍生物的合成。
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公开(公告)号：US08106016B2
公开(公告)日：2012-01-31
申请号：US11635788
申请日：2006-12-08
申请人： James Scott Moncrief , Suma Krishnan , Travis Mickle , Christopher Lauderback , Sanjib Bera , Sven Guenther , Wendy Hirschelman
发明人： James Scott Moncrief , Suma Krishnan , Travis Mickle , Christopher Lauderback , Sanjib Bera , Sven Guenther , Wendy Hirschelman
摘要： The invention relates to pharmaceutical compounds and compositions comprised of a chemical moiety attached to an opioid such as oxycodone in a manner that substantially decreases the potential of the opioid to cause overdose. When delivered at the proper dosage the pharmaceutical composition provides therapeutic activity similar to that of the parent active agent. Further the compounds and compositions of the invention are useful in preventing addiction and susceptibility to addiction.
摘要翻译： 本发明涉及药物化合物和组合物，其包含与阿片样物质如羟考酮连接的化学部分，其基本上降低阿片样物质引起过量的潜力。 当以适当剂量递送时，药物组合物提供与母体活性剂类似的治疗活性。 此外，本发明的化合物和组合物可用于预防成瘾和对成瘾的易感性。
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7.发明申请公开(公告)号：US20130045247A1
公开(公告)日：2013-02-21
申请号：US13581496
申请日：2011-03-09
申请人： Travis Mickle , Sven Guenther , Sanjib Bera
发明人： Travis Mickle , Sven Guenther , Sanjib Bera
IPC分类号： A61K31/554 , A61P25/00 , A61K9/00 , A61P25/32 , A61K33/00 , A61K47/00 , A61P25/18 , A61P25/24
CPC分类号： A61K45/06 , A61K9/0053 , A61K31/554 , A61K39/39 , A61K47/542 , A61K47/543 , C07D285/36 , C07D417/04 , C07D417/14
摘要： The presently described technology provides a novel class of prodrugs of quetiapine that can be synthesized by chemically conjugating fatty acids to quetiapine. Pharmaceutical compositions and methods of synthesizing conjugates of the present technology are also provided. Methods of treating patients with the compositions of the present technology are also provided.
摘要翻译： 目前描述的技术提供了可以通过将脂肪酸与喹硫平化学偶联来合成的新一类喹硫平前药。 还提供了本技术合成缀合物的药物组合物和方法。 还提供了用本技术组合物治疗患者的方法。
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8.发明申请公开(公告)号：US20120276168A1
公开(公告)日：2012-11-01
申请号：US13518981
申请日：2010-12-22
申请人： Travis Mickle , Sven Guenther , Sanjib Bera
发明人： Travis Mickle , Sven Guenther , Sanjib Bera
IPC分类号： A61K31/554 , A61K33/00 , C07D417/04 , A61P25/20 , A61P25/22 , A61P25/32 , A61P25/24 , A61K9/00 , A61P25/18
CPC分类号： A61K47/542 , A61K9/0053 , A61K31/553 , A61K31/554 , A61K45/06 , C07D267/18
摘要： The presently described technology provides a novel class of prodrugs of quetiapine that can be synthesized bu chemically conjugating amino acids to quetiapine. The present technology also provides methods of treating patients, pharmaceutical compositions and methods of synthesizing conjugates of the present technology.
摘要翻译： 目前描述的技术提供了可以合成的化学结合氨基酸与喹硫平的喹硫平的新一类前药。 本技术还提供了治疗患者的方法，药物组合物和本技术合成缀合物的方法。
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9.发明申请Amino Acid Conjugates of Quetiapine, Process for Making and Using the Same 审中-公开喹硫平的氨基酸缀合物，其制备和使用的方法公开(公告)号：US20110183963A1
公开(公告)日：2011-07-28
申请号：US12976546
申请日：2010-12-22
申请人： Travis Mickle , Sven Guenther , Sanjib Bera
发明人： Travis Mickle , Sven Guenther , Sanjib Bera
IPC分类号： A61K31/554 , C07D267/02 , A61P25/18 , A61P25/32 , A61P25/24 , A61P25/00 , A61P25/20
CPC分类号： A61K47/542 , A61K9/0053 , A61K31/553 , A61K31/554 , A61K45/06 , C07D267/18
摘要： The presently described technology provides a novel class of prodrugs of quetiapine that can be synthesized by chemically conjugating amino acids to quetiapine. The present technology also provides methods of treating patients, pharmaceutical compositions and methods of synthesizing conjugates of the present technology.
摘要翻译： 目前描述的技术提供了可以通过将氨基酸与喹硫平化学偶联来合成的新一类喹硫平前药。 本技术还提供了治疗患者的方法，药物组合物和本技术合成缀合物的方法。
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10.发明授权公开(公告)号：US08900604B2
公开(公告)日：2014-12-02
申请号：US13581496
申请日：2011-03-09
申请人： Travis Mickle , Sven Guenther , Sanjib Bera
发明人： Travis Mickle , Sven Guenther , Sanjib Bera
IPC分类号： A61K31/554 , A61K33/00 , A61K47/00 , A61K9/00 , A61P25/00 , A61P25/18 , A61P25/24 , A61P25/32 , A61K47/48 , C07D417/04
CPC分类号： A61K45/06 , A61K9/0053 , A61K31/554 , A61K39/39 , A61K47/542 , A61K47/543 , C07D285/36 , C07D417/04 , C07D417/14
摘要： The presently described technology provides a novel class of prodrugs of quetiapine that can be synthesized by chemically conjugating fatty acids to quetiapine. Pharmaceutical compositions and methods of synthesizing conjugates of the present technology are also provided. Methods of treating patients with the compositions of the present technology are also provided.
摘要翻译： 目前描述的技术提供了可以通过将脂肪酸与喹硫平化学偶联来合成的新一类喹硫平前药。 还提供了本技术合成缀合物的药物组合物和方法。 还提供了用本技术组合物治疗患者的方法。
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