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公开(公告)号：US2771475A
公开(公告)日：1956-11-20
申请号：US47605754
申请日：1954-12-17
Applicant: UPJOHN CO
Inventor： HOGG JOHN A , BEAL PHILIP F , NATHAN ALAN H , LINCOLN JR FRANK H
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公开(公告)号：US2707184A
公开(公告)日：1955-04-26
申请号：US34567653
申请日：1953-03-30
Applicant: UPJOHN CO
Inventor： HOGG JOHN A , BEAL PHILIP F , LINCOLN JR FRANK H
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13.发明授权Process for making prostaglandins and compounds related to prostaglandins 失效制备PROSTAGLANDINS和化合物与PROSTAGLANDINS相关的方法
公开(公告)号：US3679705A
公开(公告)日：1972-07-25
申请号：US3679705D
申请日：1970-04-06
Applicant: UPJOHN CO
Inventor： BABCOCK JOHN C , BEAL PHILIP F
IPC: C07C405/00 , C07D319/06 , C07D15/00
CPC classification number: C07C405/00 , C07D319/06
Abstract: The preparation of compounds of the following formulas is disclosed:
In these formulas, R is alkyl, W is hydrogen, alkyl, haloalkyl, phenyl, or phenyl substituted with halo, nitro, or carbomethoxy, X is hydrogen or methyl, Y'' is hydrogen or carboxyacyl, Z is hydrogen or alkyl, and n is zero, one, or two. These compounds are used as intermediates to make prostaglandins of the dihydroPGF1 -type.Abstract translation: 公开了下列化学式的化合物的制备：
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公开(公告)号：US3583979A
公开(公告)日：1971-06-08
申请号：US3583979D
申请日：1969-05-06
Applicant: UPJOHN CO
Inventor： LORENTZ WILLIAM D , BEAL PHILIP F , PARIKH JEKISHAN R
IPC: C07D295/30 , C07D41/04
CPC classification number: C07D295/30
Abstract: THIS INVENTION RELATES TO A NOVEL PROCESS FOR THE PREPARATION OF N-AMINOHEXAMETHYLENEIMINE OF THE FORMULA
1-NH2-HEXAHYDROAZEPINE
WHICH COMPRISES HEATING N-NITROSOHEXAMETHYLENEIMINE OF THE FORMULA
1-(O=N-)-HEXAHYDROAZEPINE
IN A LOWER-ALKANOL-WATER CONTAINING A BASE AND AN ALKALI METAL HYDROSULFITE. N-AMINOHEXAMETHYLENEIMINE (I) IS A MAJOR REACTANT IN THE SYNTHESIS OF 1-(HEXAHYDRO-1HAZEPIN - 1 - YL) - 3 - (P-TOLYSULFONYL) UREA, THE ORAL ANTIDIABETIC DRUG TOLAZAMIDE.-
公开(公告)号：US3524867A
公开(公告)日：1970-08-18
申请号：US3524867D
申请日：1969-03-20
Applicant: UPJOHN CO
Inventor： BEAL PHILIP F , LINCOLN FRANK H JR , PIKE JOHN E
IPC: C07C405/00 , C07D311/94 , C07D7/24
CPC classification number: C07C405/00 , C07D311/94
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Patent Agency Ranking
公开(公告)号：US3505387A
公开(公告)日：1970-04-07
申请号：US3505387D
申请日：1966-04-11
Applicant: UPJOHN CO
Inventor： BEAL PHILIP F , LINCOLN FRANK H JR , BABCOCK JOHN C
CPC classification number: C07C405/00
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17.发明授权14alpha,15alpha-ketonides of alkyl 3-oxygenated-14alpha,15alpha-dihydroxy -4,17(20)-cis-pregnadien-21-oates,derivatives thereof,and intermediates and processes therefor 失效14ALPHA，烷基3-氧化-14ALPHA，15ALPHA-二羟基-4,17（20）-CIS-孕酮-2-甲酸酯，其衍生物及其中间体及其过程的15ALPHA-酮
公开(公告)号：US3502659A
公开(公告)日：1970-03-24
申请号：US3502659D
申请日：1967-04-03
Applicant: UPJOHN CO
Inventor： BEAL PHILIP F , JACKSON ROBERT W
IPC: A61K31/573 , A61K31/58 , C07C173/00 , C07C169/00
CPC classification number: A61K31/573 , A61K31/58 , Y10S435/933
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公开(公告)号：US3435053A
公开(公告)日：1969-03-25
申请号：US3435053D
申请日：1966-06-06
Applicant: UPJOHN CO
Inventor： BEAL PHILIP F , LINCOLN FRANK H JR , PIKE JOHN E
IPC: C07C405/00 , C07D311/94 , C07D317/06 , C07D7/18 , A61K27/00
CPC classification number: C07C45/62 , C07C45/69 , C07C405/00 , C07D311/94 , C07D317/06 , C07F9/5352 , C07C49/443 , C07C49/633
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19.发明授权15alpha-methyl-15beta-hydroxy analogues of 9alpha fluoro cortisone and hydrocortisoneand their delta derivatives 失效9α氟可的松和氢化可的松及其δ衍生物的15α-甲基-15β-羟基类似物
公开(公告)号：US3053864A
公开(公告)日：1962-09-11
申请号：US1056860
申请日：1960-02-24
Applicant: UPJOHN CO
Inventor： BEAL PHILIP F , FRED KAGAN
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公开(公告)号：US2813111A
公开(公告)日：1957-11-12
申请号：US59036856
申请日：1956-06-11
Applicant: UPJOHN CO
Inventor： HOGG JOHN A , BEAL PHILIP F , LINCOLN JR FRANK H
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