公开(公告)号：US20170362254A1

公开(公告)日：2017-12-21

申请号：US15532413

申请日：2015-12-03

申请人： BioVentures, LLC

发明人： Venumadhav Janganati ,  Peter Crooks ,  Narsimha Reddy Penthala ,  Craig Jordan ,  Shobanbabu Bommagani ,  Jessica Ponder

IPC分类号： C07D519/00 ,  C07F7/18

CPC分类号： C07D519/00 ,  C07F7/1804

摘要： The present disclosure provides dimers of melampomagnolide B (MMB), including carbamate, carbonate, succinic amide, ester and carboxamide dimers of MMB. These derivatives are useful for treating cancer in humans, in particular in treating leukemia, including acute myelogenous leukemia (AML). A compound comprising Formula (1) wherein: Z is independently selected from the group consisting of CH2, O, C(O), and CH, wherein when Z is CH, Z is connected to Y via a double bond and Y is N.

公开(公告)号：US10118935B2

公开(公告)日：2018-11-06

申请号：US15957524

申请日：2018-04-19

申请人： BioVentures, LLC ,  The Regents of the University of Colorado, A Body Corporate

发明人： Venumadhav Janganati ,  Peter Crooks ,  Narsimha Reddy Penthala ,  Craig Jordan ,  Shobanbabu Bommagani ,  Jessica Ponder

IPC分类号： C07D519/00 ,  C07F7/18

摘要： The present disclosure provides dimers of melampomagnolide B (MMB), including carbamate, carbonate, succinic amide, ester and carboxamide dimers of MMB. These derivatives are useful for treating cancer in humans, in particular in treating leukemia, including acute myelogenous leukemia (AML).

公开(公告)号：US20180237458A1

公开(公告)日：2018-08-23

申请号：US15957524

申请日：2018-04-19

申请人： BioVentures, LLC ,  The Regents of the University of Colorado, A Body Corporate

发明人： Venumadhav Janganati ,  Peter Crooks ,  Narsimha Reddy Penthala ,  Craig Jordan ,  Shobanbabu Bommagani ,  Jessica Ponder

IPC分类号： C07D519/00 ,  C07F7/18

CPC分类号： C07D519/00 ,  C07F7/1804

摘要： The present disclosure provides dimers of melampomagnolide B (MMB), including carbamate, carbonate, succinic amide, ester and carboxamide dimers of MMB. These derivatives are useful for treating cancer in humans, in particular in treating leukemia, including acute myelogenous leukemia (AML).

公开(公告)号：US09981990B2

公开(公告)日：2018-05-29

申请号：US15532413

申请日：2015-12-03

申请人： BioVentures, LLC

发明人： Venumadhav Janganati ,  Peter Crooks ,  Narsimha Reddy Penthala ,  Craig Jordan ,  Shobanbabu Bommagani ,  Jessica Ponder

IPC分类号： C07D519/00 ,  C07F7/18

CPC分类号： C07D519/00 ,  C07F7/1804

摘要： The present disclosure provides dimers of melampomagnolide B (MMB), including carbamate, carbonate, succinic amide, ester and carboxamide dimers of MMB. These derivatives are useful for treating cancer in humans, in particular in treating leukemia, including acute myelogenous leukemia (AML). A compound comprising Formula (1) wherein: Z is independently selected from the group consisting of CH2, O, C(O), and CH, wherein when Z is CH, Z is connected to Y via a double bond and Y is N.

公开(公告)号：US20180118710A1

公开(公告)日：2018-05-03

申请号：US15849150

申请日：2017-12-20

申请人： BioVentures, LLC

发明人： Narsimha Reddy Penthala ,  Peter Crooks ,  Vijayakumar Sonar

IPC分类号： C07D333/60 ,  C07D307/79 ,  C07D277/64 ,  C07D215/14 ,  C07D209/18 ,  C07D307/80

CPC分类号： C07D333/60 ,  C07D209/18 ,  C07D215/14 ,  C07D277/64 ,  C07D307/79 ,  C07D307/80

摘要： The present invention relates novel heterocyclic analogs of combretastatin, their synthesis, and their use as anti-cancer compounds. In particular, compounds of Formula (I), Formula (II), and Formula (V) are provided.