公开(公告)号：US11814623B2

公开(公告)日：2023-11-14

申请号：US16231129

申请日：2018-12-21

Applicant: University of Massachusetts

Inventor： Louis M. Messina

IPC: C12N15/113 ,  A61K35/28 ,  A61K31/19 ,  A61P17/02 ,  A61K31/7052

CPC classification number: C12N15/1137 ,  A61K31/19 ,  A61K31/7052 ,  A61K35/28 ,  A61P17/02 ,  C12Y106/03001 ,  C12Y201/01037 ,  C12N2310/11 ,  C12N2310/122 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2320/31

Abstract: Methods of treating wounds in a subject using one or both of a DNA methyltransferase 1 (DNMT1) inhibitor or a nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2) inhibitor, and compositions for use in these methods.

公开(公告)号：US11459568B2

公开(公告)日：2022-10-04

申请号：US16332588

申请日：2017-10-31

Applicant: University of Massachusetts

Inventor： Louis M. Messina ,  Guodong Tie

IPC: C07H21/02 ,  C07H21/04 ,  C12N15/113 ,  A61K35/28 ,  A61K45/06

Abstract: Methods and compositions for treating cancer, e.g., colorectal cancer, using a miR-101-3p inhibitor.

公开(公告)号：US20190233828A1

公开(公告)日：2019-08-01

申请号：US16231129

申请日：2018-12-21

Applicant: University of Massachusetts

Inventor： Louis M. Messina

IPC: C12N15/113 ,  A61K35/28 ,  A61K31/19 ,  A61P17/02

CPC classification number: C12N15/1137 ,  A61K31/19 ,  A61K35/28 ,  A61P17/02 ,  C12N2310/11 ,  C12N2310/122 ,  C12N2310/14 ,  C12N2320/31

Abstract: Methods of treating wounds in a subject using one or both of a DNA methyltransferase 1 (DNMT1) inhibitor or a nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2) inhibitor, and compositions for use in these methods.

公开(公告)号：US10034901B2

公开(公告)日：2018-07-31

申请号：US15004132

申请日：2016-01-22

Applicant: University of Massachusetts

Inventor： Louis M. Messina ,  Guodong Tie

IPC: A01N63/00 ,  A61K48/00 ,  A61K35/17 ,  C12N5/0783 ,  A61K35/12

CPC classification number: A61K35/17 ,  A61K2035/124 ,  A61P35/00 ,  C12N5/0646 ,  C12N2501/65 ,  C12N2501/70 ,  C12N2501/998 ,  C12N2510/00

Abstract: Methods of providing populations of NKT and/or γδ T cells, and their use, e.g., in therapies such as cancer immunotherapy.