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公开(公告)号：US20170368099A1
公开(公告)日：2017-12-28
申请号：US15538690
申请日：2016-01-22
Applicant: University of Massachusetts
Inventor： Louis M. Messina , Guodong Tie
IPC: A61K35/17 , C12N5/0783 , A61K35/12
CPC classification number: A61K35/17 , A61K2035/124 , A61P35/00 , C12N5/0646 , C12N2501/65 , C12N2501/70 , C12N2501/998 , C12N2510/00
Abstract: Methods of providing populations of NKT and/or γδ T cells, and their use, e.g., in therapies such as cancer immunotherapy.
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公开(公告)号：US09579321B2
公开(公告)日：2017-02-28
申请号：US14535690
申请日：2014-11-07
Applicant: University of Massachusetts
Inventor： Louis M. Messina
IPC: A61K31/00 , A61K31/34 , A61K31/495 , C12P13/10 , A61K31/519 , A61K31/198 , A61K31/375 , A61K45/06 , A61K48/00 , A61K35/13
CPC classification number: A61K31/519 , A61K31/198 , A61K31/375 , A61K31/495 , A61K35/13 , A61K45/06 , A61K48/005 , C12N2799/022 , C12P13/10 , A61K2300/00
Abstract: The invention relates to therapeutic applications for compositions that reduce the level of oxidative stress on cells in vivo or in vitro. The invention describes methods for improving the therapeutic properties of stem cells. The invention also provides combination therapies that are useful to balance the oxidative microenvironment of cells in vivo or in vitro.
Abstract translation: 本发明涉及用于降低体内或体外细胞氧化应激水平的组合物的治疗应用。 本发明描述了改善干细胞治疗性质的方法。 本发明还提供了用于平衡体内或体外细胞的氧化微环境的组合疗法。
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公开(公告)号：US20210277402A1
公开(公告)日：2021-09-09
申请号：US16332588
申请日：2017-10-31
Applicant: University of Massachusetts
Inventor： Louis M. Messina , Guodong Tie
IPC: C12N15/113 , A61K35/28 , A61K45/06
Abstract: Methods and compositions for treating cancer, e.g., colorectal cancer, using a miR-101-3p inhibitor.
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公开(公告)号：US11090305B2
公开(公告)日：2021-08-17
申请号：US16374369
申请日：2019-04-03
Applicant: University of Massachusetts
Inventor： Louis M. Messina
IPC: A61K31/00 , A61K31/34 , A61K31/495 , C12P13/10 , A61K31/519 , A61K31/198 , A61K31/375 , A61K45/06 , A61K48/00 , A61K35/13
Abstract: The invention relates to therapeutic applications for compositions that reduce the level of oxidative stress on cells in vivo or in vitro. The invention describes methods for improving the therapeutic properties of stem cells. The invention also provides combination therapies that are useful to balance the oxidative microenvironment of cells in vivo or in vitro.
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公开(公告)号：US20200316123A1
公开(公告)日：2020-10-08
申请号：US16809166
申请日：2020-03-04
Applicant: University of Massachusetts
Inventor： Louis M. Messina , Guodong Tie
IPC: A61K35/17 , C12N5/0783 , A61P35/00
Abstract: Methods of providing populations of NKT and/or γδ T cells, and their use, e.g., in therapies such as cancer immunotherapy.
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Patent Agency Ranking
公开(公告)号：US20190275047A1
公开(公告)日：2019-09-12
申请号：US16374369
申请日：2019-04-03
Applicant: University of Massachusetts
Inventor： Louis M. Messina
IPC: A61K31/519 , A61K31/375 , A61K31/198 , A61K45/06 , A61K48/00
Abstract: The invention relates to therapeutic applications for compositions that reduce the level of oxidative stress on cells in vivo or in vitro. The invention describes methods for improving the therapeutic properties of stem cells. The invention also provides combination therapies that are useful to balance the oxidative microenvironment of cells in vivo or in vitro.
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公开(公告)号：US10251887B2
公开(公告)日：2019-04-09
申请号：US15438244
申请日：2017-02-21
Applicant: University of Massachusetts
Inventor： Louis M. Messina
IPC: A61K31/00 , A61K31/34 , A61K31/495 , C12P13/10 , A61K31/519 , A61K31/198 , A61K31/375 , A61K45/06 , A61K48/00 , A61K35/13
Abstract: The invention relates to therapeutic applications for compositions that reduce the level of oxidative stress on cells in vivo or in vitro. The invention describes methods for improving the therapeutic properties of stem cells. The invention also provides combination therapies that are useful to balance the oxidative microenvironment of cells in vivo or in vitro.
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公开(公告)号：US20170258796A1
公开(公告)日：2017-09-14
申请号：US15438244
申请日：2017-02-21
Applicant: University of Massachusetts
Inventor： Louis M. Messina
IPC: A61K31/519 , A61K31/375 , A61K31/198
CPC classification number: A61K31/519 , A61K31/198 , A61K31/375 , A61K31/495 , A61K35/13 , A61K45/06 , A61K48/005 , A61K2300/00 , C12N2799/022 , C12P13/10
Abstract: The invention relates to therapeutic applications for compositions that reduce the level of oxidative stress on cells in vivo or in vitro. The invention describes methods for improving the therapeutic properties of stem cells. The invention also provides combination therapies that are useful to balance the oxidative microenvironment of cells in vivo or in vitro.
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公开(公告)号：US20160213715A1
公开(公告)日：2016-07-28
申请号：US15004132
申请日：2016-01-22
Applicant: University of Massachusetts
Inventor： Louis M. Messina , Guodong Tie
IPC: A61K35/17 , C12N5/0783 , C12N15/85
CPC classification number: A61K35/17 , A61K2035/124 , A61P35/00 , C12N5/0646 , C12N2501/65 , C12N2501/70 , C12N2501/998 , C12N2510/00
Abstract: Methods of providing populations of NKT and/or γδ T cells, and their use, e.g., in therapies such as cancer immunotherapy.
Abstract translation: 提供NKT和/或γδT细胞群体的方法及其用途，例如在诸如癌症免疫疗法的治疗中。
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公开(公告)号：US20150065514A1
公开(公告)日：2015-03-05
申请号：US14535690
申请日：2014-11-07
Applicant: University of Massachusetts
Inventor： Louis M. Messina
IPC: A61K31/519 , A61K31/375 , A61K31/198
CPC classification number: A61K31/519 , A61K31/198 , A61K31/375 , A61K31/495 , A61K35/13 , A61K45/06 , A61K48/005 , C12N2799/022 , C12P13/10 , A61K2300/00
Abstract: The invention relates to therapeutic applications for compositions that reduce the level of oxidative stress on cells in vivo or in vitro. The invention describes methods for improving the therapeutic properties of stem cells. The invention also provides combination therapies that are useful to balance the oxidative microenvironment of cells in vivo or in vitro.
Abstract translation: 本发明涉及用于降低体内或体外细胞氧化应激水平的组合物的治疗应用。 本发明描述了改善干细胞治疗性质的方法。 本发明还提供了用于平衡体内或体外细胞的氧化微环境的组合疗法。
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