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11.发明申请公开(公告)号：US20100063300A1
公开(公告)日：2010-03-11
申请号：US12490190
申请日：2009-06-23
申请人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, JR. , Jagadeesh Mavinahalli , Roger Sheldon
发明人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, JR. , Jagadeesh Mavinahalli , Roger Sheldon
IPC分类号： C07D209/52
CPC分类号： C07D403/04 , C07D209/02 , C07D403/12 , C07D487/04 , C12P13/24 , C12P17/10 , C12P17/188 , C12Y104/03004
摘要： The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M′, and R5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.
摘要翻译： 本公开提供了基本上对映体纯的以下结构式的杂双环化合物，其中A，M，M'和R 5如本文所述，以及其制备的生物催化方法，以及用于这些方法的酶。
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12.发明申请Biocatalytic Processes for the Preparation of Stereomerically Pure Fused Bicyclic Proline Compounds 有权用于制备立体异构纯双环脯氨酸化合物的生物催化方法公开(公告)号：US20120244581A1
公开(公告)日：2012-09-27
申请号：US13436506
申请日：2012-03-30
申请人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, JR. , Jagadeesh Mavinahalli , Roger Sheldon
发明人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, JR. , Jagadeesh Mavinahalli , Roger Sheldon
IPC分类号： C12P17/10
CPC分类号： C07D403/04 , C07D209/02 , C07D403/12 , C07D487/04 , C12P13/24 , C12P17/10 , C12P17/188 , C12Y104/03004
摘要： The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M′, and R5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.
摘要翻译： 本公开提供了基本上对映体纯的以下结构式的杂双环化合物，其中A，M，M'和R 5如本文所述，以及其制备的生物催化方法，以及用于这些方法的酶。
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13.发明申请Stereomerically Pure Fused Bicyclic Proline Compounds Useful for Preparing Hepatitis C Protease Inhibitors 有权用于制备丙型肝炎蛋白酶抑制剂的独立纯纯双环脯氨酸化合物公开(公告)号：US20120130087A1
公开(公告)日：2012-05-24
申请号：US13294930
申请日：2011-11-11
申请人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, JR. , Jagadeesh Mavinahalli , Roger Sheldon
发明人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, JR. , Jagadeesh Mavinahalli , Roger Sheldon
IPC分类号： C07D209/52 , C07D487/14
CPC分类号： C07D403/04 , C07D209/02 , C07D403/12 , C07D487/04 , C12P13/24 , C12P17/10 , C12P17/188 , C12Y104/03004
摘要： The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M′, and R5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.
摘要翻译： 本公开提供了基本上对映体纯的以下结构式的杂双环化合物，其中A，M，M'和R 5如本文所述，以及其制备的生物催化方法，以及用于这些方法的酶。
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14.发明申请Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives 有权用于生产4-取代的3-羟基丁酸衍生物的酶法公开(公告)号：US20070161094A1
公开(公告)日：2007-07-12
申请号：US11502745
申请日：2006-08-10
申请人： S. Davis , John Grate , David Gray , John Gruber , Gjalt Huisman , Steven Ma , Lisa Newman , Roger Sheldon , Li A. Wang
发明人： S. Davis , John Grate , David Gray , John Gruber , Gjalt Huisman , Steven Ma , Lisa Newman , Roger Sheldon , Li A. Wang
IPC分类号： C12P13/00
CPC分类号： C12P13/002 , C12N9/14 , C12P7/62 , C12P13/02
摘要： The present invention provides methods and compositions for preparing 4-substituted 3-hydroxybutyric acid derivatives by halohydrin dehalogenase-catalyzed conversion of 4-halo-3-hydroxybutyric acid derivatives. The present invention further provides methods and compositions for preparing 4-halo-3-hydroxybutyric acid derivatives by ketoreductase-catalyzed conversion of 4-halo-3-ketobutyric acid derivatives The present invention also provides methods and compositions for preparing vicinal cyano, hydroxyl substituted carboxylic acid esters.
摘要翻译： 本发明提供了通过卤代醇脱卤酶催化的4-卤代-3-羟基丁酸衍生物的转化来制备4-取代的3-羟基丁酸衍生物的方法和组合物。 本发明还提供了通过酮还原酶催化转化4-卤代-3-酮丁酸衍生物来制备4-卤代-3-羟基丁酸衍生物的方法和组合物。本发明还提供了用于制备邻位氰基，羟基取代的羧酸的方法和组合物 酸酯。
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15.发明授权Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives 有权用于生产4-取代的3-羟基丁酸衍生物的酶法公开(公告)号：US07125693B2
公开(公告)日：2006-10-24
申请号：US10639159
申请日：2003-08-11
申请人： S. Christopher Davis , John H. Grate , David R. Gray , John M. Gruber , Gjalt W. Huisman , Steven K. Ma , Lisa M. Newman , Roger Sheldon , Li A Wang
发明人： S. Christopher Davis , John H. Grate , David R. Gray , John M. Gruber , Gjalt W. Huisman , Steven K. Ma , Lisa M. Newman , Roger Sheldon , Li A Wang
IPC分类号： C12P13/00
CPC分类号： C12P13/002 , C12N9/14 , C12P13/02
摘要： The present invention provides methods and compositions for preparing 4-substituted 3-hydroxybutyric acid derivatives by halohydrin dehalogenase-catalyzed conversion of 4-halo-3-hydroxybutyric acid derivatives. The present invention further provides methods and compositions for preparing 4-halo-3-hydroxybutyric acid derivatives by ketoreductase-catalyzed conversion of 4-halo-3-ketobutyric acid derivatives.
摘要翻译： 本发明提供了通过卤代醇脱卤酶催化的4-卤代-3-羟基丁酸衍生物的转化来制备4-取代的3-羟基丁酸衍生物的方法和组合物。 本发明还提供了通过酮还原酶催化转化4-卤代-3-酮丁酸衍生物制备4-卤代-3-羟基丁酸衍生物的方法和组合物。
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16.发明申请Substantially Stereomerically Pure Fused Bicyclic Proline Compounds and Processes for Preparing Boceprevir 审中-公开基本上独立的纯熔融双环脯氨酸化合物和制备波普瑞韦的方法公开(公告)号：US20120289709A1
公开(公告)日：2012-11-15
申请号：US13465735
申请日：2012-05-07
申请人： James Lalonde , Tao Li , Jack Liang , Benjamin Mijts , Roger Sheldon , George S.K. Wong , Aleksey Zaks
发明人： James Lalonde , Tao Li , Jack Liang , Benjamin Mijts , Roger Sheldon , George S.K. Wong , Aleksey Zaks
IPC分类号： C07D209/52
CPC分类号： C07D403/04 , C07D209/02 , C07D403/12 , C07D487/04 , C12P13/24 , C12P17/10 , C12P17/188 , C12Y104/03004
摘要： The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M′, and R5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.
摘要翻译： 本公开提供了基本上对映体纯的以下结构式的杂双环化合物，其中A，M，M'和R 5如本文所述，以及其制备的生物催化方法，以及用于这些方法的酶。
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17.发明授权Biocatalytic processes for the preparation of substantially stereomerically pure fused bicyclic proline compounds 有权用于制备基本上立体异构纯的稠合双环脯氨酸化合物的生物催化方法公开(公告)号：US08178333B2
公开(公告)日：2012-05-15
申请号：US12490190
申请日：2009-06-23
申请人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, Jr. , Jagadeesh Mavinahalli , Roger Sheldon
发明人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, Jr. , Jagadeesh Mavinahalli , Roger Sheldon
CPC分类号： C07D403/04 , C07D209/02 , C07D403/12 , C07D487/04 , C12P13/24 , C12P17/10 , C12P17/188 , C12Y104/03004
摘要： The present disclosure provides monoamine oxidase enzymes and methods of their use in biocatalytic processes for the preparation of substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M′, and R5 are as described herein.
摘要翻译： 本公开内容提供单胺氧化酶及其在生物催化方法中用于制备基本上对映异构体纯的以下结构式的杂双环化合物的方法，其中A，M，M'和R 5如本文所述。
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18.发明授权Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives and vicinal cyano, hydroxy substituted carboxylic acid esters 有权用于生产4-取代的3-羟基丁酸衍生物和连位氰基羟基取代的羧酸酯的酶法公开(公告)号：US07132267B2
公开(公告)日：2006-11-07
申请号：US10782258
申请日：2004-02-18
申请人： S. Christopher Davis , John H. Grate , David R. Gray , John M. Gruber , Gjalt W. Huisman , Steven K. Ma , Lisa M. Newman , Roger Sheldon , Li A Wang
发明人： S. Christopher Davis , John H. Grate , David R. Gray , John M. Gruber , Gjalt W. Huisman , Steven K. Ma , Lisa M. Newman , Roger Sheldon , Li A Wang
IPC分类号： C12P13/00
CPC分类号： C12P13/002 , C12N9/14 , C12P7/62 , C12P13/02
摘要： The present invention provides methods and compositions for preparing 4-substituted 3-hydroxybutyric acid derivatives by halohydrin dehalogenase-catalyzed conversion of 4-halo-3-hydroxybutyric acid derivatives. The present invention further provides methods and compositions for preparing 4-halo-3-hydroxybutyric acid derivatives by ketoreductase-catalyzed conversion of 4-halo-3-ketobutyric acid derivatives The present invention also provides methods and compositions for preparing vicinal cyano, hydroxyl substituted carboxylic acid esters.
摘要翻译： 本发明提供了通过卤代醇脱卤酶催化的4-卤代-3-羟基丁酸衍生物的转化来制备4-取代的3-羟基丁酸衍生物的方法和组合物。 本发明还提供了通过酮还原酶催化转化4-卤代-3-酮丁酸衍生物来制备4-卤代-3-羟基丁酸衍生物的方法和组合物。本发明还提供了用于制备邻位氰基，羟基取代的羧酸的方法和组合物 酸酯。
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