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公开(公告)号：US08778652B2
公开(公告)日：2014-07-15
申请号：US13530311
申请日：2012-06-22
IPC分类号： C12N9/90
摘要： The present invention provides recombinant nucleic acid constructs comprising a xylose isomerase polynucleotide, a recombinant fungal host cell comprising a recombinant xylose isomerase polynucleotide, and related methods.
摘要翻译： 本发明提供包含木糖异构酶多核苷酸的重组核酸构建体，包含重组木糖异构酶多核苷酸的重组真菌宿主细胞和相关方法。
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2.发明申请公开(公告)号：US20130040364A1
公开(公告)日：2013-02-14
申请号：US13571248
申请日：2012-08-09
申请人： Lorraine Joan Giver , Lisa Marie Newman , Emily Mundorff , Gjalt W. Huisman , Stephane J. Jenne , Jun Zhu , Behnaz Behrouzian , John H. Grate , James Lalonde
发明人： Lorraine Joan Giver , Lisa Marie Newman , Emily Mundorff , Gjalt W. Huisman , Stephane J. Jenne , Jun Zhu , Behnaz Behrouzian , John H. Grate , James Lalonde
CPC分类号： C12P13/002 , C07C253/30 , C12N9/0008 , C12P7/42 , C12P7/62 , C07C255/20
摘要： The present disclosure provides ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, method of using the engineered ketoreductase enzymes to synthesize a variety of chirally pure compounds, and the chirally pure compounds prepared therewith.
摘要翻译： 本公开提供与天然存在的野生型酮还原酶相比具有改善的性质的酮还原酶。 还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，使用工程化酮还原酶合成各种手性纯化合物的方法，以及用其制备的手性纯化合物。
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3.发明授权Engineered ketoreductases and methods for producing stereoisomerically pure statins 有权工程化的酮还原酶和立体异构体纯的他汀类药物的制备方法公开(公告)号：US08273547B2
公开(公告)日：2012-09-25
申请号：US12978022
申请日：2010-12-23
申请人： Lorraine Joan Giver , Lisa Marie Newman , Emily Mundorff , Gjalt W. Huisman , Stephane J. Jenne , Jun Zhu , Behnaz Behrouzian , John H. Grate , James Lalonde
发明人： Lorraine Joan Giver , Lisa Marie Newman , Emily Mundorff , Gjalt W. Huisman , Stephane J. Jenne , Jun Zhu , Behnaz Behrouzian , John H. Grate , James Lalonde
CPC分类号： C12P13/002 , C07C253/30 , C12N9/0008 , C12P7/42 , C12P7/62 , C07C255/20
摘要： The present disclosure provides ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, method of using the engineered ketoreductase enzymes to synthesize a variety of chirally pure compounds, and the chirally pure compounds prepared therewith.
摘要翻译： 本公开提供与天然存在的野生型酮还原酶相比具有改善的性质的酮还原酶。 还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，使用工程化酮还原酶合成各种手性纯化合物的方法，以及用其制备的手性纯化合物。
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4.发明申请Compositions and Methods for Producing Stereoisomerically Pure Statins and Synthetic Intermediates Therefor 有权用于制备立体异构体纯他汀及其合成中间体的组合物和方法公开(公告)号：US20110195465A1
公开(公告)日：2011-08-11
申请号：US12978022
申请日：2010-12-23
申请人： Lorraine Joan Giver , Lisa Marie Newman , Emily Mundorff , Gjalt W. Huisman , Stephane J. Jenne , Jun Zhu , Behnaz Behrouzian , John H. Grate , James Lalonde
发明人： Lorraine Joan Giver , Lisa Marie Newman , Emily Mundorff , Gjalt W. Huisman , Stephane J. Jenne , Jun Zhu , Behnaz Behrouzian , John H. Grate , James Lalonde
CPC分类号： C12P13/002 , C07C253/30 , C12N9/0008 , C12P7/42 , C12P7/62 , C07C255/20
摘要： The present disclosure provides ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, method of using the engineered ketoreductase enzymes to synthesize a variety of chirally pure compounds, and the chirally pure compounds prepared therewith.
摘要翻译： 本公开提供与天然存在的野生型酮还原酶相比具有改善的性质的酮还原酶。 还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，使用工程化酮还原酶合成各种手性纯化合物的方法，以及用其制备的手性纯化合物。
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5.发明授权Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives and vicinal cyano, hydroxy substituted carboxylic acid esters 有权用于生产4-取代的3-羟基丁酸衍生物和连位氰基羟基取代的羧酸酯的酶法公开(公告)号：US07132267B2
公开(公告)日：2006-11-07
申请号：US10782258
申请日：2004-02-18
申请人： S. Christopher Davis , John H. Grate , David R. Gray , John M. Gruber , Gjalt W. Huisman , Steven K. Ma , Lisa M. Newman , Roger Sheldon , Li A Wang
发明人： S. Christopher Davis , John H. Grate , David R. Gray , John M. Gruber , Gjalt W. Huisman , Steven K. Ma , Lisa M. Newman , Roger Sheldon , Li A Wang
IPC分类号： C12P13/00
CPC分类号： C12P13/002 , C12N9/14 , C12P7/62 , C12P13/02
摘要： The present invention provides methods and compositions for preparing 4-substituted 3-hydroxybutyric acid derivatives by halohydrin dehalogenase-catalyzed conversion of 4-halo-3-hydroxybutyric acid derivatives. The present invention further provides methods and compositions for preparing 4-halo-3-hydroxybutyric acid derivatives by ketoreductase-catalyzed conversion of 4-halo-3-ketobutyric acid derivatives The present invention also provides methods and compositions for preparing vicinal cyano, hydroxyl substituted carboxylic acid esters.
摘要翻译： 本发明提供了通过卤代醇脱卤酶催化的4-卤代-3-羟基丁酸衍生物的转化来制备4-取代的3-羟基丁酸衍生物的方法和组合物。 本发明还提供了通过酮还原酶催化转化4-卤代-3-酮丁酸衍生物来制备4-卤代-3-羟基丁酸衍生物的方法和组合物。本发明还提供了用于制备邻位氰基，羟基取代的羧酸的方法和组合物 酸酯。
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公开(公告)号：US5557014A
公开(公告)日：1996-09-17
申请号：US558202
申请日：1995-11-16
IPC分类号： B01J23/44 , B01J27/198 , B01J27/199 , C07C29/141 , C07C45/28 , C07C45/30 , C07C45/35
CPC分类号： B01J23/002 , B01J23/44 , B01J27/198 , B01J27/199 , C07C45/28 , C07C45/30 , C12C11/02 , B01J2523/00
摘要： The present invention provides aqueous catalyst solutions useful for oxidation of olefins to carbonyl products, comprising a palladium catalyst and a polyoxoacid or polyoxoanion oxidant comprising vanadium. It also provides processes for oxidation of olefins to carbonyl products, comprising contacting olefin with the aqueous catalyst solutions of the present invention. It also provides processes for oxidation of olefins to carbonyl products by dioxygen, comprising contacting olefin with the aqueous catalyst solutions of the present invention, and further comprising contacting dioxygen with the aqueous catalyst solutions. In certain aqueous catalyst solutions and related processes of the present invention, the solution has a hydrogen ion concentration greater than 0.10 mole per liter when essentially all of the oxidant is in its oxidized state. In other aqueous catalyst solution and related processes of the present invention, the solution is essentially free of sulfuric acid and sulfate ions.
摘要翻译： 本发明提供了用于将烯烃氧化成羰基产物的含水催化剂溶液，其包含钯催化剂和包含钒的多氧酸或多氧阴离子氧化剂。 它还提供了将烯烃氧化成羰基产物的方法，包括使烯烃与本发明的含水催化剂溶液接触。 它还提供了通过双氧将烯烃氧化成羰基产物的方法，包括使烯烃与本发明的含水催化剂溶液接触，并且还包括使二氧化铈与含水催化剂溶液接触。 在本发明的某些水性催化剂溶液和相关方法中，当基本上所有的氧化剂都处于其氧化态时，溶液的氢离子浓度大于0.10摩尔/升。 在本发明的其它含水催化剂溶液和相关方法中，溶液基本上不含硫酸和硫酸根离子。
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公开(公告)号：US4603216A
公开(公告)日：1986-07-29
申请号：US532785
申请日：1983-09-16
IPC分类号： C07C271/06 , C07C125/065 , C07C125/067 , C07C125/073 , C07C125/075
CPC分类号： C07C271/06
摘要： This invention relates to a process for preparing urethanes by reacting a solution of a nitrogen-containing organic compound and a hydroxyl-containing organic compound with carbon monoxide in the presence of a ruthenium catalyst comprising a bis phosphine ligand.
摘要翻译： 本发明涉及通过在含有双膦配体的钌催化剂存在下使含氮有机化合物和含羟基的有机化合物的溶液与一氧化碳反应来制备聚氨酯的方法。
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公开(公告)号：US4600793A
公开(公告)日：1986-07-15
申请号：US532784
申请日：1983-09-16
IPC分类号： C07C269/00 , B01J23/46 , B01J31/20 , B01J31/24 , C07C67/00 , C07C239/00 , C07C269/04 , C07C271/06 , C07C271/26 , C07C125/065 , C07C125/073 , C07C125/077
CPC分类号： C07C271/06
摘要： A process for preparing urethanes by reacting a solution of a nitrogen-containing organic compound and a hydroxyl-containing organic compound with carbon monoxide in the presence of a halide-free ruthenium catalyst is disclosed. In the process of this invention, the rate of conversion and selectivity to urethane is increased by providing a primary amine in the reaction solution.
摘要翻译： 公开了一种在无卤化钌催化剂存在下使含氮有机化合物和含羟基有机化合物的溶液与一氧化碳反应制备聚氨酯的方法。 在本发明的方法中，通过在反应溶液中提供伯胺来提高转化率和对氨基甲酸酯的选择性。
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9.发明授权GH61 glycoside hydrolase protein variants and cofactors that enhance GH61 activity 有权GH61糖苷水解酶蛋白变体和增强GH61活性的辅因子公开(公告)号：US08877474B2
公开(公告)日：2014-11-04
申请号：US13592024
申请日：2012-08-22
申请人： Jie Yang , Xiyun Zhang , Jungjoo Yoon , Kripa Rao , John H. Grate , David Elgart , Dipnath Baidyaroy
发明人： Jie Yang , Xiyun Zhang , Jungjoo Yoon , Kripa Rao , John H. Grate , David Elgart , Dipnath Baidyaroy
IPC分类号： C12N9/96 , C12N9/16 , C12N9/20 , C12N15/00 , C12N1/00 , C07H21/04 , C12P19/14 , C12N9/30 , C12P7/10 , C12N9/42
CPC分类号： C12N9/2434 , C12N9/242 , C12N9/2437 , C12N9/2445 , C12P7/10 , C12P19/14 , C12Y302/01004 , C12Y302/01021 , C12Y302/01091 , Y02E50/16
摘要： The present invention provides various GH61 protein variants comprising various amino acid substitutions. The GH61 protein variants have an improved ability to synergize with cellulase enzymes, thereby increasing the yield of fermentable sugars obtained by saccharification of biomass. In some embodiments, sugars obtained from saccharification are fermented to produce numerous end-products, including but not limited to alcohol.
摘要翻译： 本发明提供了包含各种氨基酸取代的各种GH61蛋白质变体。 GH61蛋白质变体具有改善的与纤维素酶协同作用的能力，从而提高通过生物质糖化获得的可发酵糖的产量。 在一些实施方案中，从糖化获得的糖被发酵以产生许多终产物，包括但不限于醇。
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公开(公告)号：US20130052698A1
公开(公告)日：2013-02-28
申请号：US13592060
申请日：2012-08-22
申请人： Jie Yang , Xiyun Zhang , Jungjoo Yoon , Kripa Rao , John H. Grate , David Elgart , Dipnath Baidyaroy
发明人： Jie Yang , Xiyun Zhang , Jungjoo Yoon , Kripa Rao , John H. Grate , David Elgart , Dipnath Baidyaroy
IPC分类号： C12P19/14 , C12P7/40 , C12P7/46 , C12P7/48 , C12P13/00 , C12P7/18 , C12P5/02 , C12P7/20 , C12P7/64 , C12P7/56 , C12P13/04
CPC分类号： C12N9/2434 , C12N9/242 , C12N9/2437 , C12N9/2445 , C12P7/10 , C12P19/14 , C12Y302/01004 , C12Y302/01021 , C12Y302/01091 , Y02E50/16
摘要： The present invention provides various GH61 protein variants comprising various amino acid substitutions. The GH61 protein variants have an improved ability to synergize with cellulase enzymes, thereby increasing the yield of fermentable sugars obtained by saccharification of biomass. In some embodiments, sugars obtained from saccharification are fermented to produce numerous end-products, including but not limited to alcohol.
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