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1.发明申请公开(公告)号：US20100063300A1
公开(公告)日：2010-03-11
申请号：US12490190
申请日：2009-06-23
申请人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, JR. , Jagadeesh Mavinahalli , Roger Sheldon
发明人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, JR. , Jagadeesh Mavinahalli , Roger Sheldon
IPC分类号： C07D209/52
CPC分类号： C07D403/04 , C07D209/02 , C07D403/12 , C07D487/04 , C12P13/24 , C12P17/10 , C12P17/188 , C12Y104/03004
摘要： The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M′, and R5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.
摘要翻译： 本公开提供了基本上对映体纯的以下结构式的杂双环化合物，其中A，M，M'和R 5如本文所述，以及其制备的生物催化方法，以及用于这些方法的酶。
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2.发明授权Biocatalytic processes for the preparation of stereomerically pure fused bicyclic proline compounds 有权用于制备立体异构纯的稠合双环脯氨酸化合物的生物催化方法公开(公告)号：US08574876B2
公开(公告)日：2013-11-05
申请号：US13436506
申请日：2012-03-30
申请人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, Jr. , Jagadeesh Mavinahalli , Roger Sheldon
发明人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, Jr. , Jagadeesh Mavinahalli , Roger Sheldon
CPC分类号： C07D403/04 , C07D209/02 , C07D403/12 , C07D487/04 , C12P13/24 , C12P17/10 , C12P17/188 , C12Y104/03004
摘要： The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M′, and R5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.
摘要翻译： 本公开提供了基本上对映体纯的以下结构式的杂双环化合物，其中A，M，M'和R 5如本文所述，以及其制备的生物催化方法，以及用于这些方法的酶。
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3.发明授权Biocatalytic processes for the preparation of substantially stereomerically pure fused bicyclic proline compounds 有权用于制备基本上立体异构纯的稠合双环脯氨酸化合物的生物催化方法公开(公告)号：US08178333B2
公开(公告)日：2012-05-15
申请号：US12490190
申请日：2009-06-23
申请人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, Jr. , Jagadeesh Mavinahalli , Roger Sheldon
发明人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, Jr. , Jagadeesh Mavinahalli , Roger Sheldon
CPC分类号： C07D403/04 , C07D209/02 , C07D403/12 , C07D487/04 , C12P13/24 , C12P17/10 , C12P17/188 , C12Y104/03004
摘要： The present disclosure provides monoamine oxidase enzymes and methods of their use in biocatalytic processes for the preparation of substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M′, and R5 are as described herein.
摘要翻译： 本公开内容提供单胺氧化酶及其在生物催化方法中用于制备基本上对映异构体纯的以下结构式的杂双环化合物的方法，其中A，M，M'和R 5如本文所述。
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4.发明申请Biocatalytic Processes for the Preparation of Stereomerically Pure Fused Bicyclic Proline Compounds 有权用于制备立体异构纯双环脯氨酸化合物的生物催化方法公开(公告)号：US20120244581A1
公开(公告)日：2012-09-27
申请号：US13436506
申请日：2012-03-30
申请人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, JR. , Jagadeesh Mavinahalli , Roger Sheldon
发明人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, JR. , Jagadeesh Mavinahalli , Roger Sheldon
IPC分类号： C12P17/10
CPC分类号： C07D403/04 , C07D209/02 , C07D403/12 , C07D487/04 , C12P13/24 , C12P17/10 , C12P17/188 , C12Y104/03004
摘要： The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M′, and R5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.
摘要翻译： 本公开提供了基本上对映体纯的以下结构式的杂双环化合物，其中A，M，M'和R 5如本文所述，以及其制备的生物催化方法，以及用于这些方法的酶。
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5.发明申请Stereomerically Pure Fused Bicyclic Proline Compounds Useful for Preparing Hepatitis C Protease Inhibitors 有权用于制备丙型肝炎蛋白酶抑制剂的独立纯纯双环脯氨酸化合物公开(公告)号：US20120130087A1
公开(公告)日：2012-05-24
申请号：US13294930
申请日：2011-11-11
申请人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, JR. , Jagadeesh Mavinahalli , Roger Sheldon
发明人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, JR. , Jagadeesh Mavinahalli , Roger Sheldon
IPC分类号： C07D209/52 , C07D487/14
CPC分类号： C07D403/04 , C07D209/02 , C07D403/12 , C07D487/04 , C12P13/24 , C12P17/10 , C12P17/188 , C12Y104/03004
摘要： The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M′, and R5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.
摘要翻译： 本公开提供了基本上对映体纯的以下结构式的杂双环化合物，其中A，M，M'和R 5如本文所述，以及其制备的生物催化方法，以及用于这些方法的酶。
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6.发明授权Polypeptides for a ketoreductase-mediated stereoselective route to alpha chloroalcohols 有权用于酮还原酶介导的对α-氯代醇的立体选择性途径的多肽公开(公告)号：US08796002B2
公开(公告)日：2014-08-05
申请号：US13378618
申请日：2010-06-22
CPC分类号： C12N9/0006 , C12N9/0008 , C12P7/28 , C12P13/02 , C12P17/02 , C12Y101/01184
摘要： The present disclosure relates to engineered ketoreductase polypeptides and uses thereof for the preparation of α chloroalcohols from α chloroketones. Also provided are polynucleotides encoding the engineered ketoreductase polypeptides and host cells capable of expressing the engineered ketoreductase polypeptides.
摘要翻译： 本公开涉及工程化酮还原酶多肽及其用于从α-氯代酮制备α-氯代醇的用途。 还提供了编码工程化酮还原酶多肽和能够表达工程化酮还原酶多肽的宿主细胞的多核苷酸。
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7.发明申请公开(公告)号：US20120190086A1
公开(公告)日：2012-07-26
申请号：US13378618
申请日：2010-06-22
CPC分类号： C12N9/0006 , C12N9/0008 , C12P7/28 , C12P13/02 , C12P17/02 , C12Y101/01184
摘要： The present disclosure relates to engineered ketoreductase polypeptides and uses thereof for the preparation of α chloroalcohols from α chloroketones. Also provided are polynucleotides encoding the engineered ketoreductase polypeptides and host cells capable of expressing the engineered ketoreductase polypeptides.
摘要翻译： 本公开涉及工程化酮还原酶多肽及其用于从α-氯代酮制备α-氯代醇的用途。 还提供了编码工程化酮还原酶多肽和能够表达工程化酮还原酶多肽的宿主细胞的多核苷酸。
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公开(公告)号：US09040262B2
公开(公告)日：2015-05-26
申请号：US13695856
申请日：2011-05-04
申请人： Michael Crowe , Oscar Alvizo , Behnaz Behrouzian , Yong Koy Bong , Steven J. Collier , Anupam Gohel , Jagadeesh Mavinahalli , Naga Modukuru , Emily Mundorff , Derek Smith , Shiwei Song , Wan Lin Yeo
发明人： Michael Crowe , Oscar Alvizo , Behnaz Behrouzian , Yong Koy Bong , Steven J. Collier , Anupam Gohel , Jagadeesh Mavinahalli , Naga Modukuru , Emily Mundorff , Derek Smith , Shiwei Song , Wan Lin Yeo
CPC分类号： C12N9/0006 , A61K38/00 , C07K14/47 , C12P17/10 , C12P17/14 , C12Y101/00 , C12Y101/01184
摘要： The present disclosure relates to non-naturally occurring polypeptides useful for preparing Ezetimibe, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
摘要翻译： 本公开涉及可用于制备依泽替米贝的非天然存在的多肽，编码多肽的多核苷酸以及使用多肽的方法。
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公开(公告)号：US20130052699A1
公开(公告)日：2013-02-28
申请号：US13695856
申请日：2011-05-04
申请人： Michael Crowe , Oscar Alvizo , Behnaz Behrouzian , Yong Koy Bong , Steven J. Collier , Anupam Gohel , Jagadeesh Mavinahalli , Naga Modukuru , Emily Mundorff , Derek Smith , Shiwei Song , Wan Lin Yeo
发明人： Michael Crowe , Oscar Alvizo , Behnaz Behrouzian , Yong Koy Bong , Steven J. Collier , Anupam Gohel , Jagadeesh Mavinahalli , Naga Modukuru , Emily Mundorff , Derek Smith , Shiwei Song , Wan Lin Yeo
CPC分类号： C12N9/0006 , A61K38/00 , C07K14/47 , C12P17/10 , C12P17/14 , C12Y101/00 , C12Y101/01184
摘要： The present disclosure relates to non-naturally occurring polypeptides useful for preparing Ezetimibe, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
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