公开(公告)号：US20150018517A1

公开(公告)日：2015-01-15

申请号：US14457064

申请日：2014-08-11

Applicant: VisEn Medical, Inc.

Inventor： Milind Rajopadhye ,  Kevin Groves ,  Dorin V. Preda

IPC: A61K49/00

CPC classification number: A61K49/0032 ,  A61K47/65 ,  A61K49/0056 ,  C07K5/1019 ,  C07K7/06 ,  C07K7/64 ,  C09B23/0008 ,  C09B23/083 ,  C09B23/086

Abstract: Provided is a family of intramolecularly quenched imaging agents for use in both in vivo and in vitro imaging that contain at least one enzymatically cleavable oligopeptide and two fluorophores or a fluorophore and a quencher. When subjected to proteolytic cleavage, at least one fluorophore is unquenched and becomes capable of producing a fluorescent signal upon excitation with light of an appropriate wavelength. Also provided are in vivo and in vitro imaging methods using such imaging agents.

Abstract translation: 提供了用于体内和体外成像的分子内骤冷成像剂家族，其包含至少一种可酶促切割的寡肽和两个荧光团或荧光团和猝灭剂。 当进行蛋白水解切割时，至少一个荧光团是不淬灭的，并且在用适当波长的光激发时变得能够产生荧光信号。 还提供了使用这种成像剂的体内和体外成像方法。

公开(公告)号：US20140314677A1

公开(公告)日：2014-10-23

申请号：US14215979

申请日：2014-03-17

Applicant: VisEn Medical, Inc.

Inventor： Kevin Groves ,  Ryan Buff

IPC: C07F7/08 ,  A61K49/00 ,  G01N33/569 ,  A61K47/48

CPC classification number: A61K47/48023 ,  A61K47/48092 ,  A61K47/48384 ,  A61K49/0019 ,  A61K49/0021 ,  A61K49/0052 ,  A61K49/0054 ,  C07F7/0816 ,  C09B11/28 ,  C09B69/008 ,  G01N33/56966

Abstract: The invention provides a family of fluorescent compounds. The compounds are substituted silaxanthenium compounds that can be chemically linked to one or more biomolecules, such as a protein, nucleic acid, and therapeutic small molecule. The compounds can be used for imaging in a variety of medical, biological and diagnostic applications. The dyes are particularly useful for in vitro, in vivo and ex vivo imaging applications.

Abstract translation: 本发明提供一系列荧光化合物。 这些化合物是可以与一种或多种生物分子如蛋白质，核酸和治疗性小分子化学连接的取代的硅氧烷henium化合物。 该化合物可用于各种医学，生物和诊断应用中的成像。 染料特别适用于体外，体内和离体成像应用。