公开(公告)号：US06963768B2

公开(公告)日：2005-11-08

申请号：US10063829

申请日：2002-05-16

申请人： Vincent B. Ho ,  Thomas K. F. Foo

发明人： Vincent B. Ho ,  Thomas K. F. Foo

IPC分类号： G01R33/28 ,  A61B5/055 ,  G01R33/563 ,  A61B5/05

CPC分类号： G01R33/56375 ,  A61B5/0555 ,  G06F19/00

摘要： The present invention includes a method and apparatus for high sensitivity whole body scanning using MR imaging. The invention includes acquiring MR data as the patient moves through the iso-center of the magnet while providing interactive control for the operator to change scan parameters and table motion and direction. The technique allows efficient whole body scanning for fast screening of abnormalities while allowing operator control during the screening process to interrupt table motion and redirect the speed and direction of the table while also allowing control over the acquisition plane, number of sections imaged, inter-section spacing, and the scan location.

摘要翻译： 本发明包括使用MR成像进行高灵敏度全身扫描的方法和装置。 本发明包括当患者移动通过磁体的等中心时获取MR数据，同时为操作者提供交互式控制以改变扫描参数和表格运动和方向。 该技术允许有效的全身扫描快速筛选异常，同时允许操作者在筛选过程中控制中断台面运动并重定向表的速度和方向，同时还允许控制采集平面，成像部分数量，间隔 间距和扫描位置。

公开(公告)号：US06903548B2

公开(公告)日：2005-06-07

申请号：US10605703

申请日：2003-10-21

申请人： Thomas K. F. Foo

发明人： Thomas K. F. Foo

IPC分类号： G01R33/28 ,  A61B5/055 ,  G01R33/48 ,  G01R33/54 ,  G01R33/563 ,  G01R33/567 ,  G01V3/00

CPC分类号： G01R33/56366 ,  G01R33/281 ,  G01R33/56308

摘要： A non-selective saturation pulse together with a series of notched RF saturation pulses are used to acquire MR perfusion data. The non-selective saturation recovery RF pulse is non-selective and is designed to be effective at blood pool suppression for a first slice as well as a next slice in a series of slice locations. The first slice. location may be placed at an angle or plane that is not necessarily coaxial with the other slice locations to be imaged. The present invention supports the acquisition of MR data with efficient spatial coverage and a calibration slice of data that provides a linear measure of signal intensity versus contrast concentration in a blood pool.

摘要翻译： 使用非选择性饱和脉冲和一系列缺陷RF饱和脉冲来获取MR灌注数据。 非选择性饱和恢复RF脉冲是非选择性的，并且被设计为对于第一切片的血液池抑制以及一系列切片位置中的下一切片有效。 第一片。 位置可以放置在不一定与要成像的其它切片位置同轴的角度或平面上。 本发明支持采用有效空间覆盖的MR数据采集和数据的校准切片，其提供信号强度对血液浓度对比浓度的线性测量。

公开(公告)号：US06498946B1

公开(公告)日：2002-12-24

申请号：US09682687

申请日：2001-10-05

申请人： Thomas K. F. Foo ,  Zahi A. Fayad

发明人： Thomas K. F. Foo ,  Zahi A. Fayad

IPC分类号： A61B505

CPC分类号： G01R33/4835

摘要： The invention includes a technique for efficient multi-slice fast spin echo image acquisition with black blood contrast in cardiac imaging. The technique includes applying a non-selective inversion pulse, followed by a re-inversion pulse that is slice-selective over a region encompassing a plurality of slice selections. Execution of a series of RF excitation pulses with fast spin echo readout is timed such that signal from blood is near a null point before acquiring data for each spatial slice. For greater contrast consistency, the flip angles for the excitation pulses occurring before the null point can be reduced, and those occurring after the null point can be increased.

摘要翻译： 本发明包括在心脏成像中具有黑色血液对比度的高效多切片快速自旋回波图像采集技术。 该技术包括应用非选择性反转脉冲，随后是在包围多个切片选择的区域上切片选择的重新反转脉冲。 执行具有快速自旋回波读数的一系列RF激励脉冲的定时，使得在为每个空间切片获取数据之前，来自血液的信号接近零点。 为了获得更大的对比度一致性，可以减少在零点之前发生的激励脉冲的翻转角，并且可以增加在零点之后发生的翻转角。

公开(公告)号：US06249694B1

公开(公告)日：2001-06-19

申请号：US09118411

申请日：1998-07-17

申请人： Thomas K. F. Foo ,  Vincent B. Ho ,  Matthew A. Bernstein

发明人： Thomas K. F. Foo ,  Vincent B. Ho ,  Matthew A. Bernstein

IPC分类号： A61B5055

CPC分类号： G01R33/5635 ,  G01R33/5601 ,  G01R33/56572

摘要： A method of peripheral MR angiography is provided for imaging an artery or other vessel, wherein the vessel is of such length that MR data must be acquired at each of a plurality of scan stations spaced along the vessel. In accordance with the method, a contrast agent is intravenously injected, in order to provide a bolus which successively flows to each of the scan stations. After acquiring an initial subset of the MR data associated with a given scan station, the bolus is tracked to determine whether it has arrived at the next-following scan station. If so, at least some of the MR data associated with the next scan station are then acquired. However, if it is found that the bolus has not yet arrived at the next scan station, acquisition of further data at the given scan station is continued.

摘要翻译： 提供了一种用于对动脉或其他血管进行成像的外周MR血管造影术的方法，其中所述血管具有这样的长度，使得必须在沿着血管间隔开的多个扫描站中的每一个处获取MR数据。 根据该方法，静脉内注射造影剂，以提供连续流向每个扫描站的推注。 在获取与给定扫描站相关联的MR数据的初始子集之后，跟踪该推注以确定其是否到达下一个扫描站。 如果是，则随后获取与下一个扫描站相关联的至少一些MR数据。 然而，如果发现大剂量尚未到达下一个扫描站，则继续在给定扫描站获取进一步的数据。

公开(公告)号：US07797031B1

公开(公告)日：2010-09-14

申请号：US10249914

申请日：2003-05-16

申请人： Thomas K. F. Foo

发明人： Thomas K. F. Foo

IPC分类号： A61B5/05

CPC分类号： A61B5/055 ,  A61B5/7285 ,  G01R33/4818 ,  G01R33/482 ,  G01R33/56 ,  G01R33/5613 ,  G01R33/5616 ,  G01R33/56509 ,  G01R33/5673

摘要： A method and apparatus are presented for quickly acquiring MR cardiac images in a time equivalent to a single breath-hold. MR data acquisition is segmented across multiple cardiac cycles. MR data acquisition is interleaved from each phase of a first cardiac cycle with MR data from each phase of a subsequent cardiac cycle. Preferably, low spatial frequency data are interleaved between multiple cardiac cycles, and the subsequent cardiac cycle acquisition includes sequential acquisition of high spatial frequency data at the tail end of the acquisition window. An MR image can then be reconstructed with data acquired from each of the acquisitions that reduce ghosting and artifacts. MR images are reconstructed using this interleaved variable temporal k-space sampling technique to produce volume images of the heart within a single breath-hold. Images can be acquired throughout the cardiac cycle to measure ventricular volumes and ejection fractions. Single phase volume acquisitions can also be performed to assess myocardial infarction.

摘要翻译： 提出了一种方法和装置，用于在等同于单次呼吸的时间内快速获取MR心脏图像。 MR数据采集在多个心动周期中分段。 MR数据采集从具有来自随后心动周期的每个阶段的MR数据的第一心动周期的每个相位交错。 优选地，低空间频率数据在多个心动周期之间交错，并且随后的心动周期获取包括在采集窗口的尾端处顺序获取高空间频率数据。 然后可以用从减少重影和伪影的每个采集获得的数据来重构MR图像。 使用这种交错的可变时间k空间采样技术重建MR图像，以在单次呼吸保持中产生心脏的体积图像。 可以在整个心脏周期获取图像以测量心室体积和射血分数。 也可以进行单相体积获取以评估心肌梗死。

公开(公告)号：US07714575B2

公开(公告)日：2010-05-11

申请号：US12098866

申请日：2008-04-07

申请人： Manojkumar Saranathan ,  Thomas K. F. Foo

发明人： Manojkumar Saranathan ,  Thomas K. F. Foo

IPC分类号： G01V3/00

CPC分类号： G01R33/54 ,  G01R33/4818 ,  G01R33/5607 ,  G01R33/563 ,  G01R33/5635

摘要： The present invention provides a system and method of enhanced magnetic preparation in MR imaging. An imaging technique is disclosed such that k-space is segmented into a number of partitions, wherein the central regions of k-space is acquired prior to the periphery of k-space. The imaging technique also includes the application of magnetic preparation pulses at a variable rate. In this regard, the rate of application of magnetic preparations pulses is varied as a function of the distance from the center of k-space. The amplitude of the magnetic preparation pulses is also varied based on the incremental distance of a partition from the center of k-space.

摘要翻译： 本发明提供了一种在MR成像中增强磁性制备的系统和方法。 公开了一种成像技术，使得k空间被分割成多个分区，其中在空间的周边之前获取k空间的中心区域。 成像技术还包括以可变速率应用磁性制备脉冲。 在这方面，磁性制剂脉冲的施加速率随着与k空间中心的距离而变化。 磁准备脉冲的幅度也根据分区与k空间中心的增量距离而变化。

公开(公告)号：US07323871B2

公开(公告)日：2008-01-29

申请号：US11176718

申请日：2005-07-07

申请人： Thomas K. F. Foo

发明人： Thomas K. F. Foo

IPC分类号： G01V3/00

CPC分类号： G01R33/4828 ,  G01R33/56 ,  G01R33/5601 ,  G01R33/5602 ,  G01R33/5607

摘要： A method and system for fat suppression with T1-weighted imaging includes a pulse sequence generally constructed to have a non-spectrally selective IR pulse that is played out immediately before a spectrally selective IR tip-up pulse. Thereafter, a fat suppression RF pulse is played out followed by the acquisition of fat-suppressed MR data. The pulse sequence maintains T1 contrast by not perturbing the non-fat signals from the IR preparation. The pulse sequence also ensures that the blood pool signal is homogeneously suppressed from the non-spectrally selective IR RF pulse. The pulse sequence also allows for increased fat suppression and provides flexibility for adjustment of the degree of fat suppression without affecting the view acquisition order for an image acquisition segment.

摘要翻译： 用于T 1加权成像的脂肪抑制的方法和系统包括通常构造为具有在光谱选择性IR提升脉冲之前立即播放的非光谱选择性IR脉冲的脉冲序列。 此后，进行脂肪抑制RF脉冲，然后获取脂肪抑制MR数据。 脉冲序列通过不干扰来自IR制剂的非脂肪信号来保持T 1对比度。 脉冲序列还确保从非光谱选择性IR RF脉冲均匀抑制血液信号。 脉冲序列还允许增加脂肪抑制，并提供调整脂肪抑制程度的灵活性，而不影响图像采集段的视图采集顺序。

公开(公告)号：US06741880B1

公开(公告)日：2004-05-25

申请号：US09595117

申请日：2000-06-16

申请人： Thomas K. F. Foo ,  Vincent B. Ho ,  Manojkumar Saranathan

发明人： Thomas K. F. Foo ,  Vincent B. Ho ,  Manojkumar Saranathan

IPC分类号： A61B505

CPC分类号： G01R33/54 ,  A61B5/0263 ,  G01R33/56

摘要： A method and apparatus is disclosed in which a two-tiered approach is taken to first grade a patient to identify the presence of any suspected stenosis, and then a second step is used to acquire more detailed information to grade the stenosis. The invention includes performing a screening study by acquiring a first MR image having a low resolution to scan a suspected stenosis region. After analyzing the first MR image to identify a suspected stenosis within the suspected stenosis region, a more detailed study is performed by acquiring a second MR image having a higher resolution than the first MR image to scan the identified suspected stenosis. If no lesions, or stenotic vessels, are identified after the first MR image, the second MR image need not be obtained. Since the first MR image is designed to be more sensitive to the detection of such stenosis, by increasing the conspicuity of the lesions, and using a fast acquisition sequence, this two-tiered approach increases the efficiency for accurate coronary artery stenosis detection and assessment.

摘要翻译： 公开了一种方法和装置，其中采用双层方法来对患者进行一级评分，以确定是否存在任何可疑的狭窄，然后使用第二步来获得更详细的信息以对狭窄进行分级。 本发明包括通过获取具有低分辨率的第一MR图像来扫描疑似狭窄区域来进行筛选研究。 在分析第一MR图像以识别可疑狭窄区域中的可疑狭窄之后，通过获取具有比第一MR图像更高分辨率的第二MR图像来扫描所识别的疑似狭窄来进行更详细的研究。 如果在第一MR图像之后没有识别病变或狭窄血管，则不需要获得第二MR图像。 由于第一MR图像被设计为对这种狭窄的检测更敏感，通过增加病变的显着性并使用快速采集序列，这种双层方法提高了精确的冠状动脉狭窄检测和评估的效率。

公开(公告)号：US06662037B2

公开(公告)日：2003-12-09

申请号：US10248159

申请日：2002-12-20

申请人： Thomas K. F. Foo

发明人： Thomas K. F. Foo

IPC分类号： A61B505

CPC分类号： G01R33/5601 ,  G01R33/563

摘要： A method and apparatus-are disclosed for achieving suppression of blood pool signal to detect myocardial infarction using MR technology. An RF pulse sequence is applied that includes a notched inversion RF pulse designed to suppress blood pool in and around a region-of-interest. MR data is then acquired within the region-of-interest that not only has signals from normal myocardial tissue suppressed, but also has blood pool signal suppression to improve delineation of infarcted myocardium from the ventricular blood pool and normal myocardium.

摘要翻译： 公开了一种用于实现抑制血液池信号以使用MR技术检测心肌梗塞的方法和装置。 应用RF脉冲序列，其包括设计成抑制感兴趣区域内和周围的血液池的缺口反转RF脉冲。 然后在感兴趣区域内获取MR数据，不仅具有抑制来自正常心肌组织的信号，而且还具有血液池信号抑制以改善梗塞心肌从心室血池和正常心肌的描绘。

公开(公告)号：US06526307B2

公开(公告)日：2003-02-25

申请号：US09681081

申请日：2000-12-29

申请人： Thomas K. F. Foo

发明人： Thomas K. F. Foo

IPC分类号： A61B505

CPC分类号： G01R33/5601 ,  G01R33/563

摘要： A method and apparatus are disclosed for achieving suppression of blood pool signal to detect myocardial infarction using MR technology. After administering a contrast agent into the blood stream of a patient, an RF pulse sequence is applied that includes a slice-selective inversion pulse to suppress normal myocardial tissue followed by a notched inversion RF pulse designed to suppress blood pool in and around the region-of-interest. MR data is then acquired within the region-of-interest that not only has signals from normal myocardial tissue suppressed, but also has blood pool signal suppression to improve delineation of infarcted myocardium from the ventricular blood pool and normal myocardium.

摘要翻译： 公开了一种用于实现抑制血液池信号以使用MR技术检测心肌梗塞的方法和装置。 在将造影剂施用到患者的血液中之后，应用RF脉冲序列，其包括切片选择性反转脉冲以抑制正常的心肌组织，随后是设计用于抑制区域内和周围的血液池的缺口反转RF脉冲， 出于兴趣。 然后在感兴趣区域内获取MR数据，不仅具有抑制来自正常心肌组织的信号，而且还具有血液池信号抑制以改善梗塞心肌从心室血池和正常心肌的描绘。