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1.发明授权Method and apparatus for efficient stenosis identification and assessment using MR imaging 有权使用MR成像进行有效狭窄识别和评估的方法和装置公开(公告)号：US06741880B1
公开(公告)日：2004-05-25
申请号：US09595117
申请日：2000-06-16
IPC分类号： A61B505
CPC分类号： G01R33/54 , A61B5/0263 , G01R33/56
摘要： A method and apparatus is disclosed in which a two-tiered approach is taken to first grade a patient to identify the presence of any suspected stenosis, and then a second step is used to acquire more detailed information to grade the stenosis. The invention includes performing a screening study by acquiring a first MR image having a low resolution to scan a suspected stenosis region. After analyzing the first MR image to identify a suspected stenosis within the suspected stenosis region, a more detailed study is performed by acquiring a second MR image having a higher resolution than the first MR image to scan the identified suspected stenosis. If no lesions, or stenotic vessels, are identified after the first MR image, the second MR image need not be obtained. Since the first MR image is designed to be more sensitive to the detection of such stenosis, by increasing the conspicuity of the lesions, and using a fast acquisition sequence, this two-tiered approach increases the efficiency for accurate coronary artery stenosis detection and assessment.
摘要翻译： 公开了一种方法和装置，其中采用双层方法来对患者进行一级评分，以确定是否存在任何可疑的狭窄，然后使用第二步来获得更详细的信息以对狭窄进行分级。 本发明包括通过获取具有低分辨率的第一MR图像来扫描疑似狭窄区域来进行筛选研究。 在分析第一MR图像以识别可疑狭窄区域中的可疑狭窄之后，通过获取具有比第一MR图像更高分辨率的第二MR图像来扫描所识别的疑似狭窄来进行更详细的研究。 如果在第一MR图像之后没有识别病变或狭窄血管，则不需要获得第二MR图像。 由于第一MR图像被设计为对这种狭窄的检测更敏感，通过增加病变的显着性并使用快速采集序列，这种双层方法提高了精确的冠状动脉狭窄检测和评估的效率。
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公开(公告)号：US06265875B1
公开(公告)日：2001-07-24
申请号：US09313107
申请日：1999-05-17
IPC分类号： G01V300
CPC分类号： G01R33/446 , G01R33/4838
摘要： The present invention relates generally to magnetic resonance imaging (MRI), and more particularly to a method and apparatus for efficient MRI tissue differentiation using an RF pulse designed to provide a frequency response combining a magnetization transfer contrast and fat saturation simultaneously. The invention includes creating a spectrally selective suppression pulse having an RF pulse profile designed to produce a frequency response with adequate fat suppression and selecting a spectrally selective suppression amplitude to produce a magnetization transfer contrast between two different tissue types, such as between proteinated tissue and water-based tissue. The invention also includes applying the spectrally selective suppression pulse with a flip angle selected to optimize fat suppression and magnetization transfer contrast saturation simultaneously. The invention is particularly useful in magnetic resonance angiography (MRA) as a non-invasive alternative to x-ray angiography to image coronary arteries. The invention is capable of efficiently suppressing fat and myocardium and provide an MR image with enhanced visibility of cardiac vessels.
摘要翻译： 本发明一般涉及磁共振成像（MRI），更具体地涉及一种使用RF脉冲进行有效的MRI组织分化的方法和装置，该RF脉冲旨在同时提供组合磁化转移对比度和脂肪饱和度的频率响应。 本发明包括产生具有RF脉冲分布的频谱选择性抑制脉冲，该RF脉冲分布被设计成产生具有足够脂肪抑制的频率响应，并且选择光谱选择性抑制幅度以产生两种不同组织类型之间的磁化转移对比度，例如在蛋白质组织和水之间 的组织。 本发明还包括应用具有被选择用于同时优化脂肪抑制和磁化转移对比饱和度的翻转角的光谱选择性抑制脉冲。 本发明在磁共振血管造影术（MRA）中作为影像冠状动脉的X射线血管造影术的非侵入性替代物是特别有用的。 本发明能够有效地抑制脂肪和心肌，并提供具有增强的心脏血管可见性的MR图像。
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3.发明授权Method and apparatus for automated tracking of vessel movement using MR imaging 有权使用MR成像自动跟踪血管运动的方法和装置公开(公告)号：US08380284B2
公开(公告)日：2013-02-19
申请号：US11625054
申请日：2007-01-19
IPC分类号： A61B5/05
CPC分类号： G01R33/56509 , A61B5/0037 , A61B5/055 , A61B5/7285 , G01R33/56 , G01R33/5673
摘要： A system and method is disclosed for tracking a moving object using magnetic resonance imaging. The technique includes acquiring a scout image scan having a number of image frames and extracting non-linear motion parameters from the number of image frames of the scout image scan. The technique includes prospectively shifting slice location using the non-linear motion parameters between slice locations while acquiring a series of MR images. The system and method are particularly useful in tracking coronary artery movement during the cardiac cycle to acquire the non-linear components of coronary artery movement during a diastolic portion of the R-R interval.
摘要翻译： 公开了一种使用磁共振成像跟踪运动物体的系统和方法。 该技术包括获取具有多个图像帧的侦察图像扫描，并从侦察图像扫描的图像帧的数量中提取非线性运动参数。 该技术包括使用切片位置之间的非线性运动参数前进移位切片位置，同时获取一系列MR图像。 该系统和方法在心脏周期期间跟踪冠状动脉运动特别有用，以在R-R间期的舒张期期间获得冠状动脉运动的非线性分量。
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公开(公告)号：US06889071B2
公开(公告)日：2005-05-03
申请号：US09681068
申请日：2000-12-19
IPC分类号： G01R33/48 , A61B5/055 , G01R33/567 , A61B5/05
CPC分类号： G01R33/567
摘要： A system and method are disclosed to acquire high temporal resolution free-breathing cardiac MR images. The technique includes monitoring heart rate of a patient just prior to image acquisition to acquire a time period of an R—R interval, and using this time period from the heart rate monitoring to prospectively estimate future R—R intervals. The acquisition of MR data can then commence at any point in an R—R interval and extend for the time period recorded. The data acquisition can be segmented and acquired in successive R—R intervals, then combined to create high temporal resolution images.
摘要翻译： 公开了一种获得高时间分辨率自由呼吸心脏MR图像的系统和方法。 该技术包括在图像获取之前监测患者的心率以获取R-R间期的时间段，并且使用来自心率监测的该时间段来前瞻性地估计未来的R-R间期。 然后可以在R-R间隔中的任何点开始获取MR数据，并延长记录的时间段。 可以在连续的R-R间隔中对数据采集进行分段和采集，然后组合以创建高时间分辨率图像。
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公开(公告)号：US07714575B2
公开(公告)日：2010-05-11
申请号：US12098866
申请日：2008-04-07
IPC分类号： G01V3/00
CPC分类号： G01R33/54 , G01R33/4818 , G01R33/5607 , G01R33/563 , G01R33/5635
摘要： The present invention provides a system and method of enhanced magnetic preparation in MR imaging. An imaging technique is disclosed such that k-space is segmented into a number of partitions, wherein the central regions of k-space is acquired prior to the periphery of k-space. The imaging technique also includes the application of magnetic preparation pulses at a variable rate. In this regard, the rate of application of magnetic preparations pulses is varied as a function of the distance from the center of k-space. The amplitude of the magnetic preparation pulses is also varied based on the incremental distance of a partition from the center of k-space.
摘要翻译： 本发明提供了一种在MR成像中增强磁性制备的系统和方法。 公开了一种成像技术，使得k空间被分割成多个分区，其中在空间的周边之前获取k空间的中心区域。 成像技术还包括以可变速率应用磁性制备脉冲。 在这方面，磁性制剂脉冲的施加速率随着与k空间中心的距离而变化。 磁准备脉冲的幅度也根据分区与k空间中心的增量距离而变化。
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6.发明授权Method and apparatus for automated tracking of non-linear vessel movement using MR imaging 有权使用MR成像自动跟踪非线性血管运动的方法和装置公开(公告)号：US07209777B2
公开(公告)日：2007-04-24
申请号：US09728071
申请日：2000-11-30
IPC分类号： A61B5/05
CPC分类号： G01R33/56509 , A61B5/0037 , A61B5/055 , A61B5/7285 , G01R33/56 , G01R33/5673
摘要： A system and method is disclosed for tracking a moving object using magnetic resonance imaging. The technique includes acquiring a scout image scan having a number of image frames and extracting non-linear motion parameters from the number of image frames of the scout image scan. The technique includes prospectively shifting slice location using the non-linear motion parameters between slice locations while acquiring a series of MR images. The system and method are particularly useful in tracking coronary artery movement during the cardiac cycle to acquire the non-linear components of coronary artery movement during a diastolic portion of the R—R interval.
摘要翻译： 公开了一种使用磁共振成像跟踪运动物体的系统和方法。 该技术包括获取具有多个图像帧的侦察图像扫描，并从侦察图像扫描的图像帧的数量中提取非线性运动参数。 该技术包括使用切片位置之间的非线性运动参数前进移位切片位置，同时获取一系列MR图像。 该系统和方法在心脏周期期间跟踪冠状动脉运动特别有用，以在R-R间期的舒张期期间获得冠状动脉运动的非线性分量。
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7.发明授权Method and apparatus for efficient stenosis identification in peripheral arterial vasculature using MR imaging 有权使用MR成像的外周动脉脉管系统有效狭窄鉴别的方法和装置公开(公告)号：US06408201B1
公开(公告)日：2002-06-18
申请号：US09591300
申请日：2000-06-09
申请人： Thomas K. F. Foo , Vincent B. Ho
发明人： Thomas K. F. Foo , Vincent B. Ho
IPC分类号： A61B505
CPC分类号： A61B5/055
摘要： A method and apparatus is disclosed to initially screen a patient's peripheral arterial vasculature for lesions, or stenotic vessels, using MR technology, and then grading the severity of any located stenosis. The invention includes tracking the passage of a contrast agent bolus through a patient, while acquiring a series of first MR images having low resolution. This initial examination uses flow sensitive bi-polar gradient waveforms with a gradient echo imaging pulse sequence to increase the sensitivity to lesion detectability. The bi-polar gradients generate a broad distribution of velocities in a large voxel. Relevant stenoses present in a voxel will result in intra-voxel flow dephasing in voxels immediate to and distal to the stenosis. After identifying a stenosis, a second MR image, having a higher resolution than the first, is used to grade the stenosis.
摘要翻译： 公开了一种方法和装置，其首先使用MR技术筛选病人的外周动脉脉管系统用于病变或狭窄血管，然后对任何位置狭窄的严重程度进行分级。 本发明包括在获取一系列具有低分辨率的第一MR图像的同时跟踪造影剂推注通过患者的通过。 该初步检查使用具有梯度回波成像脉冲序列的流敏双极梯度波形来增加对病变可检测性的敏感性。 双极梯度在大体素中产生广泛的速度分布。 存在于体素中的相关狭窄将导致体内血液流动相对于狭窄直接和远端的体素变形。 在确定狭窄后，使用比第一MR分辨率高的第二MR图像对狭窄进行分级。
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公开(公告)号：US06963768B2
公开(公告)日：2005-11-08
申请号：US10063829
申请日：2002-05-16
申请人： Vincent B. Ho , Thomas K. F. Foo
发明人： Vincent B. Ho , Thomas K. F. Foo
IPC分类号： G01R33/28 , A61B5/055 , G01R33/563 , A61B5/05
CPC分类号： G01R33/56375 , A61B5/0555 , G06F19/00
摘要： The present invention includes a method and apparatus for high sensitivity whole body scanning using MR imaging. The invention includes acquiring MR data as the patient moves through the iso-center of the magnet while providing interactive control for the operator to change scan parameters and table motion and direction. The technique allows efficient whole body scanning for fast screening of abnormalities while allowing operator control during the screening process to interrupt table motion and redirect the speed and direction of the table while also allowing control over the acquisition plane, number of sections imaged, inter-section spacing, and the scan location.
摘要翻译： 本发明包括使用MR成像进行高灵敏度全身扫描的方法和装置。 本发明包括当患者移动通过磁体的等中心时获取MR数据，同时为操作者提供交互式控制以改变扫描参数和表格运动和方向。 该技术允许有效的全身扫描快速筛选异常，同时允许操作者在筛选过程中控制中断台面运动并重定向表的速度和方向，同时还允许控制采集平面，成像部分数量，间隔 间距和扫描位置。
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公开(公告)号：US06249694B1
公开(公告)日：2001-06-19
申请号：US09118411
申请日：1998-07-17
IPC分类号： A61B5055
CPC分类号： G01R33/5635 , G01R33/5601 , G01R33/56572
摘要： A method of peripheral MR angiography is provided for imaging an artery or other vessel, wherein the vessel is of such length that MR data must be acquired at each of a plurality of scan stations spaced along the vessel. In accordance with the method, a contrast agent is intravenously injected, in order to provide a bolus which successively flows to each of the scan stations. After acquiring an initial subset of the MR data associated with a given scan station, the bolus is tracked to determine whether it has arrived at the next-following scan station. If so, at least some of the MR data associated with the next scan station are then acquired. However, if it is found that the bolus has not yet arrived at the next scan station, acquisition of further data at the given scan station is continued.
摘要翻译： 提供了一种用于对动脉或其他血管进行成像的外周MR血管造影术的方法，其中所述血管具有这样的长度，使得必须在沿着血管间隔开的多个扫描站中的每一个处获取MR数据。 根据该方法，静脉内注射造影剂，以提供连续流向每个扫描站的推注。 在获取与给定扫描站相关联的MR数据的初始子集之后，跟踪该推注以确定其是否到达下一个扫描站。 如果是，则随后获取与下一个扫描站相关联的至少一些MR数据。 然而，如果发现大剂量尚未到达下一个扫描站，则继续在给定扫描站获取进一步的数据。
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10.发明授权公开(公告)号：US06425864B1
公开(公告)日：2002-07-30
申请号：US09292548
申请日：1999-04-15
IPC分类号： A61B5055
CPC分类号： G01R33/563 , G01R33/281
摘要： A system and method for optimally imaging the peripheral vasculature is disclosed which includes defining a given number of scan stations along a patient's peripheral vasculature and initially injecting a relatively small amount of contrast agent into the patient to pass a test bolus through the patient's peripheral vasculature, and thereafter tracking the test bolus through the patient and adjusting the patient on a moveable table within the MR imaging device from one scan station to a next station to determine a maximum travel time that the test bolus takes to travel through each of the given number of scan stations. Additional contrast agent is then injected into the patient to pass an exam bolus through the patient's peripheral vasculature, and using the test bolus travel time, MR data can be acquired from each scan station while it is known that the exam bolus is present in that station to optimize image resolution. Initially, central k-space data is acquired for each scan station, and if time permits, the higher spatial frequency k-space data can be acquired. Otherwise, once the central k-space data is acquired for each station, the patient table is adjusted to the scan stations that require additional data acquisition. Similarly, if there is time remaining after all MR data is acquired for a particular scan station, the patient table can be moved to a previous scan station to acquire additional data in that station before moving to a subsequent scan station to acquire the central k-space data when the exam bolus arrives in that particular scan station.
摘要翻译： 公开了一种用于对外围脉管系统进行最佳成像的系统和方法，其包括沿着患者的外周脉管系统定义给定数量的扫描站，并且首先将相对少量的造影剂注射到患者中以使测试推注通过患者的外周脉管系统， 然后通过患者跟踪测试团块并将患者调整在MR成像设备内的可移动台上，从一个扫描站到下一个站，以确定测试弹丸穿过每个给定数量的 扫描站。 然后将另外的造影剂注射到患者中以通过患者的外周脉管系统进行检查推注，并且使用测试推注旅行时间，可以从每个扫描站获取MR数据，同时已知该测试团存在于该站 以优化图像分辨率。 首先，针对每个扫描站获取中心k空间数据，并且如果时间允许，则可以获取较高的空间频率k空间数据。 否则，一旦为每个站获取中心k空间数据，则将患者表调整到需要附加数据采集的扫描站。 类似地，如果在针对特定扫描站获取所有MR数据之后剩余时间，则可以将患者表移动到先前的扫描站以在移动到随后的扫描站以获取中央k-位之前获取该站中的附加数据， 考试团到达该特定扫描站时的空间数据。
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