公开(公告)号：US20120205551A1

公开(公告)日：2012-08-16

申请号：US13456945

申请日：2012-04-26

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: H01J3/26

CPC classification number: G21K1/087 ,  A61N2005/1087 ,  G21K1/093 ,  H05H7/04 ,  H05H7/12

Abstract: The invention comprises intensity control of a charged particle beam acceleration, extraction, and/or targeting method and apparatus used in conjunction with charged particle beam radiation therapy of cancerous tumors. Particularly, intensity of a charged particle stream of a synchrotron is described. Intensity control is described in combination with turning magnets, edge focusing magnets, concentrating magnetic field magnets, winding and control coils, and extraction elements of the synchrotron. The system reduces the overall size of the synchrotron, provides a tightly controlled proton beam, directly reduces the size of required magnetic fields, directly reduces required operating power, and allows continual acceleration of protons in a synchrotron even during a process of extracting protons from the synchrotron.

Abstract translation: 本发明包括与癌肿瘤的带电粒子束放射治疗结合使用的带电粒子束加速度，提取和/或靶向方法和装置的强度控制。 特别地，描述了同步加速器的带电粒子流的强度。 强度控制与旋转磁体，边缘聚焦磁铁，集中磁场磁体，绕组和控制线圈以及同步加速器的提取元件相结合来描述。 该系统减小同步加速器的总体尺寸，提供严格控制的质子束，直接减小所需磁场的尺寸，直接降低所需的操作功率，并且允许在同步加速器中质子的连续加速，即使在从质子中提取质子的过程中 同步加速器

公开(公告)号：US08188688B2

公开(公告)日：2012-05-29

申请号：US12545815

申请日：2009-08-22

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: H05H15/00

CPC classification number: H05H13/04 ,  H05H7/04

Abstract: The invention comprises a charged particle beam acceleration, extraction, and/or targeting method and apparatus used in conjunction with charged particle beam radiation therapy of cancerous tumors. Novel design features of a synchrotron are described. Particularly, turning magnets, edge focusing magnets, concentrating magnetic field magnets, winding and control coils, flat surface incident magnetic field surfaces, and extraction elements are described that minimize the overall size of the synchrotron, provide a tightly controlled proton beam, directly reduce the size of required magnetic fields, directly reduces required operating power, and allow continual acceleration of protons in a synchrotron even during a process of extracting protons from the synchrotron.

Abstract translation: 本发明包括与癌性肿瘤的带电粒子束放射治疗一起使用的带电粒子束加速，提取和/或靶向方法和装置。 描述了同步加速器的新颖设计特征。 特别地，描述了转动磁体，边缘聚焦磁体，集中磁场磁体，绕组和控制线圈，平面入射磁场表面和提取元件，其使得同步加速器的总体尺寸最小化，提供严格控制的质子束，直接减少 即使在从同步加速器提取质子的过程中，所需磁场的尺寸也能直接降低所需的工作功率，并允许同步加速器中质子的持续加速。

公开(公告)号：US20120043472A1

公开(公告)日：2012-02-23

申请号：US13290068

申请日：2011-11-05

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: H01J3/26 ,  H01J3/34

CPC classification number: H05H13/04 ,  A61N5/10 ,  A61N2005/1074 ,  A61N2005/1087 ,  H05H7/04 ,  H05H7/10

Abstract: The invention comprises a charged particle beam acceleration and/or extraction method and apparatus used in conjunction with charged particle beam radiation therapy of cancerous tumors. Novel design features of a synchrotron are described. Particularly, turning magnets, edge focusing magnets, and extraction elements are described that minimize the overall size of the synchrotron, provide a tightly controlled proton beam, directly reduce the size of required magnetic fields, directly reduces required operating power, and allow continual acceleration of protons in a synchrotron even during a process of extracting protons from the synchrotron.

Abstract translation: 本发明包括与癌肿瘤的带电粒子束放射治疗结合使用的带电粒子束加速和/或提取方法和装置。 描述了同步加速器的新颖设计特征。 特别地，描述了旋转磁体，边缘聚焦磁体和提取元件，其使得同步加速器的总体尺寸最小化，提供严格控制的质子束，直接减小所需磁场的尺寸，直接减少所需的操作功率，并且允许连续加速 甚至在从同步加速器提取质子的过程中同步加速器中的质子。

公开(公告)号：US20110284762A1

公开(公告)日：2011-11-24

申请号：US13197480

申请日：2011-08-03

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: G21K1/08 ,  H05H13/04

CPC classification number: A61N5/10 ,  A61N2005/1087 ,  H05H7/10 ,  H05H13/04

Abstract: The invention comprises a charged particle beam extraction method and apparatus optionally used in conjunction with charged particle beam radiation therapy of cancerous tumors. The system uses a radio-frequency (RF) cavity system to induce oscillation of a charged particle stream. Sufficient amplitude modulation of the charged particle stream causes the charged particle stream to hit a material, such as a foil element of a set of foils. The foil decreases the energy of the charged particle stream, which decreases a radius of curvature of the charged particle stream in the synchrotron sufficiently to allow a physical separation of the reduced energy charged particle stream from the original charged particle stream where thickness of a selected foil is a function of energy of circulating charged particles. The physically separated charged particle stream is then removed from the system by use of an applied field and deflector.

Abstract translation: 本发明包括带电粒子束提取方法和装置，可选地与癌肿瘤的带电粒子束放射治疗一起使用。 该系统使用射频（RF）空腔系统来诱导带电粒子流的振荡。 带电粒子流的足够的幅度调制使得带电粒子流撞击一组材料，例如一组箔的箔元件。 箔片降低了带电粒子流的能量，这减少了同步加速器中的带电粒子流的曲率半径，从而允许将还原能带电粒子流与原始带电粒子流物理分离，其中所选择的箔片的厚度 是循环带电粒子的能量的函数。 然后通过使用施加的场和偏转器将物理分离的带电粒子流从系统中移除。

公开(公告)号：US20100155621A1

公开(公告)日：2010-06-24

申请号：US12714504

申请日：2010-02-28

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/00 ,  H05H13/04

CPC classification number: H05H7/10 ,  A61N5/10 ,  A61N2005/1087 ,  H05H13/04

Abstract: The invention relates to method and apparatus for treatment of solid cancer. More particularly, the invention comprises a multi-axis and/or multi-field charged particle cancer therapy system. The system independently controls patient translation position, patient rotation position, two-dimensional beam trajectory, delivered beam energy, delivered beam intensity, timing of charged particle delivery, and/or distribution of radiation striking healthy tissue. The system operates in conjunction with a negative ion beam source, synchrotron, patient positioning, imaging, and/or targeting method and apparatus to deliver an effective and uniform dose of radiation to a tumor while distributing radiation striking healthy tissue.

Abstract translation: 本发明涉及治疗实体癌的方法和装置。 更具体地，本发明包括多轴和/或多场带电粒子癌症治疗系统。 系统独立地控制患者平移位置，患者旋转位置，二维束轨迹，递送的束能，递送的束强度，带电粒子传递的时间和/或辐射进入健康组织的分布。 该系统与负离子束源，同步加速器，患者定位，成像和/或靶向方法和装置一起操作，以在分布辐射进入健康组织的同时向肿瘤递送有效且均匀的辐射。

公开(公告)号：US20100090122A1

公开(公告)日：2010-04-15

申请号：US12636745

申请日：2009-12-13

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/10 ,  H01J1/50

CPC classification number: H05H7/10 ,  A61N5/10 ,  A61N5/1043 ,  A61N5/1049 ,  A61N2005/1087 ,  A61N2005/1097 ,  H05H13/04

Abstract: The invention relates to treatment of solid cancers. More particularly, the invention relates to a combined rotation/raster method, referred to as multi-field charged particle cancer therapy. The system uses a fixed orientation proton source relative to a rotating patient to yield tumor irradiation from multiple directions. The system combines layer-wise tumor irradiation from many directions with controlled energy proton irradiation to deliver peak proton beam energy within a selected tumor volume or irradiated slice. Optionally, the selected tumor volume for irradiation from a given angle is a distal portion of the tumor. In this manner ingress Bragg peak energy is circumferentially spread about the tumor minimizing damage to healthy tissue and peak proton energy is efficiently, accurately, and precisely delivered to the tumor.

Abstract translation: 本发明涉及治疗固体癌症。 更具体地，本发明涉及称为多场带电粒子癌症治疗的组合旋转/光栅方法。 该系统相对于旋转患者使用固定取向质子源，以从多个方向产生肿瘤辐射。 该系统将来自多个方向的层次肿瘤照射与受控能量质子照射组合，以在选定的肿瘤体积或照射切片内提供峰值质子束能量。 任选地，用于从给定角度照射的所选择的肿瘤体积是肿瘤的远端部分。 以这种方式，入射布拉格峰能量围绕肿瘤周向扩散，使对健康组织的损伤最小化，并且峰值质子能量被有效，精确和精确地递送到肿瘤。

公开(公告)号：US20100014639A1

公开(公告)日：2010-01-21

申请号：US12567901

申请日：2009-09-28

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/10 ,  G21K5/04

CPC classification number: H01J3/04 ,  H01J27/028 ,  H05H7/04 ,  H05H13/04

Abstract: The invention comprises a negative ion source method and apparatus used as part of an ion beam injection system, which is used in conjunction with multi-axis charged particle or proton beam radiation therapy of cancerous tumors. The negative ion source preferably includes an inlet port for injection of hydrogen gas into a high temperature plasma chamber. In one embodiment, the plasma chamber includes a magnetic material, which provides a magnetic field barrier between the high temperature plasma chamber and a low temperature plasma region on the opposite side of the magnetic field barrier. An extraction pulse is applied to a negative ion extraction electrode to pull the negative ion beam into a negative ion beam path, which proceeds through a first partial vacuum system, through an ion beam focusing system, into the tandem accelerator, and into a synchrotron.

Abstract translation: 本发明包括负离子源方法和用作离子束注入系统的一部分的装置，其与多轴带电粒子或癌肿瘤的质子束放射治疗结合使用。 负离子源优选包括用于将氢气注入高温等离子体室的入口。 在一个实施例中，等离子体室包括磁性材料，其在高温等离子体室与磁场屏障的相对侧上的低温等离子体区域之间提供磁场屏障。 将提取脉冲施加到负离子提取电极，以将负离子束拉入负离子束路径，其通过第一部分真空系统通过离子束聚焦系统进入串联加速器，并进入同步加速器。

公开(公告)号：US20100006106A1

公开(公告)日：2010-01-14

申请号：US12493205

申请日：2009-06-28

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/00

CPC classification number: A61N5/10 ,  A61N2005/1061 ,  A61N2005/1087

Abstract: The invention comprises a semi-vertical patient positioning, alignment, and/or control method and apparatus used in conjunction with charged particle or proton beam radiation therapy of cancerous tumors. Patient positioning constraints are used to maintain the patient in a treatment position, including one or more of: a seat support, a back support, a head support, an arm support, a knee support, and a foot support. One or more of the positioning constraints are movable and/or under computer control for rapid positioning and/or immobilization of the patient. The system optionally uses an X-ray beam that lies in substantially the same path as a proton beam path of a particle beam cancer therapy system. The generated image is usable for: fine tuning body alignment relative to the proton beam path, to control the proton beam path to accurately and precisely target the tumor, and/or in system verification and validation.

Abstract translation: 本发明包括与癌性肿瘤的带电粒子或质子束放射治疗结合使用的半垂直患者定位，对准和/或控制方法和装置。 患者定位限制用于将患者维持在治疗位置，包括以下中的一个或多个：座椅支撑件，背部支撑件，头部支撑件，手臂支撑件，膝盖支撑件和脚部支撑件。 一个或多个定位限制是可移动的和/或在计算机控制下，用于病人的快速定位和/或固定。 系统可选地使用位于与粒子束癌治疗系统的质子束路径基本相同的路径中的X射线束。 生成的图像可用于：相对于质子束路径精细调整身体对准，以控制质子束路径以准确且精确地靶向肿瘤，和/或在系统验证和验证中。

公开(公告)号：US20090314961A1

公开(公告)日：2009-12-24

申请号：US12552079

申请日：2009-09-01

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: G21K1/00 ,  A61N5/00

CPC classification number: G21K1/087 ,  A61N2005/1087 ,  G21K1/093 ,  H05H7/04 ,  H05H7/12

Abstract: The invention comprises intensity control of a charged particle beam acceleration, extraction, and/or targeting method and apparatus used in conjunction with charged particle beam radiation therapy of cancerous tumors. Particularly, intensity of a charged particle stream of a synchrotron is described. Intensity control is described in combination with turning magnets, edge focusing magnets, concentrating magnetic field magnets, winding and control coils, and extraction elements of the synchrotron. The system reduces the overall size of the synchrotron, provides a tightly controlled proton beam, directly reduces the size of required magnetic fields, directly reduces required operating power, and allows continual acceleration of protons in a synchrotron even during a process of extracting protons from the synchrotron.

Abstract translation: 本发明包括与癌肿瘤的带电粒子束放射治疗结合使用的带电粒子束加速度，提取和/或靶向方法和装置的强度控制。 特别地，描述了同步加速器的带电粒子流的强度。 强度控制与旋转磁体，边缘聚焦磁铁，集中磁场磁体，绕组和控制线圈以及同步加速器的提取元件相结合来描述。 该系统减小同步加速器的总体尺寸，提供严格控制的质子束，直接减小所需磁场的尺寸，直接降低所需的操作功率，并且允许在同步加速器中质子的连续加速，即使在从质子中提取质子的过程中 同步加速器

公开(公告)号：US20090314960A1

公开(公告)日：2009-12-24

申请号：US12550379

申请日：2009-08-30

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/00

CPC classification number: A61N5/1049 ,  A61N5/1065 ,  A61N5/1069 ,  A61N2005/1061 ,  A61N2005/1087

Abstract: The invention comprises a semi-vertical or seated patient positioning, alignment, and/or control method and apparatus used in conjunction with multi-axis charged particle or proton beam radiation therapy of cancerous tumors. Patient positioning constraints are used to maintain the patient in a treatment position, including one or more of: a seat support, a back support, a head support, an arm support, a knee support, and a foot support. One or more of the positioning constraints are movable and/or under computer control for rapid positioning and/or immobilization of the patient. The system optionally uses an X-ray beam that lies in substantially the same path as a proton beam path of a particle beam cancer therapy system. The generated image is usable for: fine tuning body alignment relative to the proton beam path, to control the proton beam path to accurately and precisely target the tumor, and/or in system verification and validation.

Abstract translation: 本发明包括与多轴带电粒子或癌肿瘤的质子束放射治疗结合使用的半垂直或坐位患者定位，对准和/或控制方法和装置。 患者定位限制用于将患者维持在治疗位置，包括以下中的一个或多个：座椅支撑件，背部支撑件，头部支撑件，手臂支撑件，膝盖支撑件和脚部支撑件。 一个或多个定位限制是可移动的和/或在计算机控制下，用于病人的快速定位和/或固定。 系统可选地使用位于与粒子束癌治疗系统的质子束路径基本相同的路径中的X射线束。 生成的图像可用于：相对于质子束路径精细调整身体对准，以控制质子束路径以准确且精确地靶向肿瘤，和/或在系统验证和验证中。