Process for the preparation of optically active nicotine analogs
    19.
    发明授权
    Process for the preparation of optically active nicotine analogs 失效
    制备光学活性尼古丁类似物的方法

    公开(公告)号:US4321387A

    公开(公告)日:1982-03-23

    申请号:US132558

    申请日:1980-03-21

    CPC分类号: C07D207/08

    摘要: A method is disclosed for preparing chiral nicotine and nicotine analogues of the formula: ##STR1## wherein R.sub.1, R.sub.2, and R.sub.3 are hydrogen or alkyl and R.sub.4 is alkyl. Also disclosed are novel intermediate compounds and a novel method for preparing 1-methylprolinol from prolinol, which compounds and method are useful for the preparation of these nicotinoids.

    摘要翻译: 公开了一种制备下式的手性尼古丁和尼古丁类似物的方法:其中R1,R2和R3是氢或烷基,R4是烷基。 还公开了新型中间体化合物和用于从脯氨酸制备1-甲基丙酰醇的新方法,该化合物和方法可用于制备这些烟碱类。