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公开(公告)号:US06984403B2
公开(公告)日:2006-01-10
申请号:US10763340
申请日:2004-01-23
申请人: Timothy A. Hagen , Julian B. Lo , Avinash G. Thombre , Scott M. Herbig , Leah Elizabeth Appel , Marshall David Crew , Dwayne Thomas Friesen , David Keith Lyon , Scott Baldwin McCray , James Blair West
发明人: Timothy A. Hagen , Julian B. Lo , Avinash G. Thombre , Scott M. Herbig , Leah Elizabeth Appel , Marshall David Crew , Dwayne Thomas Friesen , David Keith Lyon , Scott Baldwin McCray , James Blair West
IPC分类号: A61K9/14
CPC分类号: A61K9/1611 , A61K9/143 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/1641 , A61K9/1694 , A61K9/2009 , A61K9/2013 , A61K9/2031 , A61K31/7052
摘要: The present invention is related to an oral dosage form comprising an effective amount of an alkalizing agent and an azithromycin multiparticulate wherein said multiparticulate comprises azithromycin, a glyceride which comprises glyceryl monobehenate, glyceryl dibehenate, glyceryl tribehenate, or a mixture thereof and a poloxamer. Typically, the oral dosage form includes any suitable oral dosing means such as a powder for oral suspension, a unit dose packet or sachet, a tablet or a capsule.
摘要翻译: 本发明涉及包含有效量的碱化剂和阿奇霉素多颗粒的口服剂型,其中所述多颗粒包含阿奇霉素,其包含甘油单硬脂酸甘油酯,二苯乙酸甘油酯,枸橼酸甘油酯或其混合物和泊洛沙姆的甘油酯。 通常,口服剂型包括任何合适的口服给药方式,例如用于口服悬浮液的粉末,单位剂量包或小药囊,片剂或胶囊。
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公开(公告)号:USD392562S
公开(公告)日:1998-03-24
申请号:US61729
申请日:1996-10-29
申请人: Julian B. Lo
设计人: Julian B. Lo
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公开(公告)号:US06401926B1
公开(公告)日:2002-06-11
申请号:US09631577
申请日:2000-08-04
申请人: Julian B. Lo
发明人: Julian B. Lo
IPC分类号: B65D8304
CPC分类号: B65D83/0463 , B65D85/58 , B65D2215/04
摘要: A child-resistant apparatus for dispensing articles which comprises a housing for retaining a blister package wherein the housing comprises a dispensing aperture; optionally, but preferably, a blister package comprising at least one blister cell containing an article to be dispensed; and a substantially rigid backing sheet substantially co-extensive with, and substantially blocking, the dispensing aperture, such that pressure exerted on an exposed top edge of the backing sheet imparts arcuate flexure thereto and dislocation thereof from the substantially co-extensive, and substantially blocking position, to a position where the dispensing aperture is unblocked permitting the at least one article contained in the at least one blister cell to be dispensed. Release of pressure on the exposed top edge of the backing sheet relaxes flexure thereof such that the substantially co-extensive, and substantially blocking position, wherein the backing sheet substantially blocks the dispensing aperture, is restored.
摘要翻译: 一种用于分配物品的防儿童装置,包括用于保持泡罩包装的壳体,其中所述壳体包括分配孔; 可选地,但优选地,包括包含至少一个含有待分配物品的泡罩细胞的泡罩包装; 以及基本上刚性的背衬片基本上与分配孔基本共同并且基本上阻塞,使得施加在背衬片的暴露的顶部边缘上的压力向其施加弓形弯曲并使其从基本上共同且基本上阻塞 位置,其中分配孔未被阻挡的位置允许包含在至少一个泡罩单元中的至少一个物品被分配。 释放背衬片的暴露的顶部边缘上的压力松弛其弯曲,使得基本上共同且基本上阻挡的位置(其中背衬片基本上阻挡分配孔)被恢复。
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公开(公告)号:US5819967A
公开(公告)日:1998-10-13
申请号:US868384
申请日:1997-06-03
申请人: Julian B. Lo
发明人: Julian B. Lo
CPC分类号: B65D50/062
摘要: A child-resistant, elderly-accessible safety container designed for storage of potentially hazardous materials. The closure includes three major components: a rotatable member secured coaxially around the neck of the container and having at least one biasing member disposed along its upper surface, at least one resilient abutment member, extending outward from the neck and terminating in a tip end, and is capable of being distended or compressed by the biasing member, and a closure member having at least one closure member stop disposed along its inner surface. Turning the rotatable member in a predetermined direction causes the biasing member to contact and compress the abutment member tangentially in relation to the outer surface of the neck. Such compression interrupts contact of the tip end of the abutment member with the closure member stop allowing the closure member to be rotated in the opposite direction and removed from the container. Alternatively, turning the rotatable member in another predetermined direction causes the biasing member to contact and distend the abutment member tangentially in relation to the outer surface of the neck. Such distension reinforces contact of the tip end of the abutment member with the closure member stop and prevents the closure member from being rotated in the opposite direction and removed from the container.
摘要翻译: 一种耐小孩,易老人的安全容器,用于储存潜在的有害物质。 闭合件包括三个主要部件:可旋转构件,其同轴地围绕容器的颈部固定,并且具有沿着其上表面设置的至少一个偏置构件,至少一个从颈部向外延伸并终止于末端的弹性邻接构件, 并且能够被偏置构件膨胀或压缩,并且具有至少一个闭合构件的封闭构件沿其内表面设置。 将可旋转构件沿预定方向转动将导致偏置构件相对于颈部的外表面相切地接触并压缩抵接构件。 这种压缩中断了邻接构件的末端与闭合构件止动件的接触,从而允许闭合构件沿相反方向旋转并从容器移除。 或者,在另一预定方向上转动可旋转构件使得偏置构件相对于颈部的外表面相切地接触和延伸抵接构件。 这种膨胀加强了邻接构件的末端与闭合构件止动件的接触,并且防止闭合构件沿相反方向旋转并从容器移除。
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公开(公告)号:US5529789A
公开(公告)日:1996-06-25
申请号:US374789
申请日:1994-09-15
申请人: Julian B. Lo
发明人: Julian B. Lo
CPC分类号: A61K9/2095
摘要: An efficient method for making high strength, highly porous, fast dissolving delivery devices. The method comprises mixing a formulation comprising menthol, a water-soluble, menthol-soluble polymer, and an active agent at a temperature such that the menthol is substantially molten. The formulation is disposed in a mold, solidified and the menthol is sublimed from the solidified molded formulation. Preferably, the solidification occurs at a temperature sufficient to provide a substantially amorphous menthol structure.
摘要翻译: PCT No.PCT / US92 / 09321 Sec。 371日期1994年9月15日 102(e)日期1994年9月15日PCT提交于1992年11月6日PCT公布。 公开号WO93 / 18757 日期1993年9月30日。一种制备高强度,高度多孔,快速溶解递送装置的有效方法。 该方法包括在使薄荷醇基本上熔融的温度下混合包含薄荷醇,水溶性,薄荷醇可溶性聚合物和活性剂的制剂。 将制剂置于模具中,固化,并将薄荷醇从固化的模制制品中升华。 优选地,固化发生在足以提供基本无定形薄荷醇结构的温度下。
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