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公开(公告)号：US06984403B2
公开(公告)日：2006-01-10
申请号：US10763340
申请日：2004-01-23
申请人： Timothy A. Hagen , Julian B. Lo , Avinash G. Thombre , Scott M. Herbig , Leah Elizabeth Appel , Marshall David Crew , Dwayne Thomas Friesen , David Keith Lyon , Scott Baldwin McCray , James Blair West
发明人： Timothy A. Hagen , Julian B. Lo , Avinash G. Thombre , Scott M. Herbig , Leah Elizabeth Appel , Marshall David Crew , Dwayne Thomas Friesen , David Keith Lyon , Scott Baldwin McCray , James Blair West
IPC分类号： A61K9/14
CPC分类号： A61K9/1611 , A61K9/143 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/1641 , A61K9/1694 , A61K9/2009 , A61K9/2013 , A61K9/2031 , A61K31/7052
摘要： The present invention is related to an oral dosage form comprising an effective amount of an alkalizing agent and an azithromycin multiparticulate wherein said multiparticulate comprises azithromycin, a glyceride which comprises glyceryl monobehenate, glyceryl dibehenate, glyceryl tribehenate, or a mixture thereof and a poloxamer. Typically, the oral dosage form includes any suitable oral dosing means such as a powder for oral suspension, a unit dose packet or sachet, a tablet or a capsule.
摘要翻译： 本发明涉及包含有效量的碱化剂和阿奇霉素多颗粒的口服剂型，其中所述多颗粒包含阿奇霉素，其包含甘油单硬脂酸甘油酯，二苯乙酸甘油酯，枸橼酸甘油酯或其混合物和泊洛沙姆的甘油酯。 通常，口服剂型包括任何合适的口服给药方式，例如用于口服悬浮液的粉末，单位剂量包或小药囊，片剂或胶囊。
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2.发明申请MULTIPARTICULATES COMPRISING LOW-SOLUBILITY DRUGS AND CARRIERS THAT RESULT IN RAPID DRUG RELEASE 审中-公开包含低溶解性药物和携带者的多重试验结果发生在快速释放药物公开(公告)号：US20110027372A1
公开(公告)日：2011-02-03
申请号：US12902033
申请日：2010-10-11
申请人： Leah Elizabeth Appel , Dwayne Thomas Friesen , David Keith Lyon , Scott Baldwin McCray , Joshua Richard Shockey
发明人： Leah Elizabeth Appel , Dwayne Thomas Friesen , David Keith Lyon , Scott Baldwin McCray , Joshua Richard Shockey
IPC分类号： A61K9/14
CPC分类号： A61K9/1617 , A61K9/1623 , A61K9/1694
摘要： Multiparticulates of low-solubility drugs and carriers that result in rapid release of the drug are disclosed.
摘要翻译： 公开了导致药物快速释放的低溶解度药物和载体的多微粒。
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3.发明申请Multiparticulates comprising low-solubility drugs and carriers that result in rapid drug release 审中-公开包含低溶解度药物和载体的多种颗粒导致快速的药物释放公开(公告)号：US20090142401A1
公开(公告)日：2009-06-04
申请号：US11920468
申请日：2006-05-26
申请人： Leah Elizabeth Appel , Dwayne Thomas Friesen , David Keith Lyon , Scott Baldwin McCray , Joshua Richard Shockey
发明人： Leah Elizabeth Appel , Dwayne Thomas Friesen , David Keith Lyon , Scott Baldwin McCray , Joshua Richard Shockey
CPC分类号： A61K9/1617 , A61K9/1623 , A61K9/1694
摘要： Multiparticulates of low-solubility drugs and carriers that result in rapid release of the drug are disclosed.
摘要翻译： 公开了导致药物快速释放的低溶解度药物和载体的多微粒。
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公开(公告)号：US07611630B2
公开(公告)日：2009-11-03
申请号：US10590989
申请日：2005-03-18
CPC分类号： B01D61/147 , B01D61/24 , B01D61/28 , B01D67/009 , B01D2325/36 , B01L3/50255 , B01L3/5085 , B01L2300/0829 , B01L2300/161 , B01L2400/0472 , G01N33/15 , G01N2013/006 , Y10S436/809 , Y10T436/255
摘要： A membrane-permeation test for evaluating pharmaceutical compositions is described. The method comprises the following steps: (1) providing a microporous membrane having a plurality of pores, the membrane having a feed side and a permeate side, wherein the feed side of the membrane is in fluid communication with the feed solution, and wherein the permeate side of the membrane is in fluid communication with a permeate solution; (2) administering a pharmaceutical composition to an aqueous solution to form a feed solution; and (3) measuring the concentration of drug in the permeate solution; wherein the feed side of the membrane is hydrophilic, and/or wherein the permeate solution comprises an organic fluid.
摘要翻译： 描述了用于评价药物组合物的膜渗透试验。 该方法包括以下步骤：（1）提供具有多个孔的微孔膜，所述膜具有进料侧和渗透侧，其中所述膜的进料侧与进料溶液流体连通，并且其中 膜的渗透侧与渗透液流体连通; （2）向水溶液施用药物组合物以形成进料溶液; 和（3）测量渗透液中药物的浓度; 其中所述膜的进料侧是亲水的，和/或其中所述渗透液包含有机流体。
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公开(公告)号：US20100089186A1
公开(公告)日：2010-04-15
申请号：US12590141
申请日：2009-11-02
IPC分类号： G01N33/15
CPC分类号： B01D61/147 , B01D61/24 , B01D61/28 , B01D67/009 , B01D2325/36 , B01L3/50255 , B01L3/5085 , B01L2300/0829 , B01L2300/161 , B01L2400/0472 , G01N33/15 , G01N2013/006 , Y10S436/809 , Y10T436/255
摘要： A membrane-permeation test for evaluating pharmaceutical compositions is described. The method comprises the following steps: (1) providing a microporous membrane having a plurality of pores, the membrane having a feed side and a permeate side, wherein the feed side of the membrane is in fluid communication with the feed solution, and wherein the permeate side of the membrane is in fluid communication with a permeate solution; (2) administering a pharmaceutical composition to an aqueous solution to form a feed solution; and (3) measuring the concentration of drug in the permeate solution; wherein the feed side of the membrane is hydrophilic, and/or wherein the permeate solution comprises an organic fluid.
摘要翻译： 描述了用于评价药物组合物的膜渗透试验。 该方法包括以下步骤：（1）提供具有多个孔的微孔膜，所述膜具有进料侧和渗透侧，其中所述膜的进料侧与进料溶液流体连通，并且其中 膜的渗透侧与渗透液流体连通; （2）向水溶液施用药物组合物以形成进料溶液; 和（3）测量渗透液中药物的浓度; 其中所述膜的进料侧是亲水的，和/或其中所述渗透液包含有机流体。
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