公开(公告)号：US20230014028A1

公开(公告)日：2023-01-19

申请号：US17946613

申请日：2022-09-16

Applicant: Wisconsin Alumni Research Foundation

Inventor： Peter Muir ,  Susannah Sample ,  John Svaren

IPC: C12Q1/6883

Abstract: Methods for diagnosing propensity to exhibit acquired peripheral neuropathy in dogs are described. The methods and kits test dogs for presence of a disease-associated genomic variant. Presence of the genomic variant indicates an increased likelihood of the dog developing an acquired peripheral neuropathy. This information can be used to guide preemptive clinical treatment of the animal for peripheral neuropathy and to choose dogs for selective breeding programs.

公开(公告)号：US10858708B2

公开(公告)日：2020-12-08

申请号：US16194659

申请日：2018-11-19

Applicant: Wisconsin Alumni Research Foundation

Inventor： Peter Muir ,  Lauren Baker

IPC: C12Q1/68 ,  C07H21/04 ,  C12Q1/6883 ,  A01K67/02

Abstract: Method and kits for diagnosing propensity to non-contact cranial cruciate ligament rupture (CCLR) in a dog are described. The method includes isolating genomic DNA from a dog and then analyzing the genomic DNA from step for a single nucleotide polymorphism occurring in selected loci that have been determined to be associated with the CCLR phenotype via a genome-wide association study.

公开(公告)号：US20200232035A1

公开(公告)日：2020-07-23

申请号：US16745608

申请日：2020-01-17

Applicant: Wisconsin Alumni Research Foundation

Inventor： Peter Muir ,  Susannah Sample ,  John Svaren

IPC: C12Q1/6883

Abstract: Methods for diagnosing propensity to exhibit acquired peripheral neuropathy in dogs are described. The methods and kits test dogs for presence of a disease-associated genomic variant. Presence of the genomic variant indicates an increased likelihood of the dog developing an acquired peripheral neuropathy. This information can be used to guide preemptive clinical treatment of the animal for peripheral neuropathy and to choose dogs for selective breeding programs.

公开(公告)号：US20190071729A1

公开(公告)日：2019-03-07

申请号：US16194659

申请日：2018-11-19

Applicant: Wisconsin Alumni Research Foundation

Inventor： Peter Muir ,  Lauren Baker

IPC: C12Q1/6883 ,  A01K67/02

Abstract: Method and kits for diagnosing propensity to non-contact cranial cruciate ligament rupture (CCLR) in a dog are described. The method includes isolating genomic DNA from a dog and then analyzing the genomic DNA from step for a single nucleotide polymorphism occurring in selected loci that have been determined to be associated with the CCLR phenotype via a genome-wide association study.

公开(公告)号：US20160222451A1

公开(公告)日：2016-08-04

申请号：US15010491

申请日：2016-01-29

Applicant: Wisconsin Alumni Research Foundation

Inventor： Peter Muir ,  Lauren Baker

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  A01K67/02 ,  C12Q2600/118 ,  C12Q2600/124 ,  C12Q2600/156 ,  C12Q2600/16 ,  C12Q2600/172

Abstract: Method and kits for diagnosing propensity to non-contact cranial cruciate ligament rupture (CCLR) in a dog are described. The method includes isolating genomic DNA from a dog and then analyzing the genomic DNA from step for a single nucleotide polymorphism occurring in selected loci that have been determined to be associated with the CCLR phenotype via a genome-wide association study.

Abstract translation: 描述了用于诊断狗中非接触性颅关节十字韧带破裂（CCLR）倾向的方法和试剂盒。 该方法包括从狗分离基因组DNA，然后分析来自步骤中的基因组DNA，以通过全基因组关联研究确定与所选CCLR表型相关的选定基因座中出现的单核苷酸多态性。