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    Hydroxyalkyl Starch Derivatives
    11.
    发明申请
    Hydroxyalkyl Starch Derivatives 失效
    羟烷基淀粉衍生物

    公开(公告)号：US20110054152A1

    公开(公告)日：2011-03-03

    申请号：US12855381

    申请日：2010-08-12

    申请人： Norbert Zander ,  Harald Conradt ,  Wolfram Eichner

    发明人： Norbert Zander ,  Harald Conradt ,  Wolfram Eichner

    IPC分类号： C07K14/505 ,  C08B31/00

    CPC分类号： C08B31/12 ,  A61K9/0021 ,  A61K38/00 ,  A61K47/61 ,  C07K14/505 ,  C07K14/53 ,  C07K14/5412 ,  C07K14/55 ,  C07K14/56 ,  C07K14/565 ,  C07K17/10 ,  C08B31/00 ,  C08B31/006 ,  C08B31/08 ,  C08B31/185 ,  C08H1/00

    摘要： The present invention relates to a method of producing a hydroxyalkyl starch derivative comprising reacting hydroxyalkyl starch of formula (I) at its reducing end which is not oxidized prior to said reaction, with a compound of formula (II) R′NH—R″ (II) wherein R1-R2 and R3 are independently hydrogen or a linear or branched hydroxyalkyl group, and wherein either R′ or R″ or R′ and R″ comprise at least one functional group X capable of being reacted with at least one other compound prior to or after the reaction of (I) and (II), as well as to the hydroxyalkyl starch derivative as such, obtainable by said method, and to a pharmaceutical composition comprising said hydroxyalkyl starch derivative.

    摘要翻译： 本发明涉及一种生产羟烷基淀粉衍生物的方法，包括使式（I）的羟烷基淀粉在其还原末端反应，其在所述反应之前未被氧化，与式（II）化合物R'NH-R“（ II）其中R 1 -R 2和R 3独立地为氢或直链或支链羟烷基，并且其中R'或R“或R”和R“包含至少一个能够与至少一种其它化合物反应的官能团X 在（I）和（II）的反应之前或之后，以及通过所述方法得到的羟烷基淀粉衍生物，以及包含所述羟烷基淀粉衍生物的药物组合物。

    Method of Producing Hydroxyalkyl Starch Derivatives
    12.
    发明申请
    Method of Producing Hydroxyalkyl Starch Derivatives 审中-公开
    生产羟烷基淀粉衍生物的方法

    公开(公告)号：US20100317609A1

    公开(公告)日：2010-12-16

    申请号：US12824618

    申请日：2010-06-28

    申请人： Norbert Zander ,  Harald Conradt ,  Wolfram Eichner

    发明人： Norbert Zander ,  Harald Conradt ,  Wolfram Eichner

    IPC分类号： A61K31/70 ,  C08B31/08

    CPC分类号： C08B31/12 ,  A61K9/0021 ,  A61K38/00 ,  A61K47/61 ,  C07K14/505 ,  C07K14/53 ,  C07K14/5412 ,  C07K14/55 ,  C07K14/56 ,  C07K14/565 ,  C07K17/10 ,  C08B31/00 ,  C08B31/006 ,  C08B31/08 ,  C08B31/185 ,  C08H1/00

    摘要： The present invention relates to methods of producing hydroxyalkyl starch (HAS) derivatives having a structure according to formula (I) comprising reacting HAS of formula (I) at its optionally oxidized reducing end or a HAS derivative, obtainable by reacting HAS of formula (I) at its optionally oxidized reducing end with a compound (D) comprising at least one functional group Z1 capable of being reacted with the optionally oxidized reducing end of the HAS and at least one functional group W, with a compound (L) comprising at least one functional group Z1 capable of being reacted with said HAS, or at least one functional group Z2 capable of being reacted with functional group W comprised in said HAS derivative, and at least one functional group X capable of being reacted with a functional group Y of a further compound. The present invention further relates to HAS derivatives and pharmaceutical compositions comprising them.

    摘要翻译： 本发明涉及制备具有式（I）结构的羟烷基淀粉（HAS）衍生物的方法，其包括使式（I）的HAS在其任意氧化的还原端或HAS衍生物上反应，所述HAS衍生物可通过使式（I ）的化合物（D），其化合物（D）包含至少一个能够与HAS​​的任选氧化的还原端和至少一个官能团W反应的官能团Z1，化合物（L）至少包含 能够与所述HAS反应的一个官能团Z1或能够与所述HAS衍生物中包含的官能团W反应的至少一个官能团Z 2和至少一个能够与官能团Y反应的官能团X 另一种化合物。 本发明还涉及包含它们的HAS衍生物和药物组合物。

    Starch derivatives, starch active substance conjugates, method for the production thereof and their use as medicaments
    15.
    发明授权
    Starch derivatives, starch active substance conjugates, method for the production thereof and their use as medicaments 失效
    淀粉衍生物，淀粉活性物质共轭物，其生产方法及其作为药物的用途

    公开(公告)号：US07285661B2

    公开(公告)日：2007-10-23

    申请号：US10504892

    申请日：2003-02-20

    申请人： Klaus Sommermeyer ,  Norbert Zander ,  Ronald Frank ,  Harald Conradt

    发明人： Klaus Sommermeyer ,  Norbert Zander ,  Ronald Frank ,  Harald Conradt

    IPC分类号： C08B31/00 ,  C08B33/00 ,  C08B35/00 ,  C07H5/04

    CPC分类号： C08B31/00 ,  A61K47/61

    摘要： The invention relates to starch derivatives of formula (I), in which: X represents a bromine or iodine atom; R″ represents a straight-chain or branched alkyl group, aryl group or aralkyl group, and; R—CO— represents an oxidized substituted or unsubstituted starch radical that is oxidized on the reducing terminal group to form a carboxylic acid. Starch derivatives of formula (I) can selectively couple to active substances containing SH groups and have a prolonged half-life period in the human body. The invention also relates to coupling products of compound (I) with active substances, to methods for the production thereof, and to their use as medicaments

    摘要翻译： 本发明涉及式（I）的淀粉衍生物，其中：X表示溴或碘原子; R“表示直链或支链烷基，芳基或芳烷基， R-CO-代表在还原端基上被氧化形成羧酸的氧化的取代或未取代的淀粉基团。 式（I）的淀粉衍生物可以选择性地偶联到含有SH基团的活性物质中，并且在人体中具有延长的半衰期。 本发明还涉及化合物（I）与活性物质的偶联产物，其制备方法及其作为药物的用途

    Starch derivatives, starch active substance conjugates, method for the production thereof and their use as medicaments
    16.
    发明申请
    Starch derivatives, starch active substance conjugates, method for the production thereof and their use as medicaments 失效
    淀粉衍生物，淀粉活性物质共轭物，其生产方法及其作为药物的用途

    公开(公告)号：US20050065113A1

    公开(公告)日：2005-03-24

    申请号：US10504892

    申请日：2003-02-20

    申请人： Klaus Sommermeyer ,  Norbert Zander ,  Ronald Frank ,  Harald Conradt

    发明人： Klaus Sommermeyer ,  Norbert Zander ,  Ronald Frank ,  Harald Conradt

    IPC分类号： A61K45/00 ,  A61K47/48 ,  A61P5/00 ,  A61P31/00 ,  C08B31/00 ,  A61K31/718 ,  C08B35/00

    CPC分类号： C08B31/00 ,  A61K47/61

    摘要： The invention relates to starch derivatives of formula (I), in which: X represents a bromine or iodine atom; R″ represents a straight-chain or branched alkyl group, aryl group or aralkyl group, and; R—CO— represents an oxidized substituted or unsubstituted starch radical that is oxidized on the reducing terminal group to form a carboxylic acid. Starch derivatives of formula (I) can selectively couple to active substances containing SH groups and have a prolonged half-life period in the human body. The invention also relates to coupling products of compound (I) with active substances, to methods for the production thereof, and to their use as medicaments.

    摘要翻译： 本发明涉及式（I）的淀粉衍生物，其中：X表示溴或碘原子; R“表示直链或支链烷基，芳基或芳烷基， R-CO-代表在还原端基上被氧化形成羧酸的氧化的取代或未取代的淀粉基团。 式（I）的淀粉衍生物可以选择性地偶联到含有SH基团的活性物质中，并且在人体中具有延长的半衰期。 本发明还涉及化合物（I）与活性物质的偶联产物，其制备方法及其作为药物的用途。