公开(公告)号：US09089699B2

公开(公告)日：2015-07-28

申请号：US13701690

申请日：2011-06-06

申请人： Xin Su ,  Dwight E. Nelson

发明人： Xin Su ,  Dwight E. Nelson

IPC分类号： A61N1/36

CPC分类号： A61N1/36007

摘要： In one example, a system includes a therapy module and a processor. The processor detects a voiding event of a patient and controls the therapy module to deliver electrical stimulation to the patient at a first intensity level for a period of time in response to the detection of the voiding event. Immediately following the period of time, the processor controls the therapy module to increase intensity of the electrical stimulation from the first intensity level to a second intensity level before a subsequent voiding event of the patient by at least controlling the therapy module to deliver stimulation to the patient at a plurality of intermediate intensity levels between the first and second intensity levels prior to delivering stimulation to the patient at the second intensity level following the detection of the voiding event.

摘要翻译： 在一个示例中，系统包括治疗模块和处理器。 处理器检测患者的排尿事件并且控制治疗模块响应于检测到排泄事件而以第一强度水平向患者递送电刺激持续一段时间。 在该时间段之后，处理器立即控制治疗模块，以通过至少控制治疗模块将刺激递送给患者，从而将电刺激的强度从第一强度水平增加到第二强度水平，直到患者随后的排尿事件发生 在检测到排尿事件之后，以第二强度水平向患者递送刺激之前，在第一和第二强度水平之间的多个中等强度水平的患者。

公开(公告)号：US08892207B2

公开(公告)日：2014-11-18

申请号：US13446678

申请日：2012-04-13

申请人： Dwight E. Nelson ,  Rahul Gupta

发明人： Dwight E. Nelson ,  Rahul Gupta

IPC分类号： A61N1/00 ,  A61N1/36 ,  A61N1/05 ,  A61B5/0484 ,  A61B5/0476

CPC分类号： A61N1/0534 ,  A61B5/0476 ,  A61B5/0484 ,  A61N1/36082 ,  A61N1/36139 ,  A61N1/36185

摘要： Methods and apparatuses are described for monitoring synchronization of two or more brain areas and delivering an electrical therapy to the brain to facilitate synchronization of the two or more brain areas. The electrical therapy can be titrated to improve synchronization between the two or more areas of the brain based on the one or more signals, the synchronization between the two or more areas of the brain occurring in response to the patient being exposed to external sensory stimulus, wherein the electrical therapy does not independently cause activation of either of the two or more areas of the brain.

摘要翻译： 描述了用于监测两个或更多个脑区域的同步并且向大脑递送电疗法以促进两个或更多个脑区域的同步的方法和装置。 基于一个或多个信号可以滴定电疗法以改善大脑两个或更多个区域之间的同步，响应于患者暴露于外部感觉刺激而发生的大脑的两个或更多个区域之间的同步， 其中所述电疗法不独立地引起脑的两个或更多个区域中的任一个的激活。

公开(公告)号：US08706233B2

公开(公告)日：2014-04-22

申请号：US13358165

申请日：2012-01-25

申请人： Xin Su ,  Dwight E. Nelson

发明人： Xin Su ,  Dwight E. Nelson

IPC分类号： A61N1/08

CPC分类号： A61N1/36167 ,  A61N1/0551 ,  A61N1/36007 ,  A61N1/36107 ,  A61N1/36139 ,  A61N1/3615 ,  A61N1/36178 ,  A61N1/36185

摘要： In some examples, a medical device delivers a first electrical stimulation therapy to a patient, and, upon detecting a trigger event, delivers a second electrical stimulation therapy to the patient. In some examples, the first stimulation therapy includes unilateral stimulation or stimulation delivered to both lateral sides of the patient at different times at a stimulation intensity lower than, equal to, or greater than a threshold intensity level for the patient, or bilateral stimulation delivered substantially simultaneously to both lateral sides of the patient, where one lateral side of the patient receives stimulation at an intensity level that is lower than the threshold intensity level and the other lateral side receives stimulation at an intensity level that is greater than or equal to the threshold intensity level. The second stimulation therapy may include substantially simultaneous bilateral stimulation therapy at an intensity level that at or above the threshold intensity level.

摘要翻译： 在一些示例中，医疗装置向患者递送第一电刺激疗法，并且在检测到触发事件时向患者传送第二电刺激疗法。 在一些实例中，第一刺激疗法包括在刺激强度低于等于或高于患者的阈值强度水平的不同时间递送至患者的两侧的单侧刺激或刺激，或基本上递送的双侧刺激 同时到患者的两个侧面，其中患者的一个侧面以低于阈值强度水平的强度水平接收刺激，另一个侧面以大于或等于阈值的强度水平接收刺激 强度水平 第二刺激疗法可以包括在等于或高于阈值强度水平的强度水平的基本上同时的双侧刺激治疗。

公开(公告)号：US20120277618A1

公开(公告)日：2012-11-01

申请号：US13447460

申请日：2012-04-16

申请人： Jonathon E. Giftakis ,  Jianping Wu ,  Dwight E. Nelson

发明人： Jonathon E. Giftakis ,  Jianping Wu ,  Dwight E. Nelson

IPC分类号： A61B5/0476 ,  A61B5/00

CPC分类号： A61B5/0476 ,  A61B5/0022 ,  A61B5/0031 ,  A61B5/4094 ,  A61B5/4812 ,  A61B5/4836 ,  A61B5/686 ,  A61B5/6868 ,  A61B5/7275 ,  A61N1/36064 ,  A61N1/36135 ,  G06F19/00

摘要： In some examples, systems, devices, and techniques for determining a particular sleep stage of a patient, determining a seizure state of the patient during the particular sleep stage, and generating a seizure probability metric for the particular sleep stage based on the sleep stage and seizure state are described. In some cases, a patient may be more susceptible to seizure events during particular sleep stages. One or more seizure probability metrics indicative of a patient's susceptibility to seizure events during a particular sleep stage may be useful in creating a patient-specific treatment regimen.

摘要翻译： 在一些示例中，用于确定患者的特定睡眠阶段的系统，设备和技术，在特定睡眠阶段确定患者的发作状态，以及基于睡眠阶段产生针对特定睡眠阶段的发作概率度量，以及 描述了发作状态。 在某些情况下，患者在特定睡眠阶段可能更容易发作。 指示患者在特定睡眠阶段期间对发作事件的易感性的一个或多个发作概率指标可用于创建患者特异性治疗方案。

公开(公告)号：US20120116475A1

公开(公告)日：2012-05-10

申请号：US13288797

申请日：2011-11-03

申请人： Dwight E. Nelson ,  Jianping Wu ,  Jonathon E. Giftakis ,  Mark T. Rise

发明人： Dwight E. Nelson ,  Jianping Wu ,  Jonathon E. Giftakis ,  Mark T. Rise

IPC分类号： A61N1/36

CPC分类号： A61N1/00 ,  A61N1/0534 ,  A61N1/37247 ,  A61N1/37264 ,  A61N1/37282

摘要： In some examples, an arousal network of a brain of a patient can be activated to modify the arousal state of the patient, which may be useful in treating a cognitive disorder of the patient. In some examples, a bioelectrical brain signal indicative of electrical activity in a first portion of the brain is monitored to determine whether the patient is in a first arousal state, and, in response to determining the patient is in the first arousal state, electrical stimulation is delivered to a second portion of the brain to activate an arousal neural network in the first portion of the brain to induce a second arousal state to treat the cognitive disorder, where the second arousal state is different than the first arousal state.

摘要翻译： 在一些实例中，患者的脑的唤醒网络可以被激活以修改患者的觉醒状态，其可用于治疗患者的认知障碍。 在一些实例中，监测指示脑的第一部分中的电活动的生物电脑信号，以确定患者是否处于第一觉醒状态，并且响应于确定患者处于第一次唤醒状态，电刺激 被输送到大脑的第二部分以激活脑的第一部分中的觉醒神经网络以诱导第二觉醒状态来治疗认知障碍，其中第二觉醒状态不同于第一觉醒状态。

公开(公告)号：US20110196446A1

公开(公告)日：2011-08-11

申请号：US12701099

申请日：2010-02-05

申请人： Jianping Wu ,  Dwight E. Nelson ,  Rahul Gupta

发明人： Jianping Wu ,  Dwight E. Nelson ,  Rahul Gupta

IPC分类号： A61N1/05

CPC分类号： A61N1/36067 ,  A61B5/048 ,  A61N1/0534 ,  A61N1/36171

摘要： This disclosure describes techniques for delivering electrical stimulation to the brain of a patient at a frequency greater than a selected frequency. The techniques may reestablish gamma frequency band activity within the brain of a patient, and thus improve the patient's movements and cognitive states. In one example, the disclosure is directed to a method that includes selecting a frequency within a gamma frequency band and delivering electrical stimulation at a frequency greater than the selected frequency.

摘要翻译： 本公开描述了以大于所选频率的频率向患者的大脑递送电刺激的技术。 这些技术可能会重新建立患者脑内的伽马频带活动，从而改善患者的运动和认知状态。 在一个示例中，本公开涉及一种方法，其包括选择伽马频带内的频率并以大于所选频率的频率递送电刺激。

公开(公告)号：US08812098B2

公开(公告)日：2014-08-19

申请号：US13447460

申请日：2012-04-16

申请人： Jonathon E. Giftakis ,  Jianping Wu ,  Dwight E. Nelson

发明人： Jonathon E. Giftakis ,  Jianping Wu ,  Dwight E. Nelson

IPC分类号： A61B5/04 ,  A61B5/00 ,  A61N1/36 ,  A61B5/0476

CPC分类号： A61B5/0476 ,  A61B5/0022 ,  A61B5/0031 ,  A61B5/4094 ,  A61B5/4812 ,  A61B5/4836 ,  A61B5/686 ,  A61B5/6868 ,  A61B5/7275 ,  A61N1/36064 ,  A61N1/36135 ,  G06F19/00

摘要： In some examples, systems, devices, and techniques for determining a particular sleep stage of a patient, determining a seizure state of the patient during the particular sleep stage, and generating a seizure probability metric for the particular sleep stage based on the sleep stage and seizure state are described. In some cases, a patient may be more susceptible to seizure events during particular sleep stages. One or more seizure probability metrics indicative of a patient's susceptibility to seizure events during a particular sleep stage may be useful in creating a patient-specific treatment regimen.

摘要翻译： 在一些示例中，用于确定患者的特定睡眠阶段的系统，设备和技术，在特定睡眠阶段确定患者的发作状态，以及基于睡眠阶段产生针对特定睡眠阶段的发作概率度量，以及 描述了发作状态。 在某些情况下，患者在特定睡眠阶段可能更容易发作。 指示患者在特定睡眠阶段期间对发作事件的易感性的一个或多个发作概率指标可用于创建患者特异性治疗方案。

公开(公告)号：US08706232B2

公开(公告)日：2014-04-22

申请号：US13358100

申请日：2012-01-25

申请人： Xin Su ,  Dwight E. Nelson

发明人： Xin Su ,  Dwight E. Nelson

IPC分类号： A61N1/36

CPC分类号： A61N1/36178 ,  A61N1/36007 ,  A61N1/36107 ,  A61N1/36135

摘要： A medical device is configured to deliver a first stimulation therapy to a patient, and, upon detecting a trigger event, deliver a second stimulation therapy to the patient. In some examples, the first stimulation therapy includes bilateral stimulation in which stimulation is delivered at different times to two lateral sides of the patient and the second stimulation therapy includes substantially simultaneous bilateral stimulation therapy to two lateral sides of the patient. In some examples, the second stimulation therapy may elicit a stronger inhibitory physiological response related to incontinence (e.g., inhibition of bladder contractions) than the first stimulation therapy. The trigger event may include, for example, any one or more of detection of a physiological condition indicative of an increased possibility of an involuntary voiding event or an imminent involuntary voiding event, input from the patient, a predetermined time of day, or expiration of a timer.

摘要翻译： 医疗装置被配置为向患者递送第一刺激疗法，并且在检测到触发事件时向患者传送第二刺激疗法。 在一些实例中，第一刺激疗法包括双侧刺激，其中在不同时间将刺激递送到患者的两个侧面，并且第二刺激疗法包括对患者的两个侧面的基本上同时的双侧刺激治疗。 在一些实例中，与第一刺激疗法相比，第二刺激疗法可引起与失禁相关的更强抑制性生理反应（例如，抑制膀胱收缩）。 触发事件可以包括例如任何一种或多种检测生理状态，其指示增加的非自愿排尿事件的可能性增加或迫在眉睫的非自愿排泄事件，从患者输入，一天的预定时间或期满 一个计时器

公开(公告)号：US08565886B2

公开(公告)日：2013-10-22

申请号：US13288797

申请日：2011-11-03

申请人： Dwight E. Nelson ,  Jianping Wu ,  Jonathon E. Giftakis ,  Mark T. Rise

发明人： Dwight E. Nelson ,  Jianping Wu ,  Jonathon E. Giftakis ,  Mark T. Rise

IPC分类号： A61N1/18

CPC分类号： A61N1/00 ,  A61N1/0534 ,  A61N1/37247 ,  A61N1/37264 ,  A61N1/37282

摘要： In some examples, an arousal network of a brain of a patient can be activated to modify the arousal state of the patient, which may be useful in treating a cognitive disorder of the patient. In some examples, a bioelectrical brain signal indicative of electrical activity in a first portion of the brain is monitored to determine whether the patient is in a first arousal state, and, in response to determining the patient is in the first arousal state, electrical stimulation is delivered to a second portion of the brain to activate an arousal neural network in the first portion of the brain to induce a second arousal state to treat the cognitive disorder, where the second arousal state is different than the first arousal state.

摘要翻译： 在一些实例中，患者的脑的唤醒网络可以被激活以修改患者的觉醒状态，其可用于治疗患者的认知障碍。 在一些实例中，监测指示脑的第一部分中的电活动的生物电脑信号，以确定患者是否处于第一觉醒状态，并且响应于确定患者处于第一次唤醒状态，电刺激 被输送到大脑的第二部分以激活脑的第一部分中的觉醒神经网络以诱导第二觉醒状态来治疗认知障碍，其中第二觉醒状态不同于第一觉醒状态。

公开(公告)号：US20120197338A1

公开(公告)日：2012-08-02

申请号：US13358165

申请日：2012-01-25

申请人： Xin Su ,  Dwight E. Nelson

发明人： Xin Su ,  Dwight E. Nelson

IPC分类号： A61N1/36

CPC分类号： A61N1/36167 ,  A61N1/0551 ,  A61N1/36007 ,  A61N1/36107 ,  A61N1/36139 ,  A61N1/3615 ,  A61N1/36178 ,  A61N1/36185

摘要： In some examples, a medical device delivers a first electrical stimulation therapy to a patient, and, upon detecting a trigger event, delivers a second electrical stimulation therapy to the patient. In some examples, the first stimulation therapy includes unilateral stimulation or stimulation delivered to both lateral sides of the patient at different times at a stimulation intensity lower than, equal to, or greater than a threshold intensity level for the patient, or bilateral stimulation delivered substantially simultaneously to both lateral sides of the patient, where one lateral side of the patient receives stimulation at an intensity level that is lower than the threshold intensity level and the other lateral side receives stimulation at an intensity level that is greater than or equal to the threshold intensity level. The second stimulation therapy may include substantially simultaneous bilateral stimulation therapy at an intensity level that at or above the threshold intensity level.

摘要翻译： 在一些示例中，医疗装置向患者递送第一电刺激疗法，并且在检测到触发事件时向患者传送第二电刺激疗法。 在一些实例中，第一刺激疗法包括在刺激强度低于等于或高于患者的阈值强度水平的不同时间递送至患者的两侧的单侧刺激或刺激，或基本上递送的双侧刺激 同时到患者的两个侧面，其中患者的一个侧面以低于阈值强度水平的强度水平接收刺激，另一个侧面以大于或等于阈值的强度水平接收刺激 强度水平 第二刺激疗法可以包括在等于或高于阈值强度水平的强度水平的基本上同时的双侧刺激治疗。