公开(公告)号：USD1052421S1

公开(公告)日：2024-11-26

申请号：US29946195

申请日：2024-06-06

Applicant: Jianping Wu

Designer： Jianping Wu

公开(公告)号：USD1050926S1

公开(公告)日：2024-11-12

申请号：US29898961

申请日：2023-08-03

Applicant: Jianping Wu

Designer： Jianping Wu

公开(公告)号：US08812098B2

公开(公告)日：2014-08-19

申请号：US13447460

申请日：2012-04-16

Applicant: Jonathon E. Giftakis ,  Jianping Wu ,  Dwight E. Nelson

Inventor： Jonathon E. Giftakis ,  Jianping Wu ,  Dwight E. Nelson

IPC: A61B5/04 ,  A61B5/00 ,  A61N1/36 ,  A61B5/0476

CPC classification number: A61B5/0476 ,  A61B5/0022 ,  A61B5/0031 ,  A61B5/4094 ,  A61B5/4812 ,  A61B5/4836 ,  A61B5/686 ,  A61B5/6868 ,  A61B5/7275 ,  A61N1/36064 ,  A61N1/36135 ,  G06F19/00

Abstract: In some examples, systems, devices, and techniques for determining a particular sleep stage of a patient, determining a seizure state of the patient during the particular sleep stage, and generating a seizure probability metric for the particular sleep stage based on the sleep stage and seizure state are described. In some cases, a patient may be more susceptible to seizure events during particular sleep stages. One or more seizure probability metrics indicative of a patient's susceptibility to seizure events during a particular sleep stage may be useful in creating a patient-specific treatment regimen.

Abstract translation: 在一些示例中，用于确定患者的特定睡眠阶段的系统，设备和技术，在特定睡眠阶段确定患者的发作状态，以及基于睡眠阶段产生针对特定睡眠阶段的发作概率度量，以及 描述了发作状态。 在某些情况下，患者在特定睡眠阶段可能更容易发作。 指示患者在特定睡眠阶段期间对发作事件的易感性的一个或多个发作概率指标可用于创建患者特异性治疗方案。

公开(公告)号：US08565886B2

公开(公告)日：2013-10-22

申请号：US13288797

申请日：2011-11-03

Applicant: Dwight E. Nelson ,  Jianping Wu ,  Jonathon E. Giftakis ,  Mark T. Rise

Inventor： Dwight E. Nelson ,  Jianping Wu ,  Jonathon E. Giftakis ,  Mark T. Rise

IPC: A61N1/18

CPC classification number: A61N1/00 ,  A61N1/0534 ,  A61N1/37247 ,  A61N1/37264 ,  A61N1/37282

Abstract: In some examples, an arousal network of a brain of a patient can be activated to modify the arousal state of the patient, which may be useful in treating a cognitive disorder of the patient. In some examples, a bioelectrical brain signal indicative of electrical activity in a first portion of the brain is monitored to determine whether the patient is in a first arousal state, and, in response to determining the patient is in the first arousal state, electrical stimulation is delivered to a second portion of the brain to activate an arousal neural network in the first portion of the brain to induce a second arousal state to treat the cognitive disorder, where the second arousal state is different than the first arousal state.

Abstract translation: 在一些实例中，患者的脑的唤醒网络可以被激活以修改患者的觉醒状态，其可用于治疗患者的认知障碍。 在一些实例中，监测指示脑的第一部分中的电活动的生物电脑信号，以确定患者是否处于第一觉醒状态，并且响应于确定患者处于第一次唤醒状态，电刺激 被输送到大脑的第二部分以激活脑的第一部分中的觉醒神经网络以诱导第二觉醒状态来治疗认知障碍，其中第二觉醒状态不同于第一觉醒状态。

公开(公告)号：US08532757B2

公开(公告)日：2013-09-10

申请号：US12639717

申请日：2009-12-16

Applicant: Gabriela C. Molnar ,  Jianping Wu

Inventor： Gabriela C. Molnar ,  Jianping Wu

IPC: A61B5/04

CPC classification number: A61N1/372 ,  A61N1/0534 ,  A61N1/36082 ,  A61N1/36185

Abstract: Bioelectrical signals may be sensed within a brain of a patient with a plurality of sense electrode combinations. A stimulation electrode combination for delivering stimulation to the patient to manage a patient condition can be selected based on a frequency domain characteristic of the sensed bioelectrical signals. In some examples, a stimulation electrode combination is selected based on a determination of which of the sense electrodes are located closest to a target tissue site, as indicated by the one or more sense electrodes that sensed a bioelectrical brain signal with a relatively highest value of the frequency domain characteristic. In some examples, determining which of the sense electrodes are located closest to the target tissue site may include executing an algorithm using relative values of the frequency domain characteristic.

Abstract translation: 可以在具有多个感测电极组合的患者的脑内感测生物电信号。 可以基于感测的生物电信号的频域特性来选择用于将刺激递送到患者以管理患者状况的刺激电极组合。 在一些示例中，基于确定哪个感测电极位于最靠近目标组织位置的位置来选择刺激电极组合，如感测出具有相对较高值的生物电脑信号的一个或多个感测电极所示 频域特性。 在一些示例中，确定哪个感测电极位于最靠近目标组织位置的位置可以包括使用频域特性的相对值来执行算法。

公开(公告)号：US20130116183A1

公开(公告)日：2013-05-09

申请号：US13256839

申请日：2010-03-19

Applicant: Jianping Wu ,  Kaustav Majumder

Inventor： Jianping Wu ,  Kaustav Majumder

IPC: A61K38/55 ,  C12P21/06

CPC classification number: C07K5/1024 ,  A23J3/34 ,  A23L33/18 ,  A23V2002/00 ,  A61K38/00 ,  C07K1/1133 ,  C07K5/0808 ,  C07K5/0821 ,  C07K5/1008 ,  C07K5/101 ,  C07K14/79 ,  C12P21/06 ,  C12Y304/15001 ,  Y02P20/52

Abstract: Described herein are methods of identifying and releasing bioactive peptides from ovotransferrin The method involves (a) contacting ovotransferrin with a reducing agent, a sonication step, a high pressure processing step, a heating step, a fermentation step, or any combination thereof, and (b) contacting the ovotransferrin after step (a) with a hydrolytic enzyme to produce bioactive peptides that exhibit angiotensin converting enzyme inhibitory activity or antioxidant activity when compared to the parent protein. The bioactive peptides may be added to foodstuffs, a medication, or to any potable, ingestible, or edible compositions.

Abstract translation: 本文描述了从转铁蛋白鉴定和释放生物活性肽的方法。该方法包括（a）将转铁蛋白与还原剂接触，超声处理步骤，高压加工步骤，加热步骤，发酵步骤或其任何组合，和（ b）在步骤（a）之后使转铁蛋白与水解酶接触以产生与亲本蛋白相比显示血管紧张素转化酶抑制活性或抗氧化活性的生物活性肽。 生物活性肽可以添加到食品，药物或任何可饮用的，可摄取的或可食用的组合物中。

公开(公告)号：US20120329716A1

公开(公告)日：2012-12-27

申请号：US13504512

申请日：2010-10-28

Applicant: Rotimi Aluko ,  Jianping Wu ,  Harold Aukema

Inventor： Rotimi Aluko ,  Jianping Wu ,  Harold Aukema

IPC: C07K5/062 ,  C07K5/072 ,  C07K5/065 ,  C07K5/097 ,  C07K5/11 ,  C07K7/06 ,  C07K5/117 ,  C07K5/107 ,  C07K7/08 ,  A61P9/12 ,  A61P13/12 ,  A61K38/05 ,  A61K38/06 ,  A61K38/07 ,  A61K38/08 ,  A61K38/10 ,  C07K5/068

CPC classification number: A61K38/08 ,  A23L33/18 ,  A23V2002/00 ,  A61K38/00 ,  C07K7/06 ,  C07K14/415 ,  A23V2250/54246 ,  A23V2200/3202 ,  A23V2250/70 ,  A23V2250/156 ,  A23V2250/628 ,  A23V2250/548

Abstract: The instant invention relates to peptides obtained from the enzymatic hydrolysis of yellow pea seed proteins that are capable of lowering the blood pressure and reducing the effects of kidney disease in a subject b\ inhibiting or reducing the affinity of the enzymes in the renin-angiotensin system for their substrates, specifically renin, to compositions comprising said peptides and to uses thereof.

Abstract translation: 本发明涉及从酶水解黄豌豆种子蛋白质获得的肽，其能够降低受试者的血压并降低肾脏疾病的作用，抑制或降低酶在肾素 - 血管紧张素系统中的亲合力 用于其底物，特别是肾素，包含所述肽的组合物及其用途。

公开(公告)号：US20110144715A1

公开(公告)日：2011-06-16

申请号：US12639717

申请日：2009-12-16

Applicant: Gabriela C. Molnar ,  Jianping Wu

Inventor： Gabriela C. Molnar ,  Jianping Wu

IPC: A61N1/08 ,  A61N1/36

CPC classification number: A61N1/372 ,  A61N1/0534 ,  A61N1/36082 ,  A61N1/36185

Abstract: Bioelectrical signals may be sensed within a brain of a patient with a plurality of sense electrode combinations. A stimulation electrode combination for delivering stimulation to the patient to manage a patient condition can be selected based on a frequency domain characteristic of the sensed bioelectrical signals. In some examples, a stimulation electrode combination is selected based on a determination of which of the sense electrodes are located closest to a target tissue site, as indicated by the one or more sense electrodes that sensed a bioelectrical brain signal with a relatively highest value of the frequency domain characteristic. In some examples, determining which of the sense electrodes are located closest to the target tissue site may include executing an algorithm using relative values of the frequency domain characteristic.

Abstract translation: 可以在具有多个感测电极组合的患者的脑内感测生物电信号。 可以基于感测的生物电信号的频域特性来选择用于将刺激递送到患者以管理患者状况的刺激电极组合。 在一些示例中，基于确定哪个感测电极位于最靠近目标组织位置的位置来选择刺激电极组合，如感测出具有相对较高值的生物电脑信号的一个或多个感测电极所示 频域特性。 在一些示例中，确定哪个感测电极位于最靠近目标组织位置的位置可以包括使用频域特性的相对值来执行算法。

公开(公告)号：US07575005B2

公开(公告)日：2009-08-18

申请号：US11131284

申请日：2005-05-18

Applicant: John Robert Mumford ,  Ronald Leon Kurtz ,  Jianping Wu

Inventor： John Robert Mumford ,  Ronald Leon Kurtz ,  Jianping Wu

IPC: A62B9/00

CPC classification number: A61M16/06 ,  A61M16/0633 ,  A61M16/0683 ,  A61M2016/0021 ,  A61M2230/04 ,  A61M2230/435 ,  A61M2230/62

Abstract: Embodiments of the invention relate to a mask assembly for use in treatment systems for treating obstructive sleep apnea using continuous positive air pressure (CPAP). The mask assembly comprises a mask or nasal interface for supplying gas to the nose of a wearer of the mask assembly. The mask assembly also comprises a strap or harness attached to the mask for securing the mask assembly to the wearer and sensors located on the mask assembly for measuring physiological signals of the wearer. These physiological signals are communicated to a monitoring unit which, in association with a CPAP device, serves to determine the efficacy of the CPAP treatment and to vary operational parameters of the treatment.

Abstract translation: 本发明的实施例涉及一种用于治疗系统的面罩组件，用于使用连续正压（CPAP）治疗阻塞性睡眠呼吸暂停。 面罩组件包括用于向面罩组件的佩戴者的鼻子供应气体的面罩或鼻接口。 面罩组件还包括附接到面罩的绑带或线束，用于将面罩组件固定到穿戴者身上，并且位于面罩组件上的传感器用于测量穿着者的生理信号。 这些生理信号被传送到监测单元，该监测单元与CPAP装置相关联地用于确定CPAP治疗的功效并改变治疗的操作参数。

公开(公告)号：US09770204B2

公开(公告)日：2017-09-26

申请号：US12616513

申请日：2009-11-11

Applicant: Jianping Wu ,  Dwight E. Nelson ,  Xin Su ,  Gregory F. Molnar

Inventor： Jianping Wu ,  Dwight E. Nelson ,  Xin Su ,  Gregory F. Molnar

IPC: A61N1/36 ,  A61B5/00 ,  A61N1/05

CPC classification number: A61B5/4812 ,  A61B5/4082 ,  A61N1/0534 ,  A61N1/36078 ,  A61N1/36082

Abstract: Delivery of electrical stimulation to the substantia nigra and the subthalamic nucleus of a brain of a patient are independently controlled in order to treat sleep and movement disorders. Electrical stimulation of the subthalamic nucleus may be effective in treating symptoms associated with a movement disorder, and electrical stimulation of the substantia nigra may be effective in treating symptoms associated with a sleep disorder. During a sleep state of the patient, a sleep stage of the patient may be determined, and an electrical stimulation device may be controlled based on the determined sleep stage. Electrical stimulation of the substantia nigra and subthalamic nucleus may be delivered at substantially the same time or at different times.