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33 条记录 (耗时 0.033 秒)

    Multiplex data collection and analysis in bioanalyte detection
    11.
    发明申请
    Multiplex data collection and analysis in bioanalyte detection 有权
    生物分析仪检测中的多重数据收集和分析

    公开(公告)号：US20070048746A1

    公开(公告)日：2007-03-01

    申请号：US11216112

    申请日：2005-09-01

    申请人： Xing Su ,  Lei Sun ,  Mineo Yamakawa ,  Jingwu Zhang ,  Qing Ma ,  Tae-Woong Koo ,  Richard Jones

    发明人： Xing Su ,  Lei Sun ,  Mineo Yamakawa ,  Jingwu Zhang ,  Qing Ma ,  Tae-Woong Koo ,  Richard Jones

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  C12M1/34

    CPC分类号： G01N33/53 ,  B82Y15/00 ,  B82Y30/00 ,  G01N33/54366 ,  G01N33/5438

    摘要： Method and device to collect multiplex data simultaneously in analyte detection and analyze the data by experimentally trained software (machine-learning) is disclosed. Various ways (magnetic particles and microcoils) are disclosed to collect multiple reporter (tag) signals. Multiplex detection can increase the biomolecule analysis efficiency by using small sample size and saving assay reagents and time. Machine learning and data analysis schemes are also disclosed. Multiple affinity binding partners, each labeled by a unique reporter, are contacted with a sample and a green spectrum is taken to detect multiple reporter signals. The spectrum is deconvoluted by experimentally trained software to identify multiple analytes.

    摘要翻译： 公开了通过实验训练的软件（机器学习）在分析物检测中同时收集多重数据并分析数据的方法和装置。 公开了各种方式（磁性颗粒和微型线圈）以收集多个报道（标签）信号。 多重检测可以通过使用小样本量和节省测定试剂和时间来增加生物分子分析效率。 还披露了机器学习和数据分析方案。 将多个亲和力结合配偶体（各自由唯一报道分子标记）与样品接触，并采用绿色光谱来检测多个报道信号。 通过实验训练的软件对光谱进行去卷积，以识别多个分析物。

    External modification of composite organic inorganic nanoclusters
    13.
    发明授权
    External modification of composite organic inorganic nanoclusters 有权
    复合有机无机纳米团簇的外部改性

    公开(公告)号：US07790286B2

    公开(公告)日：2010-09-07

    申请号：US12036869

    申请日：2008-02-25

    申请人： Jingwu Zhang ,  Xing Su ,  Lei Sun

    发明人： Jingwu Zhang ,  Xing Su ,  Lei Sun

    IPC分类号： B32B5/16

    CPC分类号： G01N21/658 ,  G01N2021/653 ,  G01N2021/655 ,  G01N2021/656 ,  Y10S977/773 ,  Y10S977/777 ,  Y10S977/783 ,  Y10T428/12049 ,  Y10T428/2991 ,  Y10T428/2998

    摘要： Modified and functionalized metallic nanoclusters capable of providing an enhanced Raman signal from an organic Raman-active molecule incorporated therein are provided. For example, modifications include coatings and layers, such as adsorption layers, metal coatings, silica coatings, and organic layers. The nanoclusters are generally referred to as COINs (composite organic inorganic nanoparticles) and are capable of acting as sensitive reporters for analyte detection. A metal that enhances the Raman signal from the organic Raman-active compound is inherent in the nanocluster. A variety of organic Raman-active compounds and mixtures of compounds can be incorporated into the nanocluster.

    摘要翻译： 提供了能够提供来自结合在其中的有机拉曼活性分子的增强拉曼信号的改性和官能化的金属纳米团簇。 例如，修饰包括涂层和层，例如吸附层，金属涂层，二氧化硅涂层和有机层。 纳米团簇通常被称为COIN（复合有机无机纳米粒子），并且能够作为敏感的报告物进行分析物检测。 从有机拉曼活性化合物增强拉曼信号的金属在纳米簇中是固有的。 可以将多种有机拉曼活性化合物和化合物的混合物掺入纳米团簇中。

    EXTERNAL MODIFICATION OF COMPOSITE ORGANIC INORGANIC NANOCLUSTERS
    14.
    发明申请
    EXTERNAL MODIFICATION OF COMPOSITE ORGANIC INORGANIC NANOCLUSTERS 有权
    复合有机无机纳米粒子的外部修饰

    公开(公告)号：US20090069481A1

    公开(公告)日：2009-03-12

    申请号：US12036869

    申请日：2008-02-25

    申请人： Jingwu Zhang ,  Xing Su ,  Lei Sun

    发明人： Jingwu Zhang ,  Xing Su ,  Lei Sun

    IPC分类号： C08K3/10

    CPC分类号： G01N21/658 ,  G01N2021/653 ,  G01N2021/655 ,  G01N2021/656 ,  Y10S977/773 ,  Y10S977/777 ,  Y10S977/783 ,  Y10T428/12049 ,  Y10T428/2991 ,  Y10T428/2998

    摘要： Modified and functionalized metallic nanoclusters capable of providing an enhanced Raman signal from an organic Raman-active molecule incorporated therein are provided. For example, modifications include coatings and layers, such as adsorption layers, metal coatings, silica coatings, and organic layers. The nanoclusters are generally referred to as COINs (composite organic inorganic nanoparticles) and are capable of acting as sensitive reporters for analyte detection. A metal that enhances the Raman signal from the organic Raman-active compound is inherent in the nanocluster. A variety of organic Raman-active compounds and mixtures of compounds can be incorporated into the nanocluster.

    摘要翻译： 提供了能够提供来自结合在其中的有机拉曼活性分子的增强拉曼信号的改性和官能化的金属纳米团簇。 例如，修饰包括涂层和层，例如吸附层，金属涂层，二氧化硅涂层和有机层。 纳米团簇通常被称为COIN（复合有机无机纳米粒子），并且能够作为敏感的报告物进行分析物检测。 从有机拉曼活性化合物增强拉曼信号的金属在纳米簇中是固有的。 可以将多种有机拉曼活性化合物和化合物的混合物掺入纳米团簇中。

    Self-assembling raman-active nanoclusters
    17.
    发明申请
    Self-assembling raman-active nanoclusters 审中-公开
    自组装拉曼活性纳米团簇

    公开(公告)号：US20080152534A1

    公开(公告)日：2008-06-26

    申请号：US11643426

    申请日：2006-12-21

    申请人： Jingwu Zhang ,  Xing Su ,  Lei Sun ,  Haovu Qin

    发明人： Jingwu Zhang ,  Xing Su ,  Lei Sun ,  Haovu Qin

    IPC分类号： C01B35/04 ,  C22C21/00 ,  C22C5/02 ,  C22C5/04 ,  C22C5/06 ,  C22C9/00

    CPC分类号： C22C21/00 ,  C22C5/02 ,  C22C5/04

    摘要： Raman-active nanoclusters comprised of a metal and a Raman-active organic molecule incorporated therein that are capable of self-assembly are described. The Raman-active nanoclusters are capable of acting as sensitive reporters for analyte detection. A metal that enhances the Raman signal from the organic Raman-active compound is inherent in the nanocluster. A variety of organic Raman-active compounds and mixtures of compounds can be incorporated into the nanocluster.

    摘要翻译： 描述了由能够自组装的金属和拉曼活性有机分子组成的拉曼活性纳米团簇。 拉曼活性纳米团簇能够作为分析物检测的敏感报告者。 从有机拉曼活性化合物增强拉曼信号的金属在纳米簇中是固有的。 可以将多种有机拉曼活性化合物和化合物的混合物掺入纳米团簇中。

    External modification of composite organic inorganic nanoclusters comprising raman active organic compound
    18.
    发明授权
    External modification of composite organic inorganic nanoclusters comprising raman active organic compound 有权
    包含拉曼活性有机化合物的复合有机无机纳米团簇的外部改性

    公开(公告)号：US07361410B2

    公开(公告)日：2008-04-22

    申请号：US10940698

    申请日：2004-09-13

    申请人： Jingwu Zhang ,  Xing Su ,  Lei Sun

    发明人： Jingwu Zhang ,  Xing Su ,  Lei Sun

    IPC分类号： B32B5/16 ,  B05D3/02

    CPC分类号： G01N21/658 ,  G01N2021/653 ,  G01N2021/655 ,  G01N2021/656 ,  Y10S977/773 ,  Y10S977/777 ,  Y10S977/783 ,  Y10T428/12049 ,  Y10T428/2991 ,  Y10T428/2998

    摘要： Modified and functionalized metallic nanoclusters capable of providing an enhanced Raman signal from an organic Raman-active molecule incorporated therein are provided. For example, modifications include coatings and layers, such as adsorption layers, metal coatings, silica coatings, and organic layers. The nanoclusters are generally referred to as COINs (composite organic inorganic nanoparticles) and are capable of acting as sensitive reporters for analyte detection. A metal that enhances the Raman signal from the organic Raman-active compound is inherent in the nanocluster. A variety of organic Raman-active compounds and mixtures of compounds can be incorporated into the nanocluster.

    摘要翻译： 提供了能够提供来自结合在其中的有机拉曼活性分子的增强拉曼信号的改性和官能化的金属纳米团簇。 例如，修饰包括涂层和层，例如吸附层，金属涂层，二氧化硅涂层和有机层。 纳米团簇通常被称为COIN（复合有机无机纳米粒子），并且能够作为敏感的报告物进行分析物检测。 从有机拉曼活性化合物增强拉曼信号的金属在纳米簇中是固有的。 可以将多种有机拉曼活性化合物和化合物的混合物掺入纳米团簇中。

    MULTIPLEX DATA COLLECTION AND ANALYSIS IN BIOANALYTE DETECTION
    20.
    发明申请
    MULTIPLEX DATA COLLECTION AND ANALYSIS IN BIOANALYTE DETECTION 有权
    多元数据收集与分析在生物检测中的应用

    公开(公告)号：US20090005260A1

    公开(公告)日：2009-01-01

    申请号：US12147440

    申请日：2008-06-26

    申请人： Xing Su ,  Lei Sun ,  Mineo Yamakawa ,  Jingwu Zhang ,  Qing Ma ,  Tae-Woong Koo ,  Richard Jones

    发明人： Xing Su ,  Lei Sun ,  Mineo Yamakawa ,  Jingwu Zhang ,  Qing Ma ,  Tae-Woong Koo ,  Richard Jones

    IPC分类号： C40B30/04

    CPC分类号： G01N33/53 ,  B82Y15/00 ,  B82Y30/00 ,  G01N33/54366 ,  G01N33/5438

    摘要： Method and device to collect multiplex data simultaneously in analyte detection and analyze the data by experimentally trained software (machine-learning) is disclosed. Various ways (magnetic particles and microcoils) are disclosed to collect multiple reporter (tag) signals. Multiplex detection can increase the biomolecule analysis efficiency by using small sample size and saving assay reagents and time. Machine learning and data analysis schemes are also disclosed. Multiple affinity binding partners, each labeled by a unique reporter, are contacted with a sample and a single spectrum is taken to detect multiple reporter signals. The spectrum is deconvoluted by experimentally trained software to identify multiple analytes.

    摘要翻译： 公开了通过实验训练的软件（机器学习）在分析物检测中同时收集多重数据并分析数据的方法和装置。 公开了各种方式（磁性颗粒和微型线圈）以收集多个报道（标签）信号。 多重检测可以通过使用小样本量和节省测定试剂和时间来增加生物分子分析效率。 还披露了机器学习和数据分析方案。 将多个亲和力结合配偶体（每个由唯一报道分子标记）与样品接触，并采用单个谱来检测多个报道信号。 通过实验训练的软件对光谱进行去卷积，以识别多个分析物。