公开(公告)号：US20200246372A1

公开(公告)日：2020-08-06

申请号：US16854978

申请日：2020-04-22

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran HORNSTEIN ,  Irit REICHENSTEIN ,  Alon CHEN

IPC: A61K31/7105 ,  A61P25/00 ,  A61K45/06 ,  C12N15/113

Abstract: A method of treating a subject having MND is provided. The method comprising administering to the subject a therapeutically effective amount of an agent selected from the group consisting of miR-218, miR-218*, precursor thereof and a polynucleotide sequence encoding miR-218 or miR-218* or precursor thereof, thereby treating the MND in the subject. A method of treating a subject having MND, the method comprising administering to the subject a therapeutically effective amount of an agent capable of downregulating an activity or expression of a gene product selected from the group consisting of KCND2, KCNH1, GABRB2, SLC6A1, SLC6A11, KCNA1, CACNB4, GRIA2, GRIK2, GABRG1 and GRIK3, is also provided.

公开(公告)号：US20180064748A1

公开(公告)日：2018-03-08

申请号：US15561990

申请日：2016-03-27

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran HORNSTEIN ,  Irit REICHENSTEIN ,  Alon CHEN

IPC: A61K31/7105 ,  C12N15/113

CPC classification number: A61K31/7105 ,  A61K45/06 ,  A61P25/00 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/141

Abstract: A method of treating a subject having MND is provided. The method comprising administering to the subject a therapeutically effective amount of an agent selected from the group consisting of miR-218, miR-218*, precursor thereof and a polynucleotide sequence encoding miR-218 or miR-218* or precursor thereof, thereby treating the MND in the subject. A method of treating a subject having MND, the method comprising administering to the subject a therapeutically effective amount of an agent capable of downregulating an activity or expression of a gene product selected from the group consisting of KCND2, KCNH1, GABRB2, SLC6A1, SLC6A11, KCNA1, CACNB4, GRIA2, GRIK2, GABRG1 and GRIK3, is also provided.

公开(公告)号：US20150164891A1

公开(公告)日：2015-06-18

申请号：US14612034

申请日：2015-02-02

Applicant: Yeda Research and Development Co., Ltd.

Inventor： Eran HORNSTEIN ,  Anna Maria Emde

IPC: A61K31/496 ,  A61K45/06

CPC classification number: A61K31/496 ,  A61K31/538 ,  A61K45/06

Abstract: A method of treating a cellular stress-related disease in a subject in need thereof is provided. The method comprising administering to the subject a therapeutically effective amount of an agent capable of enhancing processing of a pre-miRNA, thereby treating the cellular stress-related disease in the subject. Methods for treating motor neuron disease (MND) are also provided as well as pharmaceutical compositions.

Abstract translation: 提供了在有需要的受试者中治疗细胞应激相关疾病的方法。 该方法包括向受试者施用治疗有效量的能够增强pre-miRNA加工的试剂，从而治疗受试者的细胞应激相关疾病。 还提供了治疗运动神经元疾病（MND）的方法以及药物组合物。

公开(公告)号：US20150125433A1

公开(公告)日：2015-05-07

申请号：US14588945

申请日：2015-01-04

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Eran HORNSTEIN ,  Tal MELKMAN-ZEHAVI ,  Roni OREN

IPC: A61K35/39 ,  C12N5/071 ,  C12N15/113

CPC classification number: A61K35/39 ,  A01K67/0276 ,  A01K2217/15 ,  A01K2217/203 ,  A01K2217/206 ,  A01K2227/105 ,  A01K2267/03 ,  A01K2267/0362 ,  A01K2267/0393 ,  A61K31/713 ,  A61K38/465 ,  A61K48/00 ,  C12N5/0676 ,  C12N15/113 ,  C12N2310/141 ,  C12N2330/50 ,  C12N2501/65 ,  C12N2510/00

Abstract: A method of increasing insulin content in a pancreatic beta cell is disclosed. The method comprising expressing in the pancreatic beta cell an exogenous polynucleotide encoding at least one microRNA or a precursor thereof, wherein the microRNA is selected from the group consisting of miR-15, miR-16, miR-24, miR-26, miR-27, miR-29, miR-30, miR-129, miR-141, miR-148, miR-182, miR-200, miR-376 and Let-7, thereby increasing the insulin content in the pancreatic beta cell.

Abstract translation: 公开了增加胰腺β细胞中胰岛素含量的方法。 该方法包括在胰β细胞中表达编码至少一种微RNA或其前体的外源多核苷酸，其中所述微小RNA选自miR-15，miR-16，miR-24，miR-26，miR- 27，miR-29，miR-30，miR-129，miR-141，miR-148，miR-182，miR-200，miR-376和Let-7，从而增加胰腺β细胞中的胰岛素含量。