公开(公告)号：US20030219411A1

公开(公告)日：2003-11-27

申请号：US10368438

申请日：2003-02-20

Applicant: Yeda Research and Development Co., LTD

Inventor： David Wallach ,  Mark Boldin ,  Tanya Goncharov ,  Yury V. Golstev

IPC: A61K038/00 ,  A61K048/00 ,  A61K038/17 ,  C07K014/705

CPC classification number: C12N9/641 ,  A61K38/00 ,  C07K14/70575 ,  C07K14/70578 ,  C07K14/715 ,  C07K14/7151 ,  C07K16/2866 ,  C07K2319/00 ,  C12N9/6475

Abstract: The present invention provides proteins capable of modulating or mediating the FAS receptor ligand or TNF effect on cells carrying FAS receptor or p55 receptor by binding or interacting with MORT-1 protein, which in turn binds to the intracellular domain of the FAS receptor or to another protein TRADD which binds to the p55 receptor. In addition, peptide inhibitors that interfere with the proteolytic activity of MORT-1-binding proteins having proteolytic activity are provided, as well as a method of designing them.

Abstract translation: 本发明提供能够通过与MORT-1蛋白结合或相互作用而与携带FAS受体或p55受体的细胞调节或介导FAS受体配体或TNF作用的蛋白，其又结合FAS受体的细胞内结构域或另一种 结合p55受体的蛋白质TRADD。 另外，提供干扰具有蛋白水解活性的MORT-1结合蛋白质的蛋白水解活性的肽抑制剂，以及设计它们的方法。

公开(公告)号：US20030039646A1

公开(公告)日：2003-02-27

申请号：US10245593

申请日：2002-09-18

Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD.

Inventor： David Wallach ,  Andrei Kovalenko

IPC: A61K039/395 ,  C07H021/04 ,  C12P021/02 ,  C12N005/06 ,  C07K016/40

CPC classification number: C07K14/4747 ,  A61K38/00

Abstract: Proteins which are capable of modulating/mediating the function of RIP, their preparation and uses are provided.

公开(公告)号：US20020123117A1

公开(公告)日：2002-09-05

申请号：US10035408

申请日：2002-01-04

Applicant: Yeda Research and Development Co. Ltd.

Inventor： David Wallach ,  Mark P. Boldin ,  Eugene E. Varfolomeev ,  Zeev Pancer ,  Igor Mett ,  Tanya M. Goncharov

IPC: C12N009/99 ,  C12N009/64

CPC classification number: C07K14/70578 ,  A61K38/00 ,  C07K14/4747 ,  C07K14/705 ,  C07K14/7151 ,  C07K14/7155 ,  C07K16/18 ,  C07K16/2878

Abstract: A modulator of regulatory cellular events occurring intracellularly which are mediated by regulatory proteins containing a nulldeath domainnull motif is provided. The nulldeath domainnull is a regulatory portion of the regulatory proteins, and the modulator is capable of interacting with one or more nulldeath domainnull motifs contained in the regulatory proteins and affecting the regulatory action of one or more of the regulatory proteins. The modulator preferably is capable of interacting with nulldeath domainnull motifs within p55-TNF-R, FAS/APO1-R, NGF-R, MORT-1, RIP, TRADD, or ankyrin. A method for producing the modulators is also provided. The modulators are useful for modulating functions mediated in cells by proteins containing the nulldeath domainnull.

Abstract translation: 提供了由细胞内发生的调节性细胞事件的调节剂，其由含有“死亡域”基序的调节蛋白介导，“死亡域”是调控蛋白的调节部分，调节子能够与一个或多个“ 调节蛋白中包含的死亡结构域'基序并影响一种或多种调节蛋白的调节作用调节剂优选能够与p55-TNF-R，FAS / APO1-R，NGF中的“死亡域”基序相互作用 -R，MORT-1，RIP，TRADD或锚蛋白。 还提供了一种制备调制剂的方法。 调节剂可用于通过含有“死亡域”的蛋白调节细胞介导的功能。