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904 条记录 (耗时 0.044 秒)

    Apoptosis-mimicking synthetic entities and use thereof in medical treatment
    1.
    发明申请
    Apoptosis-mimicking synthetic entities and use thereof in medical treatment 审中-公开
    细胞凋亡模拟合成实体及其在医疗中的应用

    公开(公告)号：US20040265927A1

    公开(公告)日：2004-12-30

    申请号：US10488214

    申请日：2004-08-23

    发明人： Anthony E. Bolton ,  Arkady Mandel ,  Stephen J. Houldsworth ,  Natalie J. Lazarowych

    IPC分类号： G01N033/574 ,  C12N009/64

    CPC分类号： A61K9/167 ,  C07F9/091

    摘要： Synthetic bodies having a thee-dimensional structure, sized and shaped to resemble apoptotic cells and apoptotic bodies, and comprising phospho-amino acid-side group carrying entities such as beads, are provided. They can be administered to a patient, to alleviate a variety of disorders such as T-cell mediated disorders (autoimmune conditions), inflammatory disorders neurodegenerative disorders and endothelial dysfunction disorders.

    摘要翻译： 提供了具有尺寸和形状以类似凋亡细胞和凋亡小体的尺寸结构的合成物质，并且包含含有磷酸 - 氨基酸侧基的实体例如珠粒。 它们可以施用于患者，以减轻各种疾病，例如T细胞介导的病症（自身免疫病症），炎性疾病神经变性疾病和内皮功能障碍。

    Human angiomotin-like protein 1
    4.
    发明申请
    Human angiomotin-like protein 1 审中-公开
    人血管动蛋白样蛋白1

    公开(公告)号：US20040248138A1

    公开(公告)日：2004-12-09

    申请号：US10494343

    申请日：2004-04-30

    发明人： Mark Shannon ,  Thuymy Phan

    IPC分类号： C12Q001/68 ,  C07H021/04 ,  C12N009/64

    CPC分类号： C07K14/705 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/47 ,  C07K2319/00

    摘要： The invention provides isolated nucleic acids that encode human angiomotin-like protein (AMLP1), including two isoforms, and fragments thereof, vectors for propagating and expressing AMLP1 nucleic acids, host cells comprising the nucleic acids and vectors of the present invention, proteins, protein fragments, and protein fusions of the novel AMLP1 isoforms, and antibodies thereto. The invention further provides transgenic cells and non-human organisms comprising AMLP1 nucleic acids, and transgenic cells and non-human organisms with targeted disruption of the endogenous orthologue of the AMLP1 gene. The invention further provides pharmaceutical formulations of the nucleic acids, proteins, and antibodies of the present invention, and diagnostic, investigational, and therapeutic methods based on the AMLP1 nucleic acids, proteins, and antibodies of the present invention.

    摘要翻译： 本发明提供编码人类血管动蛋白样蛋白（AMLP1）的分离的核酸，包括两种同工型及其片段，用于增殖和表达AMLP1核酸的载体，包含本发明的核酸和载体的宿主细胞，蛋白质，蛋白质 片段和新型AMLP1同种型的蛋白质融合物及其抗体。 本发明进一步提供包含AMLP1核酸的转基因细胞和非人生物，以及靶向破坏AMLP1基因的内源直向同源物的转基因细胞和非人生物。 本发明还提供了本发明的核酸，蛋白质和抗体的药物制剂，以及基于本发明的AMLP1核酸，蛋白质和抗体的诊断，研究和治疗方法。

    Zinc finger binding domains for cnn
    5.
    发明申请
    Zinc finger binding domains for cnn 审中-公开
    锌指结合域为cnn

    公开(公告)号：US20040224385A1

    公开(公告)日：2004-11-11

    申请号：US10487268

    申请日：2004-06-18

    发明人： Carlos F Barbas ,  Birgit Dreier

    IPC分类号： C07H021/04 ,  C12N009/64

    CPC分类号： C07K14/4703 ,  A61K38/00 ,  C07K2319/00

    摘要： Polypeptides that contain zinc finger-nucleotide binding regions that bind to nucleotide sequences of the formula CNN are provided. Compositions containing a plurality of polypeptides, polynucleotides that encode such polypeptides and methods of regulating gene expression with such polypeptides, compositions and polynucleotides are also provided.

    摘要翻译： 提供了含有结合式CNN核苷酸序列的锌指核苷酸结合区的多肽。 还提供了含有多个多肽的组合物，编码此类多肽的多核苷酸以及用这些多肽调节基因表达的方法，组合物和多核苷酸。

    Screening method based on tsap 6 binding partners
    8.
    发明申请
    Screening method based on tsap 6 binding partners 审中-公开
    基于tsap 6绑定伙伴的筛选方法

    公开(公告)号：US20040175772A1

    公开(公告)日：2004-09-09

    申请号：US10451861

    申请日：2004-03-12

    发明人： Robert Amson ,  Adam Teleman ,  Brent Passer

    IPC分类号： C12Q001/68 ,  G01N033/574 ,  C12N009/64

    CPC分类号： C40B30/04 ,  A61K38/00 ,  A61K48/00 ,  C07K14/4747 ,  C07K14/705 ,  G01N33/574 ,  G01N33/6896 ,  G01N2500/02 ,  G01N2510/00

    摘要： The invention concerns methods for detecting, identifying and/or screening compounds in particular for use in treating cancers and certain neurodegenerative diseases related to dysfunction in tumour suppression regulation and/or apoptosis, in the biological chain of p53, said methods being based on interaction between TSAP6 and its binding partners identified in the present invention.

    摘要翻译： 本发明涉及用于检测，鉴定和/或筛选化合物的方法，所述方法特别用于治疗癌症和与p53的生物学链中的肿瘤抑制调节和/或凋亡相关的功能障碍相关的某些神经变性疾病，所述方法基于 TSAP6及其在本发明中鉴定的结合伙伴。

    Alzheimer's disease secretase, app substrates therefor, and uses therefor
    9.
    发明申请
    Alzheimer's disease secretase, app substrates therefor, and uses therefor 失效
    阿尔茨海默病分泌酶，其应用底物及其用途

    公开(公告)号：US20040166507A1

    公开(公告)日：2004-08-26

    申请号：US10652045

    申请日：2003-08-29

    发明人： Mark E. Gurney ,  Michael J. Bienkowaki ,  Robert L. Heinrikson ,  Luis A. Parodi ,  Riqiang Yan

    IPC分类号： C12Q001/68 ,  C07H021/04 ,  C12N009/64

    CPC分类号： C12N9/6478 ,  C07K14/4711 ,  C07K2319/00 ,  C12N2799/026 ,  C12Q1/37 ,  G01N2333/96472

    摘要： The present invention provides the enzyme and enzymatic procedures for cleaving the null secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.

    摘要翻译： 本发明提供用于切割APP蛋白和相关核酸，肽，载体，细胞和细胞分离物和测定的β分泌酶切割位点的酶和酶程序。 本发明还提供了修饰的APP蛋白和相关核酸，肽，载体，细胞和细胞分离物以及特别可用于鉴定用于治疗或预防阿尔茨海默病的候选治疗剂的测定。

    DNA encoding human serine protease D-G
    10.
    发明申请
    DNA encoding human serine protease D-G 失效
    编码人丝氨酸蛋白酶D-G的DNA

    公开(公告)号：US20040146981A1

    公开(公告)日：2004-07-29

    申请号：US10803530

    申请日：2004-03-17

    发明人： Andrew L. Darrow ,  Jenson (Jian-Shen) Qi ,  Patricia Andrade-Gordon

    IPC分类号： C12N009/64 ,  C07H021/04

    CPC分类号： C12N9/6454 ,  A61K38/00 ,  Y10T436/24

    摘要： Here we describe the molecular identification of a cDNA encoding a novel serine protease we have termed D-G. The deduced amino acid sequence, and it's alignment with other well characterized serine proteases clearly indicates that it is a member of the S1 serine protease family. We have found that the protease D-G mRNA is widely expressed in several tissues throughout the body including epidermis, fibroblasts, keratinocytes, colon, small intestine, stomach, lung, kidney, bone marrow, lymph node, thymus, ovary, prostate, uterus and spinal cord. Interestingly, this protease contains a hydrophobic stretch of amino acids which is a putative transmembrane near the NH2-terminus. Thus, this serine protease is thought to be synthesized as a type II integral protein. We expressed a soluble form of this novel human protease by inserting the portion of the protease D-G cDNA, encoding the catalytic domain, in a zymogen activation construct designed to permit the generic activation of heterologous serine protease catalytic domains. The result is an active preparation of protease D-G that has an activity against a subset of amidolytic substrates. This enzymatically active protease D-G preparation is now amenable to further biochemical analyses for the identification of physiological substrates as well as specific inhibitors.