公开(公告)号：US20030228312A1

公开(公告)日：2003-12-11

申请号：US10423927

申请日：2003-04-28

Applicant: Yeda Research and Development Co. Ltd

Inventor： David Wallach ,  Jacek Bigda ,  Igor Beletsky ,  Igor Mett ,  Hartmut Engelmann

IPC: A61K039/395 ,  C07H021/04 ,  C12P021/02 ,  C12N005/06 ,  C07K016/24

CPC classification number: C07K16/2866 ,  A61K38/00 ,  C07K14/7151 ,  C07K16/4258 ,  C07K2319/00

Abstract: Antibodies to Tumor Necrosis Factor receptors (TNF-Rs) which inhibit the cytocidal effect of TNF but not its binding to the TNF-Rs, and ligands interacting with other receptors of the TNF/NGF family, are provided together with methods of producing them. The antibodies preferably bind to the fourth cysteine rich domain of the p75 TNF receptor or to the region between said fourth cysteine rich domain and the cell membrane.

Abstract translation: 与TNF-NGF家族的其他受体相互作用的配体，抑制肿瘤坏死因子的杀细胞活性而不是与TNF-R结合的肿瘤坏死因子受体（TNF-Rs）的抗体与生产它们的方法一起提供。 抗体优选结合p75 TNF受体的第四半胱氨酸富集结构域或所述第四富含半胱氨酸的结构域与细胞膜之间的区域。

公开(公告)号：US20010019833A1

公开(公告)日：2001-09-06

申请号：US09800909

申请日：2001-03-08

Applicant: Yeda Research and Development Co. Ltd.

Inventor： David Wallach ,  Jacek Bigda ,  Igor Beletsky ,  Igor Mett ,  Hartmut Engelmann

IPC: A61K039/395 ,  C07H021/04 ,  C12P021/02 ,  C12N005/06

CPC classification number: C07K16/2866 ,  A61K38/00 ,  C07K14/7151 ,  C07K16/4258 ,  C07K2319/00

Abstract: Antibodies to Tumor Necrosis Factor receptors (TNF-Rs) which inhibit the cytocidal effect of TNF but not its binding to the TNF-Rs, and ligands interacting with other receptors of the TNF/NGF family, are provided together with methods of producing them. The antibodies preferably bind to the fourth cysteine rich domain of the p75 TNF receptor or to the region between said fourth cysteine rich domain and the cell membrane.

Abstract translation: 与TNF-NGF家族的其他受体相互作用的配体，抑制肿瘤坏死因子的杀细胞活性而不是与TNF-R结合的肿瘤坏死因子受体（TNF-Rs）的抗体与生产它们的方法一起提供。 抗体优选结合p75 TNF受体的第四半胱氨酸富集结构域或所述第四富含半胱氨酸的结构域与细胞膜之间的区域。

公开(公告)号：US20030124675A1

公开(公告)日：2003-07-03

申请号：US10319536

申请日：2002-12-16

Applicant: Yeda Research and Development Co. Ltd.

Inventor： David Wallach ,  Hartmut Engelmann ,  Dan Aderka ,  Daniela Novick ,  Menachem Rubinstein

IPC: C12P021/02 ,  C12N005/06 ,  C07K016/24 ,  C07H021/04

CPC classification number: C07K16/2866 ,  A61K38/00 ,  C07K14/7151

Abstract: Tumor Necrosis Factor (TNF) Binding Protein is isolated and substantially purified. It has the ability to inhibit the cytotoxic effect of TNF and/or to maintain its prolonged beneficial effects. Isolated cDNA encoding TNF Binding Protein II is obtained and may be used to produce expression vectors, prokaryotic or eukaryotic expression hosts and methods of obtaining the protein by culturing of such hosts.

Abstract translation: 肿瘤坏死因子（TNF）结合蛋白被分离并基本纯化。 它具有抑制TNF的细胞毒性作用和/或维持其延长的有益效果的能力。 获得编码TNF结合蛋白II的分离的cDNA，并可用于产生表达载体，原核或真核表达宿主以及通过培养这些宿主获得蛋白质的方法。

公开(公告)号：US20020142357A1

公开(公告)日：2002-10-03

申请号：US10120397

申请日：2002-04-12

Applicant: Yeda Research and Development Co., Ltd.

Inventor： David Wallach ,  Cord Brakebusch

IPC: G01N033/53 ,  G01N033/542 ,  A61K039/395 ,  C07K016/28

CPC classification number: G01N33/6863 ,  A61K38/00 ,  A61K38/46 ,  C07K14/7151 ,  C07K16/28 ,  C07K16/2878

Abstract: A method of modulating signal transduction and/or cleavage in Tumor Necrosis Factor Receptors (TNF-Rs) is provided. Peptides or other molecules may interact either with the receptor itself, or with effector proteins interacting with the receptor, thus modulating the normal functioning of the TNF-Rs. Such peptides or other molecules may be employed for prophylactic and therapeutic applications in TNF associated diseases.

公开(公告)号：US20020058024A1

公开(公告)日：2002-05-16

申请号：US09927458

申请日：2001-08-13

Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD.

Inventor： David Wallach ,  Andrei Kovalenko

IPC: A61K048/00 ,  C07H021/04

CPC classification number: C07K14/4747 ,  A61K38/00

Abstract: Proteins which are capable of modulating/mediating the function of RIP, their preparation and uses are provided.

Abstract translation: 提供了能够调节/介导RIP功能的蛋白质，其制备和用途。

公开(公告)号：US20040230039A1

公开(公告)日：2004-11-18

申请号：US10849901

申请日：2004-05-21

Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD.

Inventor： David Wallach ,  Yura Goltsev

IPC: C07K014/705 ,  C07H021/04

CPC classification number: C12N9/6475 ,  A61K38/00 ,  A61K48/00

Abstract: Proteins capable of modulating or mediating the function of MORT-1 are disclosed. Also disclosed are DNA sequences encoding these proteins, the recombinant production of these proteins as well as their use.

Abstract translation: 公开了能调节或介导MORT-1功能的蛋白质。 还公开了编码这些蛋白质的DNA序列，这些蛋白质的重组产生及其用途。

公开(公告)号：US20020111462A1

公开(公告)日：2002-08-15

申请号：US09800908

申请日：2001-03-08

Applicant: Yeda Research and Development Co., Ltd.

Inventor： David Wallach ,  Jacek Bigda ,  Igor Beletsky ,  Igor Mett ,  Hartmut Engelmann

IPC: C07K014/705 ,  C12P021/02 ,  C07H021/04 ,  C12N005/06

CPC classification number: C07K16/2866 ,  A61K38/00 ,  C07K14/7151 ,  C07K2319/00 ,  Y02A50/412

Abstract: Antibodies to tumor necrosis factor receptors (TNF-Rs) are disclosed together with methods of producing them. The antibodies are preferably those which inhibit the cytotoxic effect of TNF but not its binding to the TNF-Rs. Most preferably, the antibodies bind to an extracellular domain of the C-terminal cysteine loop of the p75 TNF receptor, which loop consists of the amino acid sequence Cys-185 to Thr-201 of SEQ ID NO:3.

Abstract translation: 公开了肿瘤坏死因子受体（TNF-Rs）的抗体及其生产方法。 抗体优选是抑制TNF的细胞毒作用但不与TNF-R结合的抗体。 最优选地，抗体结合p75 TNF受体的C-末端半胱氨酸环的细胞外结构域，该环由SEQ ID NO：3的氨基酸序列Cys-185至Thr-201组成。

公开(公告)号：US20020058798A1

公开(公告)日：2002-05-16

申请号：US09933814

申请日：2001-08-22

Applicant: Yeda Research and Development Co. Ltd.

Inventor： David Wallach ,  Mark Boldin ,  Eugene Varfolomeev ,  Igor Mett

IPC: C12Q001/68 ,  C07H021/04 ,  A61K048/00

CPC classification number: C07K14/70578 ,  A61K38/00 ,  C07K14/715 ,  C07K16/2866 ,  C07K2319/00 ,  C12N9/641 ,  C12N9/6475

Abstract: Proteins capable of modulating the function of FAS/APO1 are provided. The proteins may be prepared by culturing a host cell transformed with a vector containing the DNA encoding such a protein under suitable conditions and isolating the protein.

Abstract translation: 提供了能够调节FAS / APO1功能的蛋白质。 可以通过在合适的条件下培养用含有编码这种蛋白质的DNA的载体转化的宿主细胞并分离蛋白质来制备蛋白质。

公开(公告)号：US20040161858A1

公开(公告)日：2004-08-19

申请号：US10632929

申请日：2003-08-04

Applicant: Yeda Research and Development Co., Ltd.

Inventor： David Wallach ,  Jacek Bigda ,  Igor Beletsky ,  Igor Mett ,  Hartmut Engelmann

IPC: G01N033/558

CPC classification number: C07K16/2866 ,  A61K38/00 ,  C07K14/7151 ,  C07K2319/00 ,  Y02A50/412

Abstract: Antibodies to tumor necrosis factor receptors (TNF-Rs) are disclosed together with methods of producing them and methods of use of such antibodies in immunoassays and purification of TBP-II by affinity chromatography. A diagnostic assay for endogenous antibodies to TBP-II is also disclosed.

Abstract translation: 公开了肿瘤坏死因子受体（TNF-Rs）的抗体及其制备方法以及免疫测定中使用此类抗体的方法，并通过亲和层析纯化TBP-II。 还公开了对TBP-II的内源性抗体的诊断测定。

公开(公告)号：US20040013646A1

公开(公告)日：2004-01-22

申请号：US10349977

申请日：2003-01-24

Applicant: Yeda Research and Development Co. Ltd.

Inventor： David Wallach ,  Mark Boldin ,  Igor Mett ,  Eugene Varfolomeev

IPC: A61K048/00 ,  A61K039/395 ,  C07K016/30 ,  C07H021/04

CPC classification number: C07K14/47 ,  A61K38/00 ,  C07K14/525 ,  C07K14/70575 ,  C07K14/7151 ,  C07K16/2878 ,  C07K2317/82 ,  C07K2319/00

Abstract: The present invention generally concerns novel proteins which bind to the intracellular domains of the p55 and p75 TNF-Rs and the FAS-R, which are capable of modulating the function of the p55 and p75 TNF-Rs and the FAS-R, and the DNA sequences which encode them. The present invention also concerns new soluble oligomeric TNF-Rs, oligomeric FAS-Rs and oligomeric receptors having a mixture of TNF-Rs and FAS-Rs. In addition, the present invention concerns methods of preparation and uses of all of the aforementioned.

Abstract translation: 本发明通常涉及能够调节p55和p75 TNF-R和FAS-R功能的p55和p75 TNF-R和FAS-R的细胞内结构域的新型蛋白质，以及 编码它们的DNA序列。 本发明还涉及具有TNF-R和FAS-R的混合物的新的可溶性寡聚TNF-R，寡聚FAS-Rs和寡聚受体。 此外，本发明涉及上述所有方法的制备和用途。