公开(公告)号：US07247380B2

公开(公告)日：2007-07-24

申请号：US10435035

申请日：2003-05-12

申请人： Akiko Shimizu

发明人： Akiko Shimizu

IPC分类号： B32B18/00 ,  B32B27/32 ,  B32B27/36 ,  G02F1/1335 ,  G02B5/30

CPC分类号： G02F1/133634 ,  G02B5/3083 ,  G02F1/1393 ,  Y10T428/10 ,  Y10T428/1018 ,  Y10T428/25 ,  Y10T428/252 ,  Y10T428/31507 ,  Y10T428/31667

摘要： The objective of the present invention is to provide a laminated phase retarder film that is superior in evenness, exhibits a biaxial optical property as a whole, and makes it possible to set the biaxial optical property over a wide range. This object is achieved by a laminated phase retarder film comprising a transparent resin film as a substrate and at least one coat layer having a refractive-index anisotropy laminated on at least one surface of the substrate, wherein a in-plane retardation value (R0) is not less than 20 nm, a retardation value (R′) in the film-thickness direction, which is calculated from a retardation value (R40) measured by inclining by 40 degrees around the slow axis of the film and the in-plane retardation value (R0), is greater than 40 nm.

摘要翻译： 本发明的目的是提供一种均匀性优异的叠层相延迟膜，整体呈双轴光​​学特性，可以在宽范围内设定双轴光学特性。 该目的通过层叠型相延迟膜实现，该层叠相延迟膜包含透明树脂膜作为基板，并且至少一层具有折射率各向异性的涂层层叠在基板的至少一个表面上，其中面内延迟值（R < SUB> 0 <＆gt;）不小于20nm，通过倾斜测量由延迟值（R≥40）计算的膜厚度方向上的延迟值（R'） 围绕薄膜的慢轴和面内延迟值（R LOW）的大约40度大于40nm。

公开(公告)号：US6097460A

公开(公告)日：2000-08-01

申请号：US233962

申请日：1999-01-20

申请人： Akiko Shimizu ,  Koji Higashi ,  Takahiro Hishinuma

发明人： Akiko Shimizu ,  Koji Higashi ,  Takahiro Hishinuma

IPC分类号： B32B7/02 ,  G02B5/30 ,  G02F1/1335

CPC分类号： G02B5/3083

摘要： A phase retarder film is provided wherein at least one oblique evaporation layer comprising an inorganic dielectric mainly containing TiO.sub.2 is formed on at least one surface of a transparent polymer film with an intermediate layer between, the evaporation layer having positive refractive index anisotropy and a principal optic axis tilted 20 degrees to 70 degrees from a normal direction to said transparent polymer film. The phase retarder film is suitable for improving viewing angle characteristics of the TN-LCD.

摘要翻译： 提供了一种相位延迟膜，其中至少一个包含主要含有TiO 2的无机电介质的倾斜蒸发层形成在透明聚合物膜的至少一个表面上，中间层之间具有正折射率各向异性的蒸发层和主光学器件 轴向从所述透明聚合物膜的法线方向倾斜20度至70度。 相位延迟膜适用于改善TN-LCD的视角特性。

公开(公告)号：US5631755A

公开(公告)日：1997-05-20

申请号：US415254

申请日：1995-04-03

申请人： Taiichi Sakaya ,  Toshiya Kuroda ,  Koji Higashi ,  Tadashi Shindo ,  Akiko Shimizu

发明人： Taiichi Sakaya ,  Toshiya Kuroda ,  Koji Higashi ,  Tadashi Shindo ,  Akiko Shimizu

IPC分类号： G02B5/30 ,  G02F1/13363 ,  G02F1/1335

CPC分类号： G02B5/3083 ,  G02F1/13363 ,  Y10T428/25

摘要： A phase retarder including a layered inorganic compound-containing sheet or layered inorganic compound-containing film, the inorganic compound being selected from the group consisting of a clay mineral, a chalcogen compound, a zirconium phosphate compound, an oxyacid salt of a transition metal, a layered polysilicate, a metal oxyhalogenide, and an intercalary decoration thereof intercalated with ions or molecules between crystalline layer units, the inorganic compound having a mean particle size of 5000 nm or less and a stratified structure with a plurality of crystalline layer units wherein the phase retarder has a refractive index in the plane of the phase retarder that is different from a refractive index in the thickness direction of the phase retarder.

摘要翻译： 一种含有含层状无机化合物的片材或层状无机化合物的膜的相变缓凝剂，所述无机化合物选自粘土矿物，硫属化合物，磷酸锆化合物，过渡金属的含氧酸盐， 层状聚硅酸盐，金属卤氧化物，以及在结晶层单元之间插入离子或分子的嵌入式装饰物，所述无机化合物具有5000nm以下的平均粒径和具有多个结晶层单元的分层结构，其中所述相 延迟器在相位延迟器的平面中具有与相位延迟器的厚度方向上的折射率不同的折射率。

公开(公告)号：US5529906A

公开(公告)日：1996-06-25

申请号：US154354

申请日：1993-11-18

申请人： Akiko Shimizu ,  Akihiro Shinzaki ,  Tadao Suzuki ,  Miwa Watanabe

发明人： Akiko Shimizu ,  Akihiro Shinzaki ,  Tadao Suzuki ,  Miwa Watanabe

IPC分类号： C12Q1/42 ,  G01N33/535 ,  G01N33/53

CPC分类号： C12Q1/42 ,  C12Q2326/96 ,  Y10S435/81 ,  Y10S435/975

摘要： A system or kit for analysis of phosphatase comprising a reagent I containing NADP or NADPH as a main component, and a reagent II containing components for color-development signal amplification utilizing NAD-NADH interconversion, wherein at least one of the hydrogen donors participating in the NAD-NADH interconversion is included in reagent I, but not in reagent II, which eliminates the necessity that the reagent II is further separated into two parts. This enables the preparation of reagent II as a mixture which can be readily used and which can be preserved for a long period of time without "reagent blank" occurring. Additionally, the present kit eliminates the necessity of mixing reagents I and II immediately before actual use and thus permits periodical analysis of samples with a reagent having the same components for long time periods with reliable and uniform sensitivity.

摘要翻译： 一种用于分析磷酸酶的系统或试剂盒，其包含含有NADP或NADPH作为主要成分的试剂I和含有利用NAD-NADH相互转化的显色信号扩增成分的试剂II，其中至少一个氢供体参与 NAD-NADH相互转化包括在试剂I中，但不包括在试剂II中，这不需要将试剂II进一步分成两部分。 这使得可以制备试剂II作为混合物，其可以容易地使用并且可以长时间保存而没有发生“试剂空白”。 另外，本试剂盒消除了在实际使用之前混合试剂I和II的必要性，因此允许用具有相同组分的试剂在长时间段内具有可靠和均匀的灵敏度的定期分析。

公开(公告)号：US20140186349A1

公开(公告)日：2014-07-03

申请号：US14215556

申请日：2014-03-17

申请人： Kenya Shitara ,  Kazuyasu Nakamura ,  Emi Hosaka ,  Akiko Shimizu ,  Masamichi Koike

发明人： Kenya Shitara ,  Kazuyasu Nakamura ,  Emi Hosaka ,  Akiko Shimizu ,  Masamichi Koike

IPC分类号： C07K16/28

CPC分类号： C07K16/2896 ,  A61K2039/505 ,  C07K14/7158 ,  C07K16/2866 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/732 ,  G01N33/57492 ,  G01N33/6863 ,  G01N2333/4719 ,  G01N2333/7158

摘要： A human CDR-grafted antibody or the antibody fragment thereof which specifically reacts with the extracellular region of human CC chemokine receptor 4 (CCR4) but does not react with a human blood platelet; a human CDR-grafted antibody or the antibody fragment thereof which specifically reacts with the extracellular region of CCR4 and has a cytotoxic activity against a CCR4-expressing cell; and a medicament, a therapeutic agent or a diagnostic agent comprising at least one of the antibodies and the antibody fragments thereof as an active ingredient.

摘要翻译： 与人CC趋化因子受体4（CCR4）的细胞外区特异性反应但不与人血小板反应的人CDR-移植抗体或其抗体片段; 与CCR4的胞外区特异性反应并对CCR4表达细胞具有细胞毒活性的人CDR-移植抗体或其抗体片段; 以及包含至少一种抗体及其抗体片段作为活性成分的药物，治疗剂或诊断剂。

公开(公告)号：US06056900A

公开(公告)日：2000-05-02

申请号：US951052

申请日：1997-10-16

申请人： Akiko Shimizu ,  Yukio Kageyama ,  Shigeo Nakamura

发明人： Akiko Shimizu ,  Yukio Kageyama ,  Shigeo Nakamura

IPC分类号： B29D11/00 ,  B29K83/00 ,  C08F283/12 ,  C08L83/04 ,  G02B1/04 ,  G02B3/00

CPC分类号： C08F283/12 ,  G02B1/041 ,  Y10S425/808

摘要： A cast-molding material for a plastic lens which is almost free from causing defective dyeing when dyed, and a process for producing plastic lenses almost free from causing defective dyeing, the cast-molding material containing, as essential components, a combination of (A) diethylene glycol bisallylcarbonate or a mixture of diethylene glycol bisallylcarbonate and a monomer copolymerizable therewith, with (B) a polyether-modified silicone compound, and the process including cast-molding the above cast-molding material in a mold.

摘要翻译： 一种用于塑料透镜的铸塑材料，其在染色时几乎不会引起染色不良，以及用于生产几乎不引起染色不良的塑料透镜的方法，所述浇铸模塑材料作为必要组分含有（A ）二甘醇双烯丙基碳酸酯或二甘醇双烯丙基碳酸酯和可与其共聚的单体的混合物与（B）聚醚改性的硅氧烷化合物，并且该方法包括将上述浇铸成型材料浇铸成型。

公开(公告)号：US5926313A

公开(公告)日：1999-07-20

申请号：US956453

申请日：1997-10-23

申请人： Takahiro Hishinuma ,  Akiko Shimizu ,  Koji Higashi

发明人： Takahiro Hishinuma ,  Akiko Shimizu ,  Koji Higashi

IPC分类号： G02B5/30 ,  G02F1/13363

CPC分类号： G02F1/133632 ,  G02B5/3083

摘要： As a phase retarder film in which at least one oblique evaporation layer of an inorganic dielectric having positive refractive index anisotropy and having its principal optic axis tilted 20 degrees to 70 degrees from the direction of the normal to the film is formed on at least one surface of a transparent polymer film with an intermediate layer between, a large area film is easily and inexpensivly obtained.

摘要翻译： 作为相位延迟膜，其中至少一个具有正折射率各向异性且其主光轴从膜的法线方向倾斜20度至70度的无机电介质的倾斜蒸发层形成在至少一个表面上 具有中间层之间的透明聚合物膜，容易且廉价地获得大面积的膜。

公开(公告)号：US5888634A

公开(公告)日：1999-03-30

申请号：US845471

申请日：1997-04-25

申请人： Akiko Shimizu ,  Koji Higashi

发明人： Akiko Shimizu ,  Koji Higashi

IPC分类号： G02B5/30

CPC分类号： G02B5/3083 ,  Y10T428/24942 ,  Y10T428/31507 ,  Y10T428/31533

摘要： Disclosed is a phase retarder film made of a thermoplastic resin having an in-plane retardation of 50 to 300 nm and a ratio of the in-plane retardation to the retardation normal to the plane of not less than 0.5, but not more than 1.8, a process for the production thereof and a laminate phase retarder film using said phase retarder film above.

摘要翻译： 公开了一种由面内相位差为50〜300nm的热塑性树脂制成的相位滞后膜，面内延迟与平面相位差的比例为0.5以上且1.8以下， 其制造方法和使用上述相延迟膜的层压相延迟膜。

公开(公告)号：US5285303A

公开(公告)日：1994-02-08

申请号：US705203

申请日：1991-05-24

申请人： Toyokazu Okada ,  Kazuaki Sakakura ,  Koji Higashi ,  Akiko Shimizu

发明人： Toyokazu Okada ,  Kazuaki Sakakura ,  Koji Higashi ,  Akiko Shimizu

IPC分类号： B29C61/00 ,  G02B5/30 ,  G02F1/13363 ,  G02B1/04

CPC分类号： B29C61/00 ,  G02B5/3083 ,  G02F1/13363

摘要： A phase retarder and a process for producing the same are disclosed. The phase retarder is obtained by shrinking a uniaxially stretched thermoplastic high polymer film in the direction perpendicular to the stretching direction at a lengthwise shrink of at least 2%. The phase retarder has a ratio of a retardation value (R.sub.30) measured on the phase retarder being inclined at a angle of 30.degree. with respect to the orientation axis as an axis of rotation to a retardation value (R.sub.0) measured on the phase retarder being held horizontally, each measured with a polarizing microscope, (R.sub.30 /R.sub.0) of not more than 1.10, and preferably not more than 1.07. A liquid crystal display fitted with the phase retarder exhibits broad viewing angle characteristics while achieving a satisfactory B/W display level.

摘要翻译： 公开了一种相位延迟器及其制造方法。 相延迟器是通过在垂直于拉伸方向的方向上以至少2％的纵向收缩收缩单轴拉伸的热塑性聚合物膜而获得的。 相位延迟器具有在相位延迟器上测量的延迟值（R30）相对于作为旋转轴的取向轴以相位延迟器测量的延迟值（R0）为30度的倾斜角度的比率为 每个用偏光显微镜测量，（R30 / R0）不大于1.10，优选不大于1.07。 配有相位延迟器的液晶显示器在获得令人满意的B / W显示电平的同时表现出广阔的视角特性。

公开(公告)号：US08143058B2

公开(公告)日：2012-03-27

申请号：US12903780

申请日：2010-10-13

申请人： Kenya Shitara ,  Kazuyasu Nakamura ,  Emi Hosaka ,  Akiko Shimizu ,  Masamichi Koike

发明人： Kenya Shitara ,  Kazuyasu Nakamura ,  Emi Hosaka ,  Akiko Shimizu ,  Masamichi Koike

IPC分类号： C12N5/16

CPC分类号： C07K16/2896 ,  A61K2039/505 ,  C07K14/7158 ,  C07K16/2866 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/732 ,  G01N33/57492 ,  G01N33/6863 ,  G01N2333/4719 ,  G01N2333/7158

摘要： A human CDR-grafted antibody or the antibody fragment thereof which specifically reacts with the extracellular region of human CC chemokine receptor 4 (CCR4) but does not react with a human blood platelet; a human CDR-grafted antibody or the antibody fragment thereof which specifically reacts with the extracellular region of CCR4 and has a cytotoxic activity against a CCR4-expressing cell; and a medicament, a therapeutic agent or a diagnostic agent comprising at least one of the antibodies and the antibody fragments thereof as an active ingredient.

摘要翻译： 与人CC趋化因子受体4（CCR4）的细胞外区特异性反应但不与人血小板反应的人CDR-移植抗体或其抗体片段; 与CCR4的胞外区特异性反应并对CCR4表达细胞具有细胞毒活性的人CDR-移植抗体或其抗体片段; 以及包含至少一种抗体及其抗体片段作为活性成分的药物，治疗剂或诊断剂。