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191 条记录 (耗时 0.027 秒)

    Method of multiple quantification of cholesterol in low-density lipoproteins
    11.
    发明申请
    Method of multiple quantification of cholesterol in low-density lipoproteins 有权
    低密度脂蛋白胆固醇多重定量的方法

    公开(公告)号：US20060078958A1

    公开(公告)日：2006-04-13

    申请号：US10537992

    申请日：2003-12-12

    申请人： Hiroshi Matsui

    发明人： Hiroshi Matsui

    IPC分类号： C12Q1/60

    CPC分类号： G01N33/92 ,  G01N2800/044

    摘要： The present invention is intended to provide a method for simultaneously measuring cholesterol in low density lipoprotein and total cholesterol as test components in blood. Specifically, a method is used for simultaneously measuring cholesterol in low density lipoprotein and total cholesterol in a biological sample, whereby cholesterol in low density lipoprotein and total cholesterol in a biological sample are quantified with a single measurement.

    摘要翻译： 本发明旨在提供一种同时测量低密度脂蛋白胆固醇和总胆固醇作为血液中测试成分的方法。 具体地，使用一种方法同时测量生物样品中低密度脂蛋白和总胆固醇的胆固醇，由此通过单次测量量化生物样品中低密度脂蛋白和总胆固醇的胆固醇。

    Method of determining cholesterol content of high-density lipoproteins
    12.
    发明授权
    Method of determining cholesterol content of high-density lipoproteins 有权
    测定高密度脂蛋白胆固醇含量的方法

    公开(公告)号：US06479249B2

    公开(公告)日：2002-11-12

    申请号：US09117806

    申请日：1998-08-06

    申请人： Hiroshi Matsui ,  Yasuki Ito ,  Shuichi Ohara ,  Akira Fujiwara

    发明人： Hiroshi Matsui ,  Yasuki Ito ,  Shuichi Ohara ,  Akira Fujiwara

    IPC分类号： C12Q160

    CPC分类号： C12Q1/60 ,  Y10S436/824

    摘要： Disclosed is a method for quantifying cholesterol in HDL, which does not require complex fragmentation and separation operations, and by which the HDL cholesterol in test samples containing HDL and other lipoproteins such as low density lipoprotein (LDL), very low density lipoprotein (VLDL) and chylomicron (CM) may be quantified selectively, simply and accurately. The method for quantifying cholesterol in high density lipoprotein comprises a first step of erasing cholesterol in lipoproteins other than high density lipoprotein in a test sample, and a second step of adding a surfactant which specifically acts on high density lipoprotein to the product of the first step and enzymatically quantifying cholesterol in high density lipoprotein.

    摘要翻译： 本发明公开了一种定量HDL中的胆固醇的方法，其不需要复杂的分离和分离操作，并且含有HDL和其它脂蛋白（例如低密度脂蛋白（LDL），极低密度脂蛋白（VLDL））的测试样品中的HDL胆固醇， 和乳糜微粒（CM）可以选择性，简单和精确地量化。 用于定量高密度脂蛋白中的胆固醇的方法包括在测试样品中除去高密度脂蛋白以外的脂蛋白中的胆固醇的第一步骤，以及将特异性作用于高密度脂蛋白的表面活性剂加入到第一步骤的产物的第二步骤 并在高密度脂蛋白中酶法定量胆固醇。

    Heterocyclic derivatives, method of production thereof and pharmaceutical use thereof
    13.
    发明授权
    Heterocyclic derivatives, method of production thereof and pharmaceutical use thereof 失效
    杂环衍生物，其制备方法和药物用途

    公开(公告)号：US06414012B1

    公开(公告)日：2002-07-02

    申请号：US09373163

    申请日：1999-08-12

    申请人： Hiroshi Matsui ,  Shoji Kamiya ,  Hiroaki Shirahase ,  Shohei Nakamura ,  Katsuo Wada

    发明人： Hiroshi Matsui ,  Shoji Kamiya ,  Hiroaki Shirahase ,  Shohei Nakamura ,  Katsuo Wada

    IPC分类号： A61P910

    CPC分类号： C07D231/12 ,  A61K31/404 ,  A61K31/47 ,  C07D209/08 ,  C07D215/06 ,  C07D215/26 ,  C07D233/56 ,  C07D249/08 ,  C07D401/12 ,  Y10S514/824 ,  Y10S514/866

    摘要： Heterocyclic derivatives of the formula (I) wherein each symbol is as defined in the specification, pharmaceutically acceptable salts thereof and method of producing them. Pharmaceutical compositions containing the heterocyclic derivative or a pharmaceutically acceptable salt thereof, particularly, ACAT inhibitors and lipoperoxidation inhibitors. The heterocyclic derivatives and pharmaceutically acceptable salts thereof of the present invention show superior ACAT inhibitory activity and lipoperoxidation inhibitory activity, and are useful as ACAT inhibitors and hyperlipemia inhibitors. To be specific, they are useful for the prevention and treatment of arteriosclerotic lesions of arteriosclerosis, hyperlipemia and diabetes, as well as ischemic diseases of brain, heart and the like.

    摘要翻译： 式（I）的杂环衍生物，其中每个符号如说明书中所定义，其药学上可接受的盐及其制备方法。 含有杂环衍生物或其药学上可接受的盐，特别是ACAT抑制剂和脂质过氧化抑制剂的药物组合物。 本发明的杂环衍生物及其药学上可接受的盐显示出优异的ACAT抑制活性和脂质过氧化抑制活性，并且可用作ACAT抑制剂和高脂血症抑制剂。 具体而言，它们可用于预防和治疗动脉硬化，高脂血症和糖尿病的动脉硬化病变，以及脑，心脏等的缺血性疾病。

    Pressing and rotating operation type electronic parts and communication terminal equipment using the electronic parts
    15.
    发明授权
    Pressing and rotating operation type electronic parts and communication terminal equipment using the electronic parts 失效
    使用电子部件按压旋转操作型电子部件和通讯终端设备

    公开(公告)号：US06396006B1

    公开(公告)日：2002-05-28

    申请号：US09529158

    申请日：2000-06-29

    申请人： Shigeru Yokoji ,  Koji Tamano ,  Hiroshi Matsui

    发明人： Shigeru Yokoji ,  Koji Tamano ,  Hiroshi Matsui

    IPC分类号： H01H2506

    CPC分类号： G06F3/0312 ,  G06F3/0338 ,  G06F3/0362 ,  H01H19/11 ,  H01H25/008 ,  H01H25/041 ,  H01H25/06 ,  H01H25/065 ,  H01H2025/048 ,  H01H2217/048 ,  H04M1/0202 ,  H04M1/72519

    摘要： A push and rotary operating type electronic device comprises a push switch unit 37 composed in a center of a bottom surface of a case 30, a rotary encoder unit 35 composed at a periphery of the push switch unit, a discoidal operating knob 39 mounted in a manner to be independently movable vertically, while also rotatable conjunctly with the rotary encoder unit 35, wherein the both component units 35 and 37 are operative by depression on a peripheral portion of the operating knob 39 during a rotary manipulation and a center portion of the same in a depressing manipulation. Communication terminal equipment uses this push and rotary operating type electronic device. This structure realizes a small projected area, and allows the rotary manipulation and the depressing manipulation by operating different portions of the single operating knob 39.

    摘要翻译： 推动和旋转操作型电子设备包括构成在壳体30的底面的中心的按钮开关单元37，组成在按钮开关单元周围的旋转编码器单元35，安装在 方式可独立地垂直移动，同时也可与旋转编码器单元35一起旋转，其中两个部件单元35和37通过在旋转操纵期间的操作旋钮39的周边部分上的凹陷和相同的中心部分 在一个令人沮丧的操纵。 通讯终端设备采用这种推，旋式操作型电子设备。 这种结构实现了小的投影面积，并且通过操作单个操作旋钮39的不同部分来允许旋转操纵和按压操作。

    Rotary-push type electronic component and electronic appliance using the same
    16.
    发明授权
    Rotary-push type electronic component and electronic appliance using the same 失效
    旋转式电子部件及使用其的电子设备

    公开(公告)号：US06333473B1

    公开(公告)日：2001-12-25

    申请号：US09469788

    申请日：1999-12-22

    申请人： Masaki Sawada ,  Hiroto Inoue ,  Hiroshi Matsui

    发明人： Masaki Sawada ,  Hiroto Inoue ,  Hiroshi Matsui

    IPC分类号： A01H2500

    CPC分类号： H01H25/008 ,  G05G9/047 ,  H01H2019/146

    摘要： A rotary-push type electronic component is provided for use in an electronic appliance such as a mobile phone. The electronic component includes a base unit, a frame mounted to the base unit, a support shaft coupling the frame to the base unit for pivotal and vertical movement of the frame relative to the base unit, a generally cylindrical operation knob rotatably mounted to the frame, a rotary operation device for emitting an electric signal upon rotation of the generally cylindrical operation knob, and a pair of self-restoring push operation parts spaced apart on the base unit below the frame so as to be operated by pivoting of the frame about the support shaft relative to the base unit. The support shaft is disposed at a rear portion of the frame, and the push operation parts are disposed beneath a front portion of the frame.

    摘要翻译： 提供用于诸如移动电话的电子设备中的旋转式电子部件。 电子部件包括基座单元，安装到基座单元的框架，将框架联接到基座单元的支撑轴，用于框架相对于基座单元的枢转​​和垂直运动;大致圆柱形的操作旋钮，可旋转地安装到框架 旋转操作装置，用于在大体上圆柱形的操作旋钮旋转时发出电信号;以及一对自恢复推动操作部件，其间隔地设置在框架下方的基座部件上， 支撑轴相对于基座单元。 支撑轴设置在框架的后部，并且推动操作部分设置在框架的前部下方。

    Heterocyclic derivatives and pharmaceutical use thereof
    17.
    发明授权
    Heterocyclic derivatives and pharmaceutical use thereof 失效
    杂环衍生物及其药物用途

    公开(公告)号：US06200988B1

    公开(公告)日：2001-03-13

    申请号：US09506839

    申请日：2000-02-18

    申请人： Shoji Kamiya ,  Hiroaki Shirahase ,  Hiroshi Matsui ,  Shohei Nakamura ,  Katsuo Wada

    发明人： Shoji Kamiya ,  Hiroaki Shirahase ,  Hiroshi Matsui ,  Shohei Nakamura ,  Katsuo Wada

    IPC分类号： C07D21540

    CPC分类号： C07D209/08

    摘要： A heterocyclic derivative of the formula (I) wherein each symbol is as defined in the specification, and pharmaceutically acceptable salts thereof. The compound (I) of the present invention and pharmaceutically acceptable salts thereof exhibit superior ACAT inhibitory activity and lipoperoxidation inhibitory activity in mammals, and are useful as ACAT inhibitors and lipoperoxidation inhibitors. Specifically, they are useful for the prophylaxis and treatment of arteriosclerosis, hyperlipemia, arteriosclerosis in diabetes, and cerebrovascular and cardiovascular ischemic diseases.

    摘要翻译： 式（I）的杂环衍生物，其中每个符号如说明书中所定义，及其药学上可接受的盐。 本发明的化合物（I）及其药学上可接受的盐在哺乳动物中表现出优异的ACAT抑制活性和脂过氧化抑制活性，可用作ACAT抑制剂和脂质过氧化抑制剂。 具体地说，它们可用于预防和治疗动脉硬化，高脂血症，糖尿病中的动脉硬化，以及脑血管和心血管缺血性疾病。

    Rotary encoder
    18.
    发明授权
    Rotary encoder 失效
    旋转编码器

    公开(公告)号：US06194673B1

    公开(公告)日：2001-02-27

    申请号：US09467813

    申请日：1999-12-20

    申请人： Jun Sato ,  Hiroshi Matsui

    发明人： Jun Sato ,  Hiroshi Matsui

    IPC分类号： H01H900

    CPC分类号： H01H19/005 ,  H01H25/008 ,  H01H2019/006 ,  H01H2019/146

    摘要： A rotary encoder used mainly in a peripheral apparatus for computers, a portable telephone, an on-board electronic device for automobiles, and the like, in which an encoder unit and a linearly-driven type component are operable by a rotating manipulation and a tilting manipulation of an operating axle. The rotary encoder provides accuracy and is capable of producing a large number of output signals without requiring an increase in external dimensions. The rotary encoder is so constructed that flexible contacts and make resilient contact with movable contacts on a peripheral surface of a cylindrical rotor in a main unit of the encoder. The operating axle is pivotally supported by fitting it in an axle-supporting portion of the rotor in a manner that the operating axle is rotatable together with the rotor and is also tiltable. A cylindrical operating knob is attached to the operating axle that protrudes sideways from the rotor, and a push switch is disposed in a position to be in contact with a distal end of the same operating axle, and thereby making the main unit of the encoder operable by rotating manipulation and the push switch by tilting manipulation of the operating axle.

    摘要翻译： 主要用于计算机的周边设备，便携式电话机，车载电子设备等的旋转编码器，其中编码器单元和线性驱动型部件通过旋转操作和倾斜操作 操纵轴的操作。 旋转编码器提供精度并且能够产生大量的输出信号，而不需要增加外部尺寸。 旋转编码器被构造成使得柔性接触件与编码器主单元中的圆柱形转子的外周表面上的活动触头弹性接触。 操作轴通过将其安装在转子的轴支撑部分中以使得操作轴与转子一起旋转并且也可倾斜的方式枢转地支撑。 一个圆柱形操作旋钮连接到从转子侧向突出的操作轴上，并且按钮开关设置在与相同操作轴的远端接触的位置，从而使编码器的主单元可操作 通过使操作轴的操纵倾斜来旋转操作和按压开关。

    Indolyl or indolinyl derivatives and medicinal use thereof as ACAT or lipid peroxidation inhibitors
    19.
    发明授权
    Indolyl or indolinyl derivatives and medicinal use thereof as ACAT or lipid peroxidation inhibitors 失效
    吲哚基或二氢吲哚衍生物及其作为ACAT或脂质过氧化抑制剂的药用

    公开(公告)号：US6063806A

    公开(公告)日：2000-05-16

    申请号：US51202

    申请日：1998-04-03

    申请人： Shoji Kamiya ,  Hiroaki Shirahase ,  Hiroshi Matsui ,  Shohei Nakamura ,  Katsuo Wada

    发明人： Shoji Kamiya ,  Hiroaki Shirahase ,  Hiroshi Matsui ,  Shohei Nakamura ,  Katsuo Wada

    IPC分类号： C07D209/08 ,  A61K31/40 ,  C07D209/12 ,  C07D209/14 ,  C07D209/18

    CPC分类号： C07D209/08

    摘要： A heterocyclic derivative of the formula (I) ##STR1## wherein each symbol is as defined in the specification, and pharmaceutically acceptable salts thereof. The compound (I) of the present invention and pharmaceutically acceptable salts thereof exhibit superior ACAT inhibitory activity and lipoperoxidation inhibitory activity in mammals, and are useful as ACAT inhibitors and lipoperoxidation inhibitors. Specifically, they are useful for the prophylaxis and treatment of arteriosclerosis, hyperlipemia, arteriosclerosis in diabetes, and cerebrovascular and cardiovascular ischemic diseases.

    摘要翻译： PCT No.PCT / JP96 / 02852 Sec。 371日期：1998年4月3日 102（e）1998年4月3日PCT PCT 1996年9月30日PCT公布。 公开号WO97 / 12860 PCT 日期1997年4月10日一种式（I）的杂环衍生物，其中每个符号如说明书中所定义，及其药学上可接受的盐。 本发明的化合物（I）及其药学上可接受的盐在哺乳动物中表现出优异的ACAT抑制活性和脂过氧化抑制活性，可用作ACAT抑制剂和脂质过氧化抑制剂。 具体地说，它们可用于预防和治疗动脉硬化，高脂血症，糖尿病中的动脉硬化，以及脑血管和心血管缺血性疾病。