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11.发明申请公开(公告)号：US20080113942A1
公开(公告)日：2008-05-15
申请号：US11664670
申请日：2005-11-28
申请人： Yukimitsu Suda , Kazuyuki Miyazawa
发明人： Yukimitsu Suda , Kazuyuki Miyazawa
IPC分类号： A61K31/685 , C07F9/22
CPC分类号： C07F9/091
摘要： The present invention is a phosphorylcholine-containing chemical compound represented by the following formula (1) or (2). (CH3)3N+CH2CH2PO4−CH2COOH (1) (CH3)3N+CH2CH2PO4−CH2COONa (2) The object of the present invention is to provide a new phosphorylcholine-containing compound that is useful as a surface treatment agent or a source material of a surface treatment agent. Another object is to provide a manufacturing method that has a high industrial utility value.
摘要翻译： 本发明是由下式（1）或（2）表示的含磷酰胆碱的化合物。 <？in-line-formula description =“In-line Formulas”end =“lead”？>（CH 3）<3> + CH 2 CO 2（CO）（1） in-line-formula description =“In-line Formulas”end =“tail”？> <？in-line-formula description =“In-line formula”end =“lead”？>（CH < 3＆lt; 3＆gt;＆lt; 3＆gt; N＆lt; 2＆gt; CH 2＆gt; 2＆lt; 2＆lt; CH 2 COONa（2）<？in-line-formula description =“In-line Formulas”end =“tail”？>本发明的目的是提供一种 新的含磷酰胆碱的化合物可用作表面处理剂或表面处理剂的原料。 另一个目的是提供具有很高工业实用价值的制造方法。
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12.发明授权公开(公告)号：US07674782B2
公开(公告)日：2010-03-09
申请号：US11664670
申请日：2005-11-28
申请人： Yukimitsu Suda , Kazuyuki Miyazawa
发明人： Yukimitsu Suda , Kazuyuki Miyazawa
IPC分类号： A61K31/685 , C07F9/02 , C08F30/02
CPC分类号： C07F9/091
摘要： The present invention is a phosphorylcholine-containing chemical compound represented by the following formula (1) or (2). (CH3)3N+CH2CH2PO4−CH2COOH (1) (CH3)3N+CH2CH2PO4−CH2COONa (2) The object of the present invention is to provide a new phosphorylcholine-containing compound that is useful as a surface treatment agent or a source material of a surface treatment agent. Another object is to provide a manufacturing method that has a high industrial utility value.
摘要翻译： 本发明是由下式（1）或（2）表示的含磷酰胆碱的化合物。 （CH3）3N + CH2CH2PO4-CH2COOH（1）（CH3）3N + CH2CH2PO4-CH2COONa（2）本发明的目的是提供一种新的含磷酰胆碱的化合物，其可用作表面处理剂或源材料 表面处理剂。 另一个目的是提供具有很高工业实用价值的制造方法。
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公开(公告)号：US20080300369A1
公开(公告)日：2008-12-04
申请号：US10593682
申请日：2005-05-18
IPC分类号： C08L67/00
CPC分类号： C08J7/12 , A61F2/16 , A61F2002/1699 , A61L27/28 , G02B1/043
摘要： The present invention is a method of manufacturing an eye lens material having a process in which a phosphorylcholine group-containing chemical compound represented by the following formula (1) is reacted and covalently bonded to the surface of an eye lens material having hydroxyl groups wherein the chemical compound represented by the following formula (2) is reacted and covalently bonded through ester-bonding to the eye lens material in an organic solvent.The object of the present invention is to provide an eye lens material that prevents protein adsorption and a method of manufacturing thereof.
摘要翻译： 本发明是一种眼镜透镜材料的制造方法，其具有下述通式（1）所示的含磷酰胆碱基的化合物与具有羟基的眼晶状体材料的表面反应并共价键合的方法，其中， 由下式（2）表示的化合物通过酯键在有机溶剂中与眼晶体材料反应并共价键合。 本发明的目的是提供一种防止蛋白质吸附的眼用透镜材料及其制造方法。
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14.发明申请公开(公告)号：US20080038221A1
公开(公告)日：2008-02-14
申请号：US10592772
申请日：2005-05-18
IPC分类号： A61K31/80
摘要： The present invention is a method of manufacturing an eye lens material having a process in which a phosphorylcholine group-containing chemical compound represented by the following formula (1) is reacted and covalently bonded onto the surface of an eye lens material wherein a chemical compound having an end amino group is introduced to said eye lens material and then the chemical compound represented by the following formula (2) or (3) is introduced through said chemical compound having an end amino group. The object of the present invention is to provide a method of manufacturing a contact lens that prevents protein adsorption. n denotes a natural number 1-18.
摘要翻译： 本发明是一种眼透镜材料的制造方法，其具有以下处理：将由下式（1）表示的含磷酰胆碱基的化合物反应并共价键合到眼晶状体材料的表面上，其中具有 将末端氨基引入所述眼晶状体材料中，然后通过具有末端氨基的化合物引入由下式（2）或（3）表示的化合物。 本发明的目的是提供一种制造防止蛋白质吸附的隐形眼镜的方法。 n表示自然数1-18。
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15.发明授权公开(公告)号：US08092834B2
公开(公告)日：2012-01-10
申请号：US10481852
申请日：2002-06-28
申请人： Norinobu Yoshikawa , Kenichi Sakuma , Katsuki Ogawa , Satoshi Tomomasa , Eriko Kawai , Hiroyuki Yokoyama , Yukimitsu Suda
发明人： Norinobu Yoshikawa , Kenichi Sakuma , Katsuki Ogawa , Satoshi Tomomasa , Eriko Kawai , Hiroyuki Yokoyama , Yukimitsu Suda
CPC分类号： A61K8/891 , A61K8/02 , A61K8/0204 , A61K8/022 , A61K8/11 , A61K8/25 , A61K8/27 , A61K8/89 , A61K38/49 , A61K2800/612 , A61Q1/02 , A61Q1/06 , A61Q1/10 , A61Q1/12 , A61Q19/00 , A61Q19/005
摘要： A complex powder comprising an adsorption site and operation site, wherein said adsorption site attracts or adsorbs a specific enzyme, wherein said operation site inhibits or activates said enzyme, and wherein each of the both sites are appeared on the surface of the powder. In the complex powder described above, it is preferable that ζ-potential of the adsorption site at the pH employed is negative value, wherein said adsorption site attracts or adsorbs the specific enzyme whose ζ-potential is positive value, and wherein said adsorption site inhibits or activates said specific enzyme. And it is preferable that said adsorption site has ζ-potential at pH7.5 of −10 mV or below.In the complex powder described above, it is preferable that said specific enzyme is a plasminogen activator, and the operation site inhibits said plasminogen activator.The complex powder described above can be used as an external composition for improving a rough skin and an external composition for a sensitive skin.
摘要翻译： 包含吸附位点和操作部位的复合粉末，其中所述吸附部位吸引或吸附特定酶，其中所述操作部位抑制或激活所述酶，并且其中两个部位中的每一个出现在粉末的表面上。 在上述复合粉末中，优选吸附部位在所用pH下的ζ-电位为负值，其中所述吸附部位吸引或吸附ζ-电位为正值的特异性酶，其中所述吸附位点抑制 或激活所述特异性酶。 并且所述吸附部位优选在pH7.5为-10mV以下的ζ-电位。 在上述复合粉末中，优选所述特异性酶是纤溶酶原激活剂，操作部位抑制所述纤溶酶原激活剂。 上述复合粉末可以用作改善粗糙皮肤的外用组合物和用于敏感皮肤的外用组合物。
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公开(公告)号：US08318865B2
公开(公告)日：2012-11-27
申请号：US10593682
申请日：2005-05-18
IPC分类号： C08C19/24
CPC分类号： C08J7/12 , A61F2/16 , A61F2002/1699 , A61L27/28 , G02B1/043
摘要： The present invention is a method of manufacturing an eye lens material having a process in which a phosphorylcholine group-containing chemical compound represented by the following formula (1) is reacted and covalently bonded to the surface of an eye lens material having hydroxyl groups wherein the chemical compound represented by the following formula (2) is reacted and covalently bonded through ester-bonding to the eye lens material in an organic solvent.The object of the present invention is to provide an eye lens material that prevents protein adsorption and a method of manufacturing thereof.
摘要翻译： 本发明是一种眼镜透镜材料的制造方法，其具有下述通式（1）所示的含磷酰胆碱基的化合物与具有羟基的眼晶状体材料的表面反应并共价键合的方法，其中， 由下式（2）表示的化合物通过酯键在有机溶剂中与眼晶体材料反应并共价键合。 本发明的目的是提供一种防止蛋白质吸附的眼用透镜材料及其制造方法。
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17.发明授权公开(公告)号：US08277834B2
公开(公告)日：2012-10-02
申请号：US10592772
申请日：2005-05-18
IPC分类号： A61K31/80
摘要： The present invention is a method of manufacturing an eye lens material having a process in which a phosphorylcholine group-containing chemical compound represented by the following formula (1) is reacted and covalently bonded onto the surface of an eye lens material wherein a chemical compound having an end amino group is introduced to said eye lens material and then the chemical compound represented by the following formula (2) or (3) is introduced through said chemical compound having an end amino group.The object of the present invention is to provide a method of manufacturing a contact lens that prevents protein adsorption.
摘要翻译： 本发明是一种眼透镜材料的制造方法，其具有以下处理：将由下式（1）表示的含磷酰胆碱基的化合物反应并共价键合到眼晶状体材料的表面上，其中具有 将末端氨基引入所述眼晶状体材料中，然后通过具有末端氨基的化合物引入由下式（2）或（3）表示的化合物。 本发明的目的是提供一种制造防止蛋白质吸附的隐形眼镜的方法。
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18.发明授权公开(公告)号：US08236873B2
公开(公告)日：2012-08-07
申请号：US10593544
申请日：2005-05-18
IPC分类号： G02B1/04
摘要： An eye lens material preventing protein adsorption is manufactured by reacting in a reaction medium of either water, an organic solvent, or a water/organic solvent mixture an eye lens material having OH groups with a phosphorylcholine group-containing compound of formula (1), thereby forming an acetal bond according to formula (2) which covalently bonds the phosphorylcholine group-containing compound to a surface of the eye lens material.
摘要翻译： 通过在水，有机溶剂或水/有机溶剂混合物，具有OH基的眼晶状体材料与含磷酰胆碱基团的式（1）化合物的反应介质中反应来制造防止蛋白质吸附的眼镜片材料， 从而形成根据式（2）的缩醛键，其将含磷酰胆碱基团的化合物共价键合到眼晶状体材料的表面。
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公开(公告)号：US08222443B2
公开(公告)日：2012-07-17
申请号：US12521788
申请日：2008-01-18
申请人： Kazuyuki Miyazawa , Yukimitsu Suda
发明人： Kazuyuki Miyazawa , Yukimitsu Suda
IPC分类号： C07F9/09
CPC分类号： A61Q19/00 , A61K8/553 , A61K2800/56 , C07F9/091
摘要： A phosphorylcholine group-containing compound that is a structure having a phosphorylcholine group represented by the following formula 1 and an amino group or a group derived from an amino group in an identical compound. (In the formula, m is 2 or more and 6 or less and p is 1 or 2. Each of X1, X2 and X3 is an alkyl group whose carbon number is 1 or more and 6 or less.)
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公开(公告)号：US20120059183A1
公开(公告)日：2012-03-08
申请号：US13287530
申请日：2011-11-02
申请人： Kazuyuki MIYAZAWA , Yukimitsu Suda
发明人： Kazuyuki MIYAZAWA , Yukimitsu Suda
IPC分类号： C07F9/09
CPC分类号： A61Q19/00 , A61K8/553 , A61K2800/56 , C07F9/091
摘要： A phosphorylcholine group-containing compound that is a structure having a phosphorylcholine group represented by the following formula 1 and an amino group or a group derived from an amino group in an identical compound. (In the formula, m is 2 or more and 6 or less and p is 1 or 2. Each of X1, X2 and X3 is an alkyl group whose carbon number is 1 or more and 6 or less.)
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