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公开(公告)号：US20070059370A1
公开(公告)日：2007-03-15
申请号：US11229129
申请日：2005-09-15
申请人： Po-Fu Chou , Pei Kan , Chun Jung Chen , Shih-Liang Yang , Chun Fu Leu , Shin-San Su
发明人： Po-Fu Chou , Pei Kan , Chun Jung Chen , Shih-Liang Yang , Chun Fu Leu , Shin-San Su
CPC分类号： A61K9/5123 , A61K9/5138 , A61K9/5192
摘要： An apparatus and method for forming nanoparticles employs an inkjet dispenser and a nanoparticle formation device. The inkjet dispenser includes at least one orifice. A liquid solution with a substance to be transformed into nanoscale is received in the inkjet dispenser, and is dispensed from the at least one orifice to generate a plurality of microdroplets. The nanoparticle formation device is disposed to receive the microdroplets dispensed by the inkjet dispenser and form the nanoparticles therein.
摘要翻译： 用于形成纳米颗粒的装置和方法采用喷墨分配器和纳米颗粒形成装置。 喷墨分配器包括至少一个孔口。 将具有待转化成纳米尺度的物质的液体溶液接收在喷墨分配器中，并从至少一个孔口分配以产生多个微滴。 纳米颗粒形成装置设置成接收由喷墨分配器分配的微滴并在其中形成纳米颗粒。
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公开(公告)号：US07179867B2
公开(公告)日：2007-02-20
申请号：US10721877
申请日：2003-11-26
申请人： Ken-Yuan Chang , Ming-Hsi Yeh , Ming-Fa Hsieh , Pei Kan , Yu-Yan Jan , Shu-Hua Jan , Xi-Zhang Lin
发明人： Ken-Yuan Chang , Ming-Hsi Yeh , Ming-Fa Hsieh , Pei Kan , Yu-Yan Jan , Shu-Hua Jan , Xi-Zhang Lin
IPC分类号： C08L67/08
CPC分类号： C08G63/664 , A61K9/0024 , A61L24/0042 , A61L31/06 , A61L31/148 , C08G2261/126 , C08L67/04
摘要： A thermo-sensitve copolymer of following formula; is disclosed; wherein R1 is hydrogen, or —C(═O)—R2; R2 is C7-30 alkyl substituted or unsubstituted with functional groups; R3 is hydrogen, or C1-6 alkyl; and x, y or z individually is an integer greater than 0. The thermo-sensitive copolymers disclosed here are easy to be implanted into a human body through injection. The biodegradability is greatly improved and the cytotoxicity of the copolymers is low.
摘要翻译： 下式的热敏共聚物; 被披露 其中R 1是氢或-C（-O）-R 2; R 2是被官能团取代或未取代的C 7-30烷基; R 3是氢或C 1-6烷基; 并且x，y或z分别是大于0的整数。这里公开的热敏共聚物通过注射容易地植入人体。 生物降解性大大提高，共聚物的细胞毒性低。
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公开(公告)号：US07485320B2
公开(公告)日：2009-02-03
申请号：US10624362
申请日：2003-07-23
申请人： Pei Kan , Ae-June Wang , Won-Ko Chen , Chih-Wan Tsao
发明人： Pei Kan , Ae-June Wang , Won-Ko Chen , Chih-Wan Tsao
IPC分类号： A61K31/07 , A61K31/135 , A61K31/165 , A61K31/21 , A61K31/215 , A61K31/235 , A61K31/24 , A61K31/335 , A61K31/40 , A61K31/44 , A61K31/66 , A61K31/685
CPC分类号： A61K9/1271
摘要： A liposome formulation for stably incorporating high content of hydrophobic substance is disclosed. The liposome includes two phospholipids with different phase transition temperatures such as saturated and unsaturated phosphatidyl cholines, hydrophobic substances, cholesterol, cholesterol derivatives, antioxidant and hydrophilic polymer-modified lipids such as MPEG-DSPE.
摘要翻译： 公开了用于稳定掺入高含量疏水物质的脂质体制剂。 脂质体包括两种具有不同相变温度的磷脂，例如饱和和不饱和磷脂酰胆碱，疏水物质，胆固醇，胆固醇衍生物，抗氧化剂和亲水性聚合物修饰的脂质如MPEG-DSPE。
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公开(公告)号：US20050113531A1
公开(公告)日：2005-05-26
申请号：US10721877
申请日：2003-11-26
申请人： Ken-Yuan Chang , Ming-Hsi Yeh , Ming-Fa Hsieh , Pei Kan , Yu-Yan Jan , Shu-Hua Jan , Xi-Zhang Lin
发明人： Ken-Yuan Chang , Ming-Hsi Yeh , Ming-Fa Hsieh , Pei Kan , Yu-Yan Jan , Shu-Hua Jan , Xi-Zhang Lin
CPC分类号： C08G63/664 , A61K9/0024 , A61L24/0042 , A61L31/06 , A61L31/148 , C08G2261/126 , C08L67/04
摘要： A thermo-sensitve copolymer of following formula; is disclosed; wherein R1 is hydrogen, or —C(═O)—R2; R2 is C7-30 alkyl substituted or unsubstituted with functional groups; R3 is hydrogen, or C1-6 alkyl; and x, y or z individually is an integer greater than 0. The thermo-sensitive copolymers disclosed here are easy to be implanted into a human body through injection. The biodegradability is greatly improved and the cytotoxicity of the copolymers is low.
摘要翻译： 下式的热敏共聚物; 被披露 其中R 1是氢或-C（-O）-R 2; R 2是被官能团取代或未取代的C 7-30烷基; R 3是氢或C 1-6烷基; 并且x，y或z分别是大于0的整数。这里公开的热敏共聚物通过注射容易地植入人体。 生物降解性大大提高，共聚物的细胞毒性低。
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