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公开(公告)号：US07485320B2
公开(公告)日：2009-02-03
申请号：US10624362
申请日：2003-07-23
申请人： Pei Kan , Ae-June Wang , Won-Ko Chen , Chih-Wan Tsao
发明人： Pei Kan , Ae-June Wang , Won-Ko Chen , Chih-Wan Tsao
IPC分类号： A61K31/07 , A61K31/135 , A61K31/165 , A61K31/21 , A61K31/215 , A61K31/235 , A61K31/24 , A61K31/335 , A61K31/40 , A61K31/44 , A61K31/66 , A61K31/685
CPC分类号： A61K9/1271
摘要： A liposome formulation for stably incorporating high content of hydrophobic substance is disclosed. The liposome includes two phospholipids with different phase transition temperatures such as saturated and unsaturated phosphatidyl cholines, hydrophobic substances, cholesterol, cholesterol derivatives, antioxidant and hydrophilic polymer-modified lipids such as MPEG-DSPE.
摘要翻译： 公开了用于稳定掺入高含量疏水物质的脂质体制剂。 脂质体包括两种具有不同相变温度的磷脂，例如饱和和不饱和磷脂酰胆碱，疏水物质，胆固醇，胆固醇衍生物，抗氧化剂和亲水性聚合物修饰的脂质如MPEG-DSPE。
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2.发明授权Delivery carrier for targeting to cells expressed with somatostatin receptors 有权用于靶向生长抑素受体表达的细胞的递送载体公开(公告)号：US07588778B2
公开(公告)日：2009-09-15
申请号：US10747125
申请日：2003-12-30
申请人： Pei Kan , Ae-June Wang
发明人： Pei Kan , Ae-June Wang
IPC分类号： A61K9/127 , A61K31/355 , C07D311/00
CPC分类号： A61K9/1271
摘要： The present invention relates to a delivery carrier including liposomes or nanoparticles for targeting the cells expressed with somatostatin receptor, consisting of a plurality of liposomes that have one phospholipid bilayer coating, one hydrophilic core and a bioactive substance. The bioactive substance is packaged in the hydrophilic core, or embedded in the phospholipid bilayer, or electrically bound with liposomes as a complex, wherein the phospholipid bilayer coating is conjugated with a plurality of molecules in the outer surface. The molecules recognize the somatostatin receptor in the surface of the target cells and induce receptor-mediated endocytosis.
摘要翻译： 本发明涉及包含用于靶向由生长抑素受体表达的细胞的脂质体或纳米颗粒的递送载体，其由具有一个磷脂双层涂层的多个脂质体，一个亲水核心和生物活性物质组成。 生物活性物质包装在亲水核心中，或嵌入在磷脂双层中，或与作为复合物的脂质体电结合，其中磷脂双层涂层与外表面中的多个分子缀合。 分子识别靶细胞表面的生长抑素受体并诱导受体介导的内吞作用。
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公开(公告)号：US07700564B2
公开(公告)日：2010-04-20
申请号：US12263885
申请日：2008-11-03
申请人： Ae-June Wang , Chi-Heng Jian , Shyh-Dar Li , Yi-Fong Lin , Shih-Jr Liu
发明人： Ae-June Wang , Chi-Heng Jian , Shyh-Dar Li , Yi-Fong Lin , Shih-Jr Liu
CPC分类号： A61K9/127 , A61K38/063 , A61K47/6911 , Y10S977/773
摘要： A delivery system. The delivery system includes a carrier or an active compound and a glutathione or a glutathione derivative grafted thereon. The invention also provides a compound including a moiety comprising a vitamin E derivative or a phospholipid derivative, a polyethylene glycol (PEG) or a polyethylene glycol derivative bonded thereto, and a glutathione (GSH) or a glutathione derivative bonded to the polyethylene glycol or the polyethylene glycol derivative.
摘要翻译： 送货系统。 递送系统包括载体或活性化合物和接枝在其上的谷胱甘肽或谷胱甘肽衍生物。 本发明还提供了包含包含维生素E衍生物或磷脂衍生物，聚乙二醇（PEG）或与其结合的聚乙二醇衍生物的部分的化合物以及与聚乙二醇结合的谷胱甘肽（GSH）或谷胱甘肽衍生物 聚乙二醇衍生物。
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4.发明授权公开(公告)号：US08128945B2
公开(公告)日：2012-03-06
申请号：US12886083
申请日：2010-09-20
申请人： Shyh-Dar Li , Ae-June Wang , Chung-Kung Lai
发明人： Shyh-Dar Li , Ae-June Wang , Chung-Kung Lai
IPC分类号： A61K9/51
CPC分类号： B82Y5/00 , A61K31/137 , A61K47/548 , A61K47/6911 , A61K47/6935 , Y10S977/773 , Y10S977/774
摘要： A vector for targeted delivery of drugs into estrogen receptors over-expressed cells is disclosed. The vector of the present invention is mainly about an active targeting delivery carrier which consists of a plurality of nanoparticles including: (i) a plurality of targeted moiety conjugated to the outer surface of the nanoparticles, the moiety being capable of binding with the estrogen receptor of a target cell, and (ii) bioactive agents encapsulated in the nanoparticles or forming complex with the nanoparticles. The targeted moiety of the present invention can also be conjugated to parent drugs for prodrug design.
摘要翻译： 公开了用于将药物靶向递送到雌激素受体过表达细胞的载体。 本发明的载体主要涉及由多个纳米颗粒组成的主动靶向递送载体，其包括：（i）与纳米颗粒的外表面缀合的多个靶向部分，所述部分能够与雌激素受体结合 的靶细胞，和（ii）包封在纳米颗粒中或与纳米颗粒形成复合物的生物活性剂。 本发明的靶向部分也可以与母体药物缀合用于前药设计。
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5.发明申请公开(公告)号：US20110008262A1
公开(公告)日：2011-01-13
申请号：US12886083
申请日：2010-09-20
申请人： Shyh-Dar LI , Ae-June Wang , Chung-Kung Lai
发明人： Shyh-Dar LI , Ae-June Wang , Chung-Kung Lai
IPC分类号： A61K31/683 , A61K9/00 , A61K9/127 , A61K49/00 , A61K31/7042 , A61K31/7088
CPC分类号： B82Y5/00 , A61K31/137 , A61K47/548 , A61K47/6911 , A61K47/6935 , Y10S977/773 , Y10S977/774
摘要： A vector for targeted delivery of drugs into estrogen receptors over-expressed cells is disclosed. The vector of the present invention is mainly about an active targeting delivery carrier which consists of a plurality of nanoparticles including: (i) a plurality of targeted moiety conjugated to the outer surface of the nanoparticles, the moiety being capable of binding with the estrogen receptor of a target cell, and (ii) bioactive agents encapsulated in the nanoparticles or forming complex with the nanoparticles. The targeted moiety of the present invention can also be conjugated to parent drugs for prodrug design.
摘要翻译： 公开了用于将药物靶向递送到雌激素受体过表达细胞的载体。 本发明的载体主要涉及由多个纳米颗粒组成的主动靶向递送载体，其包括：（i）与纳米颗粒的外表面缀合的多个靶向部分，所述部分能够与雌激素受体结合 的靶细胞，和（ii）包封在纳米颗粒中或与纳米颗粒形成复合物的生物活性剂。 本发明的靶向部分也可以与母体药物缀合用于前药设计。
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公开(公告)号：US20070141133A1
公开(公告)日：2007-06-21
申请号：US11303934
申请日：2005-12-19
申请人： Ae-June Wang , Chi-Heng Jian , Shyh-Dar Li , Yi-Fong Lin , Shih-Jr Liu
发明人： Ae-June Wang , Chi-Heng Jian , Shyh-Dar Li , Yi-Fong Lin , Shih-Jr Liu
CPC分类号： A61K9/127 , A61K38/063 , A61K47/6911 , Y10S977/773
摘要： A delivery system. The delivery system includes a carrier or an active compound and a glutathione or a glutathione derivative grafted thereon. The invention also provides a compound including a moiety comprising a vitamin E derivative or a phospholipid derivative, a polyethylene glycol (PEG) or a polyethylene glycol derivative bonded thereto, and a glutathione (GSH) or a glutathione derivative bonded to the polyethylene glycol or the polyethylene glycol derivative.
摘要翻译： 送货系统。 递送系统包括载体或活性化合物和接枝在其上的谷胱甘肽或谷胱甘肽衍生物。 本发明还提供了包含包含维生素E衍生物或磷脂衍生物，聚乙二醇（PEG）或与其结合的聚乙二醇衍生物的部分的化合物以及与聚乙二醇结合的谷胱甘肽（GSH）或谷胱甘肽衍生物 聚乙二醇衍生物。
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公开(公告)号：US20070087045A1
公开(公告)日：2007-04-19
申请号：US11249326
申请日：2005-10-14
申请人： Shyh-Dar Li , Ae-June Wang
发明人： Shyh-Dar Li , Ae-June Wang
CPC分类号： C12N15/88 , A61K9/1271 , A61K9/1272 , C12N2810/50
摘要： A lipid carrier. The carrier includes a lipid based particle comprising a cationic lipid, a cholesterol, a neutral phospholipid, and a neutral lipid, wherein the cationic lipid is about 100 parts by weight, the cholesterol is about 25˜100 parts by weight, the neutral phospholipid is about 25˜100 parts by weight, and the neutral lipid is about 25˜150 parts by weight. The invention also provides a method of preparing the lipid carrier.
摘要翻译： 脂质载体。 载体包括包含阳离子脂质，胆固醇，中性磷脂和中性脂质的脂质颗粒，其中阳离子脂质为约100重量份，胆固醇为约25〜100重量份，中性磷脂为 约25〜100重量份，中性脂质为约25〜150重量份。 本发明还提供了制备脂质载体的方法。
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公开(公告)号：US08067380B2
公开(公告)日：2011-11-29
申请号：US12244563
申请日：2008-10-02
申请人： Ae-June Wang , Chi-Heng Jian , Shyh-Dar Li , Yi-Fong Lin , Shin-Jr Liu
发明人： Ae-June Wang , Chi-Heng Jian , Shyh-Dar Li , Yi-Fong Lin , Shin-Jr Liu
CPC分类号： A61K9/127 , A61K9/0051 , A61K38/063 , A61K47/6911 , Y10S977/773 , A61K2300/00
摘要： A delivery system is provided. The delivery system includes a carrier or an active compound and a glutathione or a glutathione derivative grafted thereon. The invention also provides a compound including a moiety comprising a vitamin E derivative or a phospholipid derivative, a polyethylene glycol (PEG) or a polyethylene glycol derivative bonded thereto, and a glutathione (GSH) or a glutathione derivative bonded to the polyethylene glycol or the polyethylene glycol derivative.
摘要翻译： 提供传送系统。 递送系统包括载体或活性化合物和接枝在其上的谷胱甘肽或谷胱甘肽衍生物。 本发明还提供了包含包含维生素E衍生物或磷脂衍生物，聚乙二醇（PEG）或与其结合的聚乙二醇衍生物的部分的化合物以及与聚乙二醇结合的谷胱甘肽（GSH）或谷胱甘肽衍生物 聚乙二醇衍生物。
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公开(公告)号：US20080292688A1
公开(公告)日：2008-11-27
申请号：US12076295
申请日：2008-03-17
申请人： Ae-June Wang , Pei-Lin Wang , Wan-Ko Chen , Chi-Heng Jian
发明人： Ae-June Wang , Pei-Lin Wang , Wan-Ko Chen , Chi-Heng Jian
IPC分类号： A61K9/127 , A61K31/355 , A61K31/07 , A61K31/05 , A61K31/24
CPC分类号： A61K8/678 , A61K8/14 , A61K8/553 , A61K9/0014 , A61K9/127 , A61K47/22 , A61Q19/00 , A61Q19/005
摘要： The present invention relates to a composition and a method for preparing a liposome, the liposome including a lipid bilayer and an aqueous core contains a hydrophobic or a hydrophilic drug and a component—Vitamin E derivative (d-α tocopheryl polyethylene glycol 1000 succinate; TPGS). TPGS is able to increase the encapsulation efficiency of drug in liposome as well as to enhance the stability of drug in liposomes. Such liposome is capable to increase the skin permeation of drugs. The preparation method comprises the following steps: (1) adding the drug to a Vitamin E derivative solution to form a mixture; and (2) adding at least one phosphatidyl choline to the mixture, after hydration from either sonication or homogenization.
摘要翻译： 本发明涉及一种制备脂质体的组合物和方法，所述脂质体包括脂质双层和含水芯包含疏水或亲水性药物和组分维生素E衍生物（d-α生育酚聚乙二醇1000琥珀酸酯; TPGS ）。 TPGS能够提高药物在脂质体中的包封效率，并提高药物在脂质体中的稳定性。 这样的脂质体能够增加药物的皮肤渗透。 制备方法包括以下步骤：（1）将药物加入到维生素E衍生物溶液中形成混合物; 和（2）在从超声或均质化水合后，向混合物中加入至少一种磷脂酰胆碱。
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公开(公告)号：US20050214357A1
公开(公告)日：2005-09-29
申请号：US11024799
申请日：2004-12-30
申请人： Ae-June Wang , Pei-Lin Wang , Wan-Ko Chen , Chi-Heng Jian
发明人： Ae-June Wang , Pei-Lin Wang , Wan-Ko Chen , Chi-Heng Jian
CPC分类号： A61K8/678 , A61K8/14 , A61K8/553 , A61K9/0014 , A61K9/127 , A61K47/22 , A61Q19/00 , A61Q19/005
摘要： The present invention relates to a composition and a method for preparing a liposome, the liposome including a lipid bilayer and an aqueous core contains a hydrophobic or a hydrophilic drug and a component—Vitamin E derivative (d-α tocopheryl polyethylene glycol 1000 succinate; TPGS). TPGS is able to increase the encapsulation efficiency of drug in liposome as well as to enhance the stability of drug in liposomes. Such liposome is capable to increase the skin permeation of drugs. The preparation method comprises the following steps: (1) adding the drug to a Vitamin E derivative solution to form a mixture; and (2) adding at least one phosphatidyl choline to the mixture, after hydration from either sonication or homogenization.
摘要翻译： 本发明涉及一种制备脂质体的组合物和方法，所述脂质体包括脂质双层和含水芯包含疏水或亲水性药物和组分维生素E衍生物（d-α生育酚聚乙二醇1000琥珀酸酯; TPGS ）。 TPGS能够提高药物在脂质体中的包封效率，并提高药物在脂质体中的稳定性。 这样的脂质体能够增加药物的皮肤渗透。 制备方法包括以下步骤：（1）将药物加入到维生素E衍生物溶液中形成混合物; 和（2）在从超声或均质化水合后，向混合物中加入至少一种磷脂酰胆碱。
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