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公开(公告)号：US08569343B2
公开(公告)日：2013-10-29
申请号：US13538540
申请日：2012-06-29
IPC分类号： A61K31/4468 , C07D211/58
CPC分类号： A61K31/485 , A61K31/402 , A61K31/4025 , A61K31/439 , A61K31/4468 , A61K47/10 , A61K47/60 , C07D489/02
摘要： The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of the compound not attached to the water-soluble oligomer.
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公开(公告)号：US20100303753A1
公开(公告)日：2010-12-02
申请号：US12682778
申请日：2008-10-17
IPC分类号： A61K31/765 , A61P9/06 , C08G69/08
CPC分类号： C07C237/04 , A61K47/55 , A61K47/60 , C07C217/18
摘要： The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer.
摘要翻译： 本发明提供通过共价连接水溶性低聚物进行化学修饰的小分子药物。
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公开(公告)号：US20100048602A1
公开(公告)日：2010-02-25
申请号：US12558395
申请日：2009-09-11
IPC分类号： A61K31/439 , C07D489/00 , A61P25/00
CPC分类号： A61K31/485 , A61K31/402 , A61K31/4025 , A61K31/439 , A61K31/4468 , A61K47/10 , A61K47/60 , C07D489/02
摘要： The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of the compound not attached to the water-soluble oligomer.
摘要翻译： 本发明提供通过共价连接水溶性低聚物进行化学改性的化合物。 本发明化合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的化合物的特征不同的特征。
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公开(公告)号：US20130317114A1
公开(公告)日：2013-11-28
申请号：US13992587
申请日：2011-12-09
IPC分类号： C07C217/52
CPC分类号： C07C217/52
摘要： The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the small molecule drug not attached to the water-soluble oligomer.
摘要翻译： 本发明提供通过共价连接水溶性低聚物进行化学修饰的小分子药物。 本发明化合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的小分子药物的特性不同的特征。
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公开(公告)号：US20130040961A1
公开(公告)日：2013-02-14
申请号：US13580580
申请日：2011-02-22
IPC分类号： C07D401/14 , A61P31/18 , A61K31/496
CPC分类号： A61K31/496 , A61K47/60
摘要： Disclosed are compounds comprising diaromatic substituted compound residues, namely the anti-viral (anti-HIV) drug delavirdine, covalently attached via a linkage to water-soluble, non-peptidic oligomers, specifically to poly(ethylene glycol) PEG) oligomers. A compound of the invention, when administered by any of a number of administration routes, exhibits advantages over non-oligomer modified diaromatic substituted compounds.
摘要翻译： 公开了包含二芳基取代的化合物残基的化合物，即通过连接至水溶性非肽寡聚物，特别是聚（乙二醇）PEG）低聚物共价连接的抗病毒（抗HIV）药物地拉夫定。 本发明的化合物当通过任何多种施用途径施用时，显示出优于非低聚物修饰的二芳基取代的化合物的优点。
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公开(公告)号：US08173666B2
公开(公告)日：2012-05-08
申请号：US12558395
申请日：2009-09-11
IPC分类号： A61K31/485 , C07D489/02
CPC分类号： A61K31/485 , A61K31/402 , A61K31/4025 , A61K31/439 , A61K31/4468 , A61K47/10 , A61K47/60 , C07D489/02
摘要： The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of the compound not attached to the water-soluble oligomer.
摘要翻译： 本发明提供通过共价连接水溶性低聚物进行化学改性的化合物。 本发明化合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的化合物的特征不同的特征。
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公开(公告)号：US09090535B2
公开(公告)日：2015-07-28
申请号：US13992587
申请日：2011-12-09
IPC分类号： C07C217/52 , C07C217/54 , A61K31/137 , A61P25/08 , A61P25/24
CPC分类号： C07C217/52
摘要： The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the small molecule drug not attached to the water-soluble oligomer.
摘要翻译： 本发明提供通过共价连接水溶性低聚物进行化学修饰的小分子药物。 本发明化合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的小分子药物的特性不同的特征。
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公开(公告)号：US08772479B2
公开(公告)日：2014-07-08
申请号：US13319824
申请日：2010-05-13
IPC分类号： C07D253/075 , A61K31/53 , A61P25/08
CPC分类号： C07D253/075 , A61K31/53 , A61K47/60
摘要： The invention relates to (among other things) oligomer-containing substituted aromatic triazine compounds. A compound of the invention, when administered by any of a number of administration routes, exhibits one or more advantages over corresponding compounds lacking the oligomer.
摘要翻译： 本发明涉及（尤其是）含低聚物的取代的芳族三嗪化合物。 当通过任何多种施用途径给药时，本发明的化合物相对于缺乏寡聚体的相应化合物显示出一个或多个优点。
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公开(公告)号：US08575196B2
公开(公告)日：2013-11-05
申请号：US13386327
申请日：2010-07-21
IPC分类号： A61K31/4468 , C07D211/58
CPC分类号： A61K31/485 , A61K31/402 , A61K31/4025 , A61K31/439 , A61K31/4468 , A61K47/10 , A61K47/60 , C07D489/02
摘要： The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of the compound not attached to the water-soluble oligomer.
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公开(公告)号：US20120264775A1
公开(公告)日：2012-10-18
申请号：US13426521
申请日：2012-03-21
IPC分类号： C07D489/08 , A61P25/00 , A61K31/485
CPC分类号： A61K31/485 , A61K31/402 , A61K31/4025 , A61K31/439 , A61K31/4468 , A61K47/10 , A61K47/60 , C07D489/02
摘要： The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of the compound not attached to the water-soluble oligomer.
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