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公开(公告)号：US20210368087A1
公开(公告)日：2021-11-25
申请号：US17281534
申请日：2019-10-23
发明人： Karl RATCLIFF
摘要： A fluorescence in situ hybridization, FISH, image acquisition apparatus and a method for controlling a FISH image acquisition apparatus. A FISH probe image is acquired (S24, S44). Image processing using morphological operations is applied to identify areas of interest around locations of elevated image intensity. From this, a mask is generated (S22, S42) which filters out all but the areas of interest. The mask is applied to determine image intensity in the areas of interest. If the image intensity does not have a desired value (S26), indicating incorrect exposure of the image, then the method is repeated with one or more different exposures until an adequately exposed FISH probe image is obtained (S29, S47, S48). The correct exposure is determined either empirically by iteratively applying stepwise increases (S28), or analytically by applying a formula (S46).
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公开(公告)号：US11106726B2
公开(公告)日：2021-08-31
申请号：US16902086
申请日：2020-06-15
发明人： Ole Eichhorn , Dirk Soenksen
IPC分类号： G06F16/58 , G06F16/54 , G06Q10/10 , G06Q30/06 , G16H30/20 , G16H30/40 , G16H70/00 , G06Q20/14 , G16Z99/00
摘要： Systems and methods for managing an image repository for pathology. In an embodiment, a search request is received. One or more digital slide images are identified from an image repository based on the search request. A user is provided access to the identified digital slide images. In addition, each of a plurality of collections of digital slide images are associated with a search rating, and a value for each of the plurality of collections is computed based on the associated search rating and a size of the collection.
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公开(公告)号：US20210048606A1
公开(公告)日：2021-02-18
申请号：US17085962
申请日：2020-10-30
发明人： Allen OLSON , Kiran SALIGRAMA , Yunlu ZOU , Peyman NAJMABADI
摘要： A digital scanning apparatus is provided that includes imaging and focusing sensors and a processor to analyze the image data captured by the imaging and focusing sensors and adjust the focus of the scanning apparatus in real time during a scanning operation. The individual pixels of the imaging sensor are all in the same image plane with respect to the optical path of the digital scanning apparatus. The individual pixels of the focusing sensor are each in a different image plane with respect to the optical path, and one pixel of the focusing sensor is on the same image plane as the image sensor. The processor analyzes image data from the imaging sensor and the focusing sensor and determines a distance and direction to adjust the relative position of an objective lens and a stage of the digital scanning apparatus to achieve optimal focus during the scanning operation.
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公开(公告)号：US10823936B2
公开(公告)日：2020-11-03
申请号：US16601355
申请日：2019-10-14
发明人： Allen Olson , Kiran Saligrama , Yunlu Zou , Peyman Najmabadi
摘要： A digital scanning apparatus is provided that includes imaging and focusing sensors and a processor to analyze the image data captured by the imaging and focusing sensors and adjust the focus of the scanning apparatus in real time during a scanning operation. The individual pixels of the imaging sensor are all in the same image plane with respect to the optical path of the digital scanning apparatus. The individual pixels of the focusing sensor are each in a different image plane with respect to the optical path, and one pixel of the focusing sensor is on the same image plane as the image sensor. The processor analyzes image data from the imaging sensor and the focusing sensor and determines a distance and direction to adjust the relative position of an objective lens and a stage of the digital scanning apparatus to achieve optimal focus during the scanning operation.
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公开(公告)号：US10732394B2
公开(公告)日：2020-08-04
申请号：US16205011
申请日：2018-11-29
发明人： Timothy Dailey , Aaron Stearrett
IPC分类号： G06F15/16 , G02B21/00 , G06F9/4401 , G01N35/00
摘要： Systems and methods for managing a plurality of scanning devices in a high-throughput laboratory environment. Each of the scanning devices is configured for a remote boot operation from an administrative server that is communicatively coupled with the plurality of scanning devices via a local network. The remote boot replaces the complete operational firmware of a scanning device. The scanning devices are each configured to periodically provide operational information to the administrative server for centralized storage. The centralized storage of operational information for each of the plurality of scanning devices, coupled with the ability of the administrative server to initiate a reboot of any scanning device and thereby update the complete operational firmware of the scanning device, allows for centralized administration of multiple scanning devices that facilitates configuration, support, image data storage, and/or communication with outside servers.
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公开(公告)号：USD891637S1
公开(公告)日：2020-07-28
申请号：US29631499
申请日：2017-12-29
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公开(公告)号：US10685056B2
公开(公告)日：2020-06-16
申请号：US14437821
申请日：2013-03-15
发明人： Ole Eichhorn , Dirk Soenksen
摘要： Systems and methods for managing an image repository for pathology. In an embodiment, a search request is received. One or more digital slide images are identified from an image repository based on the search request. A user is provided access to the identified digital slide images. In addition, each of a plurality of collections of digital slide images are associated with a search rating, and a value for each of the plurality of collections is computed based on the associated search rating and a size of the collection.
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公开(公告)号：US10591710B2
公开(公告)日：2020-03-17
申请号：US15763061
申请日：2016-09-23
发明人： Yunlu Zou , Allen Olson , Kiran Saligrama , Ruby Chen , Peyman Najmabadi , Greg Crandall
摘要： System for acquiring a digital image of a sample on a microscope slide. In an embodiment, the system comprises a stage configured to support a sample, an objective lens having a single optical axis that is orthogonal to the stage, an imaging sensor, and a focusing sensor. The system further comprises at least one beam splitter optically coupled to the objective lens and configured to receive a field of view corresponding to the optical axis of the objective lens, and simultaneously provide at least a first portion of the field of view to the imaging sensor and at least a second portion of the field of view to the focusing sensor. The focusing sensor may simultaneously acquire image(s) at a plurality of different focal distances and/or simultaneously acquire a pair of mirrored images, each comprising pixels acquired at a plurality of different focal distances.
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公开(公告)号：US10585273B2
公开(公告)日：2020-03-10
申请号：US16146991
申请日：2018-09-28
发明人： Leng-Chun Chen , Yunlu Zou , Allen Olson , Peyman Najmabadi , Greg Crandall , Nicholas Newberg , Aaron Stearrett
摘要： Two-pass capture of a macro image. In an embodiment, a scanning apparatus comprises a stage, a high-resolution camera, and a lens that provides a field of view, substantially equal in width to a slide width, to the high-resolution camera. The apparatus also comprises a first illumination system for transmission-mode illumination, and a second illumination system for reflection-mode illumination. Processor(s) move the stage in a first direction to capture a first macro image of a specimen during a single pass while the field of view is illuminated by the first illumination system, and move the stage in a second direction to capture a second macro image of the specimen during a single pass while the field of view is illuminated by the second illumination system. The processor(s) identify artifacts in the second macro image, and, based on those artifacts, correct the first macro image to generate a modified first macro image.
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公开(公告)号：USD852976S1
公开(公告)日：2019-07-02
申请号：US29631495
申请日：2017-12-29
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