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公开(公告)号：US20220326494A1
公开(公告)日：2022-10-13
申请号：US17631385
申请日：2020-08-05
摘要： Control processes for a slide-scanning system comprising a carousel with a plurality of rack slots configured to receive slide racks via an exposed portion of the scanning system. In an embodiment, initializing the scanning system comprises automatically homing back-end and front-end components, wherein the front-end components comprise the carousel. An inventory of all slide racks in the carousel is automatically generated. If any slide rack was being processed by any back-end components, the slide rack is automatically unloaded into a corresponding rack slot. In addition, the carousel is automatically positioned to expose a starting subset of the rack slots within the exposed portion. This starting subset may comprise a maximum segment of adjacent empty rack slots.
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公开(公告)号：US20200209600A1
公开(公告)日：2020-07-02
申请号：US16812010
申请日：2020-03-06
发明人： Leng-Chun CHEN , Yunlu ZOU , Allen OLSON , Peyman NAJMABADI , Greg CRANDALL , Nicholas NEWBERG , Aaron STEARRETT
摘要： Two-pass capture of a macro image. In an embodiment, a scanning apparatus comprises a stage, a high-resolution camera, and a lens that provides a field of view, substantially equal in width to a slide width, to the high-resolution camera. The apparatus also comprises a first illumination system for transmission-mode illumination, and a second illumination system for reflection-mode illumination. Processor(s) move the stage in a first direction to capture a first macro image of a specimen during a single pass while the field of view is illuminated by the first illumination system, and move the stage in a second direction to capture a second macro image of the specimen during a single pass while the field of view is illuminated by the second illumination system. The processor(s) identify artifacts in the second macro image, and, based on those artifacts, correct the first macro image to generate a modified first macro image.
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公开(公告)号：US20210103134A1
公开(公告)日：2021-04-08
申请号：US17105251
申请日：2020-11-25
发明人： Leng-Chun CHEN , Allen OLSON , Yunlu ZOU , Peyman NAJMABADI , Greg CRANDALL
摘要： Real-time autofocus. In an embodiment, a scanning apparatus includes an imaging sensor, a focusing sensor, an objective lens, and processor(s) configured to analyze image data captured by the imaging and focusing sensors, and move the objective lens. Real-time autofocus during scanning of a sample is achieved by determining a true-Z value for the objective lens for a point on a sample and for each of a plurality of regions on the sample. The true-Z values and/or surfaces calculated therefrom are used to determine a predicted-Z value for an unscanned region of the sample. The objective lens is adjusted to the predicted-Z value at the beginning of the unscanned region. After scanning the region, a true-Z value is determined for the region and compared to the predicted-Z value. A rescan of the region is initiated if the comparison exceeds a predetermined threshold.
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公开(公告)号：US20190101723A1
公开(公告)日：2019-04-04
申请号：US16147448
申请日：2018-09-28
发明人： Allen OLSON , Kiran SALIGRAMA , Yunlu ZOU , Peyman NAJMABADI
摘要： A digital scanning apparatus is provided that includes imaging and focusing sensors and a processor to analyze the image data captured by the imaging and focusing sensors and adjust the focus of the scanning apparatus in real time during a scanning operation. The individual pixels of the imaging sensor are all in the same image plane with respect to the optical path of the digital scanning apparatus. The individual pixels of the focusing sensor are each in a different image plane with respect to the optical path, and one pixel of the focusing sensor is on the same image plane as the image sensor. The processor analyzes image data from the imaging sensor and the focusing sensor and determines a distance and direction to adjust the relative position of an objective lens and a stage of the digital scanning apparatus to achieve optimal focus during the scanning operation.
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公开(公告)号：US20210048606A1
公开(公告)日：2021-02-18
申请号：US17085962
申请日：2020-10-30
发明人： Allen OLSON , Kiran SALIGRAMA , Yunlu ZOU , Peyman NAJMABADI
摘要： A digital scanning apparatus is provided that includes imaging and focusing sensors and a processor to analyze the image data captured by the imaging and focusing sensors and adjust the focus of the scanning apparatus in real time during a scanning operation. The individual pixels of the imaging sensor are all in the same image plane with respect to the optical path of the digital scanning apparatus. The individual pixels of the focusing sensor are each in a different image plane with respect to the optical path, and one pixel of the focusing sensor is on the same image plane as the image sensor. The processor analyzes image data from the imaging sensor and the focusing sensor and determines a distance and direction to adjust the relative position of an objective lens and a stage of the digital scanning apparatus to achieve optimal focus during the scanning operation.
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公开(公告)号：US20190101736A1
公开(公告)日：2019-04-04
申请号：US16146991
申请日：2018-09-28
发明人： Leng-Chun CHEN , Yunlu ZOU , Allen OLSON , Peyman NAJMABADI , Greg CRANDALL , Nicholas NEWBERG , Aaron STEARRETT
摘要： Two-pass capture of a macro image. In an embodiment, a scanning apparatus comprises a stage, a high-resolution camera, and a lens that provides a field of view, substantially equal in width to a slide width, to the high-resolution camera. The apparatus also comprises a first illumination system for transmission-mode illumination, and a second illumination system for reflection-mode illumination. Processor(s) move the stage in a first direction to capture a first macro image of a specimen during a single pass while the field of view is illuminated by the first illumination system, and move the stage in a second direction to capture a second macro image of the specimen during a single pass while the field of view is illuminated by the second illumination system. The processor(s) identify artifacts in the second macro image, and, based on those artifacts, correct the first macro image to generate a modified first macro image.
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公开(公告)号：US20180275388A1
公开(公告)日：2018-09-27
申请号：US15763061
申请日：2016-09-23
发明人： Yunlu ZOU , Allen OLSON , Kiran SALIGRAMA , Ruby CHEN , Peyman NAJMABADI , Greg CRANDALL
CPC分类号： G02B21/244 , G02B7/38 , G02B21/02 , G02B21/18 , G02B21/245 , G02B21/26 , G02B21/34 , G02B21/361 , G03B13/36 , H04N5/23212
摘要： System for acquiring a digital image of a sample on a microscope slide. In an embodiment, the system comprises a stage configured to support a sample, an objective lens having a single optical axis that is orthogonal to the stage, an imaging sensor, and a focusing sensor. The system further comprises at least one beam splitter optically coupled to the objective lens and configured to receive a field of view corresponding to the optical axis of the objective lens, and simultaneously provide at least a first portion of the field of view to the imaging sensor and at least a second portion of the field of view to the focusing sensor. The focusing sensor may simultaneously acquire image(s) at a plurality of different focal distances and/or simultaneously acquire a pair of mirrored images, each comprising pixels acquired at a plurality of different focal distances.
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公开(公告)号：US20220357565A1
公开(公告)日：2022-11-10
申请号：US17814180
申请日：2022-07-21
发明人： Leng-Chun CHEN , Allen OLSON , Yunlu ZOU , Peyman NAJMABADI , Greg CRANDALL
摘要： Real-time autofocus. In an embodiment, a scanning apparatus includes an imaging sensor, a focusing sensor, an objective lens, and processor(s) configured to analyze image data captured by the imaging and focusing sensors, and move the objective lens. Real-time autofocus during scanning of a sample is achieved by determining a true-Z value for the objective lens for a point on a sample and for each of a plurality of regions on the sample. The true-Z values and/or surfaces calculated therefrom are used to determine a predicted-Z value for an unscanned region of the sample. The objective lens is adjusted to the predicted-Z value at the beginning of the unscanned region. After scanning the region, a true-Z value is determined for the region and compared to the predicted-Z value. A rescan of the region is initiated if the comparison exceeds a predetermined threshold.
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公开(公告)号：US20200218053A1
公开(公告)日：2020-07-09
申请号：US16818916
申请日：2020-03-13
发明人： Yunlu ZOU , Allen OLSON , Kiran SALIGRAMA , Ruby CHEN , Peyman NAJMABADI , Greg CRANDALL
IPC分类号： G02B21/24 , G03B13/36 , G02B7/38 , H04N5/232 , G02B21/36 , G02B21/34 , G02B21/26 , G02B21/18 , G02B21/02
摘要： System for acquiring a digital image of a sample on a microscope slide. In an embodiment, the system comprises a stage configured to support a sample, an objective lens having a single optical axis that is orthogonal to the stage, an imaging sensor, and a focusing sensor. The system further comprises at least one beam splitter optically coupled to the objective lens and configured to receive a field of view corresponding to the optical axis of the objective lens, and simultaneously provide at least a first portion of the field of view to the imaging sensor and at least a second portion of the field of view to the focusing sensor. The focusing sensor may simultaneously acquire image(s) at a plurality of different focal distances and/or simultaneously acquire a pair of mirrored images, each comprising pixels acquired at a plurality of different focal distances.
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公开(公告)号：US20200064612A1
公开(公告)日：2020-02-27
申请号：US16674742
申请日：2019-11-05
发明人： Leng-Chun CHEN , Allen OLSON , Yunlu ZOU , Peyman NAJMABADI , Greg CRANDALL
摘要： Real-time autofocus. In an embodiment, a scanning apparatus includes an imaging sensor, a focusing sensor, an objective lens, and processor(s) configured to analyze image data captured by the imaging and focusing sensors, and move the objective lens. Real-time autofocus during scanning of a sample is achieved by determining a true-Z value for the objective lens for a point on a sample and for each of a plurality of regions on the sample. The true-Z values and/or surfaces calculated therefrom are used to determine a predicted-Z value for an unscanned region of the sample. The objective lens is adjusted to the predicted-Z value at the beginning of the unscanned region. After scanning the region, a true-Z value is determined for the region and compared to the predicted-Z value. A rescan of the region is initiated if the comparison exceeds a predetermined threshold.
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