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    SYNTHESIS PROCESS
    11.
    发明公开
    SYNTHESIS PROCESS 审中-公开

    公开(公告)号：US20240083950A1

    公开(公告)日：2024-03-14

    申请号：US18260672

    申请日：2022-01-10

    Applicant: Xellia Pharmaceuticals APS

    Inventor： Vidar Bjørnstad ,  Karl James Bonney

    IPC: C07K9/00

    CPC classification number: C07K9/008

    Abstract: An optimized method for synthesizing dalbavancin is provided in which an organic antisolvent such as tert-butyl methyl ether (TBME) or dimethoxyethane (DME) is used to precipitate the product of the esterification of A-40926.

    Glycopeptide compositions
    13.
    发明授权
    Glycopeptide compositions 有权

    公开(公告)号：US11628200B2

    公开(公告)日：2023-04-18

    申请号：US17215675

    申请日：2021-03-29

    Applicant: Xellia Pharmaceuticals APS

    Inventor： Ivona Jasprica ,  Sabina Keser ,  Katarina Pindric

    IPC: A61K38/14 ,  A61K9/00 ,  A61K47/18 ,  A61K9/08

    Abstract: Solutions comprising a glycopeptide antibiotic, for example Vancomycin, and an amino acid or amino acid derivative such as N-acetyl-Glycine or N-acetyl-D-Alanine are provided. These solutions are stable or stabilized for long-term periods at conditions of normal use and storage, and can be formulated as pharmaceutical solutions for use in subjects. Methods of manufacturing and using these solutions are also provided, as are methods of stabilizing a glycopeptide antibiotic, for example Vancomycin, using amino acids or amino acid derivatives such as N-acetyl-Glycine or N-acetyl-D-Alanine.

    Glycopeptide compositions
    14.
    发明授权
    Glycopeptide compositions 有权

    公开(公告)号：US11000567B2

    公开(公告)日：2021-05-11

    申请号：US16677057

    申请日：2019-11-07

    Applicant: XELLIA PHARMACEUTICALS APS

    Inventor： Ivona Jasprica ,  Sabina Keser ,  Katarina Pindric

    IPC: A61K38/14 ,  A61K9/00 ,  A61K47/18 ,  A61K9/08

    Abstract: Solutions comprising a glycopeptide antibiotic, for example Vancomycin, and an amino acid or amino acid derivative such as N-acetyl-Glycine or N-acetyl-D-Alanine are provided. These solutions are stable or stabilized for long-term periods at conditions of normal use and storage, and can be formulated as pharmaceutical solutions for use in subjects. Methods of manufacturing and using these solutions are also provided, as are methods of stabilizing a glycopeptide antibiotic, for example Vancomycin, using amino acids or amino acid derivatives such as N-acetyl-Glycine or N-acetyl-D-Alanine.

    Glycopeptide compositions
    16.
    发明授权
    Glycopeptide compositions 有权

    公开(公告)号：US10188697B2

    公开(公告)日：2019-01-29

    申请号：US15524653

    申请日：2015-11-06

    Applicant: XELLIA PHARMACEUTICALS APS

    Inventor： Ivona Jasprica ,  Sabina Keser ,  Katarina Pindric

    IPC: A61K38/14 ,  A61K9/00 ,  A61K47/18 ,  A61K9/08

    Abstract: Solutions comprising a glycopeptide antibiotic, for example Vancomycin, and an amino acid or amino acid derivative such as N-acetyl-Glycine or N-acetyl-D-Alanine are provided. These solutions are stable or stabilized for long-term periods at conditions of normal use and storage, and can be formulated as pharmaceutical solutions for use in subjects. Methods of manufacturing and using these solutions are also provided, as are methods of stabilizing a glycopeptide antibiotic, for example Vancomycin, using amino acids or amino acid derivatives such as N-acetyl-Glycine or N-acetyl-D-Alanine.

    Process for the purification of macrolide antibiotics
    18.
    发明授权
    Process for the purification of macrolide antibiotics 有权
    大环内酯类抗生素纯化方法

    公开(公告)号：US08268963B2

    公开(公告)日：2012-09-18

    申请号：US12095642

    申请日：2006-12-07

    Applicant: Vincenzo De Tommaso

    Inventor： Vincenzo De Tommaso

    IPC: C07K1/34

    CPC classification number: C07K9/008

    Abstract: The present invention concerns a process for the purification of macrolide antibiotics. More specifically it concerns a process for the purification of macrolide antibiotics that result in a white powder. The powder remains white also after some time of storage. The process of the present invention is performed by dissolving the macrolide antibiotics, e.g. commercial vancomycin hydrochloride, in water and subjecting the solution to ultrafiltration with a membrane having nominal retention lower than 30,000 Da, preferably of 10,000 Da. The purified solution is preferably concentrated by reversed osmosis and then lyophilized at the optimized conditions of pressure and temperature to obtain a white powder.

    Abstract translation: 本发明涉及大环内酯类抗生素的纯化方法。 更具体地说，它涉及导致白色粉末的大环内酯类抗生素的纯化方法。 一段时间后，粉末仍然保持白色。 本发明的方法通过将大环内酯类抗生素例如 商业万古霉素盐酸盐，在水中，并且用具有标称保持度低于30,000Da，优选10,000Da的膜对溶液进行超滤。 纯化的溶液优选通过反渗透浓缩，然后在优化的压力和温度条件下冻干，得到白色粉末。

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