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83 条记录 (耗时 0.015 秒)

    2,4-Disubstituted-5-oxo-5H-dibenzo[a,d]cycloheptenes
    15.
    发明授权
    2,4-Disubstituted-5-oxo-5H-dibenzo[a,d]cycloheptenes 失效
    2,4-二取代-5-氧代-5H-二苯并{8α，d {9环庚烯

    公开(公告)号：US4172949A

    公开(公告)日：1979-10-30

    申请号：US920047

    申请日：1978-06-28

    申请人： James P. Dunn ,  Peter H. Nelson ,  Karl G. Untch

    发明人： James P. Dunn ,  Peter H. Nelson ,  Karl G. Untch

    IPC分类号： C07C51/36 ,  C07C59/90 ,  C07C65/28 ,  C07C65/40 ,  C07C65/14 ,  C07C69/76

    CPC分类号： C07C65/40 ,  C07C51/36 ,  C07C59/90 ,  C07C65/28 ,  Y10S514/825 ,  Y10S514/916

    摘要： Compounds of the formula ##STR1## wherein R is hydrogen or methyl; R.sup.1 is hydrogen, C.sub.1 to C.sub.8 linear or branched alkyl or C.sub.1 to C.sub.8 linear or branched alkanoyl; X is oxygen or sulfur; R.sup.2 is selected from the group hydrogen, C.sub.1 to C.sub.18 linear or branched alkyl and the radicals --(CH.sub.2).sub.n --NR.sup.3 R.sup.4, --CH.sub.2 --CH(OH)--CH.sub.2 --OH or a ketal thereof formed from the aldehyde or ketone R.sup.5 R.sup.6 CO, wherein R.sup.3 and R.sup.4 are each independently C.sub.1 to C.sub.6 linear or branched alkyl or R.sup.3 and R.sup.4 taken together with the nitrogen atom of the first radical are attached to form a 5- or 6-membered heterocyclic ring, R.sup.5 and R.sup.6 are each independently hydrogen, C.sub.1 to C.sub.6 linear or branched alkyl, phenyl or benzyl or R.sup.5 and R.sup.6 taken together represent an alkylene bridge of from 4 to 6 carbon atoms; n is an integer of from 2 to 4; and the dotted line represents an optional double bond; and the pharmaceutically acceptable salts thereof. The compounds have anti-inflammatory, analgesic and anti-pyretic activities and, accordingly, are useful in the treatment of inflammation, pain and/or pyrexia.

    摘要翻译： 式（I）的化合物，其中R是氢或甲基; R1是氢，C1至C8直链或支链烷基或C1至C8直链或支链烷酰基; X是氧或硫; R2选自氢，C1至C18直链或支链烷基和由醛或酮R5R6CO形成的基团 - （CH2）n-NR3R4，-CH2-CH（OH）-CH2-OH或其缩酮，其中 R 3和R 4各自独立地为C 1至C 6直链或支链烷基或与第一基团的氮原子一起的R 3和R 4连接以形成5-或6-元杂环，R 5和R 6各自独立地为氢，C 1 C 6直链或支链烷基，苯基或苄基或R 5和R 6一起表示4至6个碳原子的亚烷基桥; n为2〜4的整数， 虚线表示任选的双键; 及其药学上可接受的盐。 这些化合物具有抗炎，止痛和抗热解活性，因此可用于治疗炎症，疼痛和/或发热。

    {62 -Hydroxy-{62 -(cycloalkenylphenyl)alkanoic acids, esters and salts
    20.
    发明授权
    {62 -Hydroxy-{62 -(cycloalkenylphenyl)alkanoic acids, esters and salts 失效
    {62-羟基 - {62-（环烯基苯基）链烷酸，酯和盐

    公开(公告)号：US3919304A

    公开(公告)日：1975-11-11

    申请号：US16750771

    申请日：1971-07-29

    申请人： CIBA GEIGY CORP

    发明人： ROSSI ALBERTO

    IPC分类号： C07C57/46 ,  C07C57/48 ,  C07C67/00 ,  C07C69/616 ,  C07C69/618 ,  C07C69/732 ,  C07D317/16 ,  C07D317/20 ,  C07D317/22 ,  C07C65/14

    CPC分类号： C07D317/22 ,  C07C57/46 ,  C07C57/48 ,  C07C67/00 ,  C07C69/616 ,  C07C69/618 ,  C07C69/732 ,  C07D317/16 ,  C07D317/20 ,  Y10S514/916

    摘要： Compounds of the formula

    in which X represents a free, esterified or amidated carboxyl group; A represents a free or substituted hydroxyl group or A+B stand for a second carbon-to-carbon bond; B represents a hydrogen atom, together with R2 a divalent hydrocarbon residue of aliphatic character or together with A a second carbon-to-carbon bond; R1 represents a hydrogen atom or a monovalent hydrocarbon residue of aliphatic character; R2 represents a hydrogen atom, a monovalent hydrocarbon residue of aliphatic character or together with B a divalent hydrocarbon residue of aliphatic character; Ph represents a phenylene group optionally substituted by alkyl groups, halogen atoms, trifluoromethyl groups, amino groups and/or nitro groups and R a cycloaliphatic hydrocarbon residue which may be substituted, and their therapeutically acceptable salts are useful as analgesic and anti-in-flammatory agents.

    摘要翻译： 式AB || R-Ph-C-C-X || R1R2的化合物，其中X表示游离的，酯化的或酰胺化的羧基; A表示游离或取代的羟基或A + B代表第二碳 - 碳键; B代表氢原子，与R2一起是脂肪族特征的二价烃残基或与A一起形成第二碳 - 碳键; R1表示氢原子或脂肪族特征的一价烃残基; R 2表示氢原子，脂肪族特征的一价烃残基或与B一起具有脂肪族特征的二价烃残基; Ph表示任选被烷基，卤素原子，三氟甲基，氨基和/或硝基取代的亚苯基，R a可被取代的脂环族烃残基，其治疗上可接受的盐可用作镇痛和抗炎症 代理商