公开(公告)号：US20230346733A1

公开(公告)日：2023-11-02

申请号：US18053193

申请日：2022-11-07

申请人： Diffusion Pharmaceuticals LLC

发明人： John L. Gainer ,  Robert Murray

IPC分类号： A61K31/202 ,  A61K31/724 ,  A61K9/20 ,  A61K9/28 ,  A61K9/48

CPC分类号： A61K31/202 ,  A61K31/724 ,  A61K9/205 ,  A61K9/2054 ,  A61K9/2866 ,  A61K9/4866 ,  A61K9/4891

摘要： The subject invention relates to a variety of formulations of bipolar trans carotenoids including pharmaceutical compositions for oral delivery of a bipolar trans carotenoid comprising i) a bipolar trans carotenoid, ii) a cyclodextrin, and iii) a coating. The invention also relates to preparation of such formulations and their uses.

公开(公告)号：US20230302096A1

公开(公告)日：2023-09-28

申请号：US18047129

申请日：2022-10-17

申请人： UNIVERSITY HEALTH NETWORK

发明人： Philippe P. MONNIER ,  Nardos G. TASSEW

IPC分类号： A61K38/44 ,  A61K31/137 ,  C07K16/28 ,  A61K31/724 ,  A61K31/365 ,  A61K31/7048 ,  A61K38/48 ,  C07K14/435 ,  C07K14/705 ,  G01N33/53 ,  A61K31/495 ,  A61K38/17 ,  G01N33/50

CPC分类号： A61K38/443 ,  A61K31/137 ,  C07K16/28 ,  C12Y101/03006 ,  A61K31/724 ,  A61K31/365 ,  A61K31/7048 ,  A61K38/482 ,  C07K14/435 ,  C07K14/705 ,  G01N33/53 ,  A61K31/495 ,  A61K38/177 ,  G01N33/5058 ,  A61K2039/505

摘要： Disclosed herein is an agent that modulates a cis interaction between Repulsive Guidance Molecule A (RGMa) and Neogenin or lipid rafts. Modulation by the agent may include blocking the cis interaction between RGMa and Neogenin and/or disrupting lipid rafts. In turn, this promotes neuronal cell survival and axon growth and/or regeneration. Also disclosed herein is a method of treating a disease in a subject in need thereof. The method may include administering the agent to the subject. Further disclosed herein is a method of identifying an agent that modulates the cis interaction between RGMa and Neogenin.

公开(公告)号：US20230293697A1

公开(公告)日：2023-09-21

申请号：US18166412

申请日：2023-02-08

申请人： Nayan Patel ,  Chinh Tran

发明人： Nayan Patel ,  Chinh Tran

IPC分类号： A61K47/40 ,  A61K38/06 ,  A61K38/16 ,  A61K47/18 ,  A61K47/22 ,  A61K9/00 ,  A61K47/42 ,  A61K9/16 ,  A61K31/34 ,  A61K31/375 ,  A61K31/385 ,  A61K31/724 ,  A61K31/198 ,  A61K31/355

CPC分类号： A61K47/40 ,  A61K38/063 ,  A61K38/16 ,  A61K47/186 ,  A61K47/22 ,  A61K9/0014 ,  A61K47/42 ,  A61K9/1617 ,  A61K31/34 ,  A61K31/375 ,  A61K31/385 ,  A61K31/724 ,  A61K31/198 ,  A61K31/355

摘要： A method of treatment is disclosed, comprising administering a composition of Cyclodextrin and reduced, nanonized L-Glutathione to a patient in need of treatment, wherein the L-Glutathione molecule is non-acetylated, non-Esterified, and non-fatty acid attached.

公开(公告)号：US20230218657A1

公开(公告)日：2023-07-13

申请号：US18000492

申请日：2021-06-02

申请人： National University of Singapore ,  Singapore Health Services Pte Ltd

发明人： Veronique Sandrine Angeli ,  Bien Keem Tan

IPC分类号： A61K31/724 ,  A61P7/10

CPC分类号： A61K31/724 ,  A61P7/10 ,  A61K9/0021

摘要： The present invention relates to a method of treating lymphedema comprising administering an effective amount of a composition to a patient in need thereof. The composition consisting essentially of cyclodextrin or a pharmaceutically acceptable salt, solvate or prodrug thereof. The present invention also relates to a composition consisting essentially of cyclodextrin.

公开(公告)号：US20230167203A1

公开(公告)日：2023-06-01

申请号：US17904195

申请日：2021-01-13

申请人： MEDICHEM, S.A.

发明人： Jordi PUIG SERRANO ,  Ernesto DURAN LÓPEZ ,  Jordi MARKALAIN BARTA ,  Joana Raquel FERREIRA DA COSTA

IPC分类号： C08B37/16 ,  A61K31/724

CPC分类号： C08B37/0012 ,  A61K31/724

摘要： This invention relates to a process for preparing Sugammadex or its salts, preferably Sugammadex sodium, with a low content of organic solvents, preferably water-miscible organic solvents, more preferably ethanol, 2-propanol and/or acetone. The process comprises exposing Sugammadex or its salts, preferably Sugammadex sodium, to a medium with a high relative humidity.

公开(公告)号：US20230082992A1

公开(公告)日：2023-03-16

申请号：US17472604

申请日：2021-09-11

申请人： Bhanu Pratap Jena

发明人： Bhanu Pratap Jena

IPC分类号： A61K31/724 ,  A61K31/352 ,  A61K33/30 ,  A61K9/12 ,  A61K47/02 ,  A61K47/18 ,  A61K9/00

摘要： The invention provides the use of a formulation containing cyclodextrine, quercetin and zinc, at appropriate concentrations to mitigate infections by enveloped viruses like SARS-CoV-2, influenza and HIV/AIDS, when administered via pulmonary and dermal route. While the different forms of cyclodextrin prevent the entry of coated virus into host cells by extracting and sequestering cholesterol molecules at the virus coat and at the host cell plasma membrane, the natural plant-based ionophore quercetin in the formulation, enables cellular entry of zinc, inhibiting viral replication by altering polymerase activity in the host cell. Hence cyclodextrine, and quercetin plus zinc, either in combination or in tandem order of administration, serves both as prophylactic and therapeutic.

公开(公告)号：US11603385B2

公开(公告)日：2023-03-14

申请号：US17061728

申请日：2020-10-02

申请人： Cytogel Pharma, LLC.

发明人： Theodore E. Maione ,  Constantine Basil Maglaris

IPC分类号： C07K5/107 ,  A61K47/40 ,  A61K38/07 ,  A61K47/69 ,  A61K47/61 ,  A61K9/08 ,  A61K31/724

摘要： The subject invention provides compositions and methods for alleviating pain. Specifically, the subject invention provides pharmaceutical formulations of peptides, and/or their salts, having advantageous μ-opioid receptor binding activity.

公开(公告)号：US11590160B2

公开(公告)日：2023-02-28

申请号：US17745497

申请日：2022-05-16

申请人： Mandos LLC

发明人： Bernardus Nicolaas Machielse ,  Allan Darling

IPC分类号： A61K31/724 ,  A61K9/00 ,  A61K9/08

摘要： This disclosure provides mixtures of beta-cyclodextrin molecules substituted at one or more hydroxyl positions by hydroxypropyl groups, the mixture optionally including unsubstituted beta-cyclodextrin molecules, for use as a pharmaceutically active ingredient; methods of making such mixtures; methods of qualifying such mixtures for use in a pharmaceutical composition suitable for intrathecal or intracerebroventricular administration; pharmaceutical compositions suitable for intrathecal or intracerebroventricular administration comprising such mixtures; and methods of using the pharmaceutical compositions for treatment of Niemann-Pick disease Type C.

公开(公告)号：US11534454B2

公开(公告)日：2022-12-27

申请号：US17546880

申请日：2021-12-09

申请人： Bexson Biomedical, Inc.

发明人： Jeffrey Becker ,  Gregg Peterson ,  Jason Wallach

IPC分类号： A61K31/724 ,  A61K45/06

摘要： Provided herein are pharmaceutical formulations and pharmaceutical compound salts which utilize complexing agents as counterions. Such formulations and salts are useful for treating a variety of disease and disorders.

公开(公告)号：US11510940B2

公开(公告)日：2022-11-29

申请号：US17745470

申请日：2022-05-16

申请人： Mandos LLC

发明人： Bernardus Nicolaas Machielse ,  Allan Darling

IPC分类号： A61K31/724 ,  A61K9/08 ,  A61K9/00

摘要： This disclosure provides mixtures of beta-cyclodextrin molecules substituted at one or more hydroxyl positions by hydroxypropyl groups, the mixture optionally including unsubstituted beta-cyclodextrin molecules, for use as a pharmaceutically active ingredient; methods of making such mixtures; methods of qualifying such mixtures for use in a pharmaceutical composition suitable for intrathecal or intracerebroventricular administration; pharmaceutical compositions suitable for intrathecal or intracerebroventricular administration comprising such mixtures; and methods of using the pharmaceutical compositions for treatment of Niemann-Pick disease Type C.