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公开(公告)号：US20230355595A1
公开(公告)日：2023-11-09
申请号：US18324980
申请日：2023-05-28
发明人： Michael HAYDEN , Michal GEVA
摘要： Provided herein a method of maintaining, improving, or lessening the decline of functional capacity, cognition, motor function and quality of life of a subject afflicted with Huntington disease, including those afflicted with early-stage Huntington disease (HD1 and HD2, TFC 7-13) by orally administering to the subject a pharmaceutical composition comprising pridopidine or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20230330073A1
公开(公告)日：2023-10-19
申请号：US18306257
申请日：2023-04-25
发明人： Michael HAYDEN , Michal GEVA
摘要： This invention provides a method of maintaining, improving or lessening the decline of functional capacity or motor function in a human patient in a human patient with Huntington disease (HD) comprising orally administering to the patient a pharmaceutical composition comprising pridopidine.
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公开(公告)号：US20230322854A1
公开(公告)日：2023-10-12
申请号：US18044028
申请日：2021-09-03
发明人： Richard W. ROBERTS , Ralf LANGEN , Jeannie CHEN , Jose Mario ISAS , Kaori NORIDOMI , Terry TAKAHASHI
CPC分类号： C07K7/06 , G01N33/6896 , A61P25/14 , G01N2800/2835 , G01N2800/50
摘要： Presented herein are novel peptides and peptide agents for diagnosing, preventing or treating Huntingtin's Disease.
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公开(公告)号：US20230227540A1
公开(公告)日：2023-07-20
申请号：US16475853
申请日：2018-01-05
申请人： ABL Bio Inc.
发明人： Jinhyung AHN , Sungwon AN , Dongin KIM , Eunsil SUNG , Jaehyun EOM , Sang Hoon LEE , Seung-Jae LEE , Tae Kyung KIM , Min Sun CHOI , Weonkyoo YOU , Jaeho JUNG , Juhee KIM , Jinwon JUNG , Yeunju KIM , Yonggyu SON , Byungje SUNG
CPC分类号： C07K16/18 , A61P25/14 , G01N33/6896 , A61K2039/505 , C07K2317/565
摘要： The disclosure discloses anti α-Syn antibodies preferentially recognizing α-Syn aggregates. The antibodies of the present invention bind to α-Syn aggregates with high affinity and specificity and inhibit accumulation or intercellular transfer of α-Syn aggregates, and thus can be used for detection, diagnosis and/or treatment or prevention of various diseases caused by the accumulation of α-Syn aggregates.
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公开(公告)号：US20230181548A1
公开(公告)日：2023-06-15
申请号：US18164587
申请日：2023-02-05
发明人： Michael HAYDEN , Michal GEVA
摘要： This invention provides a method of maintaining functional capacity, improving functional capacity, or lessening the decline of functional capacity in a human patient comprising periodically orally administering to the patient a pharmaceutical composition comprising pridopidine such that a dose of 90 mg of pridopidine is administered to the patient per day, so as to thereby maintain functional capacity, improve functional capacity, or lessen the decline of functional capacity in the human patient.
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公开(公告)号：US11666566B2
公开(公告)日：2023-06-06
申请号：US16859514
申请日：2020-04-27
发明人： Andreas Sommer , Chengzhi Zhang , John Carter , John Charles Arthur , Margaret Bradbury , Thomas George Gant , Manouchehr Shahbaz
IPC分类号： A61K9/20 , A61K9/28 , A61K47/38 , A61P25/14 , A61K31/473 , A61K9/00 , A61K9/16 , A61K9/48 , A61K9/50 , A61K31/4745 , A61K45/06 , C07D455/06
CPC分类号： A61K31/473 , A61K9/0053 , A61K9/0065 , A61K9/1676 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2072 , A61K9/2077 , A61K9/2095 , A61K9/28 , A61K9/284 , A61K9/288 , A61K9/2846 , A61K9/2866 , A61K9/4808 , A61K9/5047 , A61K9/5073 , A61K9/5078 , A61K9/5084 , A61K31/4745 , A61K45/06 , C07D455/06 , C07B2200/05
摘要： The present invention relates to new pharmaceutical compositions comprising benzoquinoline compounds, and methods to inhibit vesicular monoamine transporter 2 (VMAT2) activity in a subject for the treatment of chronic hyperkinetic movement disorders.
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公开(公告)号：US11648244B2
公开(公告)日：2023-05-16
申请号：US15667483
申请日：2017-08-02
IPC分类号： A61K31/473 , A61K9/20 , A61K45/06 , A61K31/4375 , A61P25/14 , A61K31/4745
CPC分类号： A61K31/473 , A61K9/20 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K31/4375 , A61K31/4745 , A61K45/06 , A61P25/14
摘要： Disclosed herein are new dosage regimens for deuterium-substituted benzoquinoline compounds, and methods for the treatment of abnormal muscular activity, movement disorders, and related conditions.
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公开(公告)号：US11628170B2
公开(公告)日：2023-04-18
申请号：US16503128
申请日：2019-07-03
发明人： Aarash Bordbar
IPC分类号： A61K31/519 , A61K9/00 , A61K45/06 , A61K31/53 , A61K31/5377 , A61P25/14 , A61P25/18 , A61K31/198
摘要： Disclosed herein are methods, pharmaceutical combinations, or kits for the prevention or treatment of extrapyramidal syndromes, for example, dyskinesia, dystonia, akathisia, or drug-induced Parkinsonism, with the administration of a therapeutic effective amount of Trapidil, a derivative, a metabolite, a prodrug, an analog, or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US11542297B2
公开(公告)日：2023-01-03
申请号：US17695033
申请日：2022-03-15
IPC分类号： C07J43/00 , A61K9/20 , A61K31/4164 , A61K31/58 , A61P25/14 , A61P25/24 , A61K45/06 , C07J9/00 , A61K31/575 , C07J1/00 , C07J3/00 , C07J5/00 , C07J7/00 , C07J11/00 , C07J13/00 , C07J21/00 , C07J31/00 , C07J41/00 , C07J51/00 , C07J71/00
摘要： Described herein are neuroactive steroids of the Formula (I): or a pharmaceutically acceptable salt thereof, wherein , A, R1, R2, R3a, R4a, R4b, R5, R7a, and R7b are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.
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公开(公告)号：US20220409597A1
公开(公告)日：2022-12-29
申请号：US17718441
申请日：2022-04-12
IPC分类号： A61K31/4375 , A61P25/14
摘要： The disclosure is directed to methods of treating dyskinesia in cerebral palsy in human patients using deutetrabenazine and its active metabolites.
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