公开(公告)号：US20230025493A1

公开(公告)日：2023-01-26

申请号：US17788949

申请日：2020-12-23

Applicant: Kowa Company, Ltd.

Inventor： Reiko ARITA ,  Katsumi YABUSAKI ,  Miyako SUZUKI

IPC: G06T7/00 ,  G06V10/44 ,  G06T7/13

Abstract: An ophthalmic image of an evaluation target is acquired, a plurality of subsection images is extracted from the ophthalmic image, a state of a subject's eye is predicted for each of the subsection images based on a learned model in which learning has been performed in advance regarding extracting a plurality of subsection images from an ophthalmic image for learning, and predicting a state of a subject's eye for the each of subsection image by machine learning using correct answer data related to a state of each subsection image, and the subsection image is extracted from the ophthalmic image so as to have an image size corresponding to a state of a subject's eye of an evaluation target.

公开(公告)号：US20220362109A1

公开(公告)日：2022-11-17

申请号：US17441611

申请日：2020-03-27

Applicant: KOWA COMPANY, LTD.

Inventor： Misako NAKASHIMA ,  Koichiro IOHARA

IPC: A61K6/54 ,  A61K31/4375 ,  A61K38/18 ,  A61K38/19 ,  A61K38/48 ,  A61K6/69

Abstract: A non-cellular root canal filler comprises a tetrahydroisoquinoline compound or a pharmaceutically acceptable salt thereof, or a solvate of the compound or the salt, and a dental tissue regeneration promotion kit comprises a pretreatment agent comprising a serine protease, and the non-cellular root canal filler.

公开(公告)号：US11387943B2

公开(公告)日：2022-07-12

申请号：US17056480

申请日：2019-05-22

Applicant: KOWA COMPANY, LTD.

Inventor： Tomohisa Azegami ,  Kenichi Namiki

IPC: H04L1/08 ,  H04L1/16 ,  H04L1/18

Abstract: A first communication unit 11 repeatedly transmits the same data signal as a transmitted data signal to a second communication unit 23 at shorter time intervals than an acknowledgement time in which an ACK signal is returned from the second communication unit 23 without any failure. As a result, even when the transmitted data signal is garbled in the middle of a transmission path due to noise, the second communication unit 23 can rapidly receive the repeatedly transmitted same data signal.

公开(公告)号：US20220151996A1

公开(公告)日：2022-05-19

申请号：US17591108

申请日：2022-02-02

Applicant: KOWA COMPANY, LTD.

Inventor： Shin SUGIMOTO ,  Akito MINAMIZONO

IPC: A61K31/423

Abstract: Provided is a pharmaceutical composition which contains pemafibrate, a salt thereof or a solvate thereof and has excellent stability. A pharmaceutical composition is provided containing pemafibrate, a salt thereof or a solvate thereof and having a moisture content of 2.4 mass % or less.

公开(公告)号：US20220148179A1

公开(公告)日：2022-05-12

申请号：US17429298

申请日：2020-02-14

Applicant: KOWA COMPANY, LTD.

Inventor： Nobuhiko TAKEUCHI

IPC: G06T7/00 ,  G06T7/90 ,  G06T7/11 ,  A61B3/00

Abstract: A method for inspecting an ophthalmic device which allows reflected light from an imaging inspection subject, which has been irradiated with light by using an illumination optical system of the ophthalmic device, to be received by using an image-capturing optical system of the ophthalmic device to capture an image of the imaging inspection subject; extracts color information from the captured image of the imaging inspection subject; and determines whether or not the color information satisfies a prescribed reference condition by comparing the extracted color information with reference information. An inspection jig for an ophthalmic device is used in the method for inspecting an ophthalmic device. Furthermore, the ophthalmic device includes the inspection jig.

公开(公告)号：US11328417B2

公开(公告)日：2022-05-10

申请号：US16756928

申请日：2018-10-29

Applicant: KOWA COMPANY, LTD.

Inventor： Katsumi Yabusaki

IPC: G06T7/00 ,  G06T7/62

Abstract: A non-transitory computer-readable medium stores a program capable of improving the accuracy of detection of a target object. The program causes a computer to execute operations including, acquiring data in which a physical quantity is associated with each unit area acquired by dividing a given space; setting a detection region in a time space of three or more dimensions in the space or the time space; setting a control region at a position surrounding a gap with the gap surrounding the detection region disposed in a space having the same dimensions as those of the detection region; and determined whether or not one or more unit areas included in the detection region are predetermined areas on the basis of comparison between physical quantities of one or more unit areas included in the detection region and the control region that are set.

公开(公告)号：US20220133714A1

公开(公告)日：2022-05-05

申请号：US17430068

申请日：2020-02-27

Applicant: Friedrich E. KRUSE ,  Ursula SCHLOTZER-SCHREHARDT ,  KOWA COMPANY, LTD.

Inventor： Friedrich E. KRUSE ,  Ursula SCHLOTZER-SCHREHARDT

IPC: A61K31/496 ,  A61P27/02

Abstract: The present invention provide an agent for modulating expression of extracellular matrix by corneal endothelial cells. The present invention pertains to an agent for modulating expression of extracellular matrix by corneal endothelial cells containing, 1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl-1,4-homopiperazine or a salt thereof, or a solvate thereof.

公开(公告)号：US11298340B2

公开(公告)日：2022-04-12

申请号：US16627178

申请日：2018-06-29

Applicant: KOWA COMPANY, LTD.

Inventor： Shin Sugimoto ,  Akito Minamizono

IPC: A61K31/423

Abstract: Provided is a pharmaceutical composition which contains pemafibrate, a salt thereof or a solvate thereof and has excellent stability. A pharmaceutical composition is provided containing pemafibrate, a salt thereof or a solvate thereof and having a moisture content of 2.4 mass % or less.

公开(公告)号：US20220054458A1

公开(公告)日：2022-02-24

申请号：US17418129

申请日：2019-12-27

Applicant: KOWA COMPANY, LTD.

Inventor： Chisa NISHIDA

IPC: A61K31/423 ,  A61K47/38

Abstract: Provided is a technique for suppressing the composition changes between pemafibrate, a salt thereof or a solvate thereof and an alkylcellulose species. A pharmaceutical preparation is provided by storing a pharmaceutical composition containing the following components (A) and (B) in a tight package: (A) pemafibrate, a salt thereof or a solvate thereof; and (B) an alkylcellulose species.

公开(公告)号：US20220022434A1

公开(公告)日：2022-01-27

申请号：US17299360

申请日：2019-12-04

Applicant: NATIONAL AGRICULTURE AND FOOD RESEARCH ORGANIZATION ,  KOWA COMPANY, LTD.

Inventor： Taiyo YOSHIOKA ,  Tsunenori KAMEDA ,  Takahiro KITAMURA ,  Akimune ASANUMA

IPC: A01K67/04 ,  D01B7/04

Abstract: An object of the present invention is to develop: a method of efficiently producing a long bagworm silk thread containing no contaminant while preventing a change in the spinning direction and the runaway of the bagworm from a rail, and alleviating a burden on the bagworm; and an apparatus for implementing the thread-producing method. Provided is an apparatus for producing a bagworm silk thread, having a movable rail having a width smaller than the maximum width between the right and left legs of a bagworm and configured to move in the longitudinal direction and to be able to hold with the legs of the bagworm; and a fixator configured to fix a bagworm, wherein the fixator is placed at a position such that the fixed bagworm can hold the movable rail.