公开(公告)号：US11200699B2

公开(公告)日：2021-12-14

申请号：US16609669

申请日：2018-04-27

Applicant: KOWA COMPANY, LTD.

Inventor： Katsumi Yabusaki

IPC: G06T7/00 ,  G06T7/90

Abstract: Provided are an analysis evaluation method and device, and a computer program for the state of a subject surface in a still image. The method includes: a step of acquiring color information of each pixel in a predetermined region in a still image, a step of calculating a numerical value indicating a diversity of color from the acquired color information, a step of calculating an average value of the color information, and a step of calculating a coefficient of variation on the basis of the calculated numerical value indicating the diversity of color and the calculated average value of the color information. Herein, the coefficient of variation is used as an index for evaluating the surface state of an object.

公开(公告)号：US20210215705A1

公开(公告)日：2021-07-15

申请号：US17214585

申请日：2021-03-26

Applicant: TSUTOMU TAKEUCHI ,  KEIKO YOSHIMOTO ,  KOWA COMPANY, LTD.

Inventor： Tsutomu Takeuchi ,  Keiko Yoshimoto

IPC: G01N33/68 ,  C07K14/705 ,  C07K16/24 ,  G01N33/74 ,  G01N33/564

Abstract: An antibody against a peptide having an amino acid sequence AVQGPEETVT QDC (expressed in single letter amino acid code) as represented by SEQ ID: NO. 1 corresponding to the 134- to 146-positions in human BAFF (B cell activating factor belonging to the TNF family) protein which is preferably a monoclonal antibody; a method of producing the above antibody; a medicinal composition containing the antibody; utilization of the antibody; and a method of screening an inhibitory effect or an activating effect on BAFF with the use of the antibody.

公开(公告)号：US20210172089A1

公开(公告)日：2021-06-10

申请号：US17271518

申请日：2019-08-27

Applicant: NATIONAL AGRICULTURE AND FOOD RESEARCH ORGANIZATION ,  KOWA COMPANY, LTD.

Inventor： Taiyo YOSHIOKA ,  Tsunenori KAMEDA ,  Akimune ASANUMA ,  Norihiko FUKUOKA

IPC: D01F4/02 ,  D04H1/4266

Abstract: A bagworm silk thread spun on a base material was conventionally difficult to be collected, and thus, cannot be utilized. An object of the present invention is to develop and provide a method in which such a bagworm silk thread is peeled off from a base material with a weak force without being damaged and is collected as a thread bundle.
Provided is a method for producing a thread bundle of a bagworm silk thread, including: applying, to a bagworm silk thread spun on the surface of a base material, a wetting liquid which presents a liquid form at least in the range of 20° C. or more and less than 30° C. and does not damage, denature, or dissolve the silk thread; and then separating the bagworm silk thread from the base material.

公开(公告)号：US20210161115A1

公开(公告)日：2021-06-03

申请号：US17046467

申请日：2019-04-16

Applicant: NATIONAL AGRICULTURE AND FOOD RESEARCH ORGANIZATION ,  KOWA COMPANY, LTD.

Inventor： Taiyo YOSHIOKA ,  Tsunenori KAMEDA ,  Akimune ASANUMA ,  Keitaro HATTORI ,  Norihiko FUKUOKA

IPC: A01K67/04 ,  D01B7/00 ,  D01C3/02

Abstract: Provided is a method developed for producing a thread bundle with high efficiency in terms of spun thread collection and without causing mechanical damage to a foothold silk thread spun by a bagworm onto a base material. After a bagworm is placed along with a solvent-soluble base material and allowed to spin the foothold silk thread onto the surface of the base material, the base material is dissolved with a solvent to separate the foothold silk thread therefrom.

公开(公告)号：US20210077491A1

公开(公告)日：2021-03-18

申请号：US16772646

申请日：2018-12-14

Applicant: Kowa Company, Ltd.

Inventor： Kentaro Mikami ,  Rie Ishida ,  Takashi Nakagawa

IPC: A61K31/513 ,  A61P11/00

Abstract: The present invention addresses the problem of providing a pharmaceutical composition for the prevention and/or treatment of diseases related to pulmonary fibrosis. Provided is a pharmaceutical composition for the prevention and/or treatment of diseases involving pulmonary fibrosis, in which the active ingredient is 3-[2-(5-{[1-(5-ethoxypyrimidin-2-yl)-2-isopropyl-6-oxo-4-propyl-1,6-dihydropyrimidin-5-yl]methyl}pyridin-2-yl)phenyl]-1,2,4-oxadiazol-5(4H)-one, or a salt thereof, or a solvate of these.

公开(公告)号：US10751211B2

公开(公告)日：2020-08-25

申请号：US15123612

申请日：2015-03-03

Applicant: KOWA COMPANY, LTD. ,  ADVANCING INC. ,  DMCHAIN COOPERATIVE

Inventor： Akiharu Tsuchiya ,  Kenta Tsuzuranuki ,  Hitoshi Ojima ,  Hidenori Kaseno

IPC: A61F5/00 ,  A61F13/00 ,  A61F5/01 ,  A61F13/06

Abstract: A knee joint supporter includes a first anchor having a loop face, a main body including second anchor, first supporting and second supporting, connections joining the anchors and connecting the first anchor and main body, a first engaging joined to the second supporting and having a hook face to stick to the loop face, a second engaging joined to the first anchor and having a hook face to stick to the loop face, and a third engaging joined to the first supporting and having a hook face to the loop face. The first anchor fastens around a thigh of a wear. The second anchor extends below popliteal region. The first supporting extends on one side from below part corresponding to a patella, and the second supporting extends on the other side of the part corresponding to the patella and crosses the first supporting below the part corresponding to the patella.

公开(公告)号：US20200178808A1

公开(公告)日：2020-06-11

申请号：US16606720

申请日：2018-04-17

Applicant: Kowa Company, Ltd.

Inventor： Takaharu ASANO

IPC: A61B5/00

Abstract: Provided is an information processing method configured to further accurately calculate an absorption spectrum of blood based on light applied to a living body such as a human finger. The information processing method includes the steps of: irradiating a living body with near-infrared light having a plurality of wavelengths; measuring, based on the near-infrared light received from the living body, a pulsating signal corresponding to each of the plurality of wavelengths; performing a principal component analysis on multi-wavelength time-series data including the measured pulsating signal corresponding to each of the wavelengths so as to remove noise from the pulsating signal; and calculating an absorption spectrum based on a variation width of the pulsating signal that is removed noise.

公开(公告)号：US20200155514A1

公开(公告)日：2020-05-21

申请号：US16627141

申请日：2018-06-29

Applicant: KOWA COMPANY, LTD.

Inventor： Shin SUGIMOTO ,  Akito MINAMIZONO

IPC: A61K31/423 ,  A61K47/26 ,  A61K47/38

Abstract: Provided is a pharmaceutical composition containing pemafibrate, a salt thereof or a solvate thereof and having excellent homogeneity. The pharmaceutical composition is provided containing the following components (A) and (B): (A) pemafibrate, a salt thereof or a solvate thereof; and (B) a disaccharide species.

公开(公告)号：US10646328B2

公开(公告)日：2020-05-12

申请号：US15111158

申请日：2015-01-16

Applicant: KOWA COMPANY, LTD.

Inventor： Kimiya Shimizu ,  Haruo Ishikawa

IPC: A61F2/16 ,  G02C7/04 ,  G02C7/02

Abstract: A tonic ophthalmic lens is described in which refractivity of the lens differs between a first direction on a plane perpendicular to an optical axis of the lens and a second direction which differs from the first direction on the plane. In addition, refractivity difference which is the difference between the refractivity in the first direction and the refractivity in the second direction varies depending on a position of the lens in a radial direction.

公开(公告)号：US20200074627A1

公开(公告)日：2020-03-05

申请号：US16609649

申请日：2018-04-27

Applicant: KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION ,  KOWA COMPANY, LTD.

Inventor： Norihiko YOKOI ,  Katsumi YABUSAKI

IPC: G06T7/00 ,  G06T7/90 ,  A61B3/10 ,  A61B5/103

Abstract: A method and device for evaluating the dynamics of a tear fluid layer to objectively and accurately evaluate breakdown of the tear fluid layer, which is a core mechanism of dry eye, are provided. The method includes a step of acquiring color information of each pixel in a predetermined region of a tear fluid layer interference fringe image, which is a moving image or a plurality of static images, a step of calculating a numerical value indicating the diversity of color from the acquired color information, a step of calculating the average value of the color information, and a step of calculating a coefficient of variation on the basis of the calculated numerical value indicating the diversity of color and the calculated average value of the color information. The coefficient of variation is used as an index for evaluating the dynamics of the tear fluid layer.