公开(公告)号：US20070259189A1

公开(公告)日：2007-11-08

申请号：US11827480

申请日：2007-07-11

Applicant: Gun Jung ,  Zhiyong Li ,  Richard Williams ,  Sivapackia Ganapathlappan

Inventor： Gun Jung ,  Zhiyong Li ,  Richard Williams ,  Sivapackia Ganapathlappan

IPC: B32B17/06

CPC classification number: G03F7/0002 ,  B05D1/185 ,  B82Y10/00 ,  B82Y30/00 ,  B82Y40/00 ,  Y10T428/31612 ,  Y10T428/31692 ,  Y10T428/31855 ,  Y10T428/31935 ,  Y10T428/31938

Abstract: A method for increasing adhesion between a substrate and a polymeric imprintable material during an imprinting procedure. The method includes chemically bonding a plurality of molecules to a surface of a substrate to form a self-assembled monolayer thereon. A monomer is copolymerized with the self-assembled monolayer to form a polymeric imprintable material that is chemically bonded to the self-assembled monolayer. Adhesion between the polymeric imprintable material and the substrate is substantially increased by the self-assembled monolayer.

公开(公告)号：US20070254377A1

公开(公告)日：2007-11-01

申请号：US11413516

申请日：2006-04-28

Applicant: Zhiyong Li ,  William Tong ,  R. Williams

Inventor： Zhiyong Li ,  William Tong ,  R. Williams

IPC: G01N21/62

CPC classification number: G01N21/658 ,  Y10T428/218 ,  Y10T428/28

Abstract: Packaged NERS-active structures are disclosed that include a NERS substrate having a NERS-active structure thereon, and a packaging substrate over the NERS substrate having an opening therethrough, the opening in alignment with the NERS-active structure. A membrane may cover the opening in the packaging substrate. In order to perform nanoenhanced Raman spectroscopy, the membrane may be removed, and an analyte placed on the NERS substrate adjacent the NERS-active structure. The membrane may be replaced with another membrane after the analyte has been placed on the substrate. The membrane may maintain the pristine state of the substrate before it is deployed, and the replacement membrane may preserve the substrate and analyte for archival purposes. Also disclosed are methods for performing NERS with packaged NERS-active structures.

Abstract translation: 公开了封装的NERS-活性结构，其包括其上具有NERS-活性结构的NERS衬底和在NERS衬底上的具有穿过其中的开口的封装衬底，该开口与NERS-活性结构对准。 膜可以覆盖封装衬底中的开口。 为了进行纳米增强拉曼光谱，可以去除膜，并将分析物放置在邻近NERS-活性结构的NERS衬底上。 在将分析物放置在基底上之后，膜可以用另一膜替代。 膜可以在其被部署之前保持基材的原始状态，并且替换膜可以保留底物和分析物用于归档目的。 还公开了使用封装的NERS-活性结构来执行NERS的方法。

公开(公告)号：US20070178507A1

公开(公告)日：2007-08-02

申请号：US11655388

申请日：2007-01-19

Applicant: Wei Wu ,  Zhiyong Li ,  Shih-Yuan Wong ,  Duncan Stewart

Inventor： Wei Wu ,  Zhiyong Li ,  Shih-Yuan Wong ,  Duncan Stewart

IPC: C12Q1/68 ,  G01N33/53 ,  C12M3/00

CPC classification number: G01N33/48721 ,  C12Q1/6825 ,  C12Q1/6869 ,  G01N27/414 ,  G01N33/54373 ,  C12Q2565/631 ,  C12Q2565/601

Abstract: A molecular analysis device comprises a molecule sensor and a nanopore that passes through, partially through, or substantially near the molecule sensor. The molecule sensor may comprise a single electron transistor including a first terminal, a second terminal, and a nanogap or at least one quantum dot positioned between the first terminal and the second terminal. The molecular sensor may also comprise a nanowire that operably couples a first and a second terminal. A nitrogenous material that may be disposed on at least part of the molecule sensor is configured for a chemical interaction with an identifiable configuration of a molecule. The molecule sensor develops an electronic effect responsive to a molecule or responsive to a chemical interaction.

Abstract translation: 分子分析装置包括分子传感器和穿过分子传感器部分通过或基本上接近分子传感器的纳米孔。 分子传感器可以包括单电子晶体管，其包括位于第一端子和第二端子之间的第一端子，第二端子和纳米隙隙或至少一个量子点。 分子传感器还可以包括可操作地连接第一和第二端子的纳米线。 可以设置在分子传感器的至少一部分上的含氮材料被配置为与分子的可识别构型的化学相互作用。 分子传感器产生响应于分子或响应于化学相互作用的电子效应。

公开(公告)号：US07245370B2

公开(公告)日：2007-07-17

申请号：US11030733

申请日：2005-01-06

Applicant: Alexandre Bratkovski ,  M. Salf Islam ,  Theodore I. Kamins ,  Zhiyong Li ,  Shih-Yuan Wang

Inventor： Alexandre Bratkovski ,  M. Salf Islam ,  Theodore I. Kamins ,  Zhiyong Li ,  Shih-Yuan Wang

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01N21/658

Abstract: A SERS-active structure is disclosed that includes a substrate and at least two nanowires disposed on the substrate. Each of the at least two nanowires has a first end and a second end, the first end being attached to the substrate and the second end having a SERS-active tip. A SERS system is also disclosed that includes a SERS-active structure. Also disclosed are methods for forming a SERS-active structure and methods for performing SERS with SERS-active structures.

Abstract translation: 公开了一种SERS-活性结构，其包括衬底和设置在衬底上的至少两个纳米线。 所述至少两个纳米线中的每一个具有第一端和第二端，所述第一端附接到所述基底，所述第二端具有SERS活性末端。 还公开了包括SERS活性结构的SERS系统。 还公开了形成SERS活性结构的方法和用SERS活性结构进行SERS的方法。

公开(公告)号：US20060275779A1

公开(公告)日：2006-12-07

申请号：US11144588

申请日：2005-06-03

Applicant: Zhiyong Li ,  Shih-Yuan Wang ,  Wei Wu ,  M. Islam

Inventor： Zhiyong Li ,  Shih-Yuan Wang ,  Wei Wu ,  M. Islam

IPC: C12Q1/68 ,  C12M1/34

CPC classification number: G01N33/48721 ,  B82Y5/00 ,  B82Y15/00

Abstract: Devices and methods for detecting the constituent parts of biological polymers are disclosed. A molecular analysis device comprises a molecule sensor and a molecule guide. The molecule sensor comprises a nanowire operably coupling a first terminal and a second terminal and a nitrogenous material disposed on the nanowire. The nitrogenous material is configured to interact with an identifiable configuration of a molecule such that the molecule sensor develops a conductance change responsive to the interaction. The molecule guide is configured for guiding at least a portion of the molecule near the molecule sensor to enable the interaction.

Abstract translation: 公开了用于检测生物聚合物的组成部分的装置和方法。 分子分析装置包括分子传感器和分子引导件。 分子传感器包括可操作地耦合第一端子和第二端子的纳米线和设置在纳米线上的含氮材料。 含氮材料被配置为与分子的可识别构型相互作用，使得分子传感器响应于相互作用产生电导变化。 分子引导件被配置用于引导分子传感器附近的分子的至少一部分以实现相互作用。

公开(公告)号：US20060243897A1

公开(公告)日：2006-11-02

申请号：US11116657

申请日：2005-04-27

Applicant: Shih-Yuan Wang ,  Zhiyong Li

Inventor： Shih-Yuan Wang ,  Zhiyong Li

IPC: H05H3/04

CPC classification number: G21K1/006

Abstract: For manipulation of a specimen, the specimen and a focusing location of a composite material lens are brought into spatial coincidence. The composite material lens has at least one of a negative effective permittivity and a negative effective permeability at a frequency of an applied light beam. The composite material lens focuses the light beam toward the focusing location and forms an optical trap for the specimen.

Abstract translation: 对于样品的操作，复合材料透镜的样品和聚焦位置变得空间重合。 复合材料透镜在所施加的光束的频率处具有负的有效介电常数和负的有效磁导率中的至少一个。 复合材料透镜将光束聚焦到聚焦位置并形成样品的光阱。

公开(公告)号：US07102747B2

公开(公告)日：2006-09-05

申请号：US10964523

申请日：2004-10-13

Applicant: Shih-Yuan Wang ,  Zhiyong Li ,  M. Saif Islam

Inventor： Shih-Yuan Wang ,  Zhiyong Li ,  M. Saif Islam

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01N21/658

Abstract: Devices, systems, and methods using Surface Enhanced Raman Spectroscopy (SERS) are disclosed. A device for generating Raman scattered radiation comprises a laser source and a SERS-active structure. The laser source may be configured for emanating radiation from an emanating surface or by forming a depression in the laser source, which creates a region of increased evanescent field from the laser source. SERS systems and methods include a device for generating Raman scattered radiation with a detector configured to receive the Raman scattered radiation.

Abstract translation: 公开了使用表面增强拉曼光谱（SERS）的器件，系统和方法。 用于产生拉曼散射辐射的装置包括激光源和SERS-活性结构。 激光源可以被配置用于从发射表面发射辐射，或者通过在激光源中形成凹陷，其产生从激光源增加的渐逝场的区域。 SERS系统和方法包括用配置成接收拉曼散射辐射的检测器产生拉曼散射辐射的装置。

公开(公告)号：US20060055921A1

公开(公告)日：2006-03-16

申请号：US10942079

申请日：2004-09-14

Applicant: Shih-Yuan Wang ,  Zhiyong Li ,  M. Islam

Inventor： Shih-Yuan Wang ,  Zhiyong Li ,  M. Islam

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01N21/658

Abstract: Structures for amplifying light include a resonant cavity in which an analyte may be positioned. The structures for amplifying light may be used to amplify the incident light employed in surface enhanced Raman spectroscopy (SERS). SERS systems employing the structures for amplifying light of the present invention and methods of performing SERS are also disclosed.

Abstract translation: 用于放大光的结构包括其中可以定位分析物的谐振腔。 用于放大光的结构可以用于放大表面增强拉曼光谱（SERS）中使用的入射光。 还公开了采用本发明的光放大结构的SERS系统和执行SERS的方法。

公开(公告)号：US20060055920A1

公开(公告)日：2006-03-16

申请号：US10941714

申请日：2004-09-14

Applicant: Shih-Yuan Wang ,  M. Islam ,  Zhiyong Li

Inventor： Shih-Yuan Wang ,  M. Islam ,  Zhiyong Li

IPC: G01J3/44

CPC classification number: G01N21/658 ,  G01J3/26

Abstract: Wavelength-tunable radiation amplifying structures for Raman spectroscopy are disclosed that include resonant cavities having Raman signal-enhancing structures disposed therein. Systems that include the amplifying structures and methods of performing spectroscopic analysis using the structures and systems are also disclosed.

Abstract translation: 公开了用于拉曼光谱的波长可调辐射放大结构，其包括其中布置有拉曼信号增强结构的谐振腔。 还公开了包括放大结构的系统和使用该结构和系统进行光谱分析的方法。

公开(公告)号：US20060046069A1

公开(公告)日：2006-03-02

申请号：US10929810

申请日：2004-08-30

Applicant: Gun Jung ,  Zhiyong Li ,  Richard Williams ,  Sivapackia Ganapathiappan

Inventor： Gun Jung ,  Zhiyong Li ,  Richard Williams ,  Sivapackia Ganapathiappan

IPC: B32B17/06 ,  B32B9/00

CPC classification number: G03F7/0002 ,  B05D1/185 ,  B82Y10/00 ,  B82Y30/00 ,  B82Y40/00 ,  Y10T428/31612 ,  Y10T428/31692 ,  Y10T428/31855 ,  Y10T428/31935 ,  Y10T428/31938

Abstract: A method for increasing adhesion between a substrate and a polymeric imprintable material during an imprinting procedure. The method includes chemically bonding a plurality of molecules to a surface of a substrate to form a self-assembled monolayer thereon. A monomer is copolymerized with the self-assembled monolayer to form a polymeric imprintable material that is chemically bonded to the self-assembled monolayer. Adhesion between the polymeric imprintable material and the substrate is substantially increased by the self-assembled monolayer.

Abstract translation: 一种在印刷过程中增加基材和聚合物可压印材料之间的粘合力的方法。 该方法包括将多个分子化学键合到基底的表面以在其上形成自组装单层。 单体与自组装单层共聚以形成化学键合到自组装单层的聚合物可压印材料。 通过自组装单层，聚合物可压印材料和基材之间的粘合力显着增加。