公开(公告)号：US08687186B2

公开(公告)日：2014-04-01

申请号：US13383387

申请日：2009-07-30

Applicant: Shih-Yuan Wang ,  Jingjing Li ,  Huei Pei Kuo ,  David A. Fattal ,  Nobuhiko Kobayashi ,  Zhiyong Li

Inventor： Shih-Yuan Wang ,  Jingjing Li ,  Huei Pei Kuo ,  David A. Fattal ,  Nobuhiko Kobayashi ,  Zhiyong Li

IPC: G01J3/44

CPC classification number: G01N21/658 ,  B82Y15/00 ,  G01J3/44

Abstract: Embodiments of the present invention are directed to nanowire-based systems for performing surface-enhanced Raman spectroscopy. In one embodiment, a system comprises a substrate having a surface and a plurality of tapered nanowires disposed on the surface. Each nanowire has a tapered end directed away from the surface. The system also includes a plurality of nanoparticles disposed near the tapered end of each nanowire. When each nanowire is illuminated with light of a pump wavelength, Raman excitation light is emitted from the tapered end of the nanowire to interact with the nanoparticles and produce enhanced Raman scattered light from molecules located in close proximity to the nanoparticles.

Abstract translation: 本发明的实施方案涉及用于进行表面增强拉曼光谱的基于纳米线的系统。 在一个实施例中，系统包括具有设置在表面上的表面和多个锥形纳米线的基板。 每个纳米线具有远离表面的锥形端。 该系统还包括设置在每个纳米线的锥形端附近的多个纳米颗粒。 当每个纳米线被泵浦波长的光照射时，拉曼激发光从纳米线的锥形端发射以与纳米颗粒相互作用，并从位于紧邻纳米颗粒的分子产生增强的拉曼散射光。

公开(公告)号：US08603606B2

公开(公告)日：2013-12-10

申请号：US12916239

申请日：2010-10-29

Applicant: Michael Josef Stuke ,  Zhiyong Li ,  Shih-Yuan Wang ,  Fung Suong Ou ,  Min Hu ,  Wei Wu ,  Lars Helge Thylen

Inventor： Michael Josef Stuke ,  Zhiyong Li ,  Shih-Yuan Wang ,  Fung Suong Ou ,  Min Hu ,  Wei Wu ,  Lars Helge Thylen

IPC: B32B3/00 ,  B05D7/00

CPC classification number: G01N21/658 ,  B81B3/0005 ,  Y10T428/24355 ,  Y10T428/24612

Abstract: A device for Surface Enhanced Raman Scattering (SERS). The device includes a plurality of nanostructures protruding from a surface of a substrate, a SERS active metal disposed on a portion of said plurality of nanostructures, and a low friction film disposed over the plurality of nanostructures and the SERS active metal. The low friction film is to prevent adhesion between the plurality of nanostructures.

Abstract translation: 用于表面增强拉曼散射（SERS）的器件。 该装置包括从衬底表面突出的多个纳米结构，设置在所述多个纳米结构的一部分上的SERS活性金属，以及设置在多个纳米结构和SERS活性金属上的低摩擦膜。 低摩擦膜是为了防止多个纳米结构之间的粘附。

公开(公告)号：US08279437B2

公开(公告)日：2012-10-02

申请号：US12836097

申请日：2010-07-14

Applicant: Min Hu ,  Alexandre M. Bratkovski ,  Huel Pei Kuo ,  Jingjing Li ,  Zhiyong Li ,  Fung Suong Ou ,  Michael Josef Stuke ,  Michael Renne Ty Tan ,  Shih-Yuan Wang ,  Wei Wu

Inventor： Min Hu ,  Alexandre M. Bratkovski ,  Huel Pei Kuo ,  Jingjing Li ,  Zhiyong Li ,  Fung Suong Ou ,  Michael Josef Stuke ,  Michael Renne Ty Tan ,  Shih-Yuan Wang ,  Wei Wu

IPC: G01J3/44

CPC classification number: G01J3/18 ,  G01J3/44 ,  G01N21/65 ,  G01N2021/651

Abstract: An apparatus for detecting at least one species using Raman light detection includes at least one laser source for illuminating a sample containing the at least one species. The apparatus also includes a modulating element for modulating a spatial relationship between the sample and the light beams to cause relative positions of the sample and the light beams to be oscillated, in which Raman light at differing intensity levels are configured to be emitted from the at least one species based upon the different wavelengths of the light beams illuminating the sample. The apparatus also includes a Raman light detector and a post-signal processing unit configured to detect the at least one species.

Abstract translation: 用于使用拉曼光检测来检测至少一种物质的装置包括用于照亮含有至少一种物质的样品的至少一个激光源。 该装置还包括用于调制样品与光束之间的空间关系的调制元件，以使得样品和光束的相对位置发生振荡，其中以不同强度水平的拉曼光被配置为从at 基于照射样品的光束的不同波长的至少一种物质。 该装置还包括拉曼光检测器和被配置为检测至少一种物种的后信号处理单元。

公开(公告)号：US20110228266A1

公开(公告)日：2011-09-22

申请号：US13129571

申请日：2008-11-17

Applicant: Huei Pei Kuo ,  Jing Tang ,  Fung Suong Ou ,  Zhiyong Li ,  Shih-Yuan Wang

Inventor： Huei Pei Kuo ,  Jing Tang ,  Fung Suong Ou ,  Zhiyong Li ,  Shih-Yuan Wang

IPC: G01J3/44 ,  B05D5/06 ,  B05D3/10 ,  B05D3/00 ,  C23C16/44 ,  B82Y40/00 ,  B82Y20/00

CPC classification number: B82Y20/00 ,  G01N21/658

Abstract: A substrate for Surface Enhanced Raman Scattering (SERS). The substrate comprises at least one nanostructure protruding from a surface of the substrate and a SERS active metal over the at least one nanostructure, wherein the SERS active metal substantially covers the at least one nanostructure and the SERS active metal creates a textured layer on the at least one nanostructure.

Abstract translation: 用于表面增强拉曼散射（SERS）的衬底。 衬底包括从衬底的表面突出的至少一个纳米结构和在至少一个纳米结构上的SERS活性金属，其中SERS活性金属基本上覆盖至少一个纳米结构，并且SERS活性金属在其上形成纹理化层 至少一个纳米结构。

公开(公告)号：US07947485B2

公开(公告)日：2011-05-24

申请号：US11144586

申请日：2005-06-03

Applicant: Wei Wu ,  Zhiyong Li ,  Shih-Yuan Wang ,  Philip J. Kuekes

Inventor： Wei Wu ,  Zhiyong Li ,  Shih-Yuan Wang ,  Philip J. Kuekes

IPC: C12M1/00 ,  G01N15/06 ,  C07H21/04

CPC classification number: G01N33/48721 ,  B82Y5/00 ,  B82Y10/00 ,  G01N27/414

Abstract: Devices and methods for detecting the constituent parts of biological polymers are disclosed. A molecular analysis device comprises a molecule sensor and a molecule guide. The molecule sensor comprises a single electron transistor including a first terminal, a second terminal, and a nanogap or at least one quantum dot positioned between the first terminal and the second terminal. A nitrogenous material disposed on the at least one quantum dot is configured for an interaction with an identifiable configuration of a molecule. The molecule sensor develops an electronic effect responsive to the interaction. The molecule guide is configured for guiding at least a portion of the molecule substantially near the molecule sensor to enable the interaction.

Abstract translation: 公开了用于检测生物聚合物的组成部分的装置和方法。 分子分析装置包括分子传感器和分子引导件。 分子传感器包括单电子晶体管，其包括位于第一端子和第二端子之间的第一端子，第二端子和纳米隙隙或至少一个量子点。 设置在至少一个量子点上的含氮材料被配置用于与分子的可识别构型的相互作用。 分子传感器产生响应于相互作用的电子效应。 分子引导件被配置用于基本上在分子传感器附近引导分子的至少一部分，以实现相互作用。

公开(公告)号：US07805028B2

公开(公告)日：2010-09-28

申请号：US12253123

申请日：2008-10-16

Applicant: Zhiyong Li ,  Michael Tan ,  Shih-Yuan Wang ,  Wei Wu ,  Jing Tang

Inventor： Zhiyong Li ,  Michael Tan ,  Shih-Yuan Wang ,  Wei Wu ,  Jing Tang

IPC: G02B6/00 ,  G02B6/32 ,  G02B6/10

CPC classification number: G02B6/02328 ,  B82Y20/00 ,  G01N21/05 ,  G01N21/31 ,  G01N21/645 ,  G01N21/658 ,  G01N2021/0346 ,  G01N2021/052 ,  G01N2021/6467 ,  G01N2021/7763 ,  G01N2021/7783 ,  G02B6/1226

Abstract: An optical sensor, sensing system and method of sensing employ a half-core hollow optical waveguide adjacent to a surface of an optical waveguide layer of a substrate. The half-core hollow optical waveguide and the adjacent optical waveguide layer cooperatively provide both an optical path that confines and guides an optical signal and an internal hollow channel. The optical path and channel extend longitudinally along a hollow core of the half-core hollow optical waveguide. The system further includes an optical source at an input of the optical path and an optical detector at an output of the optical path. A spectroscopic interaction between an analyte material that is introduced into the channel and an optical signal propagating along the optical path determines a characteristic of the analyte material.

Abstract translation: 光学传感器，感测系统和感测方法使用与衬底的光波导层的表面相邻的半芯空心光波导。 半芯空心光波导和相邻的光波导层协同地提供限制和引导光信号和内部中空通道的光路。 光路和通道沿半芯空心光波导的中空芯纵向延伸。 该系统还包括在光路的输入处的光源和在光路的输出处的光学检测器。 引入到通道中的分析物质与沿光路传播的光信号之间的光谱相互作用决定了分析物质的特性。

公开(公告)号：US07639354B2

公开(公告)日：2009-12-29

申请号：US11701045

申请日：2007-01-31

Applicant: Shih-Yuan Wang ,  Zhiyong Li

Inventor： Shih-Yuan Wang ,  Zhiyong Li

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01N21/658

Abstract: Raman systems include a radiation source, a radiation detector configured to detect Raman scattered radiation, and a Raman signal-enhancing structure. The Raman signal-enhancing structure includes a first layer of Raman signal-enhancing material, a substantially monomolecular layer of molecules disposed on at least a portion of the first layer of Raman signal-enhancing material, and a second layer of Raman signal-enhancing material disposed on at least a portion of the substantially monomolecular layer of molecules. The second layer of Raman signal-enhancing material is disposed on a side of the layer of molecules opposite the first layer of Raman signal-enhancing material. Methods of performing Raman spectroscopy include providing such a Raman signal-enhancing structure, providing an analyte on the Raman signal-enhancing structure, irradiating the analyte and the structure, and detecting Raman scattered radiation.

Abstract translation: 拉曼系统包括辐射源，被配置为检测拉曼散射辐射的辐射检测器和拉曼信号增强结构。 拉曼信号增强结构包括第一层拉曼信号增强材料，设置在第一层拉曼信号增强材料的至少一部分上的基本上单分子层的分子，以及第二层拉曼信号增强材料 设置在分子的基本单分子层的至少一部分上。 第二层拉曼信号增强材料设置在与第一层拉曼信号增强材料相对的分子层的一侧。 执行拉曼光谱的方法包括提供这样的拉曼信号增强结构，在拉曼信号增强结构上提供分析物，照射分析物和结构，以及检测拉曼散射辐射。

公开(公告)号：US07391511B1

公开(公告)日：2008-06-24

申请号：US11700986

申请日：2007-01-31

Applicant: Alexandre M. Bratkovski ,  Shih-Yuan Wang ,  Zhiyong Li

Inventor： Alexandre M. Bratkovski ,  Shih-Yuan Wang ,  Zhiyong Li

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01N21/658

Abstract: A Raman signal-enhancing structure includes a substrate and a plurality of protrusions located at predetermined positions relative to a surface of the substrate. Each protrusion includes a Raman signal-enhancing material and has cross-sectional dimensions of less than about 50 nanometers. The structure also includes an edge that includes an intersection between two nonparallel surfaces of at least one protrusion. A Raman spectroscopy system includes such a Raman signal-enhancing structure, and Raman spectroscopy may be performed on an analyte using such structures and systems. A method for forming such a Raman signal-enhancing structure includes nanoimprint lithography.

Abstract translation: 拉曼信号增强结构包括基板和位于相对于基板的表面的预定位置处的多个突起。 每个突起包括拉曼信号增强材料并且具有小于约50纳米的横截面尺寸。 该结构还包括边缘，其包括至少一个突起的两个不平行表面之间的交叉点。 拉曼光谱系统包括这样的拉曼信号增强结构，并且可以使用这种结构和系统对分析物进行拉曼光谱。 形成这种拉曼信号增强结构的方法包括纳米压印光刻。

公开(公告)号：US20070252980A1

公开(公告)日：2007-11-01

申请号：US11413377

申请日：2006-04-28

Applicant: Shih-Yuan Wang ,  Zhiyong Li

Inventor： Shih-Yuan Wang ,  Zhiyong Li

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01J3/02 ,  G01J3/0208 ,  G01N21/658

Abstract: Raman-enhancing structures include a layer of dielectric material, a superlens configured to focus electromagnetic radiation having a wavelength greater than about 100 nanometers to a two-dimensional focal area having linear dimensions less than about 100 nanometers on a surface of the layer of dielectric material, and at least two nanoparticles comprising a Raman-enhancing material disposed proximate the focal area. Additional Raman-enhancing structures include a layer of dielectric material, a layer of conductive material, and at least two nanoparticles comprising a Raman-enhancing material disposed on a second, opposite surface of the layer of dielectric material. The layer of conductive material has a plurality of apertures therethrough that are arranged in a two-dimensional array. Methods for conducting Raman spectroscopy are performed using such structures and systems.

Abstract translation: 拉曼增强结构包括介电材料层，配置成将具有大于约100纳米的波长的电磁辐射聚焦到具有小于约100纳米的线性尺寸的二维聚焦区域的超薄膜在电介质材料层的表面上 以及至少两个纳米颗粒，其包含靠近焦点区域设置的拉曼增强材料。 附加的拉曼增强结构包括电介质材料层，导电材料层，以及至少两个包含拉曼增强材料的纳米颗粒，该拉曼增强材料设置在电介质材料层的第二相对表面上。 导电材料层具有以二维阵列布置的穿过其中的多个孔。 使用这种结构和系统进行拉曼光谱的方法。

公开(公告)号：US07158219B2

公开(公告)日：2007-01-02

申请号：US10942693

申请日：2004-09-16

Applicant: Zhiyong Li ,  Shih-Yuan Wang

Inventor： Zhiyong Li ,  Shih-Yuan Wang

IPC: G01N1/00 ,  G01J3/44

CPC classification number: G01N21/658 ,  B82Y30/00

Abstract: A SERS-active structure is disclosed that includes a substrate and at least one nanowire disposed on the substrate. The at least one nanowire includes a core including a first material and a coating including a SERS-active material. A SERS system is also disclosed that includes a SERS-active structure. Also disclosed are methods for forming a SERS-active structure and methods for performing SERS with SERS-active structures.

Abstract translation: 公开了一种SERS-活性结构，其包括衬底和设置在衬底上的至少一个纳米线。 所述至少一个纳米线包括包含第一材料和包含SERS-活性材料的涂层的芯。 还公开了包括SERS活性结构的SERS系统。 还公开了形成SERS活性结构的方法和用SERS活性结构进行SERS的方法。