公开(公告)号：US20080142112A1

公开(公告)日：2008-06-19

申请号：US12025362

申请日：2008-02-04

Applicant: Daniel Py ,  Julian V. Chan

Inventor： Daniel Py ,  Julian V. Chan

IPC: B65B1/04

CPC classification number: B65D83/62 ,  A61J1/00 ,  A61J1/1443 ,  B65B3/30 ,  B65B31/044 ,  B65D83/425

Abstract: A dispenser for holding multiple doses of fluids or other substances, and for dispensing the substances, has a vial, a flexible bladder received within the vial, and a variable volume storage chamber formed between the bladder and vial. A filling valve is coupled in fluid communication with the storage chamber and defines (1) a normally closed, fluid-tight position hermetically sealing the storage chamber from the ambient atmosphere, and (2) an open position allowing the passage of fluid through the valve both to evacuate the storage chamber and to introduce fluid through the valve to fill the storage chamber. A pump is coupled in fluid communication with the storage chamber for pumping fluids out of the storage chamber. A dispensing valve is coupled in fluid communication with the pump and defines (1) a normally closed, fluid-tight position preventing the passage of fluid out of the dispenser, and (2) an open position for dispensing pumped fluid therethrough. The sealed, empty dispenser is sterilized, such as by applying gamma radiation thereto. Then, the sterilized, sealed, empty dispenser is filled with fluid by engaging the filling valve with an evacuating/dispensing member to evacuate the storage chamber, and by introducing fluid from the filling member through the open filling valve and into the storage chamber. The filling member is withdrawn from the valve, and a spring moves the valve to a closed position to hermetically seal the fluid within the dispenser.

Abstract translation: 用于保持多个剂量的流体或其它物质并用于分配物质的分配器具有小瓶，容纳在小瓶内的柔性囊，以及形成在膀胱和小瓶之间的可变体积存储室。 填充阀与储存室流体连通地联接并且限定（1）将储存室与环境大气密封的常闭密封的流体密封位置，和（2）允许流体通过阀门的打开位置 两者都抽真空储存室并引入流体通过阀门填充储存室。 泵与储存室流体连通地联接，用于将流体泵出储存室。 分配阀与泵流体连通地联接并限定（1）常闭的，流体密封的位置，防止流体从分配器通过，以及（2）用于分配泵送的流体通过的打开位置。 密封的空分配器被灭菌，例如通过对其施加γ射线。 然后，通过使填充阀与排气/分配构件接合以消除储存室，并且通过将来自填充构件的流体通过打开的填充阀引入并进入储存室，灭菌的密封的空分配器充满流体。 填充构件从阀中取出，并且弹簧将阀移动到关闭位置以将分配器内的流体气密地密封。

公开(公告)号：US20080135130A1

公开(公告)日：2008-06-12

申请号：US11935194

申请日：2007-11-05

Applicant: Daniel Py ,  Nobert M. Assion ,  Julian V. Chan

Inventor： Daniel Py ,  Nobert M. Assion ,  Julian V. Chan

IPC: B65B1/04 ,  G01F11/00

CPC classification number: B65D51/002 ,  A45D34/04 ,  A45D2200/055 ,  A61J1/1406 ,  A61J7/0053 ,  B05B11/02 ,  B67D99/00 ,  G01F11/027

Abstract: A syringe is provided for the delivery of controlled, metered amounts of any of numerous different substances to humans or animals, such as medicaments, pharmaceuticals, cosmetics, and food products, or to deliver materials which may react upon exposure to air, such as glue. The syringes include a body and a plunger. Means are provided in the syringe body and the plunger to effect controlled movement of the plunger into the syringe to permit delivery of a pre-determined amount of the substance contained in the syringe. A one-way valve is provided at the dispensing tip of the syringe to hermetically seal the portion of the syringe containing the substance to be dispensed.

Abstract translation: 提供注射器用于向人或动物（例如药物，药物，化妆品和食品）递送受控量的计量量的任何不同物质，或者输送在暴露于空气中可能反应的材料，例如胶 。 注射器包括身体和柱塞。 装置设置在注射器主体和柱塞中以实现柱塞到注射器中的受控运动，以允许输送预定量的包含在注射器中的物质。 在注射器的分配尖端处设置单向阀以气密地密封包含待分配物质的注射器的部分。

公开(公告)号：USD570052S1

公开(公告)日：2008-05-27

申请号：US29291014

申请日：2007-08-10

Applicant: Daniel Py ,  Julian V. Chan ,  Stephanie Ferreira ,  Gladys Valencia

Designer： Daniel Py ,  Julian V. Chan ,  Stephanie Ferreira ,  Gladys Valencia

公开(公告)号：USD555784S1

公开(公告)日：2007-11-20

申请号：US29258873

申请日：2006-04-28

Applicant: Daniel Py ,  Julian V. Chan

Designer： Daniel Py ,  Julian V. Chan

公开(公告)号：US07264142B2

公开(公告)日：2007-09-04

申请号：US11043365

申请日：2005-01-26

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65D88/54

CPC classification number: G01F11/021 ,  B05B11/3001 ,  B05B11/3015 ,  B05B11/3032 ,  B05B11/3047 ,  B05B11/3074 ,  B65D47/2031 ,  B65D83/00 ,  B65D83/0033 ,  B65D83/0072 ,  G01F11/02

Abstract: A dispenser has a housing, and a variable-volume storage chamber formed within the housing and defining a substantially fluid-tight seal between the chamber and exterior of the housing for storing a substance to be dispensed. A piston is mounted within the housing, and a one-way valve is mounted within the housing and coupled in fluid communication with the variable-volume storage chamber. A compression chamber is coupled in fluid communication between the piston and one-way valve, and at least one of the piston and valve is manually depressible relative to the other between (i) a first position in which the piston is located at least partially outside of the compression chamber for permitting substance to flow from the variable-volume storage chamber into the compression chamber, and (ii) a second position in which the piston is located at least partially within the compression chamber for pressurizing substance within the compression chamber above a valve opening pressuring and, in turn, dispensing substance through the one-way valve and out of the dispenser.

Abstract translation: 分配器具有壳体和形成在壳体内的可变容积的储存室，并且在壳体的室和外部之间限定基本上流体密封的密封，用于存储待分配的物质。 活塞安装在壳体内，并且单向阀安装在壳体内并且与可变容积存储室流体连通地联接。 压缩室在活塞和单向阀之间流体连通地联接，并且活塞和阀门中的至少一个在第一位置之间相对于另一个手动地相对地被压下，其中活塞位于至少部分外部 的压缩室，用于允许物质从可变容积的储存室流入压缩室，以及（ii）第二位置，其中活塞至少部分地位于压缩室内，用于将压缩室内的物质加压在压缩室的上方 阀开启压力，而又通过单向阀将分配物质分配到分配器中。

公开(公告)号：USD548889S1

公开(公告)日：2007-08-14

申请号：US29265236

申请日：2006-08-28

Applicant: Daniel Py ,  Julian V. Chan ,  Stephanie Ferreira ,  Gladys Valencia

Designer： Daniel Py ,  Julian V. Chan ,  Stephanie Ferreira ,  Gladys Valencia

公开(公告)号：US20070114690A1

公开(公告)日：2007-05-24

申请号：US11582291

申请日：2006-10-17

Applicant: Daniel Py ,  Benoit Adamo ,  John Guthy ,  Nathaniel Houle ,  Giovanni Rodriguez

Inventor： Daniel Py ,  Benoit Adamo ,  John Guthy ,  Nathaniel Houle ,  Giovanni Rodriguez

IPC: B29C45/00

CPC classification number: B29C45/1701 ,  B29C37/0007 ,  B29C45/006 ,  B29C45/1753 ,  B29C45/40 ,  B29C45/42 ,  B29C2045/1797 ,  B29C2791/005

Abstract: An apparatus and method are provided for molding sterile parts. The apparatus has a first mold portion and a second mold portion. At least one of the first and second mold portions defines a mold cavity configured to receive a molten plastic and form therefrom at least one molded part At least one of the first and second mold portions is movable relative to the other between (i) a closed position for sealing the mold cavity or cavities and molding at least one part therein, and (ii) an open position defining a fluid passageway between the first and second mold portions and permitting the passage of a fluid sterilant therein. A fluid source that contains or otherwise generates a fluid sterilant, such as vaporized hydrogen peroxide, is connectable in fluid communication with the fluid passageway for introducing the sterilant into the fluid passageway with at least one of the first and second mold portions in the open position, and in turn contacting with the sterilant the surfaces of the first and second mold portions forming the fluid passageway and located adjacent to the at least one mold cavity, but not contacting an interior surface of a molded part within the mold cavity, to sterilize the exposed mold surfaces and thereby prevent contamination of the molded part.

Abstract translation: 提供了用于模制无菌部件的装置和方法。 该装置具有第一模具部分和第二模具部分。 第一模具部分和第二模具部分中的至少一个限定了模腔，其被配置为容纳熔融塑料并从其形成至少一个模制部件。第一模具部分和第二模具部分中的至少一个可相对于彼此移动， 用于密封模腔或空腔并在其中模制至少一个部件的位置，以及（ii）限定第一和第二模具部分之间的流体通道并允许其中的流体灭菌剂通过的打开位置。 包含或以其它方式产生流体灭菌剂的流体源例如蒸发的过氧化氢可连接到流体通道，用于将灭菌剂引入流体通道，其中第一和第二模具部分中的至少一个处于打开位置 ，并且还与灭菌剂接触形成第一和第二模具部分的表面，形成流体通道并且位于与至少一个模具腔相邻但不与模腔内的模制部件的内表面接触，以消除 暴露的模具表面，从而防止模制部件的污染。

公开(公告)号：US20070095857A1

公开(公告)日：2007-05-03

申请号：US11588968

申请日：2006-10-26

Applicant: Daniel Py ,  Miles Flamenbaum ,  Eric Hartman ,  Nathaniel Houle

Inventor： Daniel Py ,  Miles Flamenbaum ,  Eric Hartman ,  Nathaniel Houle

IPC: B67D5/00

CPC classification number: B65D51/227 ,  B65D47/205 ,  B65D2251/0025 ,  B65D2251/0093

Abstract: A device for storing and dispensing a substance includes a container having a body defining therein a storage chamber for receiving and storing the substance. The container includes a first passageway that is in fluid communication with the storage chamber of the body and defines a flow path therebetween. The container also includes a pierceable wall located on an opposite side of the first passageway relative to the storage chamber, and a first threaded connecting portion located at one end of the body for connecting another component thereto. The device also includes a one-way valve assembly that includes a valve body including a body base defining a second passageway and a piercing portion mounted within the valve body and engageable with the pierceable wall of the container. At least one of the piercing portion and the pierceable wall is movable relative to the other between a first position wherein the pierceable portion is not piercing the pierceable wall, and a second position wherein the pierceable portion is piercing the pierceable wall and the first passageway of the container is in fluid communication with the second passageway of the valve body for allowing the flow of substance from the storage chamber therethrough. The valve assembly includes a second threaded connecting portion that is threadedly connectable to the first threaded connecting portion of the container for fixedly securing the valve assembly to the container when the valve assembly and container are located in the second position. A manually-engageable and removable member is disposed intermediate the valve body and the container that prevents movement of at least one of the piercing portion and pierceable wall to the second position until the removable member is removed. The valve assembly includes a valve seat and at least one flow aperture extending through the valve body adjacent to the valve seat and in fluid communication with the second passageway for receiving the substance from the storage chamber there through.

公开(公告)号：US20060231519A1

公开(公告)日：2006-10-19

申请号：US11339966

申请日：2006-01-25

Applicant: Daniel Py ,  Norbert Assion ,  Nathaniel Houle ,  Debashis Sahoo ,  M. Willey ,  Eric Hartman

Inventor： Daniel Py ,  Norbert Assion ,  Nathaniel Houle ,  Debashis Sahoo ,  M. Willey ,  Eric Hartman

IPC: B65D53/00 ,  B65D51/00 ,  B65D43/18

CPC classification number: B65B55/10 ,  B65B3/003 ,  B65B7/2842 ,  B65B51/22 ,  B65B55/025 ,  B65D51/002 ,  B65D51/18 ,  B65D2251/0015 ,  B65D2251/0078

Abstract: A container and method are provided for storing fat containing liquid products, such as infant or baby formula, or other milk-based products. The container includes a body defining a storage chamber for receiving the aseptic fat containing liquid product, and a first aperture in fluid communication with the storage chamber. The body does not leach more than a predetermined amount of leachables into the fat containing liquid product and does not undesirably alter a taste profile of the fat containing liquid product. A container closure assembly includes a stopper receivable within the first aperture for hermetically sealing the storage chamber. The stopper includes a first material portion defining an internal surface in fluid communication with the storage chamber forming at least most of the surface area of the container closure that can contact any fat containing liquid product within the storage chamber and that does not leach more than a predetermined amount of leachables into the fat containing liquid product or undesirably alter a taste profile of the fat containing liquid product. A second material portion of the stopper either (i) overlies the first material portion and cannot contact any product within the storage chamber, or (ii) forms a substantially lesser surface area of the container closure that can contact any product within the storage chamber in comparison to the first material portion. The second material portion is needle penetrable for filling the storage chamber with product, and a resulting needle aperture formed in the second material portion is thermally resealable such as by the application of laser energy to seal the product within the storage chamber. A sealing portion of the container closure is engageable with the body prior to needle filling the storage chamber to thereby form a substantially dry hermetic seal between the container closure and body.

公开(公告)号：US07111649B2

公开(公告)日：2006-09-26

申请号：US11103803

申请日：2005-04-11

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65B1/20

CPC classification number: B65B3/04 ,  A61L2/08 ,  A61L2/087 ,  A61L2/24 ,  A61L2202/14 ,  B65B3/003 ,  B65B7/16 ,  B65B7/161 ,  B65B55/025 ,  B65B55/08 ,  B65B55/16

Abstract: A sterile filling machine and related method are provided for sterile filling a container with a substance. The container includes a heat resealable stopper and a chamber for receiving the substance therein. The sealed, empty containers are subjected to radiation capable of penetrating through the stopper and chamber for sterilizing the container. The previously sterilized containers are then transported through an e-beam chamber, wherein an electron beam is directed onto a penetrable surface of the stopper to sterilize the penetrable surface. A needle is mounted within the e-beam chamber and moved into engagement with the stopper to pierce the sterilized penetrable surface of the stopper and inject the substance through the needle and into the chamber of the container. The needle is then withdrawn from the stopper and the filled container is transported outside of the e-beam chamber. Laser energy is then transmitted onto the penetrated surface of the stopper to fuse the stopper material and hermetically re-seal the stopper.

Abstract translation: 提供了一种无菌灌装机及相关方法，用于无菌填充具有物质的容器。 容器包括可热再封塞的塞子和用于在其中容纳物质的腔室。 密封的空容器经受能够穿过塞子和室的辐射，以对容器进行灭菌。 先前灭菌的容器然后通过电子束室传送，其中电子束被引导到塞子的可穿透表面上以对可穿透表面进行消毒。 针安装在电子束室内并与止动器接合，以刺穿塞子的消毒的可渗透表面并将物质通过针头注入容器的腔室。 然后将针从止动器中取出，并将填充的容器运送到电子束室外部。 然后将激光能量传递到塞子的穿透表面上，以使塞子材料熔化并密封地重新密封塞子。