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公开(公告)号：US20210208058A1
公开(公告)日：2021-07-08
申请号：US17056543
申请日：2019-05-29
Applicant: Cytiva Sweden AB
Inventor： Hanno Ehring , Mats Lundkvist , David Carl Martin Bergman , Andreas Marcstrom
Abstract: Disclosed is an optical flow cell (300′) comprising: a housing (910) forming; an enclosed and elongated fluid channel (920) arranged along a first axis (923); a first light guide (961) and a second light guide (962) generally concentrically arranged along a second axis (970) and on opposite side walls of the fluid channel, said first and second light guides having ends (961c,962c) removed in situ to provide a sensing gap (d).
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公开(公告)号：US20210140558A1
公开(公告)日：2021-05-13
申请号：US17259709
申请日：2019-07-19
Applicant: Cytiva Sweden AB
Inventor： Prashanth Hosabettu Mohan , Ajit S. Vernekar , Praveen Paul , Krishnadev Madhavan Nair , Manjunath Bhat
Abstract: A valve (100) for a bioprocess liquid apparatus (199) comprises tubular sections (101, 102, 103) inside which valve seat means (155) are arranged. A plunger arrangement (150) is configured to selectively interact with the valve seat means to close and open the tubular sections in response to a magnetic field provided by solenoid arrangements (104, 105), the solenoid arrangements being arranged at the bioprocess liquid apparatus. A flow path device comprising such a valve and a bioprocess liquid apparatus and a method of handling a bioprocess liquid are also disclosed.
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公开(公告)号：US10996220B2
公开(公告)日：2021-05-04
申请号：US15938903
申请日：2018-03-28
Applicant: CYTIVA SWEDEN AB
Inventor： Johan Dan Johansson , Tomas Dalmo
IPC: G01N33/543 , G01N1/38 , G01N21/552 , G01N33/531 , G01N35/00
Abstract: Methods for preparing a dilution series for use in forming calibration curves, preferably in the field of surface plasmon resonance, are provided. In one example, a dilution series is prepared by using receptacles such as tubes of a micro well plate in which samples of the dilution series are mixed. In another example, a dilution series is prepared by using a convection mix in a receptacle for achieving a concentration gradient in the sample. A biosensor system arranged to perform steps of methods disclosed are provided. A data processing apparatus and a software for performing steps of methods disclosed, and a computer readable medium for storing the software are also provided.
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Patent Agency Ranking
公开(公告)号：US20210086101A1
公开(公告)日：2021-03-25
申请号：US17113311
申请日：2020-12-07
Applicant: Cytiva Sweden AB
Inventor： Klaus Gebauer , Bjorn Markus Olovsson
Abstract: Disclosed is a device for chromatographic separations comprising: a manifold comprising a manifold body defining an elongate central duct, the central duct comprising a centrally-located closable duct valve providing selective fluid communication between a first portion of the central duct and an opposed second portion of the central duct, a first plurality of connectors, each connector of the first plurality of connectors for connecting to a distinct chromatographic separation column and/or feed or extraction tubing or to a connector of an adjacent manifold; a second plurality of connectors, each connector of the second plurality of connectors for connecting to a distinct chromatographic separation column and/or feed or extraction tubing or to a connector of an adjacent manifold; wherein said manifold body further defines: a first plurality of branch ducts, each branch duct of which extending from the first portion of the central duct to an individual one of the first plurality of connectors, each of the branch ducts of the first plurality of branch ducts comprising a closable branch valve providing selectable fluid communication between a respective connector and the first portion of the central duct, a second plurality of branch ducts, each branch duct of which extending from the second portion of the central duct to an individual one of the second plurality of connectors, each of the branch ducts of the second plurality of branch ducts comprising a closable branch valve providing selectable fluid communication between a respective connector and the second portion of the central duct; first and second ports in fluid communication with the centrally-located closable duct valve wherein said first port communicates with said first portion of the central duct and said second port communicates with said second portion of said central duct, wherein one of said first and second ports is further positioned to communicate with said central duct at a location between the centrally-located closable duct valve and the first and second plurality of branch ducts, respectively.
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公开(公告)号：US20210080434A1
公开(公告)日：2021-03-18
申请号：US17102865
申请日：2020-11-24
Applicant: Cytiva Sweden AB
Inventor： Karol Lacki
Abstract: A chromatography system with a main column comprising a chromatography resin, a first guard column and a second guard column, wherein the first guard column is connected to a first end of the main column, the second guard column is connected to a second end of the main column and the bed volumes of said first and second guard columns are each less than about 50% of the bed volume of the main column.
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公开(公告)号：US10940402B2
公开(公告)日：2021-03-09
申请号：US16338117
申请日：2017-09-29
Applicant: CYTIVA SWEDEN AB
Inventor： Johan Fredrik Avallin
Abstract: A method and a system for transferring a slurry of a separation resin, from at least one first container to a second container, said method comprising the steps of: connecting the at least one first container to the second container by a transferring connection; providing a degree of vacuum to the second container by a vacuum production device connected to the second container; allowing the vacuum in the second container to affect the content in the at least one first container through the transferring connection such that the slurry initially provided in the at least one first container is transferred to the second container through the transferring connection.
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公开(公告)号：US10888799B2
公开(公告)日：2021-01-12
申请号：US15534540
申请日：2015-12-23
Applicant: Cytiva Sweden AB
Inventor： Klaus Gebauer , Bjorn Markus Olovsson
Abstract: Disclosed is a device for chromatographic separations comprising: a manifold comprising a manifold body defining an elongate central duct, the central duct comprising a centrally-located closable duct valve providing selective fluid communication between a first portion of the central duct and an opposed second portion of the central duct, a first plurality of connectors, each connector of the first plurality of connectors for connecting to a distinct chromatographic separation column and/or feed or extraction tubing or to a connector of an adjacent manifold; a second plurality of connectors, each connector of the second plurality of connectors for connecting to a distinct chromatographic separation column and/or feed or extraction tubing or to a connector of an adjacent manifold; wherein said manifold body further defines: a first plurality of branch ducts, each branch duct of which extending from the first portion of the central duct to an individual one of the first plurality of connectors, each of the branch ducts of the first plurality of branch ducts comprising a closable branch valve providing selectable fluid communication between a respective connector and the first portion of the central duct, a second plurality of branch ducts, each branch duct of which extending from the second portion of the central duct to an individual one of the second plurality of connectors, each of the branch ducts of the second plurality of branch ducts comprising a closable branch valve providing selectable fluid communication between a respective connector and the second portion of the central duct; first and second ports in fluid communication with the centrally-located closable duct valve wherein said first port communicates with said first portion of the central duct and said second port communicates with said second portion of said central duct, wherein one of said first and second ports is further positioned to communicate with said central duct at a location between the centrally-located closable duct valve and the first and second plurality of branch ducts, respectively.
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公开(公告)号：US10795141B2
公开(公告)日：2020-10-06
申请号：US15533686
申请日：2015-12-18
Applicant: CYTIVA SWEDEN AB
Inventor： Jeremy R. Cooper
Abstract: Disclosed is an LED arrangement for a microscopy instrument (200 FIG. 2) comprising a light emitting area (112), and a part-spherical solid and light transmissive cap (120), in light communication with the light emitting area, the cap having a hemispherical surface (126) including a portion (124) at which light from the light emitting area is reflected and a portion (128) at which light from the emitter can exit the cap, in order to provide a usable light cone L which includes light recycled from the more divergent emitted light, and is thereby more intense.
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