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公开(公告)号：US20250067258A1
公开(公告)日：2025-02-27
申请号：US18847659
申请日：2023-04-12
Applicant: CYTIVA SWEDEN AB
Inventor： Andreas Lundin , Christopher Ford , Klaus Gebauer , Per Stromberg
IPC: F04B43/073 , F04B43/00 , F04B53/16
Abstract: The present disclosure relates to a pump (100, 1100, 2100) for providing substantially continuous liquid flow in a bioprocessing system (200), the pump (100, 1100, 2100) comprising: a pressurisable outlet chamber (122, 1122) in fluidic communication with an outlet (126, 1126, 2126) of the pump (100, 1100, 2100); and a pressurisable feed chamber (120, 1120) connected in series with the outlet chamber (122, 1122), wherein the feed chamber (120, 1120) is configured to fill the outlet chamber (122, 1122) during discharge of liquid from the outlet chamber (122, 1122).
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公开(公告)号：US12223716B2
公开(公告)日：2025-02-11
申请号：US18525144
申请日：2023-11-30
Applicant: Cytiva Sweden AB
Inventor： Petra Bangtsson , Johan Arthursson , Key Hyckenberg , Lotta Hedkvist
Abstract: A method of automated configuration in a bioprocess system and to verify a process defined by a flow path representation. The method comprises the steps of: capturing one image of the bioprocess system comprising tubing for the fluid communication between units of the bioprocess system; analyzing the captured image to identify the tubing connecting units of the bioprocess system; producing a processed representation from the captured image wherein at least a part of the tubing is identified; and comparing the processed representation with the flow path representation to verify their functional concordance.
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公开(公告)号：US20250018313A1
公开(公告)日：2025-01-16
申请号：US18898242
申请日：2024-09-26
Applicant: Cytiva Sweden AB
Inventor： Per Karlberg , Erik Rurling , Joakim Lundkvist
Abstract: A method for packing a media bed in a column. According to the invention the method comprises the steps of: providing data to a control unit connected to the column, said data comprising at least a measured slurry concentration, a target bed height, a target packing factor or compression factor and minimum and maximum acceptable values for at least one of target bed height and target packing or compression factor; forcing a movable adapter along a longitudinal axis of the column in order to pack the media; detecting when the media bed is consolidated; the control unit processing the provided data and the information about the consolidated bed height in order to present to the user acceptable bed heights, if there are any, giving acceptable packing or compression factors.
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公开(公告)号：US12066413B2
公开(公告)日：2024-08-20
申请号：US17294710
申请日：2019-12-04
Applicant: Cytiva Sweden AB
Inventor： Daniel Salomonsson , Mats Lundkvist
CPC classification number: G01N30/6082 , B01D15/206 , B01D15/22
Abstract: Disclosed is a chromatographic separation column assembly (100) comprising a column cylinder (120) having a cylinder wall (126) including an inner wall surface (124) partially defining a column volume (50), and a column component (110/130) insertable into to the cylinder (120), wherein at least an edge region (113/133) of the column component is intended to be in contact or adjacent a part of the inner wall surface (124) in use, the edge region and the contacting or adjacent part of inner wall surface each being formed from a compatible heat fusible material or materials, and wherein at least the cylinder wall in the area of the contacting or adjacent part of the inner wall is formed from a material which allows transmission of the light energy needed to cause said fusing of the adapter plate edge region to the inner wall surface.
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公开(公告)号：US20240085382A1
公开(公告)日：2024-03-14
申请号：US17767795
申请日：2020-10-15
Applicant: Cytiva Sweden AB
Inventor： Stephan Menzel
IPC: G01N30/02
CPC classification number: G01N30/02 , G01N2015/084
Abstract: Disclosed is a system and a method for testing at least one filtration device. The system comprises a chromatography system (3) comprising at least one pair of inlet and outlet chromatography column connections (7a), 7b for at least one chromatography column, and at least one filtration device housing (21) comprising a filtration device (23) to be tested, whereby each filtration device housing (21) is connected to one of the at least one pair of inlet and outlet chromatography column connections (7a, 7b) instead of a chromatography column in the chromatography system.
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Patent Agency Ranking
公开(公告)号：US11927503B2
公开(公告)日：2024-03-12
申请号：US17276981
申请日：2019-09-09
Applicant: Cytiva Sweden AB
Inventor： Sameera Simha Hindupur , Manoj Kumar Ramakrishna , Andreas Castan , Swapnil Puranik , Klaus Gebauer
CPC classification number: G01M3/2884 , B29C65/8246 , B29C66/522 , C12M23/40 , C12M37/04 , C12M41/40
Abstract: The present invention relates to a computer implemented method for determining a weld integrity test result performed by a system configured to aseptically transferring cells to a container (BR), the method comprising welding (710) a vial to a connector to obtain a fluid-tight seal between the vial (V) and a connector (C), the connector being provided with a pair of conduits each having one end protruding through the connector and into the vial, sealing (720) an opposite end of one of the conduits, generating (730) a fluid pressure different to an ambient fluid pressure at an opposite end of the other conduit, measuring (740) a fluid pressure within at least one of the conduits, determining (750) a fluid pressure change based on the ambient pressure and the measured fluid pressure, determining (760) the weld integrity test result as pass or as fail based on the fluid pressure change.
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公开(公告)号：US11886156B2
公开(公告)日：2024-01-30
申请号：US17130711
申请日：2020-12-22
Applicant: Cytiva Sweden AB
Inventor： Dalesh Dharamshi , Sudheer Mygapula
CPC classification number: G05B17/02 , G05B13/041 , G05B2219/23258 , G05B2219/23452 , G05B2219/32341 , G05B2219/37453 , Y02P90/02
Abstract: A system for providing an improved way of user intuitive visual management of bioprocess automation is disclosed. The system includes a processor and a memory. The processor is configured to present a graphical presentation of the bioprocess automation script and results associated with execution of the bioprocess automation script of a bioprocess, wherein the graphical presentation comprises an anticipated result and an anticipated flow path associated with the bioprocess; and modify the graphical presentation by varying at least one of the anticipated result and the anticipated flow path.
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公开(公告)号：US20240009594A1
公开(公告)日：2024-01-11
申请号：US18474000
申请日：2023-09-25
Applicant: Cytiva Sweden AB
Inventor： Bjorn Markus Olovsson
IPC: B01D15/16 , G01N30/32 , G01N30/34 , B01F23/40 , B01F25/31 , B01F35/21 , B01F35/221 , B01F35/71 , B01D15/22
CPC classification number: B01D15/166 , G01N30/32 , G01N30/34 , B01F23/49 , B01F25/31 , B01F35/2132 , B01F35/2133 , B01F35/2211 , B01F35/7176 , B01D15/22 , G01N2030/347 , B01D15/16 , G01N30/8658
Abstract: A system for preparing solutions for chromatography application is disclosed. The system comprises a T-joint for preparing a buffer solution by mixing at least one first solution and a second solution. The T-joint receives the second solution from a solution supply unit connected to the T-joint. Further one or more low pressure pumps supply the one or more first solutions into the T-joint. The high pressure pump collects the buffer solution and delivers it to a chromatography apparatus.
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公开(公告)号：US20230384741A1
公开(公告)日：2023-11-30
申请号：US18327662
申请日：2023-06-01
Applicant: Cytiva Sweden AB
Inventor： Mikael Johansson , Pasi Juntikka , Peter Toreheim , Shivakumar Selvaraj
IPC: G05B13/02
CPC classification number: G05B13/0205
Abstract: The present invention relates to a computer implemented method (600) for optimization of a bioprocessing system (100) formed by interconnected or interconnectable bioprocessing units and configured to provide a desired system functionality, the method comprising obtaining (610) requirement data of a bioprocess, the requirement data being at least indicative of the desired system functionality, and indicative of a desired substance resulting from the operation of the bioprocess system, obtaining (620) unit data indicative of characteristics of a plurality of bioprocessing units, generating (630) at least one optimized or suitable bioprocessing system configuration capable to provide the desired system functionality, the bioprocessing system configuration comprising a selection of bioprocessing units from the plurality of bioprocessing units selected using the requirement data, the unit data and an objective function dependent on the requirement data and the unit data. The invention extends to a configuration system (500).
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公开(公告)号：US11717790B2
公开(公告)日：2023-08-08
申请号：US17252358
申请日：2019-06-20
Applicant: Cytiva Sweden AB
Inventor： Nityananda Maiya , Deepak Aravind , Fredrik Lundström , Saameera Simha Hindupur , Shivakumar Selvaraj , Alagur Sahebagouda
CPC classification number: B01D61/12 , B01D61/22 , B01D65/02 , B01D2311/04 , B01D2311/06 , B01D2311/14 , B01D2311/16 , B01D2313/48 , B01D2315/10 , B01D2315/20 , B01D2321/40
Abstract: A method includes measuring, by a flow sensor (70), a flow rate of a permeate fluid (48) flowing through a filter (20) of a membrane filtration system (12). Further, the method includes receiving, by a control unit (86), the measured flow rate of the permeate fluid (48) and determining, by the control unit (86), a first flux rate of the filter (20) based on the measured flow rate of the permeate fluid (48). Furthermore, the method includes comparing, by the control unit (86), the determined first flux rate with a first predetermined flux rate. Additionally, the method includes operating the membrane filtration system (12), by the control unit (86), in a normal mode or a flux tolerant mode based on the comparison of the determined first flux rate with the first predetermined flux rate. The flux tolerant mode of the membrane filtration system (12) is further based on a determined normalized water permeability value of the filter (20).
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