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    Composition And Method For Brain Tumor Therapy
    221.
    发明申请
    Composition And Method For Brain Tumor Therapy 审中-公开
    脑肿瘤治疗的组合和方法

    公开(公告)号：US20090036380A1

    公开(公告)日：2009-02-05

    申请号：US12224999

    申请日：2007-03-14

    Applicant: Michael Fainzilber ,  Marianna Tcherpakov ,  Zehava Levy ,  Liraz Harel

    Inventor： Michael Fainzilber ,  Marianna Tcherpakov ,  Zehava Levy ,  Liraz Harel

    IPC: A61K38/16 ,  A61P35/00

    CPC classification number: A61K38/1709 ,  G01N33/57407

    Abstract: A method of treating a disease associated with abnormal apoptosis in a subject in need thereof is disclosed. The method comprises administering to the subject a therapeutically effective amount of at least one agent capable of increasing and/or stabilizing an interaction between at least an active portion of TrkA and at least an active portion of Karet, thereby treating the disease in the subject.

    Abstract translation: 公开了一种在有需要的受试者中治疗与异常细胞凋亡相关的疾病的方法。 该方法包括向受试者施用治疗有效量的至少一种能够增加和/或稳定至少一种TrkA的活性部分与至少Karet活性部分之间的相互作用的试剂，从而治疗受试者的疾病。

    AKAP84 and its use for visualization of biological structures
    224.
    发明授权
    AKAP84 and its use for visualization of biological structures 失效
    AKAP84及其用于生物结构可视化的应用

    公开(公告)号：US07455989B2

    公开(公告)日：2008-11-25

    申请号：US10524275

    申请日：2003-08-17

    Applicant: Benjamin Geiger

    Inventor： Benjamin Geiger

    IPC: C12P21/06

    CPC classification number: C12Q1/02 ,  A61K38/00 ,  C07K14/415 ,  C07K16/16 ,  C07K19/00 ,  C07K2317/622 ,  C07K2319/00 ,  C07K2319/07 ,  C07K2319/30 ,  C12Q1/04 ,  G01N33/5005 ,  G01N33/5076 ,  G01N33/5079 ,  G01N33/5097

    Abstract: A polynucleotide encoding a chimeric polypeptide is provided. The chimeric polypeptide includes (a) a first polypeptide region being capable of specifically binding at least one detectable molecule; and (b) a second polypeptide region being capable of specifically binding a biological component or macromolecule or targeting a cellular compartment. Methods utilizing the polynucleotide or the chimeric polypeptide for highlighting a cell compartment, a biological component or macromolecule are also provided.

    Abstract translation: 提供编码嵌合多肽的多核苷酸。 嵌合多肽包括（a）能够特异性结合至少一个可检测分子的第一多肽区; 和（b）能够特异性结合生物成分或大分子或靶向细胞隔室的第二多肽区域。 还提供了利用多核苷酸或嵌合多肽突出细胞室，生物成分或大分子的方法。

    METHOD FOR REDUCING NEURONAL DEGENERATION BY ADMINISTERING CNS-DERIVED PEPTIDES OR ACTIVATED T CELLS
    225.
    发明申请
    METHOD FOR REDUCING NEURONAL DEGENERATION BY ADMINISTERING CNS-DERIVED PEPTIDES OR ACTIVATED T CELLS 审中-公开
    通过中枢神经系统衍生肽或活化T细胞减少神经变性的方法

    公开(公告)号：US20080279869A1

    公开(公告)日：2008-11-13

    申请号：US11563630

    申请日：2006-11-27

    Applicant: Michal Eisenbach-Schwartz ,  Ehud Hauben

    Inventor： Michal Eisenbach-Schwartz ,  Ehud Hauben

    IPC: A61K39/00 ,  A61P25/28 ,  A61P9/10 ,  A61P25/02

    CPC classification number: A61K38/39 ,  A61K39/0007

    Abstract: Compositions are provided for promoting nerve regeneration or reducing or inhibiting degeneration in the CNS or PNS to ameliorate the effects of injury or disease. The composition includes an active ingredient selected from:(a) a peptide obtained by modification of a self-peptide derived from a CNS-specific antigen, which modification consists in the replacement of one or more amino acid residues of the self-peptide by different amino acid residues, such modified CNS peptide still being capable of recognizing the T-cell receptor recognized by the self-peptide but with less affinity; (b) a nucleotide sequence encoding such a peptide; (c) T cells activated by such peptide; and (d) any combination of (a)-(c). The peptide is preferably obtained by modification of the self-peptide p87-99 of MBP, more preferably, by replacing lysine 91 with glycine (G91) or alanine (A91) or by replacing proline 96 with alanine (A96).

    Abstract translation: 提供组合物用于促进神经再生或减少或抑制CNS或PNS中的变性，以改善损伤或疾病的影响。 该组合物包括选自以下的活性成分：（a）通过修饰衍生自CNS特异性抗原的自身肽获得的肽，该修饰是由不同的自身肽的一个或多个氨基酸残基取代 氨基酸残基，这种修饰的CNS肽仍然能够识别由自身肽识别但具有较小亲和力的T细胞受体; （b）编码这种肽的核苷酸序列; （c）由该肽激活的T细胞; 和（d）（a） - （c）的任何组合。 肽优选通过修饰MBP的自身肽p87-99，更优选通过用甘氨酸（G91）或丙氨酸（A91）代替赖氨酸91或用丙氨酸（A96）代替脯氨酸96来获得。

    System and method for increasing space or time resolution in video
    229.
    发明授权
    System and method for increasing space or time resolution in video 失效
    视频中增加空间或时间分辨率的系统和方法

    公开(公告)号：US07428019B2

    公开(公告)日：2008-09-23

    申请号：US10498345

    申请日：2002-12-26

    Applicant: Michal Irani ,  Yaron Caspi ,  Eli Shechtman

    Inventor： Michal Irani ,  Yaron Caspi ,  Eli Shechtman

    IPC: H04N5/262 ,  H04N5/225

    CPC classification number: G06T3/4069 ,  H04N5/217 ,  H04N5/225 ,  H04N5/77 ,  H04N7/01 ,  H04N7/0125 ,  H04N7/12

    Abstract: A system and method for increasing space or time resolution of an image sequence by combination of a plurality input sources with different space-time resolutions such that the single output displays increased accuracy and clarity without the calculation of motion vectors. This system of enhancement may be used on any optical recording device, including but not limited to digital video, analog video, still pictures of any format and so forth. The present invention includes support for example for such features as single frame resolution increase, combination of a number of still pictures, the option to calibrate spatial or temporal enhancement or any combination thereof, increased video resolution by using high-resolution still cameras as enhancement additions and may optionally be implemented using a camera synchronization method.

    Abstract translation: 通过组合具有不同空间 - 时间分辨率的多个输入源来增加图像序列的空间或时间分辨率的系统和方法，使得单个输出在不计算运动矢量的情况下显示增加的精度和清晰度。 该增强系统可以用于任何光学记录装置，包括但不限于数字视频，模拟视频，任何格式的静止图像等。 本发明包括例如对于诸如单帧分辨率增加，多个静止图像的组合，校准空间或时间增强的选项或其任何组合的特征的支持，通过使用高分辨率静态相机作为增强添加来增加视频分辨率 并且可以可选地使用相机同步方法来实现。

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