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公开(公告)号：US20060166186A1
公开(公告)日：2006-07-27
申请号：US10524275
申请日：2003-08-17
Applicant: Benjamin Geiger
Inventor： Benjamin Geiger
CPC classification number: C12Q1/02 , A61K38/00 , C07K14/415 , C07K16/16 , C07K19/00 , C07K2317/622 , C07K2319/00 , C07K2319/07 , C07K2319/30 , C12Q1/04 , G01N33/5005 , G01N33/5076 , G01N33/5079 , G01N33/5097
Abstract: A polynucleotide encoding a chimeric polypeptide is provided. The chimeric polypeptide includes (a) a first polypeptide region being capable of specifically binding at least one detectable molecule; and (b) a second polypeptide region being capable of specifically binding a biological component or macromolecule or targeting a cellular compartment. Methods utilizing the polynucleotide or the chimeric polypeptide for highlighting a cell compartment, a biological component or macromolecule are also provided.
Abstract translation: 提供编码嵌合多肽的多核苷酸。 嵌合多肽包括（a）能够特异性结合至少一个可检测分子的第一多肽区; 和（b）能够特异性结合生物成分或大分子或靶向细胞隔室的第二多肽区域。 还提供了利用多核苷酸或嵌合多肽突出细胞室，生物成分或大分子的方法。
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公开(公告)号：US20050261184A1
公开(公告)日：2005-11-24
申请号：US11060914
申请日：2005-02-18
Applicant: Paul Kaufman , Benjamin Geiger , Alexander Bershadsky , Teresa Borras
Inventor： Paul Kaufman , Benjamin Geiger , Alexander Bershadsky , Teresa Borras
CPC classification number: A61K38/39 , A61K38/1709 , A61K48/00
Abstract: A method for reducing intraocular pressure and increasing outflow facility from an eye of a subject having glaucoma includes the step of providing in the trabecular meshwork of the eye an amount of caldesmon effective to reduce intraocular pressure and increase outflow facility.
Abstract translation: 一种降低眼内压并增加从具有青光眼的受试者的眼睛流出的设备的方法包括在眼小梁网中提供有效降低眼内压并增加流出设施的卡培培的量。
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公开(公告)号：US06586425B2
公开(公告)日：2003-07-01
申请号：US09772412
申请日：2001-01-29
Applicant: Paul L. Kaufman , Benjamin Geiger
Inventor： Paul L. Kaufman , Benjamin Geiger
IPC: A61K3155
CPC classification number: A61K45/06 , A61K31/00 , A61K31/365 , A61K31/403 , A61K31/407 , A61K31/427 , A61K31/496 , A61K31/551
Abstract: Methods for the treatment of glaucoma are provided by the present invention. The compounds described cause a perturbation of the actin cytoskeleton in the trabecular meshwork or the modulation of its interactions with the underlying membrane. Perturbation of the cytoskeleton and the associated adhesions reduces the resistance of the trabecular meshwork to fluid flow and thereby reduces intraocular pressure.
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公开(公告)号：US20120083477A1
公开(公告)日：2012-04-05
申请号：US13322453
申请日：2010-05-26
Applicant: Irina Lavelin , Varda Rotter , Moshe Oren , Ami Navon , Zvi Kam , Benjamin Geiger
Inventor： Irina Lavelin , Varda Rotter , Moshe Oren , Ami Navon , Zvi Kam , Benjamin Geiger
IPC: A61K31/60 , C07H21/04 , C12N5/00 , A61P25/28 , A61K31/522 , A61K31/555 , A61P35/00 , A61P29/00 , C07K14/00 , C12Q1/02
CPC classification number: A61K31/555 , A61K31/47 , A61K31/52 , A61K31/522 , A61K31/60 , A61K33/34 , C07K14/4746 , C07K2319/40 , C07K2319/60 , C12N9/6421 , C12Y304/25001 , G01N33/5035
Abstract: A method of treating a disease in which inhibiting of a proteasome is advantageous is provided. The method comprises administering to the subject a therapeutically effective amount of a compound which binds to a proteasome of a cell, the compound comprising a copper bound to a ligand, the ligand being configured such that upon binding to the proteasome, the copper interacts with cysteine 31 of a Beta2 subunit of the proteasome and further interacts with cysteine 118 of a Beta3 subunit of the proteasome, thereby treating the disease. Additional novel proteasome inhibitors are also provided as well as methods of identifying proteasome inhibitors.
Abstract translation: 提供了治疗其中抑制蛋白酶体的优点的疾病的方法。 该方法包括向受试者施用治疗有效量的结合细胞蛋白酶体的化合物，所述化合物包含与配体结合的铜，所述配体被配置为使得在结合蛋白酶体时，铜与半胱氨酸相互作用 31的蛋白酶体的β2亚基，并进一步与蛋白酶体的β3亚基的半胱氨酸118相互作用，从而治疗该疾病。 还提供了另外的新型蛋白酶体抑制剂以及鉴定蛋白酶体抑制剂的方法。
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5.发明申请Methods of isolating genes encoding proteins of specific function and of screening for pharmaceutically active agents 审中-公开分离编码特定功能蛋白质的基因和筛选药物活性剂的方法公开(公告)号：US20060240404A1
公开(公告)日：2006-10-26
申请号：US11395172
申请日：2006-04-03
Applicant: Benjamin Geiger , Zvi Kam , Eli Zamir , Alexander Bershadsky , Michael Shtutman , Avri Ben-Ze'ev
Inventor： Benjamin Geiger , Zvi Kam , Eli Zamir , Alexander Bershadsky , Michael Shtutman , Avri Ben-Ze'ev
IPC: C12Q1/00
CPC classification number: C12N15/1086 , C12N15/1051 , G01N33/5076
Abstract: A method of isolating polynucleotides encoding polypeptides affecting an organization of a subcellular organelle or structure of interest is provided. The method comprises: (a) expressing within a plurality of cells an expression library including a plurality of expression constructs each encoding a polypeptide of interest; (b) highlighting the subcellular organelle or structure of interest of the plurality of cells; and (c) isolating a cell or cells of the plurality of cells in which a cellular distribution and/or level of the subcellular organelle or structure of interest is altered to thereby isolate polypeptides capable of affecting the organization of the subcellular organelle or structure of interest.
Abstract translation: 提供了分离编码影响亚细胞器或感兴趣结构的组织的多肽的方法。 该方法包括：（a）在多个细胞内表达包含编码目的多肽的多个表达构建体的表达文库; （b）突出显示多个细胞的亚细胞器或感兴趣的结构; 和（c）分离其中改变细胞分布和/或亚细胞细胞器或结构的水平的多个细胞的细胞或细胞，从而分离能够影响亚细胞器或组织结构的多肽 。
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Patent Agency Ranking
公开(公告)号：US20050121596A1
公开(公告)日：2005-06-09
申请号：US10506860
申请日：2003-03-13
Applicant: Zvi Kam , Benjamin Geiger
Inventor： Zvi Kam , Benjamin Geiger
CPC classification number: G01N21/6458 , G02B7/36 , G02B7/365 , G02B7/38 , G02B21/244
Abstract: An auto-focusing method and device are presented for determining an in-focus position of a sample supported on a substrate plate made of a material transparent with respect to incident electromagnetic radiation. The method utilizes an optical system capable of directing incident electromagnetic radiation towards the sample and collecting reflections of the incident electromagnetic radiation that are to be detected. A focal plane of an objective lens arrangement is located at a predetermined distance from a surface of the substrate, which is opposite to the sample-supporting surface of the substrate. A continuous displacement of the focal plane relative to the substrate along the optical axis of the objective lens arrangement is provided, while concurrently directing the incident radiation towards the sample through the objective lens arrangement to thereby focus the incident radiation to a location at the focal plane of the objective lens arrangement. Reflected components of the electromagnetic radiation to a location objective lens arrangement are continuously detected. The detected reflected components are characterized by a first intensity peak corresponding to an in-focus position of said opposite surface of the substrate, and a second intensity peak spaced in time from the first intensity peak and corresponding to an in-focus position of said sample-supporting surface of the substrate. This technique enables imaging of the sample when in the in-focus position of the sample-supporting surface of the substrate.
Abstract translation: 提出一种自动对焦方法和装置，用于确定由相对于入射电磁辐射透明的材料制成的基板上的样品的对焦位置。 该方法利用一种光学系统，能够将入射的电磁辐射引向样品并收集待检测的入射电磁辐射的反射。 物镜布置的焦平面位于与基板的与样品支撑表面相反的表面的预定距离处。 提供了沿着物镜装置的光轴相对于基板的焦平面的连续位移，同时通过物镜装置同时引导入射辐射朝向样品，从而将入射辐射聚焦到焦平面处的位置 的物镜布置。 连续地检测到位置物镜布置的电磁辐射的反射分量。 检测到的反射分量的特征在于对应于基板的相对表面的对焦位置的第一强度峰值和与第一强度峰值在时间上间隔开并且对应于所述样品的对焦位置的第二强度峰值 支撑表面。 当在基板的样品支撑表面的对焦位置时，该技术能够对样品进行成像。
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公开(公告)号：US5798380A
公开(公告)日：1998-08-25
申请号：US604568
申请日：1996-02-21
Applicant: Paul L. Kaufman , Benjamin Geiger
Inventor： Paul L. Kaufman , Benjamin Geiger
IPC: A61K31/00 , A61K31/365 , A61K31/403 , A61K31/407 , A61K31/427 , A61K31/496 , A61K31/551 , A61K45/06 , A67K31/35
CPC classification number: A61K45/06 , A61K31/00 , A61K31/365 , A61K31/403 , A61K31/407 , A61K31/427 , A61K31/496 , A61K31/551 , Y10S514/912 , Y10S514/913
Abstract: Methods for the treatment of glaucoma are described. The compounds described cause a perturbation of cell adhesions in the trabecular meshwork, mainly via disruption of the associated cytoskeletal structures or the modulation of their interactions with the underlying membrane. Perturbation of these adhesions reduces the resistance of the trabecular meshwork to fluid flow and thereby reduces intraocular pressure.
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公开(公告)号：US20100022626A1
公开(公告)日：2010-01-28
申请号：US11991165
申请日：2006-08-29
Applicant: Benjamin Geiger , Zvi Kam , Suha Naffar-Abu-Amara
Inventor： Benjamin Geiger , Zvi Kam , Suha Naffar-Abu-Amara
IPC: A61K31/7052 , C12N5/00 , A61P35/00
CPC classification number: A61K31/70 , C12N15/113 , C12N2310/11 , C12N2310/12 , C12N2310/14
Abstract: The present invention relates to a method of measuring cell migration, the method comprising (a) contacting a cell with a plurality of polystyrene non-fluorescent beads so as to generate a migratory track; and (b) analyzing at least one morphometric parameter of said migratory track, the morphomotric parameter being indicative of cell migration. The present invention also relates to methods of treating a medical condition associated with cell migration, the method comprising administering to a subject in need thereof a therapeutically effective amount of an agent capable of modulating the activity or expression of genes identified using the above assay, thereby treating the medical condition associated with cell migration.
Abstract translation: 本发明涉及一种测量细胞迁移的方法，所述方法包括：（a）使细胞与多个聚苯乙烯非荧光珠接触以产生迁移轨迹; 和（b）分析所述迁移轨迹的至少一个形态测量参数，所述形态特征参数指示细胞迁移。 本发明还涉及治疗与细胞迁移相关的医学病症的方法，所述方法包括向有需要的受试者施用治疗有效量的能够调节使用上述测定鉴定的基因的活性或表达的试剂，由此 治疗与细胞迁移相关的医学病症。
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公开(公告)号：US07455989B2
公开(公告)日：2008-11-25
申请号：US10524275
申请日：2003-08-17
Applicant: Benjamin Geiger
Inventor： Benjamin Geiger
IPC: C12P21/06
CPC classification number: C12Q1/02 , A61K38/00 , C07K14/415 , C07K16/16 , C07K19/00 , C07K2317/622 , C07K2319/00 , C07K2319/07 , C07K2319/30 , C12Q1/04 , G01N33/5005 , G01N33/5076 , G01N33/5079 , G01N33/5097
Abstract: A polynucleotide encoding a chimeric polypeptide is provided. The chimeric polypeptide includes (a) a first polypeptide region being capable of specifically binding at least one detectable molecule; and (b) a second polypeptide region being capable of specifically binding a biological component or macromolecule or targeting a cellular compartment. Methods utilizing the polynucleotide or the chimeric polypeptide for highlighting a cell compartment, a biological component or macromolecule are also provided.
Abstract translation: 提供编码嵌合多肽的多核苷酸。 嵌合多肽包括（a）能够特异性结合至少一个可检测分子的第一多肽区; 和（b）能够特异性结合生物成分或大分子或靶向细胞隔室的第二多肽区域。 还提供了利用多核苷酸或嵌合多肽突出细胞室，生物成分或大分子的方法。
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公开(公告)号：US07109459B2
公开(公告)日：2006-09-19
申请号：US10506860
申请日：2003-03-13
Applicant: Zvi Kam , Benjamin Geiger
Inventor： Zvi Kam , Benjamin Geiger
CPC classification number: G01N21/6458 , G02B7/36 , G02B7/365 , G02B7/38 , G02B21/244
Abstract: An auto-focusing method and device are presented for determining an in-focus position of a sample supported on a substrate plate made of a material transparent with respect to incident electromagnetic radiation. The method utilizes an optical system capable of directing incident electromagnetic radiation towards the sample and collecting reflections of the incident electromagnetic radiation that are to be detected. A focal plane of an objective lens arrangement is located at a predetermined distance from a surface of the substrate, which is opposite to the sample-supporting surface of the substrate. A continuous displacement of the focal plane relative to the substrate along the optical axis of the objective lens arrangement is provided, while concurrently directing the incident radiation towards the sample through the objective lens arrangement to thereby focus the incident radiation to a location at the focal plane of the objective lens arrangement. Reflected components of the electromagnetic radiation to a location objective lens arrangement are continuously detected. The detected reflected components are characterized by a first intensity peak corresponding to an in-focus position of said opposite surface of the substrate, and a second intensity peak spaced in time from the first intensity peak and corresponding to an in-focus position of said sample-supporting surface of the substrate. This technique enables imaging of the sample when in the in-focus position of the sample-supporting surface of the substrate.
Abstract translation: 提出一种自动对焦方法和装置，用于确定由相对于入射电磁辐射透明的材料制成的基板上的样品的对焦位置。 该方法利用一种光学系统，能够将入射的电磁辐射引向样品并收集待检测的入射电磁辐射的反射。 物镜布置的焦平面位于与基板的与样品支撑表面相反的表面的预定距离处。 提供了沿着物镜装置的光轴相对于基板的焦平面的连续位移，同时通过物镜装置同时引导入射辐射朝向样品，从而将入射辐射聚焦到焦平面处的位置 的物镜布置。 连续地检测到位置物镜布置的电磁辐射的反射分量。 检测到的反射分量的特征在于对应于基板的相对表面的对焦位置的第一强度峰值和与第一强度峰值在时间上间隔开并且对应于所述样品的对焦位置的第二强度峰值 支撑表面。 当在基板的样品支撑表面的对焦位置时，该技术能够对样品进行成像。
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