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公开(公告)号：US20130101608A1
公开(公告)日：2013-04-25
申请号：US13704388
申请日：2011-06-15
Applicant: David Satijn , Sandra Verploegen , Wim Bleeker , Steen Lisby , Jan Van De Winkel , Patrick Van Berkel , Paul Parren
Inventor： David Satijn , Sandra Verploegen , Wim Bleeker , Steen Lisby , Jan Van De Winkel , Patrick Van Berkel , Paul Parren
CPC classification number: A61K47/48561 , A61K45/06 , A61K47/6817 , A61K47/6849 , C07K16/30 , C07K16/36 , C07K2317/21 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92
Abstract: Antibody drug conjugates against tissue factor. Also disclosed are pharmaceutical compositions comprising the antibodies and antibody drug conjugates, and therapeutic and diagnostic methods for using the antibodies and antibody drug conjugates.
Abstract translation: 针对组织因子的抗体药物偶联物。 还公开了包含抗体和抗体药物偶联物的药物组合物，以及使用抗体和抗体药物偶联物的治疗和诊断方法。
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公开(公告)号：US20100325744A1
公开(公告)日：2010-12-23
申请号：US12602404
申请日：2008-05-30
Applicant: Janine Schuurman , Tom Vink , Jan Van De Winkel , Aran Frank Labrijn , Paul Parren , Willem Karel Bleeker , Patrick Van Berkel , Frank Beurskens
Inventor： Janine Schuurman , Tom Vink , Jan Van De Winkel , Aran Frank Labrijn , Paul Parren , Willem Karel Bleeker , Patrick Van Berkel , Frank Beurskens
IPC: A01K67/00 , C07K16/00 , C07K16/18 , C07K16/24 , C07K16/22 , C07K16/40 , C07K16/26 , C07K16/42 , A61K39/395 , A61P35/00 , A61P29/00 , A61P37/00 , C07H21/04 , C12P21/06 , C12N1/21 , C12N5/10 , C12N1/15
CPC classification number: C07K16/00 , C07K16/2812 , C07K16/283 , C07K16/2863 , C07K2317/21 , C07K2317/53 , C07K2317/55 , C07K2317/71 , C07K2317/732 , C07K2317/76 , C07K2317/77
Abstract: The present invention provides non-glycosylated monovalent antibodies with a long half-life when administered in vivo, methods of making such monovalent antibodies, pharmaceutical compositions comprising such antibodies, and uses of the monovalent antibodies.
Abstract translation: 本发明提供了在体内施用时具有长半衰期的非糖基化单价抗体，制备这种单价抗体的方法，包含此类抗体的药物组合物和单价抗体的用途。
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公开(公告)号：US20100303823A1
公开(公告)日：2010-12-02
申请号：US12616615
申请日：2009-11-11
Applicant: Jessica TEELING , Paul PARREN , Ole BAADSGAARD , Debra HUDSON , Jorgen PETERSEN
Inventor： Jessica TEELING , Paul PARREN , Ole BAADSGAARD , Debra HUDSON , Jorgen PETERSEN
IPC: A61K39/395 , A61P29/00 , A61P17/06 , A61P17/00 , A61P3/10 , A61P1/00 , A61P31/12 , A61P31/18 , A61P31/22 , A61P9/00 , A61P9/10 , A61P35/00 , A61P35/04 , A61P17/10
CPC classification number: C07K16/244 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/4241 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/92 , G01N33/6869
Abstract: Isolated human monoclonal antibodies which bind to IL-8 (e.g., human IL-8) are disclosed. The human antibodies can be produced in a hybridoma, transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, hybridomas, and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
Abstract translation: 公开了与IL-8结合的分离的人单克隆抗体（例如人IL-8）。 人抗体可以通过进行V-D-J重组和同种型转换，在能够产生人单克隆抗体多重同种型的杂交瘤，转染瘤或非人转基因动物例如转基因小鼠中产生。 还公开了包含人抗体，非人转基因动物，杂交瘤和产生人抗体的转染瘤的药物组合物，以及使用人抗体的治疗和诊断方法。
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264.发明申请RECOMBINANT FUCOSE MODIFIED MONOVALENT HALF-ANTIBODIES OBTAINED BY MOLECULAR ENGINEERING 审中-公开通过分子工程获得的重组型FUCOSE修饰的单价抗体公开(公告)号：US20100255012A1
公开(公告)日：2010-10-07
申请号：US12602407
申请日：2008-05-30
Applicant: Janine Schuurman , Tom Vink , Jan Van De Winkel , Aran Frank Labrijn , Paul Parren , Willem Karel Bleeker , Frank Beurskens , Patrick Van Berkel
Inventor： Janine Schuurman , Tom Vink , Jan Van De Winkel , Aran Frank Labrijn , Paul Parren , Willem Karel Bleeker , Frank Beurskens , Patrick Van Berkel
CPC classification number: C07K16/1063 , A61K2039/505 , C07K16/00 , C07K16/283 , C07K16/2863 , C07K16/2887 , C07K2317/41 , C07K2317/52 , C07K2317/55 , C07K2317/732 , C07K2317/77
Abstract: Glycosylated monovalent antibodies binding to selected antigens with a low or lacking fucose content, which are capable of inducing antibody dependent cellular cytotoxicity (ADCC) on cells expressing the selected antigens in the presence of effector cells, methods for producing the monovalent antibodies, pharmaceutical compositions comprising such monovalent antibodies and use thereof for different diagnostic and therapeutic applications.
Abstract translation: 能够在效应细胞存在下表达所选抗原的细胞上诱导抗体依赖性细胞毒性（ADCC）的低或不含岩藻糖含量的选定抗原结合的糖基化单价抗体，用于产生单价抗体的方法，包含 这种单价抗体及其用于不同诊断和治疗应用。
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公开(公告)号：US20100092489A1
公开(公告)日：2010-04-15
申请号：US12442808
申请日：2007-09-26
Applicant: Jan Van De Winkel , Paul Parren , Yvo Graus , Judith Oprins , Michel De Weers , Martine Van Vugt , Ole Baadsgaard , Steen Lisby
Inventor： Jan Van De Winkel , Paul Parren , Yvo Graus , Judith Oprins , Michel De Weers , Martine Van Vugt , Ole Baadsgaard , Steen Lisby
IPC: A61K39/395 , A61P35/00
CPC classification number: C07K16/2896 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K2317/34 , A61K2300/00
Abstract: The invention relates to novel method for the treatment of cancer using a combination therapy comprising an antibody that binds CD38, a corticosteroid and a non- corticosteroid chemotherapeutic agent.
Abstract translation: 本发明涉及使用包含结合CD38的抗体，皮质类固醇和非皮质类固醇化学治疗剂的组合疗法治疗癌症的新方法。
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Patent Agency Ranking
公开(公告)号：US20100041874A1
公开(公告)日：2010-02-18
申请号：US12443918
申请日：2007-10-02
Applicant: Arnout F. Gerritsen , Paul Parren , Martijn Bosch , Adina Van Poucke , Mischa Houtkamp
Inventor： Arnout F. Gerritsen , Paul Parren , Martijn Bosch , Adina Van Poucke , Mischa Houtkamp
CPC classification number: G01N33/5008 , C07K16/2896 , C07K2317/77 , G01N33/5014 , G01N33/5052
Abstract: The invention relates to methods for the characterization of monoclonal antibodies, in particular high throughput methods for the characterization of antibodies with respect to internalization and complement activation.
Abstract translation: 本发明涉及用于表征单克隆抗体的方法，特别是关于针对内化和补体激活表征抗体的高通量方法。
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267.发明授权Method for treating psoriasis by administering human antibodies specific for Interleukin 15 (IL-15) 有权通过施用针对白细胞介素15（IL-15）特异性的人抗体治疗牛皮癣的方法公开(公告)号：US07597892B2
公开(公告)日：2009-10-06
申请号：US11827306
申请日：2007-07-11
Applicant: Jan G. J. Van de Winkel , Marcus Antonius Van Dijk , Janine Schuurman , Arnout F. Gerritsen , Ole Baadsgaard , Jørgen Petersen
Inventor： Jan G. J. Van de Winkel , Marcus Antonius Van Dijk , Janine Schuurman , Arnout F. Gerritsen , Ole Baadsgaard , Jørgen Petersen
IPC: A61K39/395
CPC classification number: C07K16/24 , A01K2217/05 , A61K2039/505 , C07K16/244 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , Y10S514/885
Abstract: Isolated human monoclonal antibodies which specifically bind to IL-15 (e.g., human IL-15), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
Abstract translation: 公开了与IL-15（例如人IL-15）特异性结合的分离的人单克隆抗体以及相关的基于抗体的组合物和分子。 人抗体可以通过经历V-D-J重组和同种型转换而在能够产生人单克隆抗体多重同种型的转染瘤或非人转基因动物例如转基因小鼠中产生。 还公开了包含人抗体，非人转基因动物和产生人抗体的杂交瘤的药物组合物，以及使用人抗体的治疗和诊断方法。
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公开(公告)号：US20090226421A1
公开(公告)日：2009-09-10
申请号：US12095023
申请日：2006-11-28
Applicant: Paul Parren , Janine Schuurman , Tom Vink , Willem Karel Bleeker , Jan Van De Winkel , Patrick Van Berkel , Frank Beurskens
Inventor： Paul Parren , Janine Schuurman , Tom Vink , Willem Karel Bleeker , Jan Van De Winkel , Patrick Van Berkel , Frank Beurskens
CPC classification number: C07K16/2863 , C07K16/2812 , C07K16/283 , C07K16/2887 , C07K2317/21 , C07K2317/53 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77
Abstract: The present invention provides monovalent antibodies with a long half-life when administered in vivo, methods of making such monovalent antibodies, pharmaceutical compositions comprising such antibodies, and uses of the monovalent antibodies.
Abstract translation: 本发明提供了在体内施用时具有长半衰期的单价抗体，制备这种单价抗体的方法，包含这种抗体的药物组合物和单价抗体的用途。
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269.发明授权Nucleic acid encoding human antibodies specific for interleukin 15 (IL-15) 有权编码对白介素15（IL-15）特异性的人抗体的核酸公开(公告)号：US07585961B2
公开(公告)日：2009-09-08
申请号：US11827195
申请日：2007-07-11
Applicant: Jan G. J. Van De Winkel , Marcus Antonius Van Dijk , Janine Schuurman , Arnout F. Gerritsen , Ole Baadsgaard , Jørgen Petersen
Inventor： Jan G. J. Van De Winkel , Marcus Antonius Van Dijk , Janine Schuurman , Arnout F. Gerritsen , Ole Baadsgaard , Jørgen Petersen
CPC classification number: C07K16/24 , A01K2217/05 , A61K2039/505 , C07K16/244 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , Y10S514/885
Abstract: Isolated human monoclonal antibodies which specifically bind to IL-15 (e.g., human IL-15), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
Abstract translation: 公开了与IL-15（例如人IL-15）特异性结合的分离的人单克隆抗体以及相关的基于抗体的组合物和分子。 人抗体可以通过经历V-D-J重组和同种型转换而在能够产生人单克隆抗体多重同种型的转染瘤或非人转基因动物例如转基因小鼠中产生。 还公开了包含人抗体，非人转基因动物和产生人抗体的杂交瘤的药物组合物，以及使用人抗体的治疗和诊断方法。
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公开(公告)号：US20080118517A1
公开(公告)日：2008-05-22
申请号：US11823481
申请日：2007-06-27
Applicant: Jessica Teeling , Paul Parren , Ole Baadsgaard , Debra Hudson , Jorgen Petersen
Inventor： Jessica Teeling , Paul Parren , Ole Baadsgaard , Debra Hudson , Jorgen Petersen
IPC: A61K39/395 , C07K16/24
CPC classification number: C07K16/244 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/4241 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/92 , G01N33/6869
Abstract: Isolated human monoclonal antibodies which bind to IL-8 (e.g., human IL-8) are disclosed. The human antibodies can be produced in a hybridoma, transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, hybridomas, and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
Abstract translation: 公开了与IL-8结合的分离的人单克隆抗体（例如人IL-8）。 人抗体可以通过进行V-D-J重组和同种型转换，在能够产生人单克隆抗体多重同种型的杂交瘤，转染瘤或非人转基因动物例如转基因小鼠中产生。 还公开了包含人抗体，非人转基因动物，杂交瘤和产生人抗体的转染瘤的药物组合物，以及使用人抗体的治疗和诊断方法。
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