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公开(公告)号:US11491457B2
公开(公告)日:2022-11-08
申请号:US16635790
申请日:2018-08-01
Applicant: Research Triangle Institute
Inventor: Jian-Ping Shen , Jason S. Norman , Brian S. Turk , Raghubir Gupta
Abstract: Zinc oxide-based sorbents, and processes for preparing and using them are provided, wherein the sorbents are preferably used to remove one or more reduced sulfur species from gas streams. The sorbents contain an active zinc component, optionally in combination with one or more promoter components and/or one or more substantially inert components. The active zinc component is a two-phase material, consisting essentially of a zinc oxide (ZnO) phase and a zinc aluminate (ZnAl2O4) phase. Each of the two phases is characterized by a relatively small crystallite size of typically less than about 50 nm (500 Angstroms). Preferably the sorbents are prepared by using an alkali metal base to convert a precursor mixture, containing a precipitated zinc oxide precursor and a precipitated aluminum oxide precursor, to the two-phase, active zinc oxide containing component, with the resulting sorbent having a sodium level within a desired range.
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公开(公告)号:US11491136B2
公开(公告)日:2022-11-08
申请号:US16485570
申请日:2018-02-13
Applicant: RESEARCH TRIANGLE INSTITUTE
Inventor: Yanan Zhang , Thuy Nguyen
IPC: A61K31/401 , A61P25/04 , A61P25/36 , A61K31/40 , A61P25/00
Abstract: Neuropeptide FF receptor modulators based on a proline scaffold are provided which offer NPFF receptor potencies in the nanomolar range and antagonistic selectivity for the NPFF1 receptor. Methods, compounds and compositions for modulating the function of neuropeptide FF receptors are provided for pharmacotherapies capable of influencing conditions or disorders affected by the neuropeptide FF receptors.
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公开(公告)号:US20220308032A1
公开(公告)日:2022-09-29
申请号:US17616305
申请日:2020-06-05
Applicant: Research Triangle Institute
Inventor: E. Dale Hart , Nichole D. Bynum , Lisa C. Greene , Katherine M. Bollinger , Megan A. Grabenauer , Andrea C. McWilliams
IPC: G01N33/00
Abstract: Provided is a proficiency testing material, and in more particular aspects, a cannabis proficiency testing material comprising: a plant substrate; and at least one chemical and/or microbial contaminant, wherein the at least one chemical and/or microbial contaminant is chemically or physically associated with the plant substrate. Methods of preparing the proficiency testing material and kits including the same are also provided.
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公开(公告)号:US11452970B2
公开(公告)日:2022-09-27
申请号:US16802868
申请日:2020-02-27
Applicant: Research Triangle Institute
Inventor: Qinghe Zheng , Marty Lail , Shaojun Zhou
IPC: B01D53/04 , B01D53/22 , B01D53/047
Abstract: The present disclosure provides methods to use calcium cobalt zirconium perovskites as oxygen-selective sorbents for the separation of oxygen from a gas mixture such as air. Systems and high temperature oxygen detectors are also provided. In a preferred embodiment, the perovskite is configured as a membrane.
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公开(公告)号:US20220160050A1
公开(公告)日:2022-05-26
申请号:US17669759
申请日:2022-02-11
Applicant: Research Triangle Institute
Inventor: James B. CARLSON , Jonathan W. THORNBURG
Abstract: Apparatus for testing an electronic smoking (e-smoking) device includes an electronic circuit for electronically activating an e-smoking device to convert a wicking fluid therein into a plurality of puffs, and a wireless controller for controlling the electronic circuit. The electronic circuit is configured for activating the e-smoking device based on wireless signals received at the wireless controller. The apparatus is further configured for measuring a characteristic of the e-smoking device, wherein, optionally, the characteristic is a rate of conversion of the wicking fluid to vapor as a function of time for the plurality of puffs.
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公开(公告)号:US11292783B2
公开(公告)日:2022-04-05
申请号:US16333849
申请日:2017-09-15
Applicant: Research Triangle Institute
Inventor: Frank Ivy Carroll , Chad M. Kormos , Pauline W. Ondachi , Scott P. Runyon , Hernan A. Navarro , James B. Thomas , S. Wayne Mascarella
IPC: A61K31/472 , C07D217/26 , C07D401/12 , A61P25/34 , A61P25/36 , A61P25/32 , A61P25/18 , A61P25/24 , C07D211/18 , C07D413/12 , C07D487/08 , A61P25/00
Abstract: Potent opioid receptor antagonists of formula (I) and their use as pharmacotherapies for treating depression, anxiety, schizophrenia, eating disorders, and addiction to cocaine, methamphetamine, nicotine, alcohol, and opiates are disclosed. More specifically, the disclosure provides potent and selective kappa opioid receptor antagonist compounds, pharmaceutical compositions of those compounds and uses of those compounds to ameliorate or treat addictions, eating disorders, etc.
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公开(公告)号:US11078411B2
公开(公告)日:2021-08-03
申请号:US16071024
申请日:2017-01-17
Applicant: Research Triangle Institute
Inventor: Leah Marie Johnson , Ginger Denison Rothrock , Chasity Antoninette Norton , Sarah Dorothy Shepherd , Nicolas Daniel Huffman , Jeffrey Brent Mecham
Abstract: The present disclosure relates to delivery and release systems wherein a plurality of particles is provided, and the particles are formed of a vehicle component and a cargo component. The systems and methods particularly can be useful in delivery of various chemicals to a petroleum reservoir. The vehicle component can undergo a change in situ such that at least a portion of the cargo component is released.
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公开(公告)号:US11047787B2
公开(公告)日:2021-06-29
申请号:US16861550
申请日:2020-04-29
Applicant: Research Triangle Institute
Inventor: Anthony Clint Clayton , Howard Jerome Walls , Roger H. Pope
Abstract: An optical system for particle detection. The system includes a sample inlet housing; a sample outlet housing; a detection cavity having an axially surrounding wall and disposed between the sample inlet housing and the sample outlet housing; a light source configured to irradiate light through the detection cavity to particles of a sample fluid flowing inside the wall of the detection cavity; a light detector for detecting the light that is scattered by particles of the sample fluid in the detection cavity; an alignment rail having a base and sidewalls which a) extend from the sample inlet housing to the sample outlet housing and b) connect the sample inlet housing to the sample outlet housing; and the alignment rail comprising a channel formed by the base and the sidewalls, the channel having a channel lateral width fitting to a housing width of at least one of the sample inlet housing and the sample outlet housing, whereby the sample inlet housing, the housing, and the sample outlet housing are held in alignment together.
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公开(公告)号:US20210181172A1
公开(公告)日:2021-06-17
申请号:US17032614
申请日:2020-09-25
Applicant: Research Triangle Institute
Inventor: David S. Ensor , Li Han
Abstract: A chemical sensor and a system and method for sensing a chemical species. The chemical sensor includes a plurality of nanofibers whose electrical impedance varies upon exposure to the chemical species, a substrate supporting and electrically isolating the fibers, a set of electrodes connected to the plurality of fibers at spatially separated points to permit the electrical impedance of the plurality of fibers to be measured, and a membrane encasing the fibers and having a thickness ranging from 50 μm to 5.0 mm. The system includes the chemical sensor, an impedance measuring device coupled to the electrodes and configured to determine an electrical impedance of the plurality of fibers, and an analyzer configured to identify the chemical species based on a change in the electrical impedance.
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公开(公告)号:US10960345B2
公开(公告)日:2021-03-30
申请号:US16058395
申请日:2018-08-08
Applicant: Research Triangle Institute
Inventor: Marty Lail , Luke Coleman
IPC: C07C211/26 , C07C211/27 , C07C211/29 , C07C19/08 , C07C25/13 , C07C31/38 , C07C31/40 , B01D53/14 , B01D53/78 , B01D53/62 , B01D53/56 , B01D53/48 , B01D53/50
Abstract: A solvent system for the removal of acid gases from mixed gas streams is provided. Also provided is a process for removing acid gases from mixed gas streams using the disclosed solvent systems. The solvent systems may be utilized within a gas processing system.
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